J C Atherton

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc The chips are down for Helicobacter pylori
    J C Atherton
    Division of Gastroenterology and Institute of Infections and Immunity, University Hospital, Nottingham NG7 2UH, UK
    Gut 50:293-4. 2002
  2. ncbi request reprint The inflammatory and immune response to Helicobacter pylori infection
    Karen Robinson
    Wolfson Digestive Diseases Centre, University of Nottingham, C Floor, South Block, Queen s Medical Centre Campus, Nottingham University Hospital NHS Trust, Nottingham NG7 2UH, UK
    Best Pract Res Clin Gastroenterol 21:237-59. 2007
  3. pmc In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription
    Feifei Shen
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    BMC Microbiol 10:210. 2010
  4. pmc Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori
    J C Atherton
    Department of Medicine, Division of Gastroenterology, University Hospital, University of Nottingham, Nottingham, United Kingdom
    J Clin Microbiol 37:2979-82. 1999
  5. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
  6. ncbi request reprint The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases
    John C Atherton
    Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Annu Rev Pathol 1:63-96. 2006
  7. pmc Effects of Helicobacter pylori on the cadherin-catenin complex
    J R Bebb
    Wolfson Centre for Digestive Diseases and Institute of Infections, Inflammation and Immunity, University Hospital Nottingham, Nottingham, UK
    J Clin Pathol 59:1261-6. 2006
  8. doi request reprint Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008
  9. ncbi request reprint Safety and efficacy of 7-day rabeprazole- and omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with documented peptic ulcer disease
    C J Hawkey
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
    Aliment Pharmacol Ther 17:1065-74. 2003
  10. pmc Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease
    Nawfal R Hussein
    Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Clin Microbiol 46:1774-9. 2008

Collaborators

Detail Information

Publications48

  1. pmc The chips are down for Helicobacter pylori
    J C Atherton
    Division of Gastroenterology and Institute of Infections and Immunity, University Hospital, Nottingham NG7 2UH, UK
    Gut 50:293-4. 2002
  2. ncbi request reprint The inflammatory and immune response to Helicobacter pylori infection
    Karen Robinson
    Wolfson Digestive Diseases Centre, University of Nottingham, C Floor, South Block, Queen s Medical Centre Campus, Nottingham University Hospital NHS Trust, Nottingham NG7 2UH, UK
    Best Pract Res Clin Gastroenterol 21:237-59. 2007
    ..pylori itself influence T-helper differentiation and regulatory T-cell responses remains controversial. Finally, effective vaccines have still not been developed: a better understanding of the immune response to H. pylori may help...
  3. pmc In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription
    Feifei Shen
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    BMC Microbiol 10:210. 2010
    ..In this study, we investigated whether and how LuxS controls motility of H. pylori, specifically if it has its effects via luxS-required cysteine metabolism or via AI-2 synthesis only...
  4. pmc Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori
    J C Atherton
    Department of Medicine, Division of Gastroenterology, University Hospital, University of Nottingham, Nottingham, United Kingdom
    J Clin Microbiol 37:2979-82. 1999
    ..pylori and show that this system correctly identifies the signal and midregion types of vacA in 77 strains from Asia and North and South America...
  5. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
    ..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases...
  6. ncbi request reprint The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases
    John C Atherton
    Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Annu Rev Pathol 1:63-96. 2006
    ..pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear...
  7. pmc Effects of Helicobacter pylori on the cadherin-catenin complex
    J R Bebb
    Wolfson Centre for Digestive Diseases and Institute of Infections, Inflammation and Immunity, University Hospital Nottingham, Nottingham, UK
    J Clin Pathol 59:1261-6. 2006
    ..Germline mutations in E-cadherin have been described in diffuse-type gastric adenocarcinoma. Helicobacter pylori infection is the first stage in gastric carcinogenesis...
  8. doi request reprint Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008
    ..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...
  9. ncbi request reprint Safety and efficacy of 7-day rabeprazole- and omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with documented peptic ulcer disease
    C J Hawkey
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
    Aliment Pharmacol Ther 17:1065-74. 2003
    ..A double-blind, randomized study was designed to determine whether rabeprazole- and omeprazole-based triple therapy regimens are therapeutically equivalent in the eradication of Helicobacter pylori...
  10. pmc Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease
    Nawfal R Hussein
    Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Clin Microbiol 46:1774-9. 2008
    ..However, the association between strain virulence markers and disease in Iraq but not Iran suggests that other host and environmental factors may be more important in the disease-prone Iranian population...
  11. pmc Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion
    S R Patel
    Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, NG7 2RD, UK Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Cell Microbiol 15:2080-92. 2013
    ..These data indicate that H. pylori downregulates hβD1 expression via NF-κB signalling, and suggest that this may promote bacterial survival and persistence in the gastric niche...
  12. ncbi request reprint Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding
    W A Stack
    Division of Gastroenterology, University Hospital, Nottingham, UK
    Aliment Pharmacol Ther 16:497-506. 2002
    ..To investigate the role of Helicobacter pylori, expressing the virulence marker CAGA (cytotoxin associated gene product A) in ulcer complications and its interaction with nonsteroidal anti-inflammatory drugs (NSAIDs) and other risk factors...
  13. pmc Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7
    Yinfei Yin
    Division of Pre Clinical Oncology, University of Nottingham, Nottingham, UK
    Gut 59:1037-45. 2010
    ....
  14. ncbi request reprint Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells
    Nawfal R Hussein
    Nottingham Digestive Diseases Centre Biomedical Research Unit, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    J Infect Dis 202:261-9. 2010
    ..Infection with Helicobacter pylori possessing a newly described virulence factor--duodenal ulcer-promoting gene A (dupA)--has been associated with duodenal ulceration and increased gastric inflammation...
  15. ncbi request reprint Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status
    M G Rittig
    Centre for Biochemistry and Cell Biology, Institute of Infections, Immunity and Inflammation, University of Nottingham Meeical School, UK
    Cell Microbiol 5:887-99. 2003
    ..pylori-induced homotypic phagosome fusion depends on neither the vacuolating cytotoxin VacA nor the cag pathogenicity island of H. pylori and does not result in prolonged intracellular survival...
  16. pmc Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner
    J R Bebb
    Division of Gastroenterology and Institute of Infections, Immunity, and Inflammation, University Hospital, Nottingham, UK
    Gut 52:1408-13. 2003
    ..Helicobacter pylori infection is the first stage in gastric carcinogenesis, and therefore our aim was to determine if H pylori upregulated gastric MMP-7 expression and if this was affected by strain virulence...
  17. ncbi request reprint A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer
    Joanne L Rhead
    Wolfson Digestive Diseases Centre and Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, England
    Gastroenterology 133:926-36. 2007
    ..The vacA i-region types of H pylori isolates from patients undergoing routine endoscopy were determined by nucleotide sequencing and allele-specific polymerase chain reaction...
  18. ncbi request reprint The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America
    Richard H Argent
    Wolfson Digestive Diseases Centre, Queen s Medical Centre, Nottingham, United Kingdom
    Clin Infect Dis 45:1204-6. 2007
    ..We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration...
  19. doi request reprint Functional association between the Helicobacter pylori virulence factors VacA and CagA
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Med Microbiol 57:145-50. 2008
    ..VacA did not affect the phosphorylation of CagA. These data show that VacA and CagA downregulate each other's effects on epithelial cells, potentially allowing H. pylori interaction with cells whilst avoiding excessive cellular damage...
  20. pmc The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat module
    Robin M Delahay
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Mol Biol 377:956-71. 2008
    ..We provide the first insight into the structural basis for CagY(rpt2) assembly that accommodates both the variable motif sequence composition and the extensive contraction/expansion of repeat modules within the CagY(rpt2) region...
  21. doi request reprint Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park and Wolfson Digestive Diseases Centre, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    Clin Cancer Res 14:2227-35. 2008
    ..We aimed to determine whether infection with virulent H. pylori preceded precancerous gastric hypochlorhydria and atrophy in gastric cancer relatives and quantify the extent of virulence factor evolution...
  22. ncbi request reprint Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Med Microbiol 57:1062-7. 2008
    ....
  23. pmc Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCR
    Richard H Argent
    Institute of Infection, Immunity, and Inflammation, C Floor West Block, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Clin Microbiol 43:791-5. 2005
    ..We describe here a novel and rapid PCR method for determination of the pattern of repeats containing the EPIYA motif. This will aid in the identification of those strains that may be more likely to cause disease...
  24. pmc In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway
    Neil C Doherty
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    J Bacteriol 192:1184-92. 2010
    ..pylori in a process of reverse transsulfuration. We recommend that the misnamed genes cysK(Hp) and metB(Hp) be renamed mccA (methionine-to-cysteine-conversion gene A) and mccB, respectively...
  25. pmc Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach
    Francisco Aviles-Jimenez
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom
    J Bacteriol 186:5182-5. 2004
    ..The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity...
  26. ncbi request reprint Brefeldin A enhances Helicobacter pylori vacuolating cytotoxin-induced vacuolation of epithelial cells
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    FEMS Microbiol Lett 237:163-70. 2004
    ..This may explain why some forms of VacA do not cause vacuolation and why vacuolation is minimal at the low bacteria:cell ratios observed in vivo...
  27. ncbi request reprint Determinants of non-toxicity in the gastric pathogen Helicobacter pylori
    Darren P Letley
    Division of Gastroenterology and Institute of Infections, Immunity and Inflammation, University of Nottingham, C Floor, West Block, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 278:26734-41. 2003
    ..This work defines why H. pylori strains with different vacA allelic structures have differing toxicity and provides a rational basis for vacA typing schemes...
  28. ncbi request reprint Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacA
    Darren P Letley
    Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, UK
    Microbiology 152:1319-25. 2006
    ..Although less VacA was observed for the cysteine mutants, vacuolating activity was detected, showing that the cysteines were not required for VacA function...
  29. ncbi request reprint All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion
    Nicola Fitchen
    Institute of Infection, Immunity, and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham NG7 2RH, UK
    J Med Microbiol 54:621-30. 2005
    ..pylori cells...
  30. ncbi request reprint Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, England
    Gastroenterology 127:514-23. 2004
    ....
  31. pmc Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity
    D P Letley
    Division of Gastroenterology and Institute of Infections and Immunity, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Bacteriol 182:3278-80. 2000
    ..We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production...
  32. pmc Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats
    P V Sherwood
    Division of Gastroenterology, University of Nottingham, UK
    Gut 51:490-5. 2002
    ..The success of Helicobacter pylori eradication regimens depends on gastric pH, inflammation, and mucus thickness. Our aim was to investigate the effects of acid secretion, inflammation, and mucolysis on gastric antibiotic transfer...
  33. pmc Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent
    James R Bebb
    Division of Gastroenterology and Institution of Infections, Immunity and Inflammation, University of Nottingham, University Hospital, United Kingdom
    Infect Immun 71:3623-7. 2003
    ..By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin...
  34. ncbi request reprint Mastic gum has no effect on Helicobacter pylori load in vivo
    James R Bebb
    Division of Gastroenterology, University Hospital, Nottingham, NG7 2UH, UK
    J Antimicrob Chemother 52:522-3. 2003
    ..To determine whether mastic gum suppresses or eradicates Helicobacter pylori infection in humans...
  35. ncbi request reprint The effect of the human gut-signalling hormone, norepinephrine, on the growth of the gastric pathogen Helicobacter pylori
    Neil C Doherty
    Institute of Infections, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Helicobacter 14:223-30. 2009
    ..Catecholamine hormones have been shown to enhance growth of other bacterial species and are found in the gastric niche. We aimed to study growth enhancement of H. pylori by the human catecholamine hormones epinephrine and norepinephrine...
  36. doi request reprint The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control study
    Philip V Kaye
    Department of Cellular Pathology, Nottingham University Hospitals and NHS Trust and University of Nottingham, Queen s Medical Centre Campus, Nottingham, United Kingdom
    Am J Gastroenterol 103:2883-9. 2008
    ..To audit our experience with gastrointestinal investigation of iron deficiency anemia (IDA) and assess whether gastric atrophy associates with and likely causes it...
  37. ncbi request reprint Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation
    Michael F Byrne
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Gastroenterology 124:1846-54. 2003
    ..Clinical studies have suggested an association between cardiovascular disease and infection with Helicobacter pylori. We examined the effect of H. pylori on platelets and the mechanism of the interaction...
  38. pmc Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cells
    Youli Zhang
    Division of Gastroenterology, The Affiliated Hospital Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
    J Clin Microbiol 43:786-90. 2005
    ..001) more cells to elongate. We hypothesize that the preponderance of the more active East Asian form of cagA may underlie the high rate of gastric cancer in China...
  39. doi request reprint A study of age-specific Helicobacter pylori seropositivity rates in Iraq
    Nawfal R Hussein
    Helicobacter 13:306-7. 2008
  40. pmc Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells
    Susan Kenny
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 295:G431-41. 2008
    ....
  41. doi request reprint Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    ..We assessed the association of new and established cagA and vacA polymorphisms with disease...
  42. pmc Helicobacter pylori persistence: biology and disease
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
    J Clin Invest 113:321-33. 2004
    ..A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia...
  43. ncbi request reprint cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area
    Wen Qiao
    Department of Gastroenterology, First Hospital, Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China xhy1202 sohu com
    World J Gastroenterol 9:1762-6. 2003
    ....
  44. ncbi request reprint Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection
    Parjeet K Boughan
    Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guildford St, London WC1N 1EH, United Kingdom
    J Biol Chem 281:11637-48. 2006
    ....
  45. pmc Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection
    Nina R Salama
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Bacteriol 189:3834-45. 2007
    ....
  46. pmc The effect of different strains of Helicobacter pylori on platelet aggregation
    Paul A Corcoran
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Can J Gastroenterol 21:367-70. 2007
    ..It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain strains of H pylori induce platelet aggregation through interactions with platelet glycoprotein Ib have been previously described...
  47. pmc Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene
    Adriana Reyes-Leon
    Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Av Cuauhtemoc 330, Mexico, DF CP 06725, Mexico
    Infect Immun 75:3445-54. 2007
    ..cag pathogenicity island-positive H. pylori isolates displayed a high level of heterogeneity in the capacity to induce IL-8 secretion and morphological changes; an absent or modified B motif was associated with low activity...
  48. ncbi request reprint Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner
    Maria J Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal, and the Laboratory of Experimental Cancerology, Ghent University Hospital, Belgium
    J Biol Chem 281:34888-96. 2006
    ..Our findings demonstrate that H. pylori strains with a functional T4SS stimulate gastric epithelial cell invasion through a c-Met-dependent signaling pathway that comprises an increase in MMP-2 and MMP-9 activity...