Research Topics
| David BakerSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Cannabinoids control spasticity and tremor in a multiple sclerosis modelD Baker
Department of Neurochemistry, Institute of Neurology, University College London, UK
Nature 404:84-7. 2000..This provides a rationale for patients' indications of the therapeutic potential of cannabis in the control of the symptoms of multiple sclerosis, and provides a means of evaluating more selective cannabinoids in the future...- The therapeutic potential of cannabis in multiple sclerosisDavid Baker
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
Expert Opin Investig Drugs 12:561-7. 2003..Cannabinoids provide a novel therapeutic target, not only for controlling symptoms, but also slowing disease progression through inhibition of neurodegeneration, which is the cause of accumulating irreversible disability... - In silico patent searching reveals a new cannabinoid receptorDavid Baker
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
Trends Pharmacol Sci 27:1-4. 2006..This receptor is reported to be expressed in several tissues and might function in lipid or vascular biology. Thus, GPR55 might represent a new cannabinoid receptor... - Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosisJ Ludovic Croxford
Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 1PJ, United Kingdom
J Neuroimmunol 193:120-9. 2008..This further highlights the neuroprotective potential of cannabinoids to slow the progression of MS... - Cannabinoids inhibit neurodegeneration in models of multiple sclerosisGareth Pryce
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Brain 126:2191-202. 2003..Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases... 
A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitisEmma East
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield St, London, WC1N 1PJ, UK
Am J Pathol 167:545-54. 2005....
Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damageClaudie Hooper
Kings College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
J Neurochem 109:694-705. 2009..Thus, exposure of microglia in the brain to albumin may contribute to neuronal damage following blood-brain barrier breakdown and point to resident microglia rather than infiltrating macrophages as therapeutic targets...- Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosisGareth Pryce
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
J Neuroimmunol 165:41-52. 2005.... - Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine inductionMatthew E Gegg
Division of Cellular Therapy, Institute of Ophthalmology, University College London, London, United Kingdom
J Immunol 174:2327-35. 2005..These data highlight the potential differential activity of statins in different inflammatory conditions and their possible therapeutic use for the treatment of human posterior uveitis... - Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 miceLynsey G Bilsland
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
FASEB J 20:1003-5. 2006..Together these results show that cannabinoids have significant neuroprotective effects in this model of ALS and suggest that these beneficial effects may be mediated by non-CB1 receptor mechanisms... - Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitisSharmilee Gnanapavan
Department of Neuroimmunology, Institute of Neurology, London, UK
Autoimmunity 45:298-303. 2012..These data further support neurofilament levels as a good surrogate measure of neurodegeneration and their potential use as a surrogate endpoint in neuroprotective studies... - Cannabinoids and neuroprotection in CNS inflammatory diseaseSamuel J Jackson
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
J Neurol Sci 233:21-5. 2005..However there is accumulating evidence in vitro and in vivo to support the hypothesis that the cannabinoid system can limit the neurodegenerative possesses that drive progressive disease, and may provide a new avenue for disease control... - The therapeutic potential of cannabisDavid Baker
Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK
Lancet Neurol 2:291-8. 2003..Even if the results of these studies are not as positive as many expect them to be, that we are only just beginning to appreciate the huge therapeutic potential of this family of compounds is clear... - Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitisJohn Greenwood
Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
FASEB J 17:905-7. 2003..These studies demonstrate a novel effect of statins in modulating the immune response in neuroinflammtory diseases and may provide additional rationale for their use in the treatment of MS... - Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptorsJason W Brooks
Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
Eur J Pharmacol 439:83-92. 2002..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically... - Potential of statins for the treatment of multiple sclerosisDavid Baker
Neuroinflammation Group, Institute of Neurology, University College London, UK
Lancet Neurol 2:9-10. 2003 - Cannabinoid-mediated neuroprotection following interferon-gamma treatment in a three-dimensional mouse brain aggregate cell cultureSamuel J Jackson
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
Eur J Neurosci 20:2267-75. 2004.... - Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosisClaire E Walters
Department of Cell Biology, Institute of Ophthalmology, and Neuroinflammation Group, University College London, London, United Kingdom
J Immunol 168:4087-94. 2002..These studies demonstrate, for the first time, the potential for pharmacologically targeting CNS EC signaling responses, and particularly endothelial Rho proteins, as a means of attenuating leukocyte recruitment to the CNS... - Interleukin-12 induces mild experimental allergic encephalomyelitis following local central nervous system injury in the Lewis ratZubair Ahmed
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Neuroimmunol 140:109-17. 2003..These results suggest that immune-mediated events in which IL-12 production is stimulated as for example viral infection, superimposed on a brain injury, could provide a trigger for a MS-like pathology... - Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptorsFleur Pinteaux-Jones
Cell Signalling Laboratory, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
J Neurochem 106:442-54. 2008..These data show that myelin-induced microglial neurotoxicity can be prevented by regulation of mGluRs and suggest these receptors on microglia may be promising targets for therapeutic intervention in multiple sclerosis... - Emerging properties of cannabinoid medicines in management of multiple sclerosisGareth Pryce
Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
Trends Neurosci 28:272-6. 2005..This, combined with data from recent clinical trials, points to the prospect of cannabis as a medication in the treatment of multiple sclerosis and numerous other medical conditions... - Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in miceGareth Pryce
Department of Neuroinflammation, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
Neurosci Lett 341:164-6. 2003.... - A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis : inflammation versus degenerationZubair Ahmed
Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
Am J Pathol 161:1577-86. 2002..Because caspase-3 is a downstream cell death signal it may be possible to reduce apoptosis by selectively blocking caspase-3 and therefore provide a therapeutic target for EAE and potentially, multiple sclerosis... - Membrane receptor probes: solid-phase synthesis of biotin-Asp-PEG-arvanil derivativesCristina Visintin
The Wolfson Institute for Biomedical Research, Institute of Neurology, and Department of Chemistry, University College London, Gower Street, London WC1E 6BT, UK
Org Lett 7:1699-702. 2005..The versatility of the method is illustrated through the synthesis of a number of arvanil-derived cannabinoid receptor ligands displaying either a photoaffinity or a chemical cross-linking group... - Pathological and regulatory effects of anti-myelin antibodies in experimental allergic encephalomyelitis in miceMargaret M Morris-Downes
Department of Neuroinflammation, Division of Neurosciences, Imperial College School of Medicine, Charing Cross Campus, London W6 8RF, UK
J Neuroimmunol 125:114-24. 2002.... - Gene therapy in autoimmune, demyelinating disease of the central nervous systemDavid Baker
Institute of Neurology, University College London, UK
Gene Ther 10:844-53. 2003..Targeting of leucocyte activation, cytokines and nerve growth factors have shown some promising benefit in animal EAE systems, the challenge will be their application in clinical use... - A synthetic homing endonuclease-based gene drive system in the human malaria mosquitoNikolai Windbichler
Imperial College London, Department of Life Sciences, South Kensington Campus, London, SW7 2AZ, UK
Nature 473:212-5. 2011..Our results also show in principle how sequence-specific genetic drive elements like HEGs could be used to take the step from the genetic engineering of individuals to the genetic engineering of populations... - Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL miceMargaret M Morris-Downes
Department of Neuroinflammation, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London, UK
J Neuroimmunol 122:20-33. 2002.... - Cannabinoids in MS: potentially useful but not just yet!Alan J Thompson
Neurology 58:1323-4. 2002 - The endocannabinoid system and multiple sclerosisDavid Baker
Neuroimmunology Unit, Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E12AT, UK
Curr Pharm Des 14:2326-36. 2008..Therefore cannabinoids may not only offer symptom control but may also slow the neurodegenerative disease progression that ultimately leads to the accumulation of disability... - Inflammatory disorders of the central nervous systemGavin Giovannoni
Curr Opin Neurol 16:347-50. 2003 - Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosisStephan Ellmerich
Department of Infectious Diseases and Transplantation Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, GB
Eur J Immunol 34:1839-48. 2004..This model should be valuable for analyzing epitope spread in a humanized immunogenetic environment and for the testing of specific immunotherapies... - A new twist in TCR diversity revealed by a forbidden alphabeta TCRChristine McBeth
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Mol Biol 375:1306-19. 2008.... - Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130Martin J Boulanger
Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305, USA
Mol Cell 12:577-89. 2003..These observations reveal a novel and alternative mechanism for degenerate recognition from that of structural plasticity... - Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cellsKatarzyna Maresz
BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
Nat Med 13:492-7. 2007..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor... - Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophyHalyna R Shcherbata
Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
EMBO J 26:481-93. 2007..Importantly, we now report that Dg interacts with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding. This is the first demonstration of a genetic interaction between Dg and InR... - Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis miceAna Cabranes
, Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain
Brain Res 1107:199-205. 2006..These observations may explain the efficacy of cannabinoid agonists to improve motor symptoms (spasticity, tremor, ataxia) typical of MS in both humans and animal models... - Annexin II/p11 is up-regulated in Purkinje cells in EAE and MSMatthew J Craner
Department of Neurology and PVA/EPVA Center for Neuroscience Research, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208018, New Haven, CT 06520-8018, USA
Neuroreport 14:555-8. 2003..8 within Purkinje cells perturbs the temporal pattern of impulse generation in these cells, our results extend the evidence for an acquired channelopathy which interferes with cerebellar function in MS... - Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesionGang Song
CBR Institute for Biomedical Research, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:5042-9. 2006..Thus, rational design can be used to engineer novel adhesion molecules with high monomeric affinity; furthermore, the ICAM-1 mutant holds promise for targeting LFA-1-ICAM-1 interaction for biological studies and therapeutic purposes... - Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studiesDavid Baker
Division of Infectious Diseases, Department of Obstetrics Gynecology, State University of New York at Stony Brook School of Medicine, 11794 8091, USA
Cutis 71:239-42. 2003..More research with larger patient numbers is warranted to corroborate and extend these findings... - Glutamate transmission and addiction to cocainePeter W Kalivas
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29464, USA
Ann N Y Acad Sci 1003:169-75. 2003..These adaptations are hypothesized to facilitate glutamate release in response to a cocaine injection or acute stress and lead to the reinstatement of drug-seeking behavior... - Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptorsAymen I Idris
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Nat Med 11:774-9. 2005.... - Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH micePaul A Smith
Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2280 GH, Rijswijk, The Netherlands
J Neuroimmunol 164:76-84. 2005..These findings may have important implications for the efficacy of antigen-based immune therapies in autoimmune disorders... - An autoimmune diabetes locus (Idd21) on mouse chromosome 18Richard J Hall
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Mamm Genome 14:335-9. 2003..The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21... - UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disordersEva de Lago
, Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain
Eur Neuropsychopharmacol 16:7-18. 2006.... - Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH miceNicole Heijmans
Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2280 GH Rijswijk, The Netherlands
J Neuroimmunol 167:23-33. 2005.... - Biozzi mice: of mice and human neurological diseasesSandra Amor
Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
J Neuroimmunol 165:1-10. 2005..In this paper we discuss the background of the Biozzi ABH mouse and review how studies with these mice have shed light on the pathogenic mechanisms operating in chronic neurological disease... - The problem of secondary contamination following chemical agent releaseDavid Baker
SAMU 75, Hopital Necker - Enfants Malades, Paris, France
Crit Care 9:323-4. 2005 - New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosisAlessia Ligresti
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R. Pozzuoli (Napoli, Italy
Br J Pharmacol 147:83-91. 2006.... - Capnocytophaga bacteremia in a girl with relapsed acute lymphoblastic leukemiaTaha Khattab
Departments of Paediatrics and Microbiology, King Khalid National Guard Hospital, Jeddah, Saudi Arabia
Ann Saudi Med 24:391-2. 2004