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Genomes and Genes | M B AvisonSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Preliminary analysis of the genetic basis for vancomycin resistance in Staphylococcus aureus strain Mu50Matthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 49:255-60. 2002..These observations will inform targeted experiments aimed at a complete understanding of the mechanism(s) of vancomycin resistance in S. aureus Mu50 and other VRSA strains...- Role of the 'cre/blr-tag' DNA sequence in regulation of gene expression by the Aeromonas hydrophila beta-lactamase regulator, BlrAMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 53:197-202. 2004.... - Sequence and genome context analysis of a new molecular class D beta-lactamase gene from Legionella pneumophilaMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 50:331-8. 2002..Despite the presence of beta-lactamase regulator homologues, we could find no evidence of LoxA induction upon challenge of L. pneumophila Philadelphia-1 with beta-lactams... - Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophiliaMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 49:387-9. 2002..The frequency of isolating type 3 mutants is c. 10(-9), however, implying that there is a significant overlap between the regulatory mechanisms... - Analysis of AmpC beta-lactamase expression and sequence in biochemically atypical ceftazidime-resistant Enterobacteriaceae from paediatric patientsMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 53:584-91. 2004..To analyse the variation of ampC beta-lactamase gene sequence and expression in biochemically atypical Enterobacteriaceae isolates, and to identify them definitively... 
Induction of L1 and L2 beta-lactamase production in Stenotrophomonas maltophilia is dependent on an AmpR-type regulatorAki Okazaki
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 52:1525-8. 2008..AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction...- Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal mediaM B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
J Biol Chem 276:26955-61. 2001..The diverse functions encoded by the cre regulon suggest that CreBC is a global regulator that sits right at the heart of metabolic control in Escherichia coli... - A TEM-2beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophiliaM B Avison
Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 46:879-84. 2000..This represents the first identification of a TEM beta-lactamase in S. maltophilia and the first evidence that this important clinical pathogen is able to act as a reservoir for mobile beta-lactamase genes in the hospital environment... - Aeromonas hydrophila AmpH and CepH beta-lactamases: derepressed expression in mutants of Escherichia coli lacking creBM B Avison
Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 46:695-702. 2000..The entire cepH-containing fragment was sequenced, but it contained no genes that were obviously related to any known class of DNA-binding protein... - beta-lactamase expression in Plesiomonas shigelloidesM B Avison
Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 45:877-80. 2000..3. The environmental isolates produced a variety of penicillinases, indicating that there is a reservoir of heterogeneous beta-lactamase genes in this species... - Characterization, cloning and sequence analysis of the inducible Ochrobactrum anthropi AmpC beta-lactamaseC S Higgins
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 47:745-54. 2001..Genomic searches of other non-gamma-subdivision bacteria revealed a homologous ampR-ampC cluster in the plant symbiont, Sinorhizobium meliloti... - Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophiliaM B Avison
Bristol Centre for Antimicrobial Research and Evaluation BCARE, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 ITD, United Kingdom
Antimicrob Agents Chemother 45:413-9. 2001..It is therefore apparent that the L1 and L2 genes have evolved relatively quickly, perhaps because of their presence on a plasmid... - A novel metallo-beta-lactamase, Mbl1b, produced by the environmental bacterium Caulobacter crescentusA M Simm
Department of Pathology and Microbiology, University of Bristol, University Walk, UK
FEBS Lett 509:350-4. 2001..The main differences between Mbl1 and L1 are in the N-terminal region... - SmeDEF-mediated antimicrobial drug resistance in Stenotrophomonas maltophilia clinical isolates having defined phylogenetic relationshipsVirginia C Gould
Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 57:1070-6. 2006..There is strong evidence for the existence of as yet unidentified multi-drug efflux pumps in this species... - Beta-lactam resistance and beta-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationshipsVirginia C Gould
Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 57:199-203. 2006..CONCLUSIONS: The majority of S. maltophilia clinical isolates behave similarly in terms of beta-lactamase expression and beta-lactam resistance properties, despite considerable phylogenetic variability... - pUb6060: a broad-host-range, DNA polymerase-I-independent ColE2-like plasmidM B Avison
Department of Pathology and Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, Bristol, BS8 1TD, United Kingdom
Plasmid 45:88-100. 2001..Additionally, it carries two ORFs encoding products of unknown function. The pUB6060 replicon maintains a moderate plasmid copy number (10 per chromosome copy) and permits replication in diverse gram-negative bacteria... - Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coliS James L Cariss
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
J Bacteriol 190:3930-9. 2008..These observations support the hypothesis that CreBC is a functional two-component system involved in the metabolic control of transcription in E. coli and confirm that CreB is a DNA binding transcriptional regulator... 
Induction of beta-lactamase production in Aeromonas hydrophila is responsive to beta-lactam-mediated changes in peptidoglycan compositionAmy E Tayler
Department of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK
Microbiology 156:2327-35. 2010..Taken together, these data strongly suggest that the Aeromonas spp. beta-lactamase regulatory sensor kinase, BlrB, responds to the concentration of monomer-disaccharide-pentapeptide in peptidoglycan...- Enhanced membrane permeabilization and antibacterial activity of a disulfide-dimerized magainin analogueChristopher E Dempsey
Biochemistry Department and Molecular Recognition Centre, Bristol University, School of Medical Sciences, University Walk, Bristol BS8 1TD, U K
Biochemistry 42:402-9. 2003..494, 85-89]. Disulfide-dimerization of pore-forming, positively charged, amphipathic helical peptides may be a useful general approach to the generation of peptide antimicrobials having activity at very low concentrations... - Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas sppPannika Niumsup
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 51:1351-8. 2003..The same hierarchy is seen following beta-lactam challenge of A. hydrophila T429125, and correlates with the number of blr-tag sequences (TTCAC) found upstream of each beta-lactamase gene: ampH (one), cepH (two) and imiH (three)... - Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homologySarah Underwood
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 53:1076-80. 2004..We measured sequence variation at the beta-lactamase structural gene among a group of clinical isolates originally identified as C. diversus by API 20E profiling... - Evolutionary mapping of the SHV beta-lactamase and evidence for two separate IS26-dependent blaSHV mobilization events from the Klebsiella pneumoniae chromosomePeter J Ford
Bristol Centre for Antimicrobial Research and Evaluation, Bacterial Genomics Group, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 54:69-75. 2004..CONCLUSIONS: These data shed new light on the evolution and mobilization of blaSHV, and these observations may be useful in predicting what might happen in future, both for blaSHV, and for other beta-lactamase genes... - Analysis of sequence variation among smeDEF multi drug efflux pump genes and flanking DNA from defined 16S rRNA subgroups of clinical Stenotrophomonas maltophilia isolatesVirginia C Gould
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
J Antimicrob Chemother 54:348-53. 2004..maltophilia, based on genotypic properties. Isolate D457, in which most work concerning smeDEF expression has been performed, does not fall into S. maltophilia subgroup A, which is the most typical... - Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophiliaAki Okazaki
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 51:359-60. 2007..Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs... - YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coliS James L Cariss
Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
J Bacteriol 192:3329-36. 2010..Through microarray analysis and gene knockout and overexpression studies, we show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype... - Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamasesAlan M Simm
Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
Biochem J 387:585-90. 2005..Docking experiments support the conclusion that bulgecin A co-ordinates to the zinc II site in metallo-beta-lactamases via the terminal sulphonate group on the sugar moiety... - Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)K J Heesom
Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol, Avon BS81TD, UK
Biochem J 336:39-48. 1998.... - New approaches to combating antimicrobial drug resistanceMatthew B Avison
Department of Cellular and Molecular Medicine, Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Genome Biol 6:243. 2005..This finding may help in the battle against the rise of resistance to antimicrobial drugs... - Comparative genomics: digging for dataMatthew B Avison
Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol, UK
Methods Mol Biol 266:47-69. 2004..With more and more genome sequences becoming available, the rise of comparative genomics continues apace... - Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophiliaYvonne Fouhy
BIOMERIT Research Centre, Department of Microbiology, Biosciences Institute, National University of Ireland, Cork, Ireland
J Bacteriol 189:4964-8. 2007..Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen... - Comparative genomic hybridization detects secondary chromosomal deletions in Escherichia coli K-12 MG1655 mutants and highlights instability in the flhDC regionJon L Hobman
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Bacteriol 189:8786-92. 2007.... - Resistance determinants in strains of Clostridium difficile from two geographically distinct populationsJulian S Bendle
Department of Microbiology, Royal Gwent Hospital, Gwent Healthcare NHS Trust, Cardiff Road, Newport, South Wales NP20 2UB, UK
Int J Antimicrob Agents 24:619-21. 2004..The possibility that C. difficile may serve as a conservator for resistant determinants subsequent to exposure to antimicrobial agents, has important implications for infection control... - nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosaYuji Morita
Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada K7L 3N6
J Bacteriol 188:8649-54. 2006..Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter...