SIMON AVERY

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. doi request reprint Molecular targets of oxidative stress
    Simon V Avery
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Biochem J 434:201-10. 2011
  2. pmc The antimalarial drug quinine interferes with serotonin biosynthesis and action
    Farida Islahudin
    1 School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, UK 2 School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia 3
    Sci Rep 4:3618. 2014
  3. pmc Glutathione and Gts1p drive beneficial variability in the cadmium resistances of individual yeast cells
    Matthew C A Smith
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 66:699-712. 2007
  4. pmc Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata
    Samantha C Halliwell
    School of Biology, University of Nottingham, University Park, Nottingham, United Kingdom
    Eukaryot Cell 11:141-50. 2012
  5. pmc Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity
    Sara Holland
    School of Biology, Institute of Genetics, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Genome Biol 8:R268. 2007
  6. ncbi request reprint Cell individuality: the bistability of competence development
    Simon V Avery
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Trends Microbiol 13:459-62. 2005
  7. ncbi request reprint Microbial cell individuality and the underlying sources of heterogeneity
    Simon V Avery
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nat Rev Microbiol 4:577-87. 2006
  8. ncbi request reprint Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations
    Amy L Bishop
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 63:507-20. 2007
  9. ncbi request reprint Phenotypic heterogeneity: differential stress resistance among individual cells of the yeast Saccharomyces cerevisiae
    Edward R Sumner
    School of Life and Environmental Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Microbiology 148:345-51. 2002
  10. doi request reprint Chromate toxicity and the role of sulfur
    Sara L Holland
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Metallomics 3:1119-23. 2011

Collaborators

  • Stephen G Oliver
  • Daniela Delneri
  • Sara L Holland
  • Edward R Sumner
  • Angela M Avery
  • Matthew C A Smith
  • Farida Islahudin
  • Samantha C Halliwell
  • Amy L Bishop
  • Sara Holland
  • Hans E M Christensen
  • Ian R Mellor
  • Sarah M Tindall
  • Karen Swift
  • Richard J Pleass
  • Kevin C F Fone
  • Kang Nee Ting
  • Philippa Muston
  • Ekalabya Ghosh
  • Faiza A Rab
  • Theodora Sideri
  • Konstantinos Gkargkas
  • Tom Reader
  • David C Hoyle
  • Emma Lodwig
  • Ian Clarke
  • Sylvia A Willetts
  • Helen J Goddard
  • John E Houghton
  • R Adrian Robins

Detail Information

Publications14

  1. doi request reprint Molecular targets of oxidative stress
    Simon V Avery
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Biochem J 434:201-10. 2011
    ..Protein oxidation also triggers accumulation of toxic protein aggregates or induction of apoptotic cell death. This burgeoning understanding of the principal ROS targets will offer new possibilities for therapy of ROS related diseases...
  2. pmc The antimalarial drug quinine interferes with serotonin biosynthesis and action
    Farida Islahudin
    1 School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, UK 2 School of Pharmacy, University of Nottingham Malaysia Campus, 43500 Semenyih, Malaysia 3
    Sci Rep 4:3618. 2014
    ..The study shows that quinine disrupts both serotonin biosynthesis and function, giving important new insight to the action of quinine on mammalian cells. ..
  3. pmc Glutathione and Gts1p drive beneficial variability in the cadmium resistances of individual yeast cells
    Matthew C A Smith
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 66:699-712. 2007
    ..The results establish a novel molecular mechanism for single-cell heterogeneity, and demonstrate experimentally fitness advantages that depend on deterministic variation in gene expression within cell populations...
  4. pmc Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata
    Samantha C Halliwell
    School of Biology, University of Nottingham, University Park, Nottingham, United Kingdom
    Eukaryot Cell 11:141-50. 2012
    ..The study shows how heterogeneity can impact the virulence-related properties of C. glabrata cell populations, with potential implications for microbial pathogenesis more broadly...
  5. pmc Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity
    Sara Holland
    School of Biology, Institute of Genetics, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Genome Biol 8:R268. 2007
    ..Microarray-based screens of these heterozygotes are truly genome-wide as they include both essential and non-essential genes...
  6. ncbi request reprint Cell individuality: the bistability of competence development
    Simon V Avery
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Trends Microbiol 13:459-62. 2005
    ..Two experimental studies have now pinpointed the same auto-stimulatory feedback loop of gene expression as the principal requirement for the establishment of this 'bistable' response...
  7. ncbi request reprint Microbial cell individuality and the underlying sources of heterogeneity
    Simon V Avery
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nat Rev Microbiol 4:577-87. 2006
    ..However, the full contribution of factors such as stochastic gene expression is yet to be realized...
  8. ncbi request reprint Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations
    Amy L Bishop
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 63:507-20. 2007
    ....
  9. ncbi request reprint Phenotypic heterogeneity: differential stress resistance among individual cells of the yeast Saccharomyces cerevisiae
    Edward R Sumner
    School of Life and Environmental Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Microbiology 148:345-51. 2002
  10. doi request reprint Chromate toxicity and the role of sulfur
    Sara L Holland
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Metallomics 3:1119-23. 2011
    ..Sulfur deprivation could contribute to additional aspects of Cr toxicity, including oxidative DNA damage and Cr related disease...
  11. pmc Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity
    Sara L Holland
    School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham, UK
    Toxicol In Vitro 24:1764-7. 2010
    ..Therefore, Cr-induced S starvation is the cause of mRNA mistranslation. This establishes a single, novel pathway mediating the toxicity of chromate...
  12. ncbi request reprint Cell cycle- and age-dependent activation of Sod1p drives the formation of stress resistant cell subpopulations within clonal yeast cultures
    Edward R Sumner
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Mol Microbiol 50:857-70. 2003
    ..g. when faced with stress), but without the permanent metabolic costs of constitutive expression...
  13. ncbi request reprint Genetic dissection of the phospholipid hydroperoxidase activity of yeast gpx3 reveals its functional importance
    Angela M Avery
    Institute of Genetics, School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    J Biol Chem 279:46652-8. 2004
    ....
  14. pmc Iron blocks the accumulation and activity of tetracyclines in bacteria
    Angela M Avery
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Antimicrob Agents Chemother 48:1892-4. 2004
    ..Thus, synergistic suppression of bacterial growth in the presence of a low Fe concentration and tetracyclines arises because of elevated antibiotic accumulation...

Research Grants4