David Baker

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Cannabinoids control spasticity and tremor in a multiple sclerosis model
    D Baker
    Department of Neurochemistry, Institute of Neurology, University College London, UK
    Nature 404:84-7. 2000
  2. ncbi request reprint In silico patent searching reveals a new cannabinoid receptor
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Trends Pharmacol Sci 27:1-4. 2006
  3. ncbi request reprint The therapeutic potential of cannabis in multiple sclerosis
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
    Expert Opin Investig Drugs 12:561-7. 2003
  4. ncbi request reprint Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
    J Ludovic Croxford
    Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 1PJ, United Kingdom
    J Neuroimmunol 193:120-9. 2008
  5. ncbi request reprint Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 126:2191-202. 2003
  6. pmc A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis
    Emma East
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield St, London, WC1N 1PJ, UK
    Am J Pathol 167:545-54. 2005
  7. doi request reprint Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage
    Claudie Hooper
    Kings College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    J Neurochem 109:694-705. 2009
  8. ncbi request reprint Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    J Neuroimmunol 165:41-52. 2005
  9. pmc Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction
    Matthew E Gegg
    Division of Cellular Therapy, Institute of Ophthalmology, University College London, London, United Kingdom
    J Immunol 174:2327-35. 2005
  10. doi request reprint Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis
    Fabiola Puentes
    Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurol Neurosurg Psychiatry 85:274-8. 2014

Detail Information

Publications55

  1. ncbi request reprint Cannabinoids control spasticity and tremor in a multiple sclerosis model
    D Baker
    Department of Neurochemistry, Institute of Neurology, University College London, UK
    Nature 404:84-7. 2000
    ..This provides a rationale for patients' indications of the therapeutic potential of cannabis in the control of the symptoms of multiple sclerosis, and provides a means of evaluating more selective cannabinoids in the future...
  2. ncbi request reprint In silico patent searching reveals a new cannabinoid receptor
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Trends Pharmacol Sci 27:1-4. 2006
    ..This receptor is reported to be expressed in several tissues and might function in lipid or vascular biology. Thus, GPR55 might represent a new cannabinoid receptor...
  3. ncbi request reprint The therapeutic potential of cannabis in multiple sclerosis
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
    Expert Opin Investig Drugs 12:561-7. 2003
    ..Cannabinoids provide a novel therapeutic target, not only for controlling symptoms, but also slowing disease progression through inhibition of neurodegeneration, which is the cause of accumulating irreversible disability...
  4. ncbi request reprint Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
    J Ludovic Croxford
    Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 1PJ, United Kingdom
    J Neuroimmunol 193:120-9. 2008
    ..This further highlights the neuroprotective potential of cannabinoids to slow the progression of MS...
  5. ncbi request reprint Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 126:2191-202. 2003
    ..Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases...
  6. pmc A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis
    Emma East
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield St, London, WC1N 1PJ, UK
    Am J Pathol 167:545-54. 2005
    ....
  7. doi request reprint Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage
    Claudie Hooper
    Kings College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
    J Neurochem 109:694-705. 2009
    ..Thus, exposure of microglia in the brain to albumin may contribute to neuronal damage following blood-brain barrier breakdown and point to resident microglia rather than infiltrating macrophages as therapeutic targets...
  8. ncbi request reprint Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    J Neuroimmunol 165:41-52. 2005
    ....
  9. pmc Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction
    Matthew E Gegg
    Division of Cellular Therapy, Institute of Ophthalmology, University College London, London, United Kingdom
    J Immunol 174:2327-35. 2005
    ..These data highlight the potential differential activity of statins in different inflammatory conditions and their possible therapeutic use for the treatment of human posterior uveitis...
  10. doi request reprint Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis
    Fabiola Puentes
    Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurol Neurosurg Psychiatry 85:274-8. 2014
    ....
  11. ncbi request reprint Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
    Lynsey G Bilsland
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    FASEB J 20:1003-5. 2006
    ..Together these results show that cannabinoids have significant neuroprotective effects in this model of ALS and suggest that these beneficial effects may be mediated by non-CB1 receptor mechanisms...
  12. doi request reprint Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis
    Sharmilee Gnanapavan
    Department of Neuroimmunology, Institute of Neurology, London, UK
    Autoimmunity 45:298-303. 2012
    ..These data further support neurofilament levels as a good surrogate measure of neurodegeneration and their potential use as a surrogate endpoint in neuroprotective studies...
  13. ncbi request reprint Cannabinoids and neuroprotection in CNS inflammatory disease
    Samuel J Jackson
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    J Neurol Sci 233:21-5. 2005
    ..However there is accumulating evidence in vitro and in vivo to support the hypothesis that the cannabinoid system can limit the neurodegenerative possesses that drive progressive disease, and may provide a new avenue for disease control...
  14. pmc Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis
    John Greenwood
    Division of Cell Biology, Institute of Ophthalmology, University College London, Bath Street, London, EC1V 9EL, UK
    FASEB J 17:905-7. 2003
    ..These studies demonstrate a novel effect of statins in modulating the immune response in neuroinflammtory diseases and may provide additional rationale for their use in the treatment of MS...
  15. ncbi request reprint The therapeutic potential of cannabis
    David Baker
    Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK
    Lancet Neurol 2:291-8. 2003
    ..Even if the results of these studies are not as positive as many expect them to be, that we are only just beginning to appreciate the huge therapeutic potential of this family of compounds is clear...
  16. ncbi request reprint Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis
    Sarah Al-Izki
    1 Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Brain 137:92-108. 2014
    ..This class of agents inhibit microglial activity and neural sodium loading, which are both thought to contribute to progressive neurodegeneration in multiple sclerosis and possibly other neurodegenerative diseases. ..
  17. ncbi request reprint Cannabinoid-mediated neuroprotection following interferon-gamma treatment in a three-dimensional mouse brain aggregate cell culture
    Samuel J Jackson
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Eur J Neurosci 20:2267-75. 2004
    ....
  18. ncbi request reprint Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    Jason W Brooks
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pharmacol 439:83-92. 2002
    ..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically...
  19. ncbi request reprint Potential of statins for the treatment of multiple sclerosis
    David Baker
    Neuroinflammation Group, Institute of Neurology, University College London, UK
    Lancet Neurol 2:9-10. 2003
  20. doi request reprint Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors
    Fleur Pinteaux-Jones
    Cell Signalling Laboratory, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    J Neurochem 106:442-54. 2008
    ..These data show that myelin-induced microglial neurotoxicity can be prevented by regulation of mGluRs and suggest these receptors on microglia may be promising targets for therapeutic intervention in multiple sclerosis...
  21. pmc Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis
    Claire E Walters
    Department of Cell Biology, Institute of Ophthalmology, and Neuroinflammation Group, University College London, London, United Kingdom
    J Immunol 168:4087-94. 2002
    ..These studies demonstrate, for the first time, the potential for pharmacologically targeting CNS EC signaling responses, and particularly endothelial Rho proteins, as a means of attenuating leukocyte recruitment to the CNS...
  22. ncbi request reprint Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Neurosci Lett 341:164-6. 2003
    ....
  23. ncbi request reprint Interleukin-12 induces mild experimental allergic encephalomyelitis following local central nervous system injury in the Lewis rat
    Zubair Ahmed
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neuroimmunol 140:109-17. 2003
    ..These results suggest that immune-mediated events in which IL-12 production is stimulated as for example viral infection, superimposed on a brain injury, could provide a trigger for a MS-like pathology...
  24. ncbi request reprint Emerging properties of cannabinoid medicines in management of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N 1PJ, UK
    Trends Neurosci 28:272-6. 2005
    ..This, combined with data from recent clinical trials, points to the prospect of cannabis as a medication in the treatment of multiple sclerosis and numerous other medical conditions...
  25. ncbi request reprint The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis
    Eleanor James
    Blizard Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Mult Scler 19:1571-9. 2013
    ..Further larger, more prolonged studies are merited. ..
  26. pmc Inflammation in neurodegenerative diseases--an update
    Sandra Amor
    Department of Pathology, VU University Medical Centre, Amsterdam, the Netherlands Neuroimmunology Unit, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Immunology 142:151-66. 2014
    ....
  27. ncbi request reprint Membrane receptor probes: solid-phase synthesis of biotin-Asp-PEG-arvanil derivatives
    Cristina Visintin
    The Wolfson Institute for Biomedical Research, Institute of Neurology, and Department of Chemistry, University College London, Gower Street, London WC1E 6BT, UK
    Org Lett 7:1699-702. 2005
    ..The versatility of the method is illustrated through the synthesis of a number of arvanil-derived cannabinoid receptor ligands displaying either a photoaffinity or a chemical cross-linking group...
  28. pmc A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis : inflammation versus degeneration
    Zubair Ahmed
    Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
    Am J Pathol 161:1577-86. 2002
    ..Because caspase-3 is a downstream cell death signal it may be possible to reduce apoptosis by selectively blocking caspase-3 and therefore provide a therapeutic target for EAE and potentially, multiple sclerosis...
  29. ncbi request reprint Pathological and regulatory effects of anti-myelin antibodies in experimental allergic encephalomyelitis in mice
    Margaret M Morris-Downes
    Department of Neuroinflammation, Division of Neurosciences, Imperial College School of Medicine, Charing Cross Campus, London W6 8RF, UK
    J Neuroimmunol 125:114-24. 2002
    ....
  30. pmc Reprogramming homing endonuclease specificity through computational design and directed evolution
    Summer B Thyme
    Department of Biochemistry, University of Washington, UW Box 357350, 1705 NE Pacific St, Seattle, WA 98195, USA, Graduate Program in Biomolecular Structure and Design, University of Washington, UW Box 357350, 1705 NE Pacific St, Seattle, WA 98195, USA, Graduate Program in Molecular and Cellular Biology, University of Washington, UW Box 357275, 1959 NE Pacific St, Seattle, WA 98195, USA, Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, London SW7 2AZ, UK, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB1 3QA, UK, Institute for Systems Biology, 401 Terry Avenue N, Seattle, WA 98109, USA and Howard Hughes Medical Institute, University of Washington, UW Box 357350, 1705 NE Pacific St, Seattle, WA 98195, USA
    Nucleic Acids Res 42:2564-76. 2014
    ..In the course of this work we observed unanticipated context-dependence between bases which will need to be mechanistically understood for reprogramming of specificity to succeed more generally. ..
  31. ncbi request reprint Gene therapy in autoimmune, demyelinating disease of the central nervous system
    David Baker
    Institute of Neurology, University College London, UK
    Gene Ther 10:844-53. 2003
    ..Targeting of leucocyte activation, cytokines and nerve growth factors have shown some promising benefit in animal EAE systems, the challenge will be their application in clinical use...
  32. pmc A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
    Nikolai Windbichler
    Imperial College London, Department of Life Sciences, South Kensington Campus, London, SW7 2AZ, UK
    Nature 473:212-5. 2011
    ..Our results also show in principle how sequence-specific genetic drive elements like HEGs could be used to take the step from the genetic engineering of individuals to the genetic engineering of populations...
  33. ncbi request reprint Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice
    Margaret M Morris-Downes
    Department of Neuroinflammation, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London, UK
    J Neuroimmunol 122:20-33. 2002
    ....
  34. ncbi request reprint Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis
    Stephan Ellmerich
    Department of Infectious Diseases and Transplantation Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, GB
    Eur J Immunol 34:1839-48. 2004
    ..This model should be valuable for analyzing epitope spread in a humanized immunogenetic environment and for the testing of specific immunotherapies...
  35. ncbi request reprint Cannabinoids in MS: potentially useful but not just yet!
    Alan J Thompson
    Neurology 58:1323-4. 2002
  36. ncbi request reprint Inflammatory disorders of the central nervous system
    Gavin Giovannoni
    Curr Opin Neurol 16:347-50. 2003
  37. ncbi request reprint The endocannabinoid system and multiple sclerosis
    David Baker
    Neuroimmunology Unit, Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E12AT, UK
    Curr Pharm Des 14:2326-36. 2008
    ..Therefore cannabinoids may not only offer symptom control but may also slow the neurodegenerative disease progression that ultimately leads to the accumulation of disability...
  38. pmc A new twist in TCR diversity revealed by a forbidden alphabeta TCR
    Christine McBeth
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Mol Biol 375:1306-19. 2008
    ....
  39. ncbi request reprint An autoimmune diabetes locus (Idd21) on mouse chromosome 18
    Richard J Hall
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Mamm Genome 14:335-9. 2003
    ..The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21...
  40. ncbi request reprint Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice
    Paul A Smith
    Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2280 GH, Rijswijk, The Netherlands
    J Neuroimmunol 164:76-84. 2005
    ..These findings may have important implications for the efficacy of antigen-based immune therapies in autoimmune disorders...
  41. ncbi request reprint Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies
    David Baker
    Division of Infectious Diseases, Department of Obstetrics Gynecology, State University of New York at Stony Brook School of Medicine, 11794 8091, USA
    Cutis 71:239-42. 2003
    ..More research with larger patient numbers is warranted to corroborate and extend these findings...
  42. ncbi request reprint Annexin II/p11 is up-regulated in Purkinje cells in EAE and MS
    Matthew J Craner
    Department of Neurology and PVA EPVA Center for Neuroscience Research, Yale University School of Medicine, 333 Cedar Street, P O Box 208018, New Haven, CT 06520 8018, USA
    Neuroreport 14:555-8. 2003
    ..8 within Purkinje cells perturbs the temporal pattern of impulse generation in these cells, our results extend the evidence for an acquired channelopathy which interferes with cerebellar function in MS...
  43. ncbi request reprint Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
    Martin J Boulanger
    Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305, USA
    Mol Cell 12:577-89. 2003
    ..These observations reveal a novel and alternative mechanism for degenerate recognition from that of structural plasticity...
  44. ncbi request reprint Glutamate transmission and addiction to cocaine
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29464, USA
    Ann N Y Acad Sci 1003:169-75. 2003
    ..These adaptations are hypothesized to facilitate glutamate release in response to a cocaine injection or acute stress and lead to the reinstatement of drug-seeking behavior...
  45. ncbi request reprint UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
    Eva de Lago
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Eur Neuropsychopharmacol 16:7-18. 2006
    ....
  46. pmc Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
    Aymen I Idris
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nat Med 11:774-9. 2005
    ....
  47. ncbi request reprint Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice
    Nicole Heijmans
    Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2280 GH Rijswijk, The Netherlands
    J Neuroimmunol 167:23-33. 2005
    ....
  48. ncbi request reprint Biozzi mice: of mice and human neurological diseases
    Sandra Amor
    Department of Immunobiology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    J Neuroimmunol 165:1-10. 2005
    ..In this paper we discuss the background of the Biozzi ABH mouse and review how studies with these mice have shed light on the pathogenic mechanisms operating in chronic neurological disease...
  49. pmc The problem of secondary contamination following chemical agent release
    David Baker
    SAMU 75, Hopital Necker Enfants Malades, Paris, France
    Crit Care 9:323-4. 2005
  50. pmc New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C N R Pozzuoli Napoli, Italy
    Br J Pharmacol 147:83-91. 2006
    ....
  51. pmc Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion
    Gang Song
    CBR Institute for Biomedical Research, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:5042-9. 2006
    ..Thus, rational design can be used to engineer novel adhesion molecules with high monomeric affinity; furthermore, the ICAM-1 mutant holds promise for targeting LFA-1-ICAM-1 interaction for biological studies and therapeutic purposes...
  52. ncbi request reprint Capnocytophaga bacteremia in a girl with relapsed acute lymphoblastic leukemia
    Taha Khattab
    Departments of Paediatrics and Microbiology, King Khalid National Guard Hospital, Jeddah, Saudi Arabia
    Ann Saudi Med 24:391-2. 2004
  53. ncbi request reprint Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice
    Ana Cabranes
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Brain Res 1107:199-205. 2006
    ..These observations may explain the efficacy of cannabinoid agonists to improve motor symptoms (spasticity, tremor, ataxia) typical of MS in both humans and animal models...
  54. pmc Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy
    Halyna R Shcherbata
    Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    EMBO J 26:481-93. 2007
    ..Importantly, we now report that Dg interacts with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding. This is the first demonstration of a genetic interaction between Dg and InR...
  55. ncbi request reprint Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    Katarzyna Maresz
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53226, USA
    Nat Med 13:492-7. 2007
    ..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor...