J Ashmore

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Cochlear transduction: from models to molecules and back again
    Jonathan F Ashmore
    Department of Physiology, University College London, UK
    Audiol Neurootol 7:6-8. 2002
  2. pmc Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter
    P Mistrik
    UCL Ear Institute, 332 Gray s Inn Road, London WC1E 6BT, UK
    J Physiol 590:5597-610. 2012
  3. ncbi request reprint Cochlear function: hearing in the fast lane
    J Ashmore
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Biol 9:R572-4. 1999
  4. pmc Molecular mechanisms of sound amplification in the mammalian cochlea
    J F Ashmore
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 97:11759-64. 2000
  5. ncbi request reprint Pushing the envelope of sound
    Jonathan Ashmore
    UCL Ear Institute, London WC1X8EE, UK
    Neuron 70:1021-2. 2011
  6. doi request reprint The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
  7. doi request reprint Cochlear outer hair cell motility
    Jonathan Ashmore
    Department of Physiology and UCL Ear Institute, University College London, London, United Kingdom
    Physiol Rev 88:173-210. 2008
  8. ncbi request reprint Apical endocytosis in outer hair cells of the mammalian cochlea
    C B Griesinger
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 20:41-50. 2004
  9. pmc Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers
    J M Chambard
    Department of Physiology, University College London, UK
    J Physiol 550:667-77. 2003
  10. ncbi request reprint Can you still see the cochlea for the molecules?
    J F Ashmore
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:449-54. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cochlear transduction: from models to molecules and back again
    Jonathan F Ashmore
    Department of Physiology, University College London, UK
    Audiol Neurootol 7:6-8. 2002
    ....
  2. pmc Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter
    P Mistrik
    UCL Ear Institute, 332 Gray s Inn Road, London WC1E 6BT, UK
    J Physiol 590:5597-610. 2012
    ..The results show the importance of considering the effects of the endogenous bicarbonate buffering system in evaluating the function of prestin in cochlear outer hair cells...
  3. ncbi request reprint Cochlear function: hearing in the fast lane
    J Ashmore
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Biol 9:R572-4. 1999
    ..Recent work suggests that outer hair cells can indeed work at frequencies that cover the auditory range...
  4. pmc Molecular mechanisms of sound amplification in the mammalian cochlea
    J F Ashmore
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 97:11759-64. 2000
    ..The relation of these findings to a recent candidate for the molecular motor is also discussed...
  5. ncbi request reprint Pushing the envelope of sound
    Jonathan Ashmore
    UCL Ear Institute, London WC1X8EE, UK
    Neuron 70:1021-2. 2011
    ..In this issue of Neuron, Fettiplace and colleagues show that prestin-based amplification is a viable mechanism as it is not limited by the outer hair cell's membrane time constant as previously surmised...
  6. doi request reprint The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
    ..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
  7. doi request reprint Cochlear outer hair cell motility
    Jonathan Ashmore
    Department of Physiology and UCL Ear Institute, University College London, London, United Kingdom
    Physiol Rev 88:173-210. 2008
    ..The functional and structural properties of prestin are described in this review. Whether outer hair cell motility might account for sound amplification at all frequencies is also a critical question and is reviewed here...
  8. ncbi request reprint Apical endocytosis in outer hair cells of the mammalian cochlea
    C B Griesinger
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 20:41-50. 2004
    ..The results suggest that OHCs endocytose membrane and membrane proteins with a high turnover rate and that these cells may use apical endocytosis to sort proteins via an indirect pathway to the lateral membrane...
  9. pmc Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers
    J M Chambard
    Department of Physiology, University College London, UK
    J Physiol 550:667-77. 2003
    ..We suggest that the structure of SLC26 family members allows them to act as neutral substrate transporters and may explain observed properties of cochlear hair cells...
  10. ncbi request reprint Can you still see the cochlea for the molecules?
    J F Ashmore
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:449-54. 2001
    ....
  11. pmc Differential expression of outer hair cell potassium currents in the isolated cochlea of the guinea-pig
    F Mammano
    Department of Physiology, School of Medical Sciences, Bristol, UK
    J Physiol 496:639-46. 1996
    ..Differences with the properties of isolated OHCs are discussed...
  12. ncbi request reprint Fm1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea
    Claudius B Griesinger
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:3939-52. 2002
    ..We suggest that IHCs use fast calcium-dependent apical endocytosis for activity-associated replenishment of synaptic membrane...
  13. ncbi request reprint Fast vesicle replenishment allows indefatigable signalling at the first auditory synapse
    Claudius B Griesinger
    Department of Physiology, Universitat Freiburg, Hermann Herder Str 7, 79104 Freiburg, Germany
    Nature 435:212-5. 2005
    ..This may explain how the first auditory synapse can encode with indefatigable precision without having to rely on the slow, local endocytic vesicle cycle...