J G Baker

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor
    Jillian G Baker
    Cell Signalling, School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
    PLoS ONE 8:e77582. 2013
  2. pmc Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells
    Jillian G Baker
    Institute of Cell Signalling, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    BMC Pharmacol 8:9. 2008
  3. ncbi request reprint A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 320:218-28. 2007
  4. ncbi request reprint Evidence for a secondary state of the human beta3-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Mol Pharmacol 68:1645-55. 2005
  5. ncbi request reprint Site of action of beta-ligands at the human beta1-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham, UK
    J Pharmacol Exp Ther 313:1163-71. 2005
  6. pmc The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Pharmacol 144:317-22. 2005
  7. pmc A study of antagonist affinities for the human histamine H2 receptor
    J G Baker
    Institute of Cell Signalling, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Pharmacol 153:1011-21. 2008
  8. pmc The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Pharmacol 160:1048-61. 2010
  9. pmc A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e15487. 2010
  10. pmc The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, University of Nottingham, Queen s Medical Centre, UK
    Naunyn Schmiedebergs Arch Pharmacol 384:71-91. 2011

Collaborators

Detail Information

Publications24

  1. pmc Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor
    Jillian G Baker
    Cell Signalling, School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
    PLoS ONE 8:e77582. 2013
    ....
  2. pmc Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells
    Jillian G Baker
    Institute of Cell Signalling, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    BMC Pharmacol 8:9. 2008
    ....
  3. ncbi request reprint A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Pharmacol Exp Ther 320:218-28. 2007
    ..This was true even when the receptor was shown, in the same assay, to exist in two different conformational states coupled to two different G proteins...
  4. ncbi request reprint Evidence for a secondary state of the human beta3-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Mol Pharmacol 68:1645-55. 2005
    ..Both conformations are present in living cells and can be distinguished by their pharmacological characteristics. In this respect, the human beta3-adrenoceptor seems similar to the human beta1-adrenoceptor...
  5. ncbi request reprint Site of action of beta-ligands at the human beta1-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham, UK
    J Pharmacol Exp Ther 313:1163-71. 2005
    ..g., CGP 12177 [(-)-4-(3-tert-butylamino-2-hydroxypropoxy)-benzimidazol-2-one]), whereas the others (e.g., catecholamines) activate both sites to differing degrees...
  6. pmc The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Pharmacol 144:317-22. 2005
    ..There is therefore considerable potential for developing more selective beta-antagonists for clinical use and thereby reducing the side-effect profile of beta-blockers...
  7. pmc A study of antagonist affinities for the human histamine H2 receptor
    J G Baker
    Institute of Cell Signalling, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Pharmacol 153:1011-21. 2008
    ..This study evaluated antagonist affinity measurements at a different G(s)-coupled receptor, the histamine H(2) receptor, to determine whether antagonist affinity measurements made at a different family of GPCRs were constant...
  8. pmc The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Pharmacol 160:1048-61. 2010
    ..This study examined the affinity and intrinsic efficacy of 31 beta-adrenoceptor agonists at the three human beta-adrenoceptors to determine whether the current agonists are subtype selective because of affinity or intrinsic efficacy...
  9. pmc A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors
    Jillian G Baker
    Institute of Cell Signalling, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e15487. 2010
    ..This study examined the similarities and differences between these avian receptors and mammalian receptors with regards to binding characteristics and functional high and low affinity agonist conformations...
  10. pmc The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor
    Jillian G Baker
    Institute of Cell Signalling, C Floor Medical School, University of Nottingham, Queen s Medical Centre, UK
    Naunyn Schmiedebergs Arch Pharmacol 384:71-91. 2011
    ....
  11. pmc Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses
    Jillian G Baker
    Institute of Cell Signalling, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    FASEB J 25:4486-97. 2011
    ..Bucindolol, however, significantly antagonized the response to the highest doses isoprenaline. An excellent correlation was obtained between in vivo and in vitro measures of β1-adrenoceptor efficacy (R(2)=0.93; P<0.0001)...
  12. pmc Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands
    Jillian G Baker
    Institute of Cell Signalling, School of Biomedical Sciences, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Br J Pharmacol 159:772-86. 2010
    ..This study evaluated how the physicochemical nature of the linker and the fluorophore affected the pharmacological properties of fluorescent agonists and antagonists...
  13. ncbi request reprint Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 63:1312-21. 2003
    ..The different responses to beta-blockers seen in the clinic may therefore be caused in part by these beta-blocker agonist responses and the differential activation of the two sites or conformations...
  14. pmc Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor
    Jillian G Baker
    Institute of Cell Signalling, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 137:400-8. 2002
    ....
  15. doi request reprint Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human beta1-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Mol Pharmacol 74:1246-60. 2008
    ..Modeling studies provide a basis for these overlapping sites with either the tert-butylamino group or the hydroxyethyloxy and imidazolone portions of CGP 12177 capable of forming polar interactions with Asp138 and Asn363...
  16. ncbi request reprint New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells
    Richard J Middleton
    School of Pharmacy, Centre for Biomolecular Sciences, and School of Chemistry, University of Nottingham, University Park, Nottingham, United Kingdom
    J Med Chem 50:782-93. 2007
    ....
  17. pmc Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist
    Jillian G Baker
    Institute of Cell Signalling, C Floor, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Pharmacol 139:232-42. 2003
    ..5 BODIPY-TMR-CGP is therefore a long-acting fluorescent beta(2)-adrenoceptor agonist that can be used to label beta(2)-adrenoceptors in the plasma membrane of living cells...
  18. ncbi request reprint Reporter-gene systems for the study of G-protein-coupled receptors
    S J Hill
    Institute of Cell Signalling, Medical School, University of Nottingham, Queen s Medical Centre, UK
    Curr Opin Pharmacol 1:526-32. 2001
    ..In recent years reporter genes have been applied in academia and industry to the study of ligand efficacy and affinity in recombinant and primary cell lines using a variety of colour, fluorescent or luminescent read-outs...
  19. ncbi request reprint Temporal characteristics of cAMP response element-mediated gene transcription: requirement for sustained cAMP production
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Mol Pharmacol 65:986-98. 2004
    ..g., several clinically used "beta-blockers") may cause more substantial gene transcription than previously believed...
  20. ncbi request reprint Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 64:1357-69. 2003
    ..These data suggest that propranolol can simultaneously act as an inverse agonist through a Gs-coupled mechanism while stimulating the p42/44-MAP kinase pathway through an alternative G-protein-independent mechanism...
  21. ncbi request reprint Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 64:679-88. 2003
    ....
  22. pmc The ups and downs of Gs- to Gi-protein switching
    Stephen J Hill
    Institute of Cell Signalling, Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 138:1188-9. 2003
  23. pmc Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates
    Jillian G Baker
    Institute of Cell Signalling, Medical School, Nottingham, NG7 2UH, UK
    Trends Pharmacol Sci 28:374-81. 2007
    ....
  24. pmc Structure of a beta1-adrenergic G-protein-coupled receptor
    Tony Warne
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 454:486-91. 2008
    ....