A J Baines

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. doi request reprint Evolution of the spectrin-based membrane skeleton
    A J Baines
    School of Biosciences and Centre for Biomedical Informatics, University of Kent, CT2 7NJ, Canterbury, United Kingdom
    Transfus Clin Biol 17:95-103. 2010
  2. pmc A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
    BMC Genomics 7:85. 2006
  3. doi request reprint The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
    Mol Biol Evol 26:2005-14. 2009
  4. doi request reprint Evolution of spectrin function in cytoskeletal and membrane networks
    Anthony J Baines
    Department of Biosciences and Centre for Biomedical Informatics, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Biochem Soc Trans 37:796-803. 2009
  5. doi request reprint The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life
    Anthony J Baines
    School of Biosciences and Centre for Biomedical Informatics, University of Kent, Canterbury, CT2 7NJ, UK
    Protoplasma 244:99-131. 2010
  6. ncbi request reprint The postsynaptic spectrin/4.1 membrane protein "accumulation machine"
    A J Baines
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
    Cell Mol Biol Lett 6:691-702. 2001
  7. ncbi request reprint Properties of the C-terminal domain of 4.1 proteins
    C Scott
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Eur J Biochem 268:3709-17. 2001
  8. ncbi request reprint Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis
    Paola A Bignone
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, Great Britain
    J Biol Chem 282:888-96. 2007
  9. ncbi request reprint Identification of a novel C-terminal variant of beta II spectrin: two isoforms of beta II spectrin have distinct intracellular locations and activities
    N V Hayes
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, England
    J Cell Sci 113:2023-34. 2000
  10. ncbi request reprint Ca2+-dependent interaction with calmodulin is conserved in the synapsin family: identification of a high-affinity site
    S Nicol
    Research School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, England
    Biochemistry 36:11487-95. 1997

Collaborators

  • P M Bennett
  • E Kordeli
  • Paola A Bignone
  • A F Bennett
  • William J Gullick
  • Byron J T Morgan
  • Alex A Freitas
  • X An
  • Yang Yang
  • Alexander A Hopitzan
  • Pamela M Taylor-Harris
  • N V L Hayes
  • Nandini V L Hayes
  • Marcela Salomao
  • C Scott
  • Emma J Birks
  • Gisele L Pappa
  • Jennifer C Pinder
  • Magdi H Yacoub
  • Rodney C G Franklin
  • Narla Mohandas
  • Mohamed Ramez
  • N V Hayes
  • R J Newsam
  • Laura V Smart
  • Edith Blackburn
  • Mary M Boyle
  • Teresa M Frost
  • Graham A Russell
  • Walter B Gratzer
  • Xinhua Guo
  • Leanne E Felkin
  • Paul J R Barton
  • Michel Recouvreur
  • Gareth W Phillips
  • Lisa A Keating
  • Alison M Maggs
  • Marie Aline Ludosky
  • S Nicol
  • Philippe Gascard
  • Shirin Marfatia
  • Joel A Chasis
  • Sumita Chanan
  • Francoise Cluzeaud
  • Michael Patterson
  • Marcel Blot-Chabaud
  • Loren D Walensky
  • John G Conboy
  • G W Phillips
  • A M Maggs
  • J C Pinder
  • V Ohanian
  • E Heerkens
  • D Rahman
  • W Asmara
  • D J Hardman
  • U Murdiyatmo
  • A T Bull

Detail Information

Publications30

  1. doi request reprint Evolution of the spectrin-based membrane skeleton
    A J Baines
    School of Biosciences and Centre for Biomedical Informatics, University of Kent, CT2 7NJ, Canterbury, United Kingdom
    Transfus Clin Biol 17:95-103. 2010
    ..The spectrin/ankyrin/adducin/4.1 complex represents a remarkable system that underpins animal life; it has been adapted to many different functions at different times during animal evolution...
  2. pmc A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
    BMC Genomics 7:85. 2006
    ..In protein 4.1R, phosphorylation adjacent to the FERM domain regulates its activity, and membrane mechanical properties...
  3. doi request reprint The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
    Mol Biol Evol 26:2005-14. 2009
    ..Overexpression of the CKK domain in PC12 cells blocked production of neurites, a process that requires microtubule function. We conclude that the CKK domain binds microtubules and represents a domain that evolved with the metazoa...
  4. doi request reprint Evolution of spectrin function in cytoskeletal and membrane networks
    Anthony J Baines
    Department of Biosciences and Centre for Biomedical Informatics, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Biochem Soc Trans 37:796-803. 2009
    ..I hypothesize that the elasticity of mammalian non-nucleated erythrocytes depends on the dynamic rearrangement of spectrin dimers/tetramers under the shearing forces experienced in circulation...
  5. doi request reprint The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life
    Anthony J Baines
    School of Biosciences and Centre for Biomedical Informatics, University of Kent, Canterbury, CT2 7NJ, UK
    Protoplasma 244:99-131. 2010
    ..The spectrin-ankyrin-4.1-adducin complex represents a remarkable system that underpins animal life; it has been adapted to many different functions at different times during animal evolution...
  6. ncbi request reprint The postsynaptic spectrin/4.1 membrane protein "accumulation machine"
    A J Baines
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
    Cell Mol Biol Lett 6:691-702. 2001
    ..By linking these receptors to the cytoskeletal and cell adhesion molecules that specify glutamatergic synapses, the membrane protein accumulation machine is suggested to direct the formation of postsynaptic signalling complexes...
  7. ncbi request reprint Properties of the C-terminal domain of 4.1 proteins
    C Scott
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Eur J Biochem 268:3709-17. 2001
    ..Together these data indicate that the CTD probably represents an independent folding structure which has gained function since the divergence of vertebrates from invertebrates...
  8. ncbi request reprint Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis
    Paola A Bignone
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, Great Britain
    J Biol Chem 282:888-96. 2007
    ..Furthermore, because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process...
  9. ncbi request reprint Identification of a novel C-terminal variant of beta II spectrin: two isoforms of beta II spectrin have distinct intracellular locations and activities
    N V Hayes
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, England
    J Cell Sci 113:2023-34. 2000
    ..We conclude that variation in the structure of the C-terminal regions of betaII spectrin isoforms correlates with their differential intracellular targeting...
  10. ncbi request reprint Ca2+-dependent interaction with calmodulin is conserved in the synapsin family: identification of a high-affinity site
    S Nicol
    Research School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, England
    Biochemistry 36:11487-95. 1997
    ..We conclude that calmodulin binding to synapsins is likely to be a general aspect of regulation of synaptic function...
  11. ncbi request reprint Synapsin I and the cytoskeleton: calmodulin regulation of interactions
    A J Baines
    Research School of Biosciences, University of Kent, Canterbury, U K
    Biochem Soc Trans 23:65-70. 1995
  12. ncbi request reprint Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer
    Nandini V L Hayes
    Cancer Biology Laboratory, Research School of Biosciences, Centre for Biomedical Informatics, Institute of Mathematics and Statistics, University of Kent, Canterbury, UK
    Clin Cancer Res 13:3147-55. 2007
    ..The aims of this study were to establish whether the fourth member of this family, NRG4, is expressed in prostate cancer, if it is alternatively spliced and whether any functional differences between the variants could be observed...
  13. ncbi request reprint Characterization of the cell membrane-associated products of the Neuregulin 4 gene
    N V L Hayes
    Cancer Biology Laboratory, Research School of Biosciences, University of Kent, Canterbury, UK
    Oncogene 27:715-20. 2008
    ....
  14. doi request reprint Protein 4.1 and the control of ion channels
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, CT2 7NJ Kent, UK
    Blood Cells Mol Dis 42:211-5. 2009
    ..A hypothesis to investigate in the future is that differential regulation of 4.1 and ankyrins (e.g. by PIP(2)) allows highly selective control of cell surface accumulation and transport activity of a specific range of ion channels...
  15. pmc Site specificity in the interactions of synapsin 1 with tubulin
    A F Bennett
    Biological Laboratory, University of Kent, Canterbury, U K
    Biochem J 276:793-9. 1991
    ..Our results show that there are tubulin-binding sites in both head and tail domains. We conclude that synapsin 1 monomers should be able to cross-link microtubules...
  16. pmc Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site
    Paola A Bignone
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Biochem J 374:613-24. 2003
    ....
  17. pmc Protein engineering of the 2-haloacid halidohydrolase IVa from Pseudomonas cepacia MBA4
    W Asmara
    International Institute of Biotechnology, University of Kent, Canterbury, U K
    Biochem J 292:69-74. 1993
    ....
  18. ncbi request reprint The spectrin-associated cytoskeleton in mammalian heart
    Anthony J Baines
    Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
    Front Biosci 10:3020-33. 2005
    ....
  19. ncbi request reprint Predicting post-synaptic activity in proteins with data mining
    Gisele L Pappa
    Computing Laboratory, University of Kent, Canterbury, UK
    Bioinformatics 21:ii19-25. 2005
    ..The discovered rules were analysed with respect to their predictive accuracy (generalization ability) and with respect to their interestingness to biologists (in the sense of representing novel, unexpected knowledge)...
  20. ncbi request reprint Comprehensive analysis of all triple helical repeats in beta-spectrins reveals patterns of selective evolutionary conservation
    Anthony J Baines
    Randall Centre for Molecular Mechanisms of Cell Function, King s College London, Guy s Campus, UK
    Cell Mol Biol Lett 8:195-214. 2003
    ....
  21. ncbi request reprint Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR
    Pamela M Taylor-Harris
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London SE1 1UL, UK
    Cell Mol Biol Lett 10:135-49. 2005
    ..4.1R abundance was very low in both tissues. Whilst we expected that 4.1 mRNAs would feature highly in muscle and nerve, we note their high abundance in testis, indicating previously unsuspected functions in reproduction...
  22. ncbi request reprint Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure
    Pamela M Taylor-Harris
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London SE1 1UL, UK
    Mamm Genome 16:137-51. 2005
    ..We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1s are likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies...
  23. ncbi request reprint Molecular evolution of ankyrin: gain of function in vertebrates by acquisition of an obscurin/titin-binding-related domain
    Alexander A Hopitzan
    Institut Jacques Monod CNRS Universit├ęs Paris VI et VII, Paris, France
    Mol Biol Evol 23:46-55. 2006
    ..We suggest that the OTBD represents an adaptation of the cytoskeleton that confers muscle cells with resilience to the forces associated with vertebrate life...
  24. ncbi request reprint Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, 310 East 67th Street, New York, New York 10021, USA
    Biochemistry 45:5725-32. 2006
    ..1R, 4.1B, 4.1G, and 4.1N) are widely expressed and the PIP2-binding motifs are highly conserved, it is likely that the functions of other 4.1 proteins are similarly regulated by PIP2 in many different cell types...
  25. ncbi request reprint Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    J Biol Chem 281:10527-32. 2006
    ....
  26. ncbi request reprint Thermal stabilities of brain spectrin and the constituent repeats of subunits
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10021, USA
    Biochemistry 45:13670-6. 2006
    ..The greater structural stability of the repeats in alphaII- and betaII-spectrin may account, at least in part, for the higher rigidity of brain compared to erythrocyte spectrin...
  27. pmc The transitional junction: a new functional subcellular domain at the intercalated disc
    Pauline M Bennett
    Randall Division of Cell and Molecular Biophysics, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Mol Biol Cell 17:2091-100. 2006
    ..In particular, it provides a means for sarcomeres to be added to the ends of the cells during growth. This is of particular relevance to understanding myocyte elongation in dilated cardiomyopathy...
  28. ncbi request reprint Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron
    Mohamed Ramez
    Department of Subcellular Structure, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Kidney Int 63:1321-37. 2003
    ..1 proteins are encoded by four homologous genes, 4.1R, 4.1G, 4.1N, and 4.1B, which undergo complex alternative splicing. Here we performed a detailed characterization of the expression of specific 4.1 proteins in the mouse nephron...
  29. pmc Mammalian alpha I-spectrin is a neofunctionalized polypeptide adapted to small highly deformable erythrocytes
    Marcela Salomao
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:643-8. 2006
    ..We conclude that alphaI-spectrin represents a neofunctionalized spectrin adapted to the rapid make and break of tetramers...
  30. ncbi request reprint Ankyrin-G in skeletal muscle: tissue-specific alternative splicing contributes to the complexity of the sarcolemmal cytoskeleton
    Alexander A Hopitzan
    Institut Jacques Monod CNRS Universit├ęs Paris VI et VII 2 Place Jussieu, F 75251 Paris Cedex 05, France
    Exp Cell Res 309:86-98. 2005
    ..Our results demonstrate the tissue-dependent alternative splicing of Ank3 in skeletal muscle and point to novel functions of small ankyrins-G in organizing microdomains of the plasma membrane...