Research Topics
Species | David BarkerSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Coronary heart disease: a disorder of growthD J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
Horm Res 59:35-41. 2003....
The developmental origins of well-beingD J P Barker
Division for Developmental Origins of Adult Health and Disease, University of Southampton, Mailpoint 95, Southampton General Hospital, Southampton SO16 6YD, UK
Philos Trans R Soc Lond B Biol Sci 359:1359-66. 2004..A new vision of optimal early human development is emerging, which takes account of health and well-being throughout life...- The developmental origins of insulin resistanceDavid J P Barker
Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
Horm Res 64:2-7. 2005..Improving fetal nutrition remains an important long-term goal... - Mechanisms of disease: in utero programming in the pathogenesis of hypertensionDavid J P Barker
Developmental Origins of Health and Disease Division MP 887, University of Southampton, Princess Anne Hospital, Southampton SO16 5YA, UK
Nat Clin Pract Nephrol 2:700-7. 2006..By monitoring blood pressure, weight, and renal function in children, it might be possible to reduce the risk of cardiovascular and renal disease in later life... - Commentary: Developmental origins of raised serum cholesterolD J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Epidemiol 32:876-7. 2003 - Prenatal influences on stroke mortality in England and WalesDavid J P Barker
Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
Stroke 34:1598-602. 2003..We report on the geographic distribution of stroke mortality in England and Wales and compare it with that in the United States... - The origins of the developmental origins theoryD J P Barker
DOHaD Division, University of Southampton, UK
J Intern Med 261:412-7. 2007..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward... - Maternal and social origins of hypertensionDavid J P Barker
Heart Research Center, Oregon Health and Science University, Portland, USA
Hypertension 50:565-71. 2007.... - A possible link between the pubertal growth of girls and breast cancer in their daughtersDavid J P Barker
Heart Research Center, Oregon Health and Science University, Portland, OR, USA
Am J Hum Biol 20:127-31. 2008.... - Concluding remarks. The Window of Opportunity: Pre-Pregnancy to 24 Months of AgeDavid J P Barker
Developmental Origins of Health and Disease Division, University of Southampton, Princess Anne Hospital, Southampton, UK
Nestle Nutr Workshop Ser Pediatr Program 61:255-60. 2008..We discussed what is known and what needs to be known about (a) growth during this window, (b) critical periods of development, (c) the effects of nutrition, and (d) possible interventions to improve nutrition... - Fetal origins of adult disease: strength of effects and biological basisD J P Barker
Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
Int J Epidemiol 31:1235-9. 2002.... 
Human growth and cardiovascular diseaseDavid J P Barker
Department of Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
Nestle Nutr Workshop Ser Pediatr Program 61:21-38. 2008..CHD and the disorders related to it arise through a series of interactions between environmental influences and the pathways of growth and development that precede them...- A possible link between the pubertal growth of girls and ovarian cancer in their daughtersDavid J P Barker
Heart Research Center, Oregon Health and Science University, Portland, Oregon, USA
Am J Hum Biol 20:659-62. 2008..The maternal sex hormone profile that initiates ovarian cancer may be the product of poor nutrition and growth in early childhood followed by catch-up pre-pubertal growth... - Growth and living conditions in childhood and hypertension in adult life: a longitudinal studyDavid J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
J Hypertens 20:1951-6. 2002..To examine the interplay between childhood growth and living conditions in the development of hypertension... - The midwife, the coincidence, and the hypothesisDavid Barker
University of Southampton, Developmental Origins of Health and Disease Centre, Princess Anne Hospital, Southampton SO16 5YA
BMJ 327:1428-30. 2003 - Trajectories of growth among children who have coronary events as adultsDavid J P Barker
Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
N Engl J Med 353:1802-9. 2005..Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk... - Infant growth and income 50 years laterD J P Barker
DOHaD Division, University of Southampton, UK
Arch Dis Child 90:272-3. 2005..One interpretation of this is that biological processes linked to slow infant growth may lead to lifelong impairment of cognitive function... - The developmental origins of chronic adult diseaseD J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
Acta Paediatr Suppl 93:26-33. 2004..These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth... - Size at birth and resilience to effects of poor living conditions in adult life: longitudinal studyD J Barker
Medical Research Council, Environmental Epidemiology Unit, University of Southampton General Hospital, Southampton SO16 6YD, UK
BMJ 323:1273-6. 2001..To determine whether men who grew slowly in utero or during infancy are more vulnerable to the later effects of poor living conditions on coronary heart disease... - Obesity and early lifeD J P Barker
University of Southampton, Southampton, UK
Obes Rev 8:45-9. 2007 - Fetal programming of coronary heart diseaseDavid J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
Trends Endocrinol Metab 13:364-8. 2002..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth... - The developmental origins of adult diseaseD J P Barker
University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
J Am Coll Nutr 23:588S-595S. 2004..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes... - Coronary heart disease: a disorder of growthS M Robinson
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Proc Nutr Soc 61:537-42. 2002..These effects are compounded by accelerated weight gain, which may represent 'compensatory growth' in childhood... - The developmental origins of adult diseaseD J P Barker
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
Eur J Epidemiol 18:733-6. 2003 - Altered regional blood flow in the fetus: the origins of cardiovascular disease?D J P Barker
Division of Developmental Origins of Adult Health and Disease, University of Southampton, Southampton, United Kingdom
Acta Paediatr 93:1559-60. 2004..CONCLUSION: The long-term consequences of fetal redistribution of blood flow are unknown, but preliminary evidence suggests that there is an increased risk of coronary heart disease and hypertension in later life... - Impact of educational attainment on the quality of young women's dietsS M Robinson
MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
Eur J Clin Nutr 58:1174-80. 2004..This study examines the influence of sociodemographic and anthropometric factors on the quality of the diets of young women in the UK... - Cohort profile: the Hertfordshire cohort studyH E Syddall
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Epidemiol 34:1234-42. 2005 - Constraints on food choices of women in the UK with lower educational attainmentM Barker
Food Choice Group, MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Public Health Nutr 11:1229-37. 2008..The present study aimed to identify factors that influence the food choices of women with lower educational attainment and how women could be helped to improve those choices... - Growth of girls who later develop coronary heart diseaseT Forsen
Southampton General Hospital, Tremona Road, Southampton, UK
Heart 90:20-4. 2004..To determine the path of growth of girls who later develop coronary heart disease... - Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort StudyH E Syddall
Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Am J Epidemiol 161:1074-80. 2005..Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women... - Different indices of fetal growth predict bone size and volumetric density at 4 years of ageNicholas C Harvey
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
J Bone Miner Res 25:920-7. 2010..These results suggest a discordance between influences on skeletal size and volumetric density... - Why women of lower educational attainment struggle to make healthier food choices: the importance of psychological and social factorsWendy Lawrence
University of Southampton, Southampton, UK
Psychol Health 24:1003-20. 2009..These findings provide a starting point for taking forward the design of an intervention to improve the diets of young women... - Components in the interpretation of the high mortality in the county of FinnmarkD J P Barker
MRC Environmental Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
Int J Epidemiol 31:309-10. 2002 - Microalbuminuria in adults after prenatal exposure to the Dutch famineRebecca C Painter
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, The Netherlands
J Am Soc Nephrol 16:189-94. 2005..Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life... - Length of gestation and depressive symptoms at age 60 yearsKatri Raikkonen
Department of Psychology, University of Helsinki, PO Box 9, 00014 University of Helsinki, Finland
Br J Psychiatry 190:469-74. 2007..A non-optimal foetal environment, reflected in smaller birth size and shorter duration of gestation, is a risk factor for compromised health later in life... - Childhood growth and hypertension in later lifeJohan G Eriksson
National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, Helsinki, Finland
Hypertension 49:1415-21. 2007..28 to 1.57). We conclude that 2 different paths of childhood growth precede the development of hypertension. We suggest that they lead to hypertension through different biological mechanisms and may respond differently to medication... - Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growthEero Kajantie
Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
J Clin Endocrinol Metab 88:1059-65. 2003..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis... - Pathways of infant and childhood growth that lead to type 2 diabetesJohan G Eriksson
National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
Diabetes Care 26:3006-10. 2003..The aim of this study was to explore the pathways of infant and early growth that lead to type 2 diabetes in adult life... - Infant growth and stroke in adult life: the Helsinki birth cohort studyClive Osmond
MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
Stroke 38:264-70. 2007..People who had low birth weight are at increased risk of stroke. Little is known about the effects of early postnatal growth on stroke risk... - Perceived health of adults after prenatal exposure to the Dutch famineTessa J Roseboom
Department of Clinical Epidemiology and Biostatistics, ObsteAcademic Medical Centre Amsterdam, The Netherlands
Paediatr Perinat Epidemiol 17:391-7. 2003..Because poor perceived health is a strong predictor of mortality, we may expect increased mortality in people who were exposed to famine in early gestation in the future... - Self-perpetuating effects of birth size on blood pressure levels in elderly peopleHilkka Ylihärsilä
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsink, Finland
Hypertension 41:446-50. 2003..Among elderly people with established hypertension, these processes have a strong effect on blood pressure levels, because they are processes that do not respond well to treatment... - Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 yearsEero Kajantie
National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Mannerheimintie 166, 00300 Helsinki, Finland
J Clin Endocrinol Metab 92:4094-100. 2007..Studies in humans and animals have suggested intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA) function as an important mechanism in linking fetal life conditions with adult disease... - Relationship between polycystic ovaries, body mass index and insulin resistanceJanet Cresswell
University Department of Obstetrics and Gynecology, Northern General Hospital, Sheffield, UK
Acta Obstet Gynecol Scand 82:61-4. 2003..To investigate insulin levels in lean and overweight women with and without polycystic ovaries. An observational, cross-sectional study at The Northem General Hospital, Sheffield, UK... - Size at birth, gestational age and cortisol secretion in adult life: foetal programming of both hyper- and hypocortisolism?Eero Kajantie
The Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
Clin Endocrinol (Oxf) 57:635-41. 2002..We set out to study reasons for this discrepancy by examining the relationship between adult HPA axis function and birthweight and body proportions at birth in a group of elderly subjects with detailed birth records... - Exercise protects against glucose intolerance in individuals with a small body size at birthJohan G Eriksson
Department of Epidemiology and Health Promotion, National Public Health Institute, FIN 00300 Helsinki, Finland
Prev Med 39:164-7. 2004..We investigated whether regular exercise is related to lower rates of glucose intolerance in individuals with a small body size at birth and whether birth size affects exercise habits in adulthood... - The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birthJohan G Eriksson
Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
Diabetes 51:2321-4. 2002..We suggest that these findings reflect gene-environment interaction... - Infant growth and hostility in adult lifeKatri Rikkönen
Department of Psychology, University of Helsinki, P O Box 9 Siltavuorenpenger 20 D, 00014 University of Helsinki, Finland
Psychosom Med 70:306-13. 2008..A common origin in suboptimal fetal and early postnatal life may lie beneath. This study tested whether prenatal and postnatal growth predicts hostility in adult life... - Body size at birth and socio-economic status in childhood: implications for Cloninger's psychobiological model of temperament at age 60Jari Lahti
Department of Psychology, University of Helsinki, Helsinki, Finland
Psychiatry Res 160:167-74. 2008.... - Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhoodEero Kajantie
National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, 00300 Helsinki, Finland
J Clin Endocrinol Metab 91:4953-6. 2006..The relationships of early growth with coronary heart disease and type 2 diabetes have received considerable attention. It is not known whether fetal or childhood growth is linked with autoimmune disorders... - Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor geneAnna Rautanen
Department of Medical Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
J Clin Endocrinol Metab 91:4544-51. 2006..Small body size at birth is associated with cardiovascular disease and type 2 diabetes in adult life. This link may be in part mediated by early-life programming of the hypothalamic-pituitary-adrenal axis (HPAA) function... - Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene clusterIan N M Day
Human Genetics Division, Duthie Building Mp808, Tremona Road, School of Medicine, Southampton University Hospital, Southampton, United Kingdom SO16 6YD
J Clin Endocrinol Metab 89:5569-76. 2004..GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome... - The infant growth of boys who later develop coronary heart diseaseTom J Forsen
National Public Health Institute, Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, Helsinki, Finland
Ann Med 36:389-92. 2004..The association between low birth-weight and coronary heart disease has been repeatedly shown. Only two previous studies have examined the effects of weight gain during infancy and later coronary heart disease... - Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-yearsEero Kajantie
National Public Health Institute, Helsinki, Finland
Int J Epidemiol 34:655-63. 2005..Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documented... - Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medicationHilkka Ylihärsilä
National Public Health Institute, Helsinki, University of Helsinki, Finland
J Hypertens 22:1283-7. 2004..We examined whether the association between small body size at birth and adult blood pressure is modulated by PPAR-gamma 2 gene polymorphism, and whether the use of any class of antihypertensive medication is related to birth size... - The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birthAgata Kubaszek
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
J Clin Endocrinol Metab 89:2044-7. 2004..We conclude that the interaction between the K121Q polymorphism of the PC-1 gene and birth length affects insulin sensitivity and increases susceptibility to type 2 diabetes and hypertension in adulthood... - Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthoodSantosh K Bhargava
Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
N Engl J Med 350:865-75. 2004..Crossing into higher categories of body-mass index after the age of two years is also associated with these disorders... - Developmental antecedents of cardiovascular disease: a historical perspectiveDavid J P Barker
Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
J Am Soc Nephrol 16:2537-44. 2005..One such process is altered renal development, with reduced nephron numbers, which may initiate hypertension... - Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohortHarshpal S Sachdev
Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
Am J Clin Nutr 82:456-66. 2005..South Asians have a muscle-thin but adipose body phenotype and high rates of obesity-related disease. Adult body composition may be predictable in early life... - Adult mortality at age 57 after prenatal exposure to the Dutch famineRebecca C Painter
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, P O Box 22660, 1100 DD, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
Eur J Epidemiol 20:673-6. 2005..Follow-up of this cohort will resolve whether famine exposure is linked to increased adult mortality... - Adult consequences of fetal growth restrictionDavid J P Barker
Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
Clin Obstet Gynecol 49:270-83. 2006..Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them... - Cardiovascular disease in survivors of the Dutch famineAnita C J Ravelli
Department Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Nestle Nutr Workshop Ser Pediatr Program 55:183-91; discussion 191-5. 2005 - Birthsize, gestational age and adrenal function in adult life: studies of dexamethasone suppression and ACTH1-24 stimulationEero Kajantie
National Public Health Institute, 00300 Helsinki, Finland
Eur J Endocrinol 149:569-75. 2003..We have now extended these findings by examining the relationship between birthweight, gestational age and tests of adrenal suppression and stimulation... - Cohort profile: The Southampton Women's SurveyHazel M Inskip
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Epidemiol 35:42-8. 2006 - Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort studyEero Kajantie
The National Public Health Institute, Helsinki, Finland
Int J Epidemiol 37:280-9. 2008..We tested the hypothesis that this path of growth is associated with an atherogenic lipid profile in later life... - Paternal skeletal size predicts intrauterine bone mineral accrualN C Harvey
Medical Research Council Epidemiology Resource Centre, University of Southampton, and Southampton General Hospital, Southampton, United Kingdom
J Clin Endocrinol Metab 93:1676-81. 2008..However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring... - Size at birth, the metabolic syndrome and 24-h salivary cortisol profileEero Kajantie
National Public Health Institute, Helsinki, Finland
Clin Endocrinol (Oxf) 60:201-7. 2004..Our aim was to assess whether HPAA activity in everyday living circumstances is related to the metabolic syndrome and size at birth... - Associations between birth weight and antihypertensive medication in black and white medicaid recipientsDaniel T Lackland
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Hypertension 39:179-83. 2002.... - Birth weight and hypertensionDavid J P Barker
Hypertension 48:357-8. 2006 - The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weightEero Kajantie
National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
J Clin Endocrinol Metab 89:5738-41. 2004..We suggest that these findings reflect interactions between genotype and intrauterine environment with resulting changes in gene expression...