Belinda Austen

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling
    Victoria J Weston
    Cancer Research UK Institute for Cancer Studies, Birmingham University, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 104:1465-73. 2004
  2. ncbi Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
    Belinda Austen
    Cancer Research United Kingdom CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 106:3175-82. 2005
  3. ncbi A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival
    Azra J Alvi
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, B15 2TT, United Kingdom
    Blood 105:4484-91. 2005
  4. pmc ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele
    Anna Skowronska
    School of Cancer Sciences, University of Birmingham, University of Birmingham, Birmingham B15 2TT, UK
    Haematologica 97:142-6. 2012
  5. ncbi Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses
    Tatjana Stankovic
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Blood 103:291-300. 2004
  6. doi Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients
    Belinda Austen
    CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Br J Haematol 142:925-33. 2008
  7. ncbi Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
    Belinda Austen
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, United Kingdom
    J Clin Oncol 25:5448-57. 2007
  8. ncbi South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients
    Chaminda Gunawardana
    CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Br J Haematol 142:606-9. 2008
  9. doi Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
    Chris Pepper
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 112:3807-17. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling
    Victoria J Weston
    Cancer Research UK Institute for Cancer Studies, Birmingham University, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 104:1465-73. 2004
    ..We conclude that increased NF-kappaB prosurvival signaling is a frequent mechanism by which B-precursor ALL tumors develop apoptotic resistance to IR and that PARP1 inhibition may improve the DNA damage response of these leukemias...
  2. ncbi Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
    Belinda Austen
    Cancer Research United Kingdom CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 106:3175-82. 2005
    ..The majority of patients with ATM mutations were refractory to DNA damaging chemotherapeutic drugs and as such might benefit from therapies that bypass the ATM/p53 pathway...
  3. ncbi A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival
    Azra J Alvi
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, B15 2TT, United Kingdom
    Blood 105:4484-91. 2005
    ..We conclude that CYC202 is a potent inducer of apoptosis in B-CLL regardless of the functional status of the p53 pathway, and may be considered as a therapeutic agent to improve the outcome of resistant B-CLL tumors...
  4. pmc ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele
    Anna Skowronska
    School of Cancer Sciences, University of Birmingham, University of Birmingham, Birmingham B15 2TT, UK
    Haematologica 97:142-6. 2012
    ..0 of 281, P = 0.15). These results suggest that ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but rather influences rapid disease progression through ATM loss...
  5. ncbi Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses
    Tatjana Stankovic
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Blood 103:291-300. 2004
    ..Therefore, damage-induced transcriptional fingerprinting can be used to stratify tumors according to their biologic differences and simultaneously identify potential targets for treating refractory tumors...
  6. doi Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients
    Belinda Austen
    CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Br J Haematol 142:925-33. 2008
    ..We also report a 48-year-old ataxia telangiectasia patient who developed multiple myeloma. Taken together our study suggests that ATM mutation may play a role in the pathogenesis of a subset of multiple myelomas...
  7. ncbi Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
    Belinda Austen
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, United Kingdom
    J Clin Oncol 25:5448-57. 2007
    ..Our aim was to determine if CLL tumors with a chromosome 11q deletion might be divided into two subgroups based on the status of the remaining ATM allele...
  8. ncbi South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients
    Chaminda Gunawardana
    CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Br J Haematol 142:606-9. 2008
    ..026). CLL was diagnosed at younger ages in Asians and racial-specific variations in IGHV usage were demonstrated. Our findings indicate that Southern Asian race has a negative impact on CLL phenotype...
  9. doi Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
    Chris Pepper
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 112:3807-17. 2008
    ..The close correlation between Mcl-1 expression and V(H) gene mutation status, CD38 expression, and ZAP-70 expression offers a biologic explanation for their association with adverse prognosis...