Marie Claude Asselin

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi Do imaging biomarkers relate to outcome in patients treated with VEGF inhibitors?
    James P B O'Connor
    Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 18:6588-98. 2012
  2. pmc Dynamic contrast-enhanced imaging techniques: CT and MRI
    J P B O'Connor
    Imaging Science, Proteomics and Genomics Research Group, University of Manchester, Manchester, UK
    Br J Radiol 84:S112-20. 2011
  3. pmc DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6
    J P B O'Connor
    Imaging Science, Proteomics and Genomics Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Oxford Road, Manchester M13 9PT, UK
    Br J Cancer 105:139-45. 2011
  4. doi Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging
    James P B O'Connor
    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 15:6674-82. 2009
  5. doi Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Int J Radiat Oncol Biol Phys 75:1209-15. 2009
  6. doi Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 61:75-83. 2009
  7. doi Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Lancet Oncol 9:766-76. 2008
  8. ncbi Enhancing fraction predicts clinical outcome following first-line chemotherapy in patients with epithelial ovarian carcinoma
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Clin Cancer Res 13:6130-5. 2007
  9. ncbi Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, UK
    Magn Reson Med 58:490-6. 2007
  10. pmc DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    J P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9PT
    Br J Cancer 96:189-95. 2007

Collaborators

Detail Information

Publications21

  1. doi Do imaging biomarkers relate to outcome in patients treated with VEGF inhibitors?
    James P B O'Connor
    Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 18:6588-98. 2012
    ..However, lack of control data with other therapies prevents assessment of the predictive nature of these biomarkers, and such studies are urgently required...
  2. pmc Dynamic contrast-enhanced imaging techniques: CT and MRI
    J P B O'Connor
    Imaging Science, Proteomics and Genomics Research Group, University of Manchester, Manchester, UK
    Br J Radiol 84:S112-20. 2011
    ....
  3. pmc DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6
    J P B O'Connor
    Imaging Science, Proteomics and Genomics Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Oxford Road, Manchester M13 9PT, UK
    Br J Cancer 105:139-45. 2011
    ....
  4. doi Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging
    James P B O'Connor
    Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 15:6674-82. 2009
    ..Such knowledge would help guide the rational development of targeted therapeutics from bench to bedside and optimize use of imaging technologies that quantify tumor function in early-phase clinical trials...
  5. doi Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumors
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Int J Radiat Oncol Biol Phys 75:1209-15. 2009
    ..Here we report application of this method to detect alteration in tumor oxygenation status...
  6. doi Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Magn Reson Med 61:75-83. 2009
    ..These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology...
  7. doi Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Lancet Oncol 9:766-76. 2008
    ....
  8. ncbi Enhancing fraction predicts clinical outcome following first-line chemotherapy in patients with epithelial ovarian carcinoma
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Clin Cancer Res 13:6130-5. 2007
    ..To define a simple radiologic biomarker of prognosis in patients with advanced epithelial ovarian carcinoma on first-line chemotherapy...
  9. ncbi Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, and Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, UK
    Magn Reson Med 58:490-6. 2007
    ..Shortening of tissue T1 by oxygen is more pronounced and more complex than previously recognized. The effect may be useful as a biomarker of arterial flow and oxygen delivery to vascular beds...
  10. pmc DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
    J P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9PT
    Br J Cancer 96:189-95. 2007
    ..This review highlights the critical issues that influence T(1)-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date...
  11. doi Optimization of the injected activity in dynamic 3D PET: a generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans
    Matthew D Walker
    School of Cancer and Imaging Sciences, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom
    J Nucl Med 50:1409-17. 2009
    ..The magnitude of the injected activity (A(0)) has a direct impact on the statistical quality of PET images. This study aimed to develop a generalized method for maximizing the statistical quality of dynamic PET images by optimizing A(0)...
  12. ncbi Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region
    Marie Claude Asselin
    Hammersmith Imanet, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 27:378-92. 2007
    ..Binging potential estimates from the SRTM were found to be sensitive to changes in cerebral blood flow, providing further evidence for caution in the use of the cerebellum as a reference region in measures of [(11)C]FLB 457 binding...
  13. doi Quantifying heterogeneity in human tumours using MRI and PET
    Marie Claude Asselin
    Wolfson Molecular Imaging Centre, University of Manchester, UK
    Eur J Cancer 48:447-55. 2012
    ..Finally, we have reviewed the existing clinical evidence that heterogeneity metrics provide additional useful information in drug discovery and development and in clinical practice...
  14. ncbi The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study
    Sarah von Spiczak
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Brain 128:906-17. 2005
    ..We therefore discuss a possible role for opioids in the pathophysiology of RLS with respect to sensory and motor symptoms...
  15. ncbi Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:82-94. 2007
    ..86) but unacceptably low for VOI-derived VD estimates at the low doses of injected radioactivity (0.24/0.04). Our data can inform the choice of methodology for a given biological problem...
  16. ncbi Measurement of methylphenidate-induced change in extrastriatal dopamine concentration using [11C]FLB 457 PET
    Andrew J Montgomery
    MRC Clinical Sciences Centre, Cyclotron Building, Imperial College, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 27:369-77. 2007
    ....
  17. ncbi A positron emission tomography (PET) investigation of the role of striatal dopamine (D2) receptor availability in spatial cognition
    Suzanne J Reeves
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroimage 28:216-26. 2005
    ....
  18. pmc Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis
    Oliver D Howes
    Br J Psychiatry Suppl 51:s13-8. 2007
    ....
  19. ncbi Upregulation of opioid receptor binding following spontaneous epileptic seizures
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Brain 130:1009-16. 2007
    ..This study provides direct human in vivo evidence for changes in opioid receptor availability over a time course of hours following spontaneous seizures, emphasizing an important role of the opioid system in seizure control...
  20. ncbi Parametrically defined cerebral blood vessels as non-invasive blood input functions for brain PET studies
    Marie Claude Asselin
    Department of Physics and Astronomy, McMaster University, Hamilton, ON, Canada
    Phys Med Biol 49:1033-54. 2004
    ....
  21. ncbi Positron emission tomography partial volume correction: estimation and algorithms
    John A D Aston
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Cereb Blood Flow Metab 22:1019-34. 2002
    ..The suitability of their application to dynamic and static images is discussed...