Affiliation: University College London
Mehat M, Sundaram V, Ripamonti C, Robson A, Smith A, Borooah S, et al
. Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration. Ophthalmology. 2018;125:1765-1775 pubmed publisher
..Given the slow rate of progressive degeneration at this advanced stage of disease, any protection against further deterioration may be evident only after a more extended period of observation. ..
Bainbridge J, Mistry A, Thrasher A, Ali R. Gene therapy for ocular angiogenesis. Clin Sci (Lond). 2003;104:561-75 pubmed
..Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders. ..
Bainbridge J, Herbert E, Gregor Z. Macular holes: vitreoretinal relationships and surgical approaches. Eye (Lond). 2008;22:1301-9 pubmed publisher
..The use of long-acting gases, prolonged face-down positioning, and ILM peeling may be more valuable for larger holes, longstanding holes, and those that have failed to close following conventional surgery. ..
Lange C, Stavrakas P, Luhmann U, De Silva D, Ali R, Gregor Z, et al
. Intraocular oxygen distribution in advanced proliferative diabetic retinopathy. Am J Ophthalmol. 2011;152:406-412.e3 pubmed publisher
..Upregulation of vitreous VEGF may be a consequence of retinal hypoxia at unidentified sites or of chronic inflammatory processes in advanced proliferative diabetic retinopathy. ..
Pasu S, Bunce C, Hooper R, Thomson A, Bainbridge J. PIMS (Positioning In Macular hole Surgery) trial - a multicentre interventional comparative randomised controlled clinical trial comparing face-down positioning, with an inactive face-forward position on the outcome of surgery for large macular holes. Trials. 2015;16:527 pubmed publisher
..This will be the first multicentre randomised control trial to investigate the value of face-down positioning following macular hole standardised surgery. UK CRN: 17966 (date of registration 26 November 2014). ..
Robbie S, Georgiadis A, Barker S, Duran Y, Smith A, Ali R, et al
. Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. Neurobiol Aging. 2016;40:110-119 pubmed publisher
..These findings indicate that CCL2-driven recruitment of myeloid cells contributes to increased severity of CNV with age. Similar mechanisms may be involved in other age-related inflammatory diseases. ..
Lange C, Mowat F, Sayed H, Mehad M, Duluc L, Piper S, et al
. Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. Exp Eye Res. 2016;147:148-155 pubmed publisher
..Therapeutic inhibition of DDAH2 may therefore offer a potential therapeutic strategy to protect sight by promoting retinal vascular regeneration and preventing pathological angiogenesis. ..