Simon A Babayan

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 6:e1968. 2012
  2. pmc Immunity in society: diverse solutions to common problems
    Simon A Babayan
    Centre for Immunity, Infection and Evolution and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Biol 10:e1001297. 2012
  3. doi Future prospects and challenges of vaccines against filariasis
    Simon A Babayan
    Institute of Immunology and Infection Research, and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 34:243-53. 2012
  4. pmc Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000525. 2010
  5. doi Wild immunology
    Amy B Pedersen
    Centre for Immunity, Infection and Evolution, Institutes of Immunology and Infection Research and Evolutionary Biology, University of Edinburgh, Ashworth Labs, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 20:872-80. 2011
  6. ncbi CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, United Kingdom
    J Immunol 179:4626-34. 2007
  7. doi The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
    James P Hewitson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 10:e1003930. 2014
  8. doi Wild immunology: converging on the real world
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Kings Buildings, Edinburgh, United Kingdom
    Ann N Y Acad Sci 1236:17-29. 2011

Collaborators

Detail Information

Publications9

  1. pmc Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Negl Trop Dis 6:e1968. 2012
    ..As a consequence, the efficacy of a vaccine against filariasis may depend on its capacity to counter parasite-driven immunomodulation...
  2. pmc Immunity in society: diverse solutions to common problems
    Simon A Babayan
    Centre for Immunity, Infection and Evolution and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Biol 10:e1001297. 2012
    ....
  3. doi Future prospects and challenges of vaccines against filariasis
    Simon A Babayan
    Institute of Immunology and Infection Research, and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 34:243-53. 2012
    ..Nonetheless, new technological advances in addition to systems biology approaches offer hope that optimal immune responses can be induced that will prevent infection, disease and/or transmission...
  4. pmc Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000525. 2010
    ..Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology...
  5. doi Wild immunology
    Amy B Pedersen
    Centre for Immunity, Infection and Evolution, Institutes of Immunology and Infection Research and Evolutionary Biology, University of Edinburgh, Ashworth Labs, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 20:872-80. 2011
    ..Thus, wild immunology can be the missing link between laboratory-based immunology and human, wildlife and domesticated animal health...
  6. ncbi CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, United Kingdom
    J Immunol 179:4626-34. 2007
    ..This work suggests that during filarial infection CTLA-4 coinhibition and CD4+ CD25+ Treg cells form complementary components of immune regulation that inhibit protective immunity in vivo...
  7. doi The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
    James P Hewitson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 10:e1003930. 2014
    ..Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections...
  8. doi Wild immunology: converging on the real world
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Kings Buildings, Edinburgh, United Kingdom
    Ann N Y Acad Sci 1236:17-29. 2011
    ..The meeting on wild immunology, organized by Amy Pedersen, Simon Babayan, and Rick Maizels, was held at the University of Edinburgh on 30 June 2011...