T P Baglin

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi High risk of recurrent venous thromboembolism in men
    T Baglin
    Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Thromb Haemost 2:2152-5. 2004
  2. ncbi Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: not yet
    T Baglin
    Department of Haematology, Addenbrooke's Hospital, Cambridge, UK
    J Thromb Haemost 4:2530-2. 2006
  3. ncbi Unprovoked recurrent venous thrombosis: prediction by D-dimer and clinical risk factors
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 6:577-82. 2008
  4. ncbi Oral anticoagulant therapy in subjects with congenital or acquired thrombophilia
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    Semin Vasc Med 3:315-22. 2003
  5. ncbi Management of thrombophilia: who to screen?
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Pathophysiol Haemost Thromb 33:401-4. 2003
  6. ncbi Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment
    T P Baglin
    Haematology Department, Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Clin Pathol 54:272-4. 2001
  7. ncbi Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Lancet 362:523-6. 2003
  8. ncbi Avoiding overanticoagulation: knowing your antibiotics
    Trevor Baglin
    Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals Trust, Cambridge CB2 2QQ, United Kingdom
    Thromb Haemost 88:703-4. 2002
  9. ncbi Guidelines on oral anticoagulation (warfarin): third edition--2005 update
    T P Baglin
    Addenbrooke's NHS Trust, Cambridge, UK
    Br J Haematol 132:277-85. 2006
  10. ncbi Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding
    G Evans
    Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Cambridge CB2 2QQ, UK
    Br J Haematol 115:998-1001. 2001

Detail Information

Publications37

  1. ncbi High risk of recurrent venous thromboembolism in men
    T Baglin
    Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Thromb Haemost 2:2152-5. 2004
    ..We have analyzed the influence of gender on risk of recurrence after a first episode of venous thromboembolism (VTE)...
  2. ncbi Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: not yet
    T Baglin
    Department of Haematology, Addenbrooke's Hospital, Cambridge, UK
    J Thromb Haemost 4:2530-2. 2006
  3. ncbi Unprovoked recurrent venous thrombosis: prediction by D-dimer and clinical risk factors
    T Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 6:577-82. 2008
    ..The aim of the study was to determine the predictive value of D-dimer measurement for unprovoked recurrent venous thrombosis and the influence of sex, age and type of first event (unprovoked or provoked)...
  4. ncbi Oral anticoagulant therapy in subjects with congenital or acquired thrombophilia
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    Semin Vasc Med 3:315-22. 2003
    ....
  5. ncbi Management of thrombophilia: who to screen?
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Pathophysiol Haemost Thromb 33:401-4. 2003
    ..If thrombophilia testing is performed there is a strong case for selecting patients for testing as in most cases decisions regarding intensity and duration of anticoagulant therapy can be made purely in relation to clinical criteria...
  6. ncbi Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment
    T P Baglin
    Haematology Department, Addenbrooke s NHS Trust, Cambridge CB2 2QQ, UK
    J Clin Pathol 54:272-4. 2001
    ..Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of this disease in recent years...
  7. ncbi Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Lancet 362:523-6. 2003
    ..We aimed to determine the incidence of recurrence of VTE in relation to clinical risk factors and standard laboratory testing for heritable thrombophilic defects...
  8. ncbi Avoiding overanticoagulation: knowing your antibiotics
    Trevor Baglin
    Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals Trust, Cambridge CB2 2QQ, United Kingdom
    Thromb Haemost 88:703-4. 2002
  9. ncbi Guidelines on oral anticoagulation (warfarin): third edition--2005 update
    T P Baglin
    Addenbrooke's NHS Trust, Cambridge, UK
    Br J Haematol 132:277-85. 2006
  10. ncbi Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding
    G Evans
    Department of Haematology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Cambridge CB2 2QQ, UK
    Br J Haematol 115:998-1001. 2001
    ..The median INR before treatment was greater than 20 and, after treatment, 1.1. All patients had a satisfactory clinical response with immediate cessation of bleeding, and no thromboembolic complications occurred...
  11. ncbi Predicting response to recombinant factor VIIa in non-haemophiliac patients with severe haemorrhage
    K M Bowles
    Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
    Br J Anaesth 97:476-81. 2006
    ..CONCLUSIONS: High SOFA score and failure to respond to one adequate dose of rFVIIa appear to identify patients with poor prognosis. These observations may help in determining when rFVIIa treatment is likely to be futile...
  12. ncbi Fatal pulmonary embolism in hospitalised medical patients
    T P Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    J Clin Pathol 50:609-10. 1997
    ..There is, therefore, a need to perform more large prospective studies to confirm the incidence of fatal pulmonary embolism in medical patients and to identify risk factors and effective antithrombotic prophylaxis...
  13. ncbi Management of warfarin (coumarin) overdose
    T Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Blood Rev 12:91-8. 1998
    ..Further studies are required to determine the most effective use of products and the dose required for safe reversal of overanticoagulation...
  14. ncbi Suppressing thrombin generation is compatible with the development of atherosclerosis in mice
    D J Grainger
    Department of Medicine, Addenbrooke s Hospital, Box 157, Hills Road, CB2 2QQ, Cambridge, UK
    Thromb Res 102:71-80. 2001
    ..We conclude that suppressing thrombin generation does not alter the development of vascular lipid lesions in mice with a severe disorder of lipid metabolism, despite a marked reduction in fibrin(ogen) deposition...
  15. ncbi A comparison of the efficacy and rate of response to oral and intravenous Vitamin K in reversal of over-anticoagulation with warfarin
    H G Watson
    Department of Haematology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Br J Haematol 115:145-9. 2001
    ..Satisfactory, but slower, reversal of anticoagulation can be effected using oral Vitamin K, but there may be differences in efficacy between the products tested in our study...
  16. ncbi Unprovoked deep vein thrombosis should be treated with long-term anticoagulation--no
    T Baglin
    Department of Haematology, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Thromb Haemost 5:2336-9. 2007
  17. ncbi Guidelines on use of vena cava filters
    T P Baglin
    Addenbrooke's NHS Trust, Cambridge, UK
    Br J Haematol 134:590-5. 2006
  18. ncbi Venous thromboembolism in oesophago-gastric carcinoma: incidence of symptomatic and asymptomatic events following chemotherapy and surgery
    K E Rollins
    Cambridge Oesophago Gastric Centre, Addenbrookes Hospital, Hills Road, Cambridge, UK
    Eur J Surg Oncol 37:1072-7. 2011
    ..Half of the patients with VTE were asymptomatic but two had fatal PE's. Current VTE prophylaxis regimens for this patient group may be inadequate...
  19. ncbi High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study
    M Besser
    Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK
    J Thromb Haemost 6:1720-5. 2008
    ..To determine the predictive value of measurement of parameters of thrombin generation for unprovoked recurrent venous thrombosis...
  20. ncbi Travellers' thrombosis and economy class syndrome: incidence, aetiology and prevention
    D J O'Keeffe
    Haematology Department, Addenbrooke s Hospital, Cambridge, UK
    Clin Lab Haematol 25:277-81. 2003
    ..The criteria for defining risk groups remains unclear and we outline our recommendations. There is conflicting evidence with regard to the use of aspirin but considering the latest evidence we do not recommend it...
  21. ncbi Platelet size has diagnostic predictive value in patients with thrombocytopenia
    K M Bowles
    Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK
    Clin Lab Haematol 27:370-3. 2005
    ..0 fl have marrow disease (odds ratio 8.1, 95% CI 5.0-13.0). Therefore the MPV can strongly guide the clinician as to the likely presence or absence of bone marrow disease in thrombocytopenic patients...
  22. ncbi Severe factor X deficiency due to a homozygous mutation (Cys364Arg) that disrupts a disulphide bond in the catalytic domain
    T Todd
    Department of Haematology, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Haemophilia 12:621-4. 2006
    ..Our experience and a review of the literature suggest that optimal frequency of dosing is likely to be two or three times weekly and that the risk of thrombosis is very small...
  23. ncbi Guidelines on the use and monitoring of heparin
    T Baglin
    Department of Haematology, Addenbrookes NHS Trust, Cambridge, UK
    Br J Haematol 133:19-34. 2006
  24. ncbi Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism
    A Jackson
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 111:562-4. 2000
    ..The possibility that the I/D polymorphism is a risk factor for venous thromboembolism specifically after hip replacement cannot be excluded...
  25. ncbi Unraveling the thrombophilia paradox: from hypercoagulability to the prothrombotic state
    T Baglin
    Department of Haematology, Cambridge University Hospitals NHS Trust, Addenbrooke s Hospital, Cambridge, UK
    J Thromb Haemost 8:228-33. 2010
    ....
  26. ncbi Lupus anticoagulant testing with optical end point automation
    R Luddington
    Department of Haematology, Addenbrookes NHS Trust, Cambridge, United Kingdom
    Thromb Res 96:197-203. 1999
    ..The factor V ratio is a useful second-line screen for both anticoagulated patients and anticardiolipin antibody-positive samples...
  27. ncbi Effect of platelet phospholipid exposure on activated protein C resistance: implications for thrombophilia screening
    R Luddington
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge
    Br J Haematol 92:744-6. 1996
    ..For the purpose of identifying individuals at increased risk of venous thromboembolism due to the presence of the FVQ506 and associated APC resistance a PCR-based genotypic analysis is recommended...
  28. ncbi Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition
    R Luddington
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    J Thromb Haemost 2:1954-9. 2004
    ....
  29. ncbi Narrative review: aspirin resistance and its clinical implications
    Simon Sanderson
    University of Cambridge, Addenbrooke s Hospital, and Institute of Public Health, Cambridge, United Kingdom
    Ann Intern Med 142:370-80. 2005
    ..These challenges must be met before researchers conduct studies to assess the clinical utility of testing on patient outcomes and cost-effective prescribing...
  30. ncbi Is smoking a risk factor for venous thromboembolism?
    Trevor Baglin
    Thromb Haemost 88:881-2. 2002
  31. ncbi Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism
    Madeleine Verhovsek
    McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 149:481-90, W94. 2008
    ..Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation...
  32. ncbi Venous thromboembolism in hospitalised patients: a public health crisis?
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Br J Haematol 141:764-70. 2008
    ..It is anticipated that, by 2009, risk assessment will be mandatory for all hospitalised patients in England; the same strategy is likely for the whole UK...
  33. ncbi Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls
    Peter W Collins
    Department of Haematology, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK
    Br J Haematol 135:220-7. 2006
    ..005). In conclusion, global tests of haemostasis suggest that in this patient group, activation of haemostasis is delayed but once initiated thrombin generation and clot formation are normal or enhanced...
  34. ncbi Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study
    Yesim Dargaud
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 139:303-9. 2007
    ..Standardization and normalization should be considered in future clinical studies which apply TG testing to clinical decision making...
  35. ncbi Acquired bleeding disorders
    Trevor Baglin
    Department of Haematology, Addenbrooke's NHS Trust, Cambridge
    Clin Med 5:326-8. 2005
  36. ncbi Platelet-dependent thrombography: a method for diagnostic laboratories
    Yesim Dargaud
    Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK
    Br J Haematol 134:323-5. 2006
    ..This method has potential application to the measurement of platelet-dependent thrombin generation in clinical diagnostic laboratories and hence the investigation of patients with apparent hypo- or hypercoagulable phenotypes...
  37. ncbi The measurement and application of thrombin generation
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 130:653-61. 2005
    ..Ultimately management studies will be required if the clinical utility of measurement of thrombin generation is to be proven...