E A Ashley
Affiliation: University of Oxford
- Computer applications in the interpretation of the exercise electrocardiogramE A Ashley
Department of Cardiovascular Medicine, University of Oxford, Oxford Cardiac Center, England
Sports Med 30:231-48. 2000..These key features explain the pivotal role of the exercise test in the diagnostic, and increasingly prognostic, armoury of the cardiovascular clinician...
- Exercise testing in clinical medicineE A Ashley
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
Lancet 356:1592-7. 2000..Brief, inexpensive, and done in most cases without the presence of a cardiologist, the exercise test offers the highest value for predictive accuracy of any of the non-invasive tests for coronary artery disease...
- Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytesEuan A Ashley
University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
Circulation 105:3011-6. 2002..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction...
- Diagnosing coronary artery disease in diabetic patientsEuan A Ashley
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Diabetes Metab Res Rev 18:201-8. 2002..Other diagnostic tools are considered, and recommendations are made with respect to screening asymptomatic diabetic patients for coronary artery disease...
- An evidence-based review of the resting electrocardiogram as a screening technique for heart diseaseE A Ashley
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, UK
Prog Cardiovasc Dis 44:55-67. 2001..This could lead to a network of web-servers from which every patient's ECGs would be available. Such a situation could have a dramatic effect on the advisability of performing screening ECGs...
- Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handlingClaire E Sears
Department of Cardiovascular Medicine, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Circ Res 92:e52-9. 2003..The full text of this article is available at http://www.circresaha.org...
- Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?Claire E Sears
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Philos Trans R Soc Lond B Biol Sci 359:1021-44. 2004..Whether or not the role of nNOS carries implications for cardiovascular disease remains an intriguing possibility requiring future study...
- Prognostic value of heart rate increase at onset of exercise testingNicholas J Leeper
Stanford University Medical Center, Stanford University Medical School, Calif, USA
Circulation 115:468-74. 2007..Our aim was to evaluate the prognostic value of early heart rate parameters in patients referred for routine clinical treadmill testing...
- Ventricular arrhythmias during clinical treadmill testing and prognosisFrederick E Dewey
Stanford University Medical School, Palo Alto, California, USA
Arch Intern Med 168:225-34. 2008..Therefore, we aimed to evaluate the clinical correlates and prognostic significance of exercise-associated premature ventricular complexes (PVCs) during and after exercise testing...
- Does size matter? Clinical applications of scaling cardiac size and function for body sizeFrederick E Dewey
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Circulation 117:2279-87. 2008..Lack of appropriate consideration of body size in the evaluation of cardiovascular structure and function may adversely affect recognition and treatment of cardiovascular disease states in the adult patient...
- Low-dose growth hormone is cardioprotective in uremiaRalph Rabkin
Department of Medicine, Stanford University and Research Service, Veterans Administration Health Care System, Palo Alto, California 94304, USA
J Am Soc Nephrol 19:1774-83. 2008..In contrast, high-dosage GH worsened several of these variables. These results suggest that low-dosage GH may benefit the heart and possibly the carotid arteries in chronic renal failure...
- Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mousePatrick Yue
Division of Cardiovascular Medicine, Department of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5406, USA
Am J Physiol Heart Circ Physiol 292:H2106-18. 2007..In summary, as assessed by CMR, db/db mice develop characteristic structural and functional changes consistent with cardiomyopathy...
- Pathway analysis of coronary atherosclerosisJennifer Y King
Donald W. Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University, Stanford, California 94305, USA
Physiol Genomics 23:103-18. 2005....
- Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary diseaseRaymond Tabibiazar
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford, CA, USA
Physiol Genomics 22:213-26. 2005....
- The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivoEuan A Ashley
Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA
Cardiovasc Res 65:73-82. 2005..The endogenous peptide apelin is differentially regulated in cardiovascular disease but the nature of its role in cardiac function remains unclear...
- Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular diseaseRaymond Tabibiazar
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Arterioscler Thromb Vasc Biol 25:302-8. 2005..In this study, we sought to identify the genetic pathways that are differentially activated in the aortas of these mice...
- Novel role for the potent endogenous inotrope apelin in human cardiac dysfunctionMary M Chen
Donald W Reynolds Cardiovascular Research Center, Division of Cardiovascular Medicine, Falk CVRC, Stanford University, 300 Pasteur Dr, Stanford, Calif 94305, USA
Circulation 108:1432-9. 2003..Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described...
- Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosisHyung J Chun
Department of Medicine and Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 118:3343-54. 2008..Taken together, these findings indicate that apelin signaling can block Ang II actions in vascular disease by increasing NO production and inhibiting Ang II cellular signaling...