M B Avison

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi Preliminary analysis of the genetic basis for vancomycin resistance in Staphylococcus aureus strain Mu50
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 49:255-60. 2002
  2. ncbi Role of the 'cre/blr-tag' DNA sequence in regulation of gene expression by the Aeromonas hydrophila beta-lactamase regulator, BlrA
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 53:197-202. 2004
  3. ncbi Sequence and genome context analysis of a new molecular class D beta-lactamase gene from Legionella pneumophila
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 50:331-8. 2002
  4. ncbi Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophilia
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 49:387-9. 2002
  5. ncbi Analysis of AmpC beta-lactamase expression and sequence in biochemically atypical ceftazidime-resistant Enterobacteriaceae from paediatric patients
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 53:584-91. 2004
  6. pmc Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator
    Aki Okazaki
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    Antimicrob Agents Chemother 52:1525-8. 2008
  7. ncbi Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
    J Biol Chem 276:26955-61. 2001
  8. ncbi A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 46:879-84. 2000
  9. ncbi Aeromonas hydrophila AmpH and CepH beta-lactamases: derepressed expression in mutants of Escherichia coli lacking creB
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 46:695-702. 2000
  10. ncbi beta-lactamase expression in Plesiomonas shigelloides
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 45:877-80. 2000

Collaborators

Detail Information

Publications33

  1. ncbi Preliminary analysis of the genetic basis for vancomycin resistance in Staphylococcus aureus strain Mu50
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 49:255-60. 2002
    ..These observations will inform targeted experiments aimed at a complete understanding of the mechanism(s) of vancomycin resistance in S. aureus Mu50 and other VRSA strains...
  2. ncbi Role of the 'cre/blr-tag' DNA sequence in regulation of gene expression by the Aeromonas hydrophila beta-lactamase regulator, BlrA
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 53:197-202. 2004
    ....
  3. ncbi Sequence and genome context analysis of a new molecular class D beta-lactamase gene from Legionella pneumophila
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 50:331-8. 2002
    ..Despite the presence of beta-lactamase regulator homologues, we could find no evidence of LoxA induction upon challenge of L. pneumophila Philadelphia-1 with beta-lactams...
  4. ncbi Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophilia
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 49:387-9. 2002
    ..The frequency of isolating type 3 mutants is c. 10(-9), however, implying that there is a significant overlap between the regulatory mechanisms...
  5. ncbi Analysis of AmpC beta-lactamase expression and sequence in biochemically atypical ceftazidime-resistant Enterobacteriaceae from paediatric patients
    Matthew B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 53:584-91. 2004
    ..To analyse the variation of ampC beta-lactamase gene sequence and expression in biochemically atypical Enterobacteriaceae isolates, and to identify them definitively...
  6. pmc Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulator
    Aki Okazaki
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    Antimicrob Agents Chemother 52:1525-8. 2008
    ..AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction...
  7. ncbi Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
    J Biol Chem 276:26955-61. 2001
    ..The diverse functions encoded by the cre regulon suggest that CreBC is a global regulator that sits right at the heart of metabolic control in Escherichia coli...
  8. ncbi A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 46:879-84. 2000
    ..This represents the first identification of a TEM beta-lactamase in S. maltophilia and the first evidence that this important clinical pathogen is able to act as a reservoir for mobile beta-lactamase genes in the hospital environment...
  9. ncbi Aeromonas hydrophila AmpH and CepH beta-lactamases: derepressed expression in mutants of Escherichia coli lacking creB
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 46:695-702. 2000
    ..The entire cepH-containing fragment was sequenced, but it contained no genes that were obviously related to any known class of DNA-binding protein...
  10. ncbi beta-lactamase expression in Plesiomonas shigelloides
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 45:877-80. 2000
    ..3. The environmental isolates produced a variety of penicillinases, indicating that there is a reservoir of heterogeneous beta-lactamase genes in this species...
  11. ncbi Characterization, cloning and sequence analysis of the inducible Ochrobactrum anthropi AmpC beta-lactamase
    C S Higgins
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Antimicrob Chemother 47:745-54. 2001
    ..Genomic searches of other non-gamma-subdivision bacteria revealed a homologous ampR-ampC cluster in the plant symbiont, Sinorhizobium meliloti...
  12. pmc Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia
    M B Avison
    Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 ITD, United Kingdom
    Antimicrob Agents Chemother 45:413-9. 2001
    ..It is therefore apparent that the L1 and L2 genes have evolved relatively quickly, perhaps because of their presence on a plasmid...
  13. ncbi A novel metallo-beta-lactamase, Mbl1b, produced by the environmental bacterium Caulobacter crescentus
    A M Simm
    Department of Pathology and Microbiology, University of Bristol, University Walk, UK
    FEBS Lett 509:350-4. 2001
    ..The main differences between Mbl1 and L1 are in the N-terminal region...
  14. ncbi SmeDEF-mediated antimicrobial drug resistance in Stenotrophomonas maltophilia clinical isolates having defined phylogenetic relationships
    Virginia C Gould
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 57:1070-6. 2006
    ....
  15. ncbi Beta-lactam resistance and beta-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationships
    Virginia C Gould
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 57:199-203. 2006
    ..To test the hypothesis that Stenotrophomonas maltophilia isolates from certain phylogenetic groups have predictable beta-lactamase expression and beta-lactam resistance profiles...
  16. ncbi pUb6060: a broad-host-range, DNA polymerase-I-independent ColE2-like plasmid
    M B Avison
    Department of Pathology and Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, Bristol, BS8 1TD, United Kingdom
    Plasmid 45:88-100. 2001
    ..Additionally, it carries two ORFs encoding products of unknown function. The pUB6060 replicon maintains a moderate plasmid copy number (10 per chromosome copy) and permits replication in diverse gram-negative bacteria...
  17. pmc Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coli
    S James L Cariss
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Bacteriol 190:3930-9. 2008
    ..These observations support the hypothesis that CreBC is a functional two-component system involved in the metabolic control of transcription in E. coli and confirm that CreB is a DNA binding transcriptional regulator...
  18. doi Induction of beta-lactamase production in Aeromonas hydrophila is responsive to beta-lactam-mediated changes in peptidoglycan composition
    Amy E Tayler
    Department of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK
    Microbiology 156:2327-35. 2010
    ..Taken together, these data strongly suggest that the Aeromonas spp. beta-lactamase regulatory sensor kinase, BlrB, responds to the concentration of monomer-disaccharide-pentapeptide in peptidoglycan...
  19. ncbi Enhanced membrane permeabilization and antibacterial activity of a disulfide-dimerized magainin analogue
    Christopher E Dempsey
    Biochemistry Department and Molecular Recognition Centre, Bristol University, School of Medical Sciences, University Walk, Bristol BS8 1TD, U K
    Biochemistry 42:402-9. 2003
    ..494, 85-89]. Disulfide-dimerization of pore-forming, positively charged, amphipathic helical peptides may be a useful general approach to the generation of peptide antimicrobials having activity at very low concentrations...
  20. ncbi Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas spp
    Pannika Niumsup
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 51:1351-8. 2003
    ..The same hierarchy is seen following beta-lactam challenge of A. hydrophila T429125, and correlates with the number of blr-tag sequences (TTCAC) found upstream of each beta-lactamase gene: ampH (one), cepH (two) and imiH (three)...
  21. ncbi Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology
    Sarah Underwood
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 53:1076-80. 2004
    ..We measured sequence variation at the beta-lactamase structural gene among a group of clinical isolates originally identified as C. diversus by API 20E profiling...
  22. ncbi Evolutionary mapping of the SHV beta-lactamase and evidence for two separate IS26-dependent blaSHV mobilization events from the Klebsiella pneumoniae chromosome
    Peter J Ford
    Bristol Centre for Antimicrobial Research and Evaluation, Bacterial Genomics Group, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Antimicrob Chemother 54:69-75. 2004
    ..To determine the most likely evolutionary pathway that has led to the development of extended-spectrum SHV derivatives, and to the mobilization of blaSHV...
  23. ncbi Analysis of sequence variation among smeDEF multi drug efflux pump genes and flanking DNA from defined 16S rRNA subgroups of clinical Stenotrophomonas maltophilia isolates
    Virginia C Gould
    Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    J Antimicrob Chemother 54:348-53. 2004
    ..To determine the level of variation in the smeDEF efflux pump and smeT transcriptional regulator genes among three defined 16S rRNA sequence subgroups of clinical Stenotrophomonas maltophilia isolates...
  24. pmc Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia
    Aki Okazaki
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    Antimicrob Agents Chemother 51:359-60. 2007
    ..Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs...
  25. pmc YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli
    S James L Cariss
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Bacteriol 192:3329-36. 2010
    ..Through microarray analysis and gene knockout and overexpression studies, we show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype...
  26. pmc Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases
    Alan M Simm
    Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Biochem J 387:585-90. 2005
    ..Docking experiments support the conclusion that bulgecin A co-ordinates to the zinc II site in metallo-beta-lactamases via the terminal sulphonate group on the sugar moiety...
  27. pmc Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)
    K J Heesom
    Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol, Avon BS81TD, UK
    Biochem J 336:39-48. 1998
    ....
  28. pmc New approaches to combating antimicrobial drug resistance
    Matthew B Avison
    Department of Cellular and Molecular Medicine, Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Genome Biol 6:243. 2005
    ..This finding may help in the battle against the rise of resistance to antimicrobial drugs...
  29. ncbi Comparative genomics: digging for data
    Matthew B Avison
    Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol, UK
    Methods Mol Biol 266:47-69. 2004
    ..With more and more genome sequences becoming available, the rise of comparative genomics continues apace...
  30. pmc Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia
    Yvonne Fouhy
    BIOMERIT Research Centre, Department of Microbiology, Biosciences Institute, National University of Ireland, Cork, Ireland
    J Bacteriol 189:4964-8. 2007
    ..Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen...
  31. pmc Comparative genomic hybridization detects secondary chromosomal deletions in Escherichia coli K-12 MG1655 mutants and highlights instability in the flhDC region
    Jon L Hobman
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Bacteriol 189:8786-92. 2007
    ....
  32. ncbi Resistance determinants in strains of Clostridium difficile from two geographically distinct populations
    Julian S Bendle
    Department of Microbiology, Royal Gwent Hospital, Gwent Healthcare NHS Trust, Cardiff Road, Newport, South Wales NP20 2UB, UK
    Int J Antimicrob Agents 24:619-21. 2004
    ..The possibility that C. difficile may serve as a conservator for resistant determinants subsequent to exposure to antimicrobial agents, has important implications for infection control...
  33. pmc nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa
    Yuji Morita
    Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Bacteriol 188:8649-54. 2006
    ..Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter...