Research Topics
Species | J C AthertonSummaryAffiliation: University of Nottingham Country: UK Publications
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Publications
The chips are down for Helicobacter pyloriJ C Atherton
Division of Gastroenterology and Institute of Infections and Immunity, University Hospital, Nottingham NG7 2UH, UK
Gut 50:293-4. 2002
The inflammatory and immune response to Helicobacter pylori infectionKaren Robinson
Wolfson Digestive Diseases Centre, University of Nottingham, C Floor, South Block, Queen s Medical Centre Campus, Nottingham University Hospital NHS Trust, Nottingham NG7 2UH, UK
Best Pract Res Clin Gastroenterol 21:237-59. 2007..pylori itself influence T-helper differentiation and regulatory T-cell responses remains controversial. Finally, effective vaccines have still not been developed: a better understanding of the immune response to H. pylori may help...- In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcriptionFeifei Shen
Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
BMC Microbiol 10:210. 2010..In this study, we investigated whether and how LuxS controls motility of H. pylori, specifically if it has its effects via luxS-required cysteine metabolism or via AI-2 synthesis only... - Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pyloriJ C Atherton
Department of Medicine, Division of Gastroenterology, University Hospital, University of Nottingham, Nottingham, United Kingdom
J Clin Microbiol 37:2979-82. 1999..pylori and show that this system correctly identifies the signal and midregion types of vacA in 77 strains from Asia and North and South America... - The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseasesJohn C Atherton
Wolfson Digestive Diseases Centre and Institute of Infections, Immunity, and Inflammation, University of Nottingham, Nottingham NG7 2UH, United Kingdom
Annu Rev Pathol 1:63-96. 2006..pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear... - Coadaptation of Helicobacter pylori and humans: ancient history, modern implicationsJohn C Atherton
Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
J Clin Invest 119:2475-87. 2009..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases... - Effects of Helicobacter pylori on the cadherin-catenin complexJ R Bebb
Wolfson Centre for Digestive Diseases and Institute of Infections, Inflammation and Immunity, University Hospital Nottingham, Nottingham, UK
J Clin Pathol 59:1261-6. 2006..Germline mutations in E-cadherin have been described in diffuse-type gastric adenocarcinoma. Helicobacter pylori infection is the first stage in gastric carcinogenesis... - Safety and efficacy of 7-day rabeprazole- and omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with documented peptic ulcer diseaseC J Hawkey
Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
Aliment Pharmacol Ther 17:1065-74. 2003..A double-blind, randomized study was designed to determine whether rabeprazole- and omeprazole-based triple therapy regimens are therapeutically equivalent in the eradication of Helicobacter pylori... 
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responsesK Robinson
Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
Gut 57:1375-85. 2008..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...- Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated diseaseNawfal R Hussein
Institute of Infection, Immunity, and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
J Clin Microbiol 46:1774-9. 2008..However, the association between strain virulence markers and disease in Iraq but not Iran suggests that other host and environmental factors may be more important in the disease-prone Iranian population... - Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleedingW A Stack
Division of Gastroenterology, University Hospital, Nottingham, UK
Aliment Pharmacol Ther 16:497-506. 2002..pylori infection is associated with an increased risk of ulcer bleeding. The risk from non-aspirin NSAIDs is even higher, but is less in H. pylori infected people. Low-dose aspirin is now commonly associated with ulcer bleeding... - Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7Yinfei Yin
Division of Pre Clinical Oncology, University of Nottingham, Nottingham, UK
Gut 59:1037-45. 2010.... - Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cellsNawfal R Hussein
Nottingham Digestive Diseases Centre Biomedical Research Unit, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
J Infect Dis 202:261-9. 2010..Infection with Helicobacter pylori possessing a newly described virulence factor--duodenal ulcer-promoting gene A (dupA)--has been associated with duodenal ulceration and increased gastric inflammation... - Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent mannerJ R Bebb
Division of Gastroenterology and Institute of Infections, Immunity, and Inflammation, University Hospital, Nottingham, UK
Gut 52:1408-13. 2003..CONCLUSION: We speculate that increased expression of MMP-7 in H pylori gastritis may contribute to gastric carcinogenesis... - Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag statusM G Rittig
Centre for Biochemistry and Cell Biology, Institute of Infections, Immunity and Inflammation, University of Nottingham Meeical School, UK
Cell Microbiol 5:887-99. 2003..pylori-induced homotypic phagosome fusion depends on neither the vacuolating cytotoxin VacA nor the cag pathogenicity island of H. pylori and does not result in prolonged intracellular survival... - Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these familiesRichard H Argent
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park and Wolfson Digestive Diseases Centre, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
Clin Cancer Res 14:2227-35. 2008..We aimed to determine whether infection with virulent H. pylori preceded precancerous gastric hypochlorhydria and atrophy in gastric cancer relatives and quantify the extent of virulence factor evolution... - The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat moduleRobin M Delahay
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
J Mol Biol 377:956-71. 2008..We provide the first insight into the structural basis for CagY(rpt2) assembly that accommodates both the variable motif sequence composition and the extensive contraction/expansion of repeat modules within the CagY(rpt2) region... - Functional association between the Helicobacter pylori virulence factors VacA and CagARichard H Argent
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
J Med Microbiol 57:145-50. 2008..VacA did not affect the phosphorylation of CagA. These data show that VacA and CagA downregulate each other's effects on epithelial cells, potentially allowing H. pylori interaction with cells whilst avoiding excessive cellular damage... - Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretionRichard H Argent
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
J Med Microbiol 57:1062-7. 2008.... - The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North AmericaRichard H Argent
Wolfson Digestive Diseases Centre, Queen s Medical Centre, Nottingham, United Kingdom
Clin Infect Dis 45:1204-6. 2007..We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration... - A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancerJoanne L Rhead
Wolfson Digestive Diseases Centre and Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, England
Gastroenterology 133:926-36. 2007..The vacA i-region types of H pylori isolates from patients undergoing routine endoscopy were determined by nucleotide sequencing and allele-specific polymerase chain reaction... - In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathwayNeil C Doherty
Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
J Bacteriol 192:1184-92. 2010..pylori in a process of reverse transsulfuration. We recommend that the misnamed genes cysK(Hp) and metB(Hp) be renamed mccA (methionine-to-cysteine-conversion gene A) and mccB, respectively... - Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacADarren P Letley
Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, UK
Microbiology 152:1319-25. 2006..Although less VacA was observed for the cysteine mutants, vacuolating activity was detected, showing that the cysteines were not required for VacA function... - Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomachFrancisco Aviles-Jimenez
Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom
J Bacteriol 186:5182-5. 2004..The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity... - Brefeldin A enhances Helicobacter pylori vacuolating cytotoxin-induced vacuolation of epithelial cellsRichard H Argent
Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
FEMS Microbiol Lett 237:163-70. 2004..This may explain why some forms of VacA do not cause vacuolation and why vacuolation is minimal at the low bacteria:cell ratios observed in vivo... - Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pyloriRichard H Argent
Institute of Infection, Immunity and Inflammation, and the Wolfson Digestive Diseases Centre, University of Nottingham, Queen s Medical Centre, England
Gastroenterology 127:514-23. 2004.... - Simple method for determination of the number of Helicobacter pylori CagA variable-region EPIYA tyrosine phosphorylation motifs by PCRRichard H Argent
Institute of Infection, Immunity, and Inflammation, C Floor West Block, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
J Clin Microbiol 43:791-5. 2005..We describe here a novel and rapid PCR method for determination of the pattern of repeats containing the EPIYA motif. This will aid in the identification of those strains that may be more likely to cause disease... - Determinants of non-toxicity in the gastric pathogen Helicobacter pyloriDarren P Letley
Division of Gastroenterology and Institute of Infections, Immunity and Inflammation, University of Nottingham, C Floor, West Block, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom
J Biol Chem 278:26734-41. 2003..This work defines why H. pylori strains with different vacA allelic structures have differing toxicity and provides a rational basis for vacA typing schemes... - All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretionNicola Fitchen
Institute of Infection, Immunity, and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham NG7 2RH, UK
J Med Microbiol 54:621-30. 2005..pylori cells... - Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in ratsP V Sherwood
Division of Gastroenterology, University of Nottingham, UK
Gut 51:490-5. 2002..CONCLUSIONS: Metronidazole and clarithromycin are predominantly transferred with gastric acid rather than by an acid trapping mechanism. Pronase increases the appearance of amoxicillin and metronidazole in gastric secretions... - Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activityD P Letley
Division of Gastroenterology and Institute of Infections and Immunity, University of Nottingham, Nottingham NG7 2UH, United Kingdom
J Bacteriol 182:3278-80. 2000..We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production... - Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependentJames R Bebb
Division of Gastroenterology and Institution of Infections, Immunity and Inflammation, University of Nottingham, University Hospital, United Kingdom
Infect Immun 71:3623-7. 2003..By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin... - The effect of the human gut-signalling hormone, norepinephrine, on the growth of the gastric pathogen Helicobacter pyloriNeil C Doherty
Institute of Infections, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
Helicobacter 14:223-30. 2009..Catecholamine hormones have been shown to enhance growth of other bacterial species and are found in the gastric niche. We aimed to study growth enhancement of H. pylori by the human catecholamine hormones epinephrine and norepinephrine... - Mastic gum has no effect on Helicobacter pylori load in vivoJames R Bebb
Division of Gastroenterology, University Hospital, Nottingham, NG7 2UH, UK
J Antimicrob Chemother 52:522-3. 2003..e.m. 19.1 +/- 3.7, day 15 (post-treatment) 18.7 +/- 3.8, P = 0.8, paired t-test]. CONCLUSION: Despite reported anti-H. pylori action in vitro, this preliminary study shows that mastic has no effect on H. pylori in humans... - The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control studyPhilip V Kaye
Department of Cellular Pathology, Nottingham University Hospitals and NHS Trust and University of Nottingham, Queen s Medical Centre Campus, Nottingham, United Kingdom
Am J Gastroenterol 103:2883-9. 2008..To audit our experience with gastrointestinal investigation of iron deficiency anemia (IDA) and assess whether gastric atrophy associates with and likely causes it... - Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregationMichael F Byrne
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland
Gastroenterology 124:1846-54. 2003..pylori-associated peptic ulcer disease and to the association between H. pylori infection and cardiovascular disease, whereas local platelet effects may contribute to the pathogenesis of H. pylori-associated peptic ulcer disease... - A study of age-specific Helicobacter pylori seropositivity rates in IraqNawfal R Hussein
Helicobacter 13:306-7. 2008 - Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cellsSusan Kenny
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK
Am J Physiol Gastrointest Liver Physiol 295:G431-41. 2008.... - cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an areaWen Qiao
Department of Gastroenterology, First Hospital, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. xhy1202@ sohu.com
World J Gastroenterol 9:1762-6. 2003..05), and s1a was more than s1b. Vacuolating toxins were more in Xi'an area isolates. CONCLUSION: The cagA(+) vacA type s1 clinical isolates are more in Xi'an area, but this can not serve as an index to predict gastric cancer... - Helicobacter pylori persistence: biology and diseaseMartin J Blaser
Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
J Clin Invest 113:321-33. 2004..A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia... - Tyrosine phosphorylation of CagA from Chinese Helicobacter pylori isolates in AGS gastric epithelial cellsYouli Zhang
Division of Gastroenterology, The Affiliated Hospital Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
J Clin Microbiol 43:786-90. 2005..001) more cells to elongate. We hypothesize that the preponderance of the more active East Asian form of cagA may underlie the high rate of gastric cancer in China... - Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent mannerMaria J Oliveira
Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP, Portugal, and the Laboratory of Experimental Cancerology, Ghent University Hospital, Belgium
J Biol Chem 281:34888-96. 2006..Our findings demonstrate that H. pylori strains with a functional T4SS stimulate gastric epithelial cell invasion through a c-Met-dependent signaling pathway that comprises an increase in MMP-2 and MMP-9 activity... - The effect of different strains of Helicobacter pylori on platelet aggregationPaul A Corcoran
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
Can J Gastroenterol 21:367-70. 2007..It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain strains of H pylori induce platelet aggregation through interactions with platelet glycoprotein Ib have been previously described... - Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA geneAdriana Reyes Leon
Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Av Cuauhtemoc 330, Mexico, DF CP 06725, Mexico
Infect Immun 75:3445-54. 2007..cag pathogenicity island-positive H. pylori isolates displayed a high level of heterogeneity in the capacity to induce IL-8 secretion and morphological changes; an absent or modified B motif was associated with low activity... - Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfectionNina R Salama
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Bacteriol 189:3834-45. 2007.... - Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infectionParjeet K Boughan
Infectious Diseases and Microbiology Unit, Institute of Child Health, 30 Guildford St, London WC1N 1EH, United Kingdom
J Biol Chem 281:11637-48. 2006.... - Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphismsDaniela Basso
Department of Laboratory Medicine, University of Padova, Padova, Italy
Gastroenterology 135:91-9. 2008..We assessed the association of new and established cagA and vacA polymorphisms with disease...