Zsolt Bagi

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Microvascular responsiveness in obesity: implications for therapeutic intervention
    Zsolt Bagi
    Department of Pharmacology, University of Oxford, UK Department of Physiology, New York Medical College, Valhalla, New York, USA
    Br J Pharmacol 165:544-60. 2012
  2. ncbi Increased availability of angiotensin AT 1 receptors leads to sustained arterial constriction to angiotensin II in diabetes - role for Rho-kinase activation
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Br J Pharmacol 163:1059-68. 2011
  3. ncbi Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
  4. ncbi High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H835-41. 2008
  5. ncbi Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles
    Akos Koller
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2461-7. 2004
  6. ncbi H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice
    Nora Erdei
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H649-56. 2007
  7. ncbi PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 25:1590-5. 2005
  8. ncbi Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4)
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H626-33. 2004
  9. ncbi Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005
  10. ncbi Activation of hexosamine pathway impairs nitric oxide (NO)-dependent arteriolar dilations by increased protein O-GlcNAcylation
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Vascul Pharmacol 56:115-21. 2012

Collaborators

Detail Information

Publications19

  1. ncbi Microvascular responsiveness in obesity: implications for therapeutic intervention
    Zsolt Bagi
    Department of Pharmacology, University of Oxford, UK Department of Physiology, New York Medical College, Valhalla, New York, USA
    Br J Pharmacol 165:544-60. 2012
    ..LINKED ARTICLES: This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-3...
  2. ncbi Increased availability of angiotensin AT 1 receptors leads to sustained arterial constriction to angiotensin II in diabetes - role for Rho-kinase activation
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Br J Pharmacol 163:1059-68. 2011
    ..Antagonists of angiotensin AT(1) receptors elicit beneficial vascular effects in diabetes mellitus. We hypothesized that diabetes induces sustained availability of AT(1) receptors, causing enhanced arterial constriction to angiotensin II...
  3. ncbi Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
    ..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity...
  4. ncbi High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H835-41. 2008
    ..We propose that in hypertension-regardless of etiology-high intraluminal pressure, via oxidative stress, enhances the functional availability of AT1 receptors augmenting Ang II-induced constrictions...
  5. ncbi Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles
    Akos Koller
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2461-7. 2004
    ..Thus, mechanosensitive mechanisms that are sensitive to deformation, pressure, stretch, and wall shear stress elicit release of NO and H2O2, resulting in reactive dilation of isolated coronary arterioles...
  6. ncbi H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice
    Nora Erdei
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H649-56. 2007
    ..These alterations may contribute to disturbed regulation of skeletal muscle blood flow in Type 2 diabetes mellitus...
  7. ncbi PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 25:1590-5. 2005
    ....
  8. ncbi Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4)
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H626-33. 2004
    ....
  9. ncbi Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005
    ..We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms...
  10. ncbi Activation of hexosamine pathway impairs nitric oxide (NO)-dependent arteriolar dilations by increased protein O-GlcNAcylation
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Vascul Pharmacol 56:115-21. 2012
    ..We propose that interfering with the hexosamine pathway may prevent microvascular complications in diabetes...
  11. ncbi PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 286:H742-8. 2004
    ..Thus, in addition to the previously revealed beneficial metabolic effects, the antioxidant action of rosiglitazone may protect coronary arteriolar function in Type 2 DM...
  12. ncbi Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 300:H777-83. 2011
    ..Collectively, we provided evidence for a distinct upregulation of arginase 1 in coronary arterioles of patients with DM, which contributes to a reduced NO production and consequently diminished vasodilation...
  13. ncbi Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus: implications for reactive oxygen species
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 61:99-104. 2009
    ..In this review, we aim to highlight current findings supporting a potential role for ROS in preserving coronary arteriolar dilation in type 2 diabetes mellitus...
  14. ncbi Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress
    An Huang
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Regul Integr Comp Physiol 302:R674-81. 2012
    ....
  15. ncbi Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1876-81. 2009
    ....
  16. ncbi Mechanisms of coronary microvascular adaptation to obesity
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Regul Integr Comp Physiol 297:R556-67. 2009
    ....
  17. ncbi Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways
    Csongor Cseko
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    J Appl Physiol 97:1130-7. 2004
    ..Because H2O2 at low micromolar concentrations activates several intrinsic mechanisms, we suggest that H2O2 contributes to the local regulation of skeletal muscle blood flow in various physiological and pathophysiological conditions...
  18. ncbi Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H2277-83. 2003
    ..Thus our study provides evidence that oxidative stress is an important in vivo mechanism that is primarily responsible for the development of endothelial dysregulation of WSS in HHcy...
  19. ncbi Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H1404-10. 2003
    ..This alteration in the regulation of coronary microvascular resistance may contribute to the development of IHD in T2-DM...