J G Baker
Affiliation: University of Nottingham
Baker J, Proudman R, Hill S. Salmeterol's extreme Î²2 selectivity is due to residues in both extracellular loops and transmembrane domains. Mol Pharmacol. 2015;87:103-20 pubmed publisher
..This suggests that the high affinity and selectivity of salmeterol are due to specific amino acids within the receptor itself, but that the duration of action is at least in part due to other factors, for example lipophilicity. ..
Baker J, Hill S. A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. J Pharmacol Exp Ther. 2007;320:218-28 pubmed
..This was true even when the receptor was shown, in the same assay, to exist in two different conformational states coupled to two different G proteins. ..
Baker J. A study of antagonist affinities for the human histamine H2 receptor. Br J Pharmacol. 2008;153:1011-21 pubmed
..Each GPCR therefore requires careful and detailed evaluation on its own. ..
Baker J. A full pharmacological analysis of the three turkey Î²-adrenoceptors and comparison with the human Î²-adrenoceptors. PLoS ONE. 2010;5:e15487 pubmed publisher
..Furthermore, comparison of the amino-acid sequence for the turkey and human adrenoceptors may therefore shed more light on the residues involved in the existence of the secondary Î²-adrenoceptor conformation. ..
Baker J, Proudman R, Tate C. The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (?36) deletions essential for crystallisation of the turkey ?-adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:71-91 pubmed publisher
Baker J, Kemp P, March J, Fretwell L, Hill S, Gardiner S. Predicting in vivo cardiovascular properties of ?-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 2011;25:4486-97 pubmed publisher
..Bucindolol, however, significantly antagonized the response to the highest doses isoprenaline. An excellent correlation was obtained between in vivo and in vitro measures of ?1-adrenoceptor efficacy (R(2)=0.93; P<0.0001)...
Baker J. The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors. Br J Pharmacol. 2010;160:1048-61 pubmed publisher
..This study examined the affinity and intrinsic efficacy of 31 beta-adrenoceptor agonists at the three human beta-adrenoceptors to determine whether the current agonists are subtype selective because of affinity or intrinsic efficacy...
Baker J, Gardiner S, Woolard J, Fromont C, Jadhav G, Mistry S, et al
. Novel selective ?1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB J. 2017;31:3150-3166 pubmed publisher
..M., Woolard, J., Fromont, C., Jadhav, G. P., Mistry, S. N., Thompson, K. S. J., Kellam, B., Hill, S. J., Fischer, P. M. Novel selective ?1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. ..