Michael LJ Ashford
Affiliation: University of Dundee
Rzepecka J, Pineda M, Al Riyami L, Rodgers D, Huggan J, Lumb F, et al
. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1Î² production via NRF2-mediated counter-regulation of the inflammasome. J Autoimmun. 2015;60:59-73 pubmed publisher
..Collectively, these data suggest that SMA-12b could provide the basis of an entirely novel approach to fulfilling the urgent need for new treatments for RA. ..
Haythorne E, Hamilton D, Findlay J, Beall C, McCrimmon R, Ashford M. Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology. 2016;111:212-222 pubmed publisher
Meakin P, Jalicy S, Montagut G, Allsop D, Cavellini D, Irvine S, et al
. Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice. Sci Rep. 2018;8:55 pubmed publisher
..These results indicate that Bace1 inhibitors, currently in clinical trials for Alzheimer's disease, may be useful agents for the treatment of obesity and associated diabetes. ..
Dadak S, Beall C, Vlachaki Walker J, Soutar M, McCrimmon R, Ashford M. Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge. Neuroscience. 2017;346:29-42 pubmed publisher
..In conclusion, oleate induces KATP-dependent hyperpolarization and inhibition of firing of a subgroup of GE hypothalamic neurons without altering cellular energy charge. ..