Keith Baar

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Muscle growth: no IGFs, ands, or buts
    D Lee Hamilton
    Functional Molecular Biology Laboratory, Division of Molecular Physiology, University of Dundee, Dundee, UK
    J Physiol 586:5-6. 2008
  2. doi request reprint Small molecules can have big effects on endurance
    Keith Baar
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Nat Chem Biol 4:583-4. 2008
  3. ncbi request reprint Resistance exercise, muscle loading/unloading and the control of muscle mass
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee UK
    Essays Biochem 42:61-74. 2006
  4. ncbi request reprint Training for endurance and strength: lessons from cell signaling
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee, UK
    Med Sci Sports Exerc 38:1939-44. 2006
  5. pmc To perform your best: work hard not long
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee, UK
    J Physiol 575:690. 2006
  6. ncbi request reprint New dimensions in tissue engineering: possible models for human physiology
    Keith Baar
    Division of Molecular Physiology, University of Dundee, MSI WTB Dow Street, Dundee DD1 5EH, UK
    Exp Physiol 90:799-806. 2005
  7. pmc Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland
    Tissue Eng Part A 18:277-84. 2012
  8. pmc Factors affecting the longevity and strength in an in vitro model of the bone-ligament interface
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, UK
    Ann Biomed Eng 38:2155-66. 2010
  9. pmc A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise
    D Lee Hamilton
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 5:e11624. 2010
  10. pmc Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    Sean L McGee
    Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Sir James Black Centre, Dow Street, Dundee DD1 5EH, UK
    J Physiol 586:1731-41. 2008

Collaborators

Detail Information

Publications36

  1. pmc Muscle growth: no IGFs, ands, or buts
    D Lee Hamilton
    Functional Molecular Biology Laboratory, Division of Molecular Physiology, University of Dundee, Dundee, UK
    J Physiol 586:5-6. 2008
  2. doi request reprint Small molecules can have big effects on endurance
    Keith Baar
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Nat Chem Biol 4:583-4. 2008
  3. ncbi request reprint Resistance exercise, muscle loading/unloading and the control of muscle mass
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee UK
    Essays Biochem 42:61-74. 2006
    ..In this chapter, these pathways and how the balance between anabolism and catabolism is affected by loading and unloading will be discussed...
  4. ncbi request reprint Training for endurance and strength: lessons from cell signaling
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee, UK
    Med Sci Sports Exerc 38:1939-44. 2006
    ..A better understanding of the activation of these molecular pathways after exercise and how they interact will allow development of better training programs to maximize both strength and endurance...
  5. pmc To perform your best: work hard not long
    Keith Baar
    Division of Molecular Physiology, University of Dundee, Dundee, UK
    J Physiol 575:690. 2006
  6. ncbi request reprint New dimensions in tissue engineering: possible models for human physiology
    Keith Baar
    Division of Molecular Physiology, University of Dundee, MSI WTB Dow Street, Dundee DD1 5EH, UK
    Exp Physiol 90:799-806. 2005
    ..This article provides a personal view of the role of tissue engineering in advancing our understanding of physiology, with specific attention being paid to musculoskeletal tissues...
  7. pmc Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland
    Tissue Eng Part A 18:277-84. 2012
    ..1%±0.44%; CONT=4.8%±0.30%; and INT=5.9%±0.56%). These results suggest that short infrequent bouts of loading are optimal for improving engineered tendon and ligament physiology...
  8. pmc Factors affecting the longevity and strength in an in vitro model of the bone-ligament interface
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, UK
    Ann Biomed Eng 38:2155-66. 2010
    ..6 kPa, respectively. These results validate the use of brushite bone cement to engineer the bone-ligament interface in vitro and raise the potential for future use in ligament replacement surgery...
  9. pmc A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise
    D Lee Hamilton
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 5:e11624. 2010
    ....
  10. pmc Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    Sean L McGee
    Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Sir James Black Centre, Dow Street, Dundee DD1 5EH, UK
    J Physiol 586:1731-41. 2008
    ....
  11. doi request reprint A novel bioreactor for stimulating skeletal muscle in vitro
    Kenneth Donnelly
    Division of Mechanical Engineering and Mechatronics, University of Dundee, Dundee, United Kingdom
    Tissue Eng Part C Methods 16:711-8. 2010
    ..Together, these data show that the physiology and function of muscles can be improved in vitro using a bioreactor that allows the control of pulse amplitude, pulse width, pulse frequency, and work-to-rest ratio...
  12. doi request reprint Engineering an in vitro model of a functional ligament from bone to bone
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee, United Kingdom
    Tissue Eng Part A 16:3515-25. 2010
    ..This work describes a major step toward the development of tissue-engineered ligaments for the repair of ligament ruptures in humans...
  13. pmc Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation
    D Lee Hamilton
    Division of Molecular Physiology, James Black Centre, University of Dundee, Dundee, UK
    BMC Cell Biol 11:37. 2010
    ....
  14. pmc mVps34 is activated following high-resistance contractions
    Matthew G Mackenzie
    James Black Centre, University of Dundee, Dundee, DD1 5EH, UK
    J Physiol 587:253-60. 2009
    ..2-fold. These data suggest that, following high-resistance contractions, mVps34 activity is stimulated by an influx of essential amino acids such as leucine and this may prolong mTORC1 signalling and contribute to muscle hypertrophy...
  15. doi request reprint The signaling underlying FITness
    Keith Baar
    Division of Molecular Physiology, University of Dundee, James Black Centre, Dow Street, Dundee DD1 5EH, UK
    Appl Physiol Nutr Metab 34:411-9. 2009
    ..Specific attention is paid to the mammalian target of rapamycin, AMP-activated protein kinase, and the calcium-calmodulin-activated protein kinases, and the way these proteins interact during concurrent training...
  16. ncbi request reprint 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
    Daniel J Cuthbertson
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 56:2078-84. 2007
    ..3 +/- 0.6 to 10 +/- 0.6 mg x kg(-1) x min(-1) (P < 0.05). In healthy people, AICAR acutely stimulates muscle 2DG uptake with a minor effect on whole-body glucose disposal...
  17. doi request reprint Engineering the bone-ligament interface using polyethylene glycol diacrylate incorporated with hydroxyapatite
    Jennifer Z Paxton
    Division of Molecular Physiology, University of Dundee, Dundee, United Kingdom
    Tissue Eng Part A 15:1201-9. 2009
    ..This data suggests that HA, by itself or with other materials, might be well suited for engineering the ligament-bone interface...
  18. doi request reprint Regulating fibrinolysis to engineer skeletal muscle from the C2C12 cell line
    Alastair Khodabukus
    Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, United Kingdom
    Tissue Eng Part C Methods 15:501-11. 2009
    ..3 days and remain fully functional for 5 weeks over which time they continue to mature. The optimized model described here provides rapid, reliable, and functional tissues that will be useful in the study of skeletal muscle physiology...
  19. pmc Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes
    Andrew Philp
    Division of Molecular Physiology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    Am J Physiol Cell Physiol 299:C240-50. 2010
    ..The data suggest that supraphysiological doses of pyruvate decrease mitochondrial function despite limited biogenesis and that anaplerotic agents can reverse this effect...
  20. ncbi request reprint Engineered muscle: a tool for studying muscle physiology and function
    Alastair Khodabukus
    Division of Molecular Physiology, University of Dundee, Dundee, United Kingdom
    Exerc Sport Sci Rev 35:186-91. 2007
    ..Here, we present applications for this technology to further our understanding of the molecular mechanisms underlying skeletal muscle adaptation in response to exercise...
  21. pmc Inhibition of myostatin signaling through Notch activation following acute resistance exercise
    Matthew G Mackenzie
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 8:e68743. 2013
    ....
  22. ncbi request reprint Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity
    Keith Baar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 17:1666-73. 2003
    ..They also provide the new information that NRF-1 overexpression results in increased expression of GLUT4...
  23. ncbi request reprint Activation of Akt as a potential mediator of adaptations that reduce muscle injury
    Nicole C Lockhart
    Institute of Gerontology and University of Colorado, Boulder, CO, USA
    Med Sci Sports Exerc 38:1058-64. 2006
    ....
  24. ncbi request reprint Rapid formation of functional muscle in vitro using fibrin gels
    Yen Chih Huang
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    J Appl Physiol 98:706-13. 2005
    ..We conclude that fibrin-based gels provide a novel method to engineer three-dimensional functional muscle tissue and that these tissues may be used to model the development of skeletal muscle in vitro...
  25. ncbi request reprint Cultured slow vs. fast skeletal muscle cells differ in physiology and responsiveness to stimulation
    Yen Chih Huang
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA
    Am J Physiol Cell Physiol 291:C11-7. 2006
    ..We conclude that myogenic cells associated with a slow muscle are imprinted to produce muscle that contracts and relaxes slowly and that calcineurin activity cannot explain the response to a slow pattern of electrical stimulation...
  26. ncbi request reprint Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    Keith Baar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 16:1879-86. 2002
    ..These findings suggest that increases in PGC-1, NRF-1, and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 mediates the coordinated increases in GLUT4 and mitochondria...
  27. ncbi request reprint Engineering of functional tendon
    Sarah Calve
    Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
    Tissue Eng 10:755-61. 2004
    ..These physical and mechanical properties indicate that these constructs are the first viable tendons engineered in vitro, without the aid of artificial scaffolding...
  28. ncbi request reprint Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise
    Keith Baar
    Department of Mechanical Engineering and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109 2007, USA
    Proc Nutr Soc 63:269-73. 2004
    ....
  29. ncbi request reprint Self-organization of rat cardiac cells into contractile 3-D cardiac tissue
    Keith Baar
    Institute of Gerontology, Michigan, USA
    FASEB J 19:275-7. 2005
    ..Cardioids have a developmental protein phenotype that expresses both alpha- and beta-tropomyosin, very low levels of SERCA2a, and very little of the mature isoform of cardiac troponin T...
  30. ncbi request reprint Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells
    Louise Hecker
    Division of Pediatric Gastroenterology, University of Michigan Medical School, 1150 West Medical Center Dr, MSRB 1, Rm A520, Ann Arbor, MI 48109 0656, USA
    Am J Physiol Gastrointest Liver Physiol 289:G188-96. 2005
    ..This is the first report of a 3-D in vitro model of a gastrointestinal smooth muscle IAS. Bioengineered IAS rings demonstrate physiological functionality and may be used in the elucidation of the mechanisms causing sphincter malfunction...
  31. ncbi request reprint Regional variation of tibialis anterior tendon mechanics is lost following denervation
    Ellen M Arruda
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, USA
    J Appl Physiol 101:1113-7. 2006
    ..The stress-strain response in the mid-tendon region of a normal TA tendon is therefore not indicative of its overall ability to deform in vivo as it transmits forces from muscle to bone...
  32. ncbi request reprint Denervation does not change the ratio of collagen I and collagen III mRNA in the extracellular matrix of muscle
    Ellen M Arruda
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Am J Physiol Regul Integr Comp Physiol 292:R983-7. 2007
    ....
  33. pmc Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    James A Timmons
    Wenner Gren Institute, Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:4401-6. 2007
    ....
  34. doi request reprint Tension is required for fibripositor formation
    Zoher Kapacee
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, England, United Kingdom
    Matrix Biol 27:371-5. 2008
    ..In initial experiments to study the effects of tension, we showed that cutting the constructs resulted in loss of tension, loss of fibripositors and the appearance of immature fibrils with no preferred orientation...
  35. ncbi request reprint Tendon mechanics: the argument heats up
    Jennifer Z Paxton
    J Appl Physiol 103:423-4. 2007
  36. ncbi request reprint Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis
    Terry E Jones
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E96-101. 2003
    ..Our results are consistent with the interpretation that endurance exercise induces an adaptive increase in mitochondria that have a normal content of UCP3...