D Bachtrog

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Reduced levels of microsatellite variability on the neo-Y chromosome of Drosophila miranda
    D Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Curr Biol 10:1025-31. 2000
  2. pmc Towards a complete sequence of the human Y chromosome
    D Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genome Biol 2:REVIEWS1016. 2001
  3. ncbi Reduced adaptation of a non-recombining neo-Y chromosome
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Nature 416:323-6. 2002
  4. ncbi Accumulation of Spock and Worf, two novel non-LTR retrotransposons, on the neo-Y chromosome of Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 20:173-81. 2003
  5. ncbi Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Genet 34:215-9. 2003
  6. pmc On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 164:1237-40. 2003
  7. ncbi Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Nat Genet 36:518-22. 2004
  8. pmc Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 165:1221-32. 2003
  9. pmc Positive and negative selection on noncoding DNA in Drosophila simulans
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 25:1825-34. 2008
  10. pmc Genomic degradation of a young Y chromosome in Drosophila miranda
    Doris Bachtrog
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Genome Biol 9:R30. 2008

Detail Information

Publications22

  1. ncbi Reduced levels of microsatellite variability on the neo-Y chromosome of Drosophila miranda
    D Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Curr Biol 10:1025-31. 2000
    ..Because of a fusion of one of the autosomes to the Y chromosome, a neo-Y chromosome and a neo-X chromosome have been formed, resulting in the transmission of formerly autosomal genes in association with the sex chromosomes...
  2. pmc Towards a complete sequence of the human Y chromosome
    D Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genome Biol 2:REVIEWS1016. 2001
    ..A few dozen genes are known on the human Y chromosome. The completion of the human genome sequence will allow identification of the remaining loci, which should shed further light on the function and evolution of this peculiar chromosome...
  3. ncbi Reduced adaptation of a non-recombining neo-Y chromosome
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Nature 416:323-6. 2002
    ..Our results provide evidence for the importance of sexual recombination for increasing and maintaining the level of adaptation of a population...
  4. ncbi Accumulation of Spock and Worf, two novel non-LTR retrotransposons, on the neo-Y chromosome of Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 20:173-81. 2003
    ..These results support the hypothesis that transposons accumulate in nonrecombining regions and may be one cause of the heteromorphism of sex chromosomes...
  5. ncbi Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Genet 34:215-9. 2003
    ..Deleterious mutations, including repetitive DNA, accumulate on a non-recombining chromosome, whereas rapid protein evolution due to positive selection is confined to the recombining homolog...
  6. pmc On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 164:1237-40. 2003
    ..This suggests that flanking DNA should be used to confirm the positions of members of gene families...
  7. ncbi Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Nat Genet 36:518-22. 2004
    ..These results implicate positive selection as an important force driving the degeneration of Y chromosomes; adaptation at a few loci, possibly increasing male fitness, occurs at the cost of most other genes on this chromosome...
  8. pmc Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 165:1221-32. 2003
    ....
  9. pmc Positive and negative selection on noncoding DNA in Drosophila simulans
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 25:1825-34. 2008
    ..simulans lineage difficult to reconcile with demographic explanations...
  10. pmc Genomic degradation of a young Y chromosome in Drosophila miranda
    Doris Bachtrog
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Genome Biol 9:R30. 2008
    ..Here, we take advantage of the recently formed neo-Y chromosome of Drosophila miranda to study the processes involved in Y degeneration on a genomic scale...
  11. doi Evidence for male-driven evolution in Drosophila
    Doris Bachtrog
    Mol Biol Evol 25:617-9. 2008
    ..This study thus provides the first evidence for male-biased mutation rates outside vertebrates, supporting the view that DNA sequence evolution is male driven in a wide variety of taxa...
  12. ncbi A dynamic view of sex chromosome evolution
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0116, La Jolla, CA 92093, USA
    Curr Opin Genet Dev 16:578-85. 2006
    ..Furthermore, X chromosomes are not passive players in this evolutionary process but respond both to their sex-biased transmission and to Y-chromosome degeneration, through feminization and the evolution of dosage compensation...
  13. pmc Selection, recombination and demographic history in Drosophila miranda
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Genetics 174:2045-59. 2006
    ..These departures from neutral equilibrium expectations are discussed in the context of nonequilibrium models of demography and selection...
  14. ncbi The speciation history of the Drosophila nasuta complex
    Doris Bachtrog
    Section of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093, USA
    Genet Res 88:13-26. 2006
    ....
  15. ncbi Extensive introgression of mitochondrial DNA relative to nuclear genes in the Drosophila yakuba species group
    Doris Bachtrog
    Section of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, California 92093, USA
    Evolution 60:292-302. 2006
    ..Although natural selection is usually thought of as accentuating divergence between species, our results imply that it can also act as a homogenizing force...
  16. pmc X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution
    Kevin Thornton
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genome Res 16:498-504. 2006
    ..The lack of a detectable faster-X effect in these species suggests either that beneficial amino acids are not partially recessive on average, or that adaptive evolution does not often use newly arising amino acid mutations...
  17. pmc Sex chromosome evolution: molecular aspects of Y-chromosome degeneration in Drosophila
    Doris Bachtrog
    Department of Ecology, Behavior and Evolution, University of California, San Diego, La Jolla, California 92093, USA
    Genome Res 15:1393-401. 2005
    ..Despite heterogeneity in levels of dosage compensation along the neo-X chromosome of D. miranda, the neo-Y chromosome shows surprisingly uniform signs of degeneration...
  18. pmc A survey of chromosomal and nucleotide sequence variation in Drosophila miranda
    Soojin Yi
    Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637 1573, USA
    Genetics 164:1369-81. 2003
    ..miranda. However, data on an additional region of period confirm population subdivision for this gene, suggesting that local selection is operating at or near period to promote differentiation between populations...
  19. pmc The temporal dynamics of processes underlying Y chromosome degeneration
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Genetics 179:1513-25. 2008
    ..The temporal dynamics of these processes imply that a gradual restriction of recombination, as inferred in mammals, will increase the importance of genetic hitchhiking relative to Muller's ratchet and background selection...
  20. ncbi Expression profile of a degenerating neo-y chromosome in Drosophila
    Doris Bachtrog
    Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0116, La Jolla, California 92093, USA
    Curr Biol 16:1694-9. 2006
    ..Gene-poor, degenerate Y chromosomes have evolved repeatedly from ordinary autosomes, but little is known about the processes that silence most genes on an evolving Y...
  21. ncbi Reduced selection for codon usage bias in Drosophila miranda
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0116, La Jolla, CA 92093, USA
    J Mol Evol 64:586-90. 2007
    ..pseudoobscura, suggest that it has a much smaller effective population size. Reduced codon usage bias in D. miranda may thus result from the reduced efficacy of selection against newly arising mutations to unpreferred codons...
  22. ncbi Adaptive evolution of asexual populations under Muller's ratchet
    Doris Bachtrog
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Evolution 58:1403-13. 2004
    ....