J Bainbridge

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
  2. ncbi request reprint Gene therapy for ocular angiogenesis
    James W B Bainbridge
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, U K
    Clin Sci (Lond) 104:561-75. 2003
  3. doi request reprint Prospects for gene therapy of inherited retinal disease
    J W B Bainbridge
    Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Eye (Lond) 23:1898-903. 2009
  4. doi request reprint Macular holes: vitreoretinal relationships and surgical approaches
    J Bainbridge
    Moorfields Eye Hospital, London, UK
    Eye (Lond) 22:1301-9. 2008
  5. ncbi request reprint Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy
    Frank C Schlichtenbrede
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, UK
    J Gene Med 5:757-64. 2003
  6. pmc Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice
    Susie E Barker
    Division of Molecular Therapy, UCL Institute of Ophthalmology, London, UK
    J Gene Med 11:486-97. 2009
  7. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
  8. doi request reprint Delivery of anti-angiogenic molecular therapies for retinal disease
    Owen A Anderson
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V9EL, United Kingdom
    Drug Discov Today 15:272-82. 2010
  9. doi request reprint A pilot randomised controlled trial comparing the post-operative pain experience following vitrectomy with a 20-gauge system and the 25-gauge transconjunctival system
    L Wickham
    Moorfields Eye Hospital, City Road, London EC1V 2PD, UK
    Br J Ophthalmol 94:36-40. 2010
  10. ncbi request reprint A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo
    James W B Bainbridge
    Institute of Ophthalmology, Bath Street, London, UK
    Biochem Biophys Res Commun 302:793-9. 2003

Detail Information

Publications12

  1. doi request reprint Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
    ..These findings provide support for further clinical studies of this experimental approach in other patients with mutant RPE65. (ClinicalTrials.gov number, NCT00643747 [ClinicalTrials.gov].)...
  2. ncbi request reprint Gene therapy for ocular angiogenesis
    James W B Bainbridge
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, U K
    Clin Sci (Lond) 104:561-75. 2003
    ..Recent progress has enabled the planning of clinical trials of gene therapy for ocular neovascular disorders...
  3. doi request reprint Prospects for gene therapy of inherited retinal disease
    J W B Bainbridge
    Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Eye (Lond) 23:1898-903. 2009
    ....
  4. doi request reprint Macular holes: vitreoretinal relationships and surgical approaches
    J Bainbridge
    Moorfields Eye Hospital, London, UK
    Eye (Lond) 22:1301-9. 2008
    ..The use of long-acting gases, prolonged face-down positioning, and ILM peeling may be more valuable for larger holes, longstanding holes, and those that have failed to close following conventional surgery...
  5. ncbi request reprint Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy
    Frank C Schlichtenbrede
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, UK
    J Gene Med 5:757-64. 2003
    ..Here we quantify the functional rescue over a 15-week time course and present a detailed analysis of the improvement in retinal function...
  6. pmc Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice
    Susie E Barker
    Division of Molecular Therapy, UCL Institute of Ophthalmology, London, UK
    J Gene Med 11:486-97. 2009
    ..However, one potential barrier to efficacious long-term therapy is the development of immune responses against the vector or transgene product...
  7. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
    ..This study was conducted to investigate the nature of the drusenlike lesions in vivo and further evaluate the Ccl2(-/-) mouse as a model of AMD...
  8. doi request reprint Delivery of anti-angiogenic molecular therapies for retinal disease
    Owen A Anderson
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V9EL, United Kingdom
    Drug Discov Today 15:272-82. 2010
    ..A range of new anti-angiogenics are on the horizon, offering new and varied modes of drug delivery. In addition, a range of new sustained-release drug delivery technologies are being developed...
  9. doi request reprint A pilot randomised controlled trial comparing the post-operative pain experience following vitrectomy with a 20-gauge system and the 25-gauge transconjunctival system
    L Wickham
    Moorfields Eye Hospital, City Road, London EC1V 2PD, UK
    Br J Ophthalmol 94:36-40. 2010
    ..To compare post-operative pain following 25-gauge (25G) and 20-gauge (20G) vitrectomy in the first week following surgery...
  10. ncbi request reprint A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo
    James W B Bainbridge
    Institute of Ophthalmology, Bath Street, London, UK
    Biochem Biophys Res Commun 302:793-9. 2003
    ....
  11. doi request reprint Predicting visual outcome following retinectomy for retinal detachment
    D J De Silva
    Vitreoretinal Service, Moorfields Eye Hospital, City Road, London, UK
    Br J Ophthalmol 92:954-8. 2008
    ..To evaluate outcome following retinectomy surgery and to identify factors that predict visual outcome...
  12. pmc Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    J Lakowski
    Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Hum Mol Genet 19:4545-59. 2010
    ..We conclude that flow-sorted embryonic-stage Crx-positive donor cells have the potential to replace lost cones, as well as rods, an important requirement for retinal disease therapy...