C Ballard

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi APOE epsilon4 and cognitive decline in older stroke patients with early cognitive impairment
    C G Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK
    Neurology 63:1399-402. 2004
  2. ncbi The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease
    C Ballard
    Reader in Old Age Psychiatry, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 16:499-503. 2001
  3. ncbi Attention and fluctuating attention in patients with dementia with Lewy bodies and Alzheimer disease
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle, England NE4 6BE
    Arch Neurol 58:977-82. 2001
  4. ncbi The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities
    Clive G Ballard
    Institute for Aging and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 65:23-8. 2004
  5. ncbi Can psychiatric liaison reduce neuroleptic use and reduce health service utilization for dementia patients residing in care facilities
    Clive Ballard
    Newcastle General Hospital, Newcastle, UK
    Int J Geriatr Psychiatry 17:140-5. 2002
  6. ncbi A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies
    Clive Ballard
    Institute for the Health of the Elderly, University of Newcastle, Newcastle, UK
    J Affect Disord 69:219-23. 2002
  7. ncbi Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:553-8. 2002
  8. ncbi Mild cognitive impairment and vascular cognitive impairment in stroke patients
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Int Psychogeriatr 15:123-6. 2003
  9. ncbi Fluctuations in attention: PD dementia vs DLB with parkinsonism
    C G Ballard
    Institute for Ageing and Health, University of Newcastle, UK
    Neurology 59:1714-20. 2002
  10. ncbi Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004

Collaborators

Detail Information

Publications66

  1. ncbi APOE epsilon4 and cognitive decline in older stroke patients with early cognitive impairment
    C G Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK
    Neurology 63:1399-402. 2004
    ..Dementia is common post stroke, but the potential role of early cognitive impairment and APOE epsilon4 as risk factors is unclear...
  2. ncbi The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease
    C Ballard
    Reader in Old Age Psychiatry, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 16:499-503. 2001
    ..Little is known about the rate of progression or associations of cognitive impairment in dementia with Lewy bodies (DLB), or the associations of accelerated decline...
  3. ncbi Attention and fluctuating attention in patients with dementia with Lewy bodies and Alzheimer disease
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle, England NE4 6BE
    Arch Neurol 58:977-82. 2001
    ....
  4. ncbi The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities
    Clive G Ballard
    Institute for Aging and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 65:23-8. 2004
    ..g., side effects) and hence enable physicians to make rational treatment choices between different pharmacologic agents...
  5. ncbi Can psychiatric liaison reduce neuroleptic use and reduce health service utilization for dementia patients residing in care facilities
    Clive Ballard
    Newcastle General Hospital, Newcastle, UK
    Int J Geriatr Psychiatry 17:140-5. 2002
    ..The quality of care and overuse of neuroleptic medication in care environments are major issues in the care of elderly people with dementia...
  6. ncbi A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies
    Clive Ballard
    Institute for the Health of the Elderly, University of Newcastle, Newcastle, UK
    J Affect Disord 69:219-23. 2002
    ..The neurochemical basis for depression in DLB has not been investigated...
  7. ncbi Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:553-8. 2002
    ..We conducted a placebo-controlled trial to determine the value of aromatherapy with essential oil of Melissa officinalis (lemon balm) for agitation in people with severe dementia...
  8. ncbi Mild cognitive impairment and vascular cognitive impairment in stroke patients
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Int Psychogeriatr 15:123-6. 2003
    ..Given this large disparity, prospective studies to clarify the utility of different criteria as a predictor of subsequent dementia are a priority...
  9. ncbi Fluctuations in attention: PD dementia vs DLB with parkinsonism
    C G Ballard
    Institute for Ageing and Health, University of Newcastle, UK
    Neurology 59:1714-20. 2002
    ..The comparative impairment of these cognitive domains in PD and PD dementia (PD dementia) has not been studied, and is important to the conceptual understanding of parkinsonian dementias...
  10. ncbi Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004
    ..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies...
  11. ncbi Profile of neuropsychological deficits in older stroke survivors without dementia
    Clive Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Dement Geriatr Cogn Disord 16:52-6. 2003
    ..Few studies have examined the profile of cognitive impairments in older stroke patients without dementia...
  12. ncbi Prospective follow-up study between 3 and 15 months after stroke: improvements and decline in cognitive function among dementia-free stroke survivors >75 years of age
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Rd, Newcastle NE4 6BE UK
    Stroke 34:2440-4. 2003
    ..Poststroke cognitive impairment is frequent. There are, however, few longitudinal studies examining delayed changes in poststroke cognition...
  13. ncbi A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    J Clin Psychiatry 65:114-9. 2004
    ..Although few placebo-controlled neuroleptic discontinuation studies have been conducted in people with dementia, such studies are essential to inform key clinical decisions...
  14. ncbi Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England, UK
    Int Psychogeriatr 13:93-106. 2001
    ..02; SW 11.4% vs. 2.7%, t = 3.0, p = .004; EA 56.5% vs. 71.9%; t = 3.5, p = .001) were associated with reduced QOL, but symptoms from the NPI were not. More focused prescribing of psychotropics and better staff training are essential...
  15. ncbi The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: persistence and new cases over 1 year of follow-up
    C G Ballard
    Medical Research Council, Neurochemical Pathology Unit, Newcastle upon Tyne, England
    J Clin Psychiatry 62:46-9. 2001
    ..Few data are available regarding the natural course of psychiatric symptoms in dementia with Lewy bodies and Alzheimer's disease. To acquire this information is essential to inform differential diagnosis and treatment decisions...
  16. ncbi Neurocardiovascular instability, hypotensive episodes, and MRI lesions in neurodegenerative dementia
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 903:442-5. 2000
    ..Further longitudinal studies need to investigate the direction of causality to determine whether CSH or OH predispose to MRI hyperintensities and accelerate cognitive decline...
  17. ncbi One year follow-up of parkinsonism in dementia with Lewy bodies
    C Ballard
    MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 11:219-22. 2000
    ..Parkinsonism was frequent at all severities in DLB patients, but usually only present in other dementias when MMSE <10...
  18. ncbi Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes
    C Ballard
    MRC Neurochemical Pathology Unit, Newcastle General Hospital, UK
    Dement Geriatr Cogn Disord 11:59-65. 2000
    ..Microinfarction was also significantly associated with major depression...
  19. ncbi Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 56:961-5. 1999
    ..To examine the relationship between the apolipoprotein E (APOE) epsilon4 genotype, medial temporal lobe atrophy, and white matter hyperintensities on magnetic resonance imaging in late-life dementias...
  20. ncbi Impact of hypertension and apolipoprotein E4 on poststroke cognition in subjects >75 years of age
    E Rowan
    Institute for Aging and Health, University of Newcastle upon Tyne, UK
    Stroke 36:1864-8. 2005
    ..We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke...
  21. ncbi A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 12:198-205. 2001
    ....
  22. pmc White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 67:66-72. 1999
    ....
  23. ncbi The characterisation and impact of 'fluctuating' cognition in dementia with Lewy bodies and Alzheimer's disease
    C Ballard
    Institute of Health for the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 16:494-8. 2001
    ..CONCLUSIONS: Although attention is the cognitive domain which fluctuates most markedly, other cognitive domains are also affected. FC also has a significant independent impact on activities of daily living...
  24. ncbi MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 15:911-6. 2000
    ..In particular, PVH appear to be linked to atrophic processes involving ventricular enlargement and DWMH to ischaemic risk factors...
  25. ncbi Medial temporal lobe width on CT scanning in Alzheimer's disease: comparison with vascular dementia, depression and dementia with Lewy bodies
    J T O'Brien
    Institute for the Health of the Elderly, University of Newcastle upon Tyne, Glasgow, UK
    Dement Geriatr Cogn Disord 11:114-8. 2000
    ..We conclude that a single cross-sectional measurement of MTL width on CT does not help differentiate between different types of dementia, though it may provide some supportive evidence when distinguishing depression from dementia...
  26. ncbi Medial temporal lobe atrophy on MRI in dementia with Lewy bodies
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 52:1153-8. 1999
    ....
  27. ncbi Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
    J T O'Brien
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Neurology 56:1386-8. 2001
    ..The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia...
  28. ncbi Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution
    M A Piggott
    MRC Neurochemical Pathology Unit, Department of Neuropathology, Old Age Psychiatry, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Brain 122:1449-68. 1999
    ..The distinct changes in the rostrocaudal pattern of expression of dopaminergic parameters are relevant to the interpretation of the in vivo imaging and diagnosis of DLB...
  29. ncbi Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments
    M Margallo-Lana
    Centre for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Int J Geriatr Psychiatry 16:39-44. 2001
    ..More rigorous guidelines are needed pertaining to the prescription and monitoring of medication and the need to disseminate skills regarding psychosocial management approaches to care staff...
  30. ncbi MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 54:1304-9. 2000
    ..To compare global and regional atrophy on MRI in subjects with dementia with Lewy bodies (DLB), AD, vascular dementia (VaD), and normal aging. In addition, the relationship between APOE-epsilon4 genotype and volumetric indices was examined...
  31. ncbi Definition and diagnosis of dementia with Lewy bodies
    Clive G Ballard
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 17:15-24. 2004
    ....
  32. ncbi Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI
    H A Middelkoop
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 57:2117-20. 2001
    ..There were no significant differences between groups in occipital lobe volume. The authors conclude gross structural changes in the occipital lobe do not occur in patients with mild to moderate DLB or AD...
  33. ncbi Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD
    K Lobotesis
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 56:643-9. 2001
    ..Although not diagnostically specific in individual cases, occipital hypoperfusion on SPECT should raise suspicion that DLB may be the cause of dementia, prompting careful search for other features of the disorder...
  34. pmc Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 72:406-7. 2002
    ..To determine whether parkinsonian symptoms in dementia with Lewy bodies (DLB) are associated with greater atrophy of the caudate nucleus in comparison with patients with Alzheimer's disease (AD) and vascular dementia (VaD)...
  35. ncbi Dementia with Lewy bodies: clinical features and treatment
    S Campbell
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Drugs Aging 18:397-407. 2001
    ....
  36. ncbi Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
    Thanasak Teaktong
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE, UK
    Behav Brain Res 161:299-305. 2005
    ..Upregulation of M2 and M4 muscarinic receptors in cingulate and adjacent cortex may thus contribute to the development of psychosis in DLB, with potential implications for treatments with drugs acting on these receptors...
  37. ncbi Absence of cholinergic deficits in "pure" vascular dementia
    E Perry
    Newcastle General Hospital, MRC Bldg, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK
    Neurology 64:132-3. 2005
    ..8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients...
  38. ncbi Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease
    C Ballard
    Medical Research Council Neurochemical Pathology Unit, Newcastle General Hospital, U K
    Am J Psychiatry 156:1039-45. 1999
    ..The authors intended to clarify the frequency of psychiatric morbidity in dementia with Lewy bodies and how it differs from probable Alzheimer's disease...
  39. ncbi Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    Am J Psychiatry 157:1682-4. 2000
    ..The authors investigated this association by determining whether intercellular adhesion molecule-1 (ICAM-1), a marker of ischemia-induced inflammation, is elevated in the dorsolateral prefrontal cortex in depression...
  40. pmc Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions
    R A Kenny
    MRC Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 75:966-71. 2004
    ..Carotid sinus syndrome (CSS) is a common cause of syncope in older persons. There appears to be a high prevalence of carotid sinus hypersensitivity (CSH) in patients with dementia with Lewy bodies (DLB) but not in Alzheimer's disease...
  41. ncbi Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias
    Louise M Allan
    Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom
    J Am Geriatr Soc 53:1681-7. 2005
    ....
  42. pmc Incidence and prediction of falls in dementia: a prospective study in older people
    Louise M Allan
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    PLoS ONE 4:e5521. 2009
    ..This prospective study aimed to identify modifiable risk factors for falling in older people with mild to moderate dementia...
  43. ncbi Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
    ..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB...
  44. ncbi Lewy body disease: thalamic cholinergic activity related to dementia and parkinsonism
    Iryna Ziabreva
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 27:433-8. 2006
    ..These findings show that significant thalamic presynaptic cholinergic deficits occur only in cases of combined cortical and subcortical neurodegeneration in which dementia developed after prolonged parkinsonism...
  45. ncbi Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
    ..D2 receptor binding did not vary with cognitive decline (MMSE) or visual hallucinations, but was significantly higher with increased extrapyramidal symptoms...
  46. ncbi Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
    ..Similar to other common dementias consensus criteria for VaD need unambiguous definition to impact on preventative and treatment strategies and are critical for selective recruitment to clinical trials...
  47. ncbi Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  48. ncbi Stroke and cognition
    R N Kalaria
    CBV Group, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Curr Atheroscler Rep 3:334-9. 2001
    ..Although several neurotransmitter systems may be affected in post-stroke dementia, the amelioration of cholinergic function is a worthy target...
  49. ncbi Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
    E Perry
    Department of Neuropathology, MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle, UK
    Eur J Pharmacol 393:215-22. 2000
    ..These findings indicate an early involvement of the alpha4 subunit in beta-amyloidosis but not in nigro-striatal dopaminergic degeneration...
  50. ncbi Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment
    Andrea Tasker
    Institute for Ageing and Health, MRC Building, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Expert Rev Neurother 5:101-6. 2005
    ..It is a priority for future clinical trials to determine whether agents which inhibit butyrylcholinesterase and acetylcholinesterase have a greater clinical efficacy...
  51. ncbi Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex
    Clive G Ballard
    Centre Development in Clinical Brain Aging, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, London, UK
    Conscious Cogn 11:461-74. 2002
    ....
  52. ncbi Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium
    David P Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:390-4. 2007
    ..Accurate prediction is imperative for clinical trials and prevention strategies...
  53. ncbi Effectiveness and acceptability of non-pharmacological interventions to reduce wandering in dementia: a systematic review
    L Robinson
    Centre for Health Services Research, University of Newcastle, School of Population and Health Sciences, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 22:9-22. 2007
    ....
  54. ncbi Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008
    ..Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p=0.009)...
  55. ncbi Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementia
    Sally Stephens
    University of Newcastle, UK
    J Am Geriatr Soc 53:103-7. 2005
    ..To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia...
  56. ncbi Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies
    Andrew B Singleton
    Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:167-75. 2002
    ..This study demonstrates that DLB shares the APO epsilon4 allele with AD as a common risk factor, but that there are differences in the way the epsilon4 allele affects the phenotypic expression of disease...
  57. ncbi Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    ..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
  58. ncbi Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans
    Rafiqul I Hussain
    MRC Building, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Neurosci Lett 317:13-6. 2002
    ..Given the contrasting findings between reports of altered TF C2 allele frequencies, the TF locus would not appear to be a strong risk factor for AD in this population...
  59. ncbi Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital, Rogaland, Stavanger, Norway
    J Clin Psychiatry 66:633-7. 2005
    ..Severe sensitivity to neuroleptic agents is a major clinical problem in dementia with Lewy bodies (DLB), but has not been determined in Parkinson's disease (PD) and PD with dementia (PDD)...
  60. ncbi An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
    Andrew B Scholey
    Brain Sciences Institute, Swinburne University, Melbourne, Vic, 3122, Australia
    Psychopharmacology (Berl) 198:127-39. 2008
    ..In recent controlled trials, administration of sage extracts with established cholinergic properties improved cognitive function in young adults...
  61. ncbi Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies
    Gordon K Wilcock
    From the Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK
    J Clin Psychiatry 69:341-8. 2008
    ..The current retrospective analysis evaluated the efficacy and safety of memantine in a subpopulation of patients with Alzheimer's disease exhibiting behavioral symptoms of agitation/aggression or psychosis at baseline...
  62. ncbi Donepezil for the treatment of agitation in Alzheimer's disease
    Robert J Howard
    Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    N Engl J Med 357:1382-92. 2007
    ..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear...
  63. ncbi Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease
    Sally I Sharp
    King s College London, Wolfson Centre for Age Related Diseases, UK
    Am J Geriatr Psychiatry 15:435-7. 2007
    ..Aggressive behavior in dementia is a major clinical management problem...
  64. ncbi Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia
    Ezra Mulugeta
    Wolfson Centre for Age Related Diseases, Institute of Psychiatry, King s College London, London, UK
    Dement Geriatr Cogn Disord 25:278-86. 2008
    ....
  65. ncbi Endogenous neurogenesis in the human brain following cerebral infarction
    Stephen L Minger
    Stem Cell Biology Laboratory, Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Regen Med 2:69-74. 2007
    ....
  66. ncbi Cholinesterases: roles in the brain during health and disease
    Clive G Ballard
    Department of Biomedical Sciences, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, King s College, London, SE1 1UL, UK
    Curr Alzheimer Res 2:307-18. 2005
    ..Focusing on new findings relating to BuChE, we review recent evidence that has extended knowledge into the roles of ChEs in health, disease and aging...