Research Topics
| D J AustinSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators |
Detail Information
Publications
Immunodominance, competition and evolution in immunological responses to helminth parasite antigensD J Austin
Wellcome Centre for the Epidemiology of Infectious Diseases, University of Oxford
Parasitology 113:157-72. 1996....- The transmission dynamics of antibiotic-resistant bacteria: the relationship between resistance in commensal organisms and antibiotic consumptionD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, University of Oxford, UK
Proc Biol Sci 264:1629-38. 1997..The model is employed to address the issues of how best to use antibiotics in populations harbouring resistant organisms, and when resistant bacteria will out-compete sensitive strains... - The dynamics of drug action on the within-host population growth of infectious agents: melding pharmacokinetics with pathogen population dynamicsD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, University of Oxford, South Parks Road, Oxford, OX1 3PS, U K
J Theor Biol 194:313-39. 1998..Under chemotherapeutic regimens, expressions for R0 are derived allowing estimates to be made of the ideal treatment regime required to eliminate the pathogen, both for HIV and P. falciparum malaria... - The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistanceD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 96:1152-6. 1999..These results highlight the need for early intervention once resistance is detected... - Studies of antibiotic resistance within the patient, hospitals and the community using simple mathematical modelsD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, University of Oxford, UK
Philos Trans R Soc Lond B Biol Sci 354:721-38. 1999..Model output is fitted to data for Finland and Iceland and conclusions drawn concerning the key factors determining the rate of spread and decay once drug pressure is relaxed... - Transmission dynamics of epidemic methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in England and WalesD J Austin
The Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, Oxford, OX1 3PS, United Kingdom daren
J Infect Dis 179:883-91. 1999..Finally, the role of heterogeneity in hospital size is considered: "Super-spreader hospitals" may increase transmission by 40%-132% above the expected mean... - Vancomycin-resistant enterococci in intensive care hospital settingsD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, University of Oxford, UK
Mem Inst Oswaldo Cruz 93:587-8. 1998..Once infection control measures are included R0 = 0.6, suggesting that admission of VRE-colonized patients can stabilize endemic VRE... - Vancomycin-resistant enterococci in intensive-care hospital settings: transmission dynamics, persistence, and the impact of infection control programsD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 96:6908-13. 1999..Our analyses suggest that compliance for hand washing significantly in excess of reported levels, or the cohorting of nursing staff, are needed to prevent nosocomial transmission of VRE in endemic settings...