Michael Ashburner

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective
    Joshua S Kaminker
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Genome Biol 3:RESEARCH0084. 2002
  2. pmc The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 177:615-29. 2007
  3. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
  4. pmc Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome
    Casey M Bergman
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genome Biol 7:R112. 2006
  5. pmc A hat trick--Plasmodium, Anopheles and Homo
    Michael Ashburner
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB3 2EH, UK
    Genome Biol 4:103. 2003
  6. pmc The ribosomal protein genes and Minute loci of Drosophila melanogaster
    Steven J Marygold
    Growth Regulation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields, London WC2A 3PX, UK
    Genome Biol 8:R216. 2007
  7. ncbi request reprint Drosophila melanogaster: a case study of a model genomic sequence and its consequences
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom
    Genome Res 15:1661-7. 2005
  8. pmc Entity/quality-based logical definitions for the human skeletal phenome using PATO
    Georgios V Gkoutos
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, England
    Conf Proc IEEE Eng Med Biol Soc 2009:7069-72. 2009
  9. pmc Getting a buzz out of the bee genome
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genome Biol 7:239. 2006
  10. pmc The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 167:797-813. 2004

Detail Information

Publications27

  1. pmc The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective
    Joshua S Kaminker
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Genome Biol 3:RESEARCH0084. 2002
    ..We have used this genomic sequence to describe the euchromatic transposable elements in the sequenced strain of this species...
  2. pmc The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 177:615-29. 2007
    ..Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions...
  3. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
    ..Many of these changes stem from our participation in the GO Reference Genome Annotation Project--a multi-database collaboration producing comprehensive GO annotation sets for 12 diverse species...
  4. pmc Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome
    Casey M Bergman
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genome Biol 7:R112. 2006
    ..Nevertheless, the difficulties that TEs pose for genome assembly and annotation have prevented detailed, quantitative inferences about the contribution of TEs to genomes sequences...
  5. pmc A hat trick--Plasmodium, Anopheles and Homo
    Michael Ashburner
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB3 2EH, UK
    Genome Biol 4:103. 2003
    ..This has been a tremendous scientific achievement. But will it offer hope to the millions who die from malaria each year? Yes, but only if combined with political will and social change...
  6. pmc The ribosomal protein genes and Minute loci of Drosophila melanogaster
    Steven J Marygold
    Growth Regulation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields, London WC2A 3PX, UK
    Genome Biol 8:R216. 2007
    ..While more than 50 Minute loci have been defined genetically, only 15 have so far been characterized molecularly and shown to correspond to RP genes...
  7. ncbi request reprint Drosophila melanogaster: a case study of a model genomic sequence and its consequences
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom
    Genome Res 15:1661-7. 2005
    ..We discuss the impact of the growing number of genome sequences now available in the genus on current Drosophila research, and some of the biological questions that these resources will enable to be solved in the future...
  8. pmc Entity/quality-based logical definitions for the human skeletal phenome using PATO
    Georgios V Gkoutos
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, England
    Conf Proc IEEE Eng Med Biol Soc 2009:7069-72. 2009
    ....
  9. pmc Getting a buzz out of the bee genome
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Genome Biol 7:239. 2006
    ..This, and its utility to humans, makes it a fascinating object of study for biologists. Such studies are now further enabled by the release of the honey-bee genome sequence...
  10. pmc The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 167:797-813. 2004
    ..In addition, a further 37,000 deletions, selectable by molecular screening, may be generated. We are now using the collection to generate a second-generation deficiency kit that is precisely mapped to the genome sequence...
  11. pmc Drosophila Genomes by the Baker's Dozen. Preface
    Michael Ashburner
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 177:1263-8. 2007
  12. pmc Principles of genome evolution in the Drosophila melanogaster species group
    Jose M Ranz
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 5:e152. 2007
    ..Outgroup analysis also revealed evidence for widespread breakpoint recycling. Lastly, we have found that expression domains in D. melanogaster may be disrupted in D. yakuba, bringing into question their potential adaptive significance...
  13. pmc FlyMine: an integrated database for Drosophila and Anopheles genomics
    Rachel Lyne
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
    Genome Biol 8:R129. 2007
    ..It provides web access to integrated data at a number of different levels, from simple browsing to construction of complex queries, which can be executed on either single items or lists...
  14. pmc The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster
    Luis Teixeira
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e2. 2008
    ..melanogaster. The induced resistance to natural viral pathogens may explain Wolbachia prevalence in natural populations and represents a novel Wolbachia-host interaction...
  15. ncbi request reprint A new hybrid rescue allele in Drosophila melanogaster
    Daniel A Barbash
    Department of Genetics, University of Cambridge, Cambridge, UK
    Genetica 120:261-6. 2004
    ..The structure of Df(1)EP307-1-2 suggests that it was formed by a process similar to P-element induced male recombination...
  16. pmc A novel system of fertility rescue in Drosophila hybrids reveals a link between hybrid lethality and female sterility
    Daniel A Barbash
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 163:217-26. 2003
    ..These results also suggest that, while there is some common genetic basis to hybrid lethality and female sterility in D. melanogaster, hybrid females are more sensitive to fertility defects than to lethality...
  17. pmc Assessment of genome-wide protein function classification for Drosophila melanogaster
    Huaiyu Mi
    Protein Informatics, Celera Genomics, Foster City, California 94404, USA
    Genome Res 13:2118-28. 2003
    ..Often, functional associations are made by one method and not the other, indicating that one of the greatest challenges lies in improving the completeness of available ontology associations...
  18. pmc EGASP: the human ENCODE Genome Annotation Assessment Project
    Roderic Guigo
    Centre de Regulacio Genomica, Institut Municipal d Investigació Mèdica Universitat Pompeu Fabra, E08003 Barcelona, Catalonia, Spain
    Genome Biol 7:S2.1-31. 2006
    ..These annotations were not available to the prediction groups prior to the submission deadline, so that their predictions were blind and an external advisory committee could perform a fair assessment...
  19. pmc Annotation of the Drosophila melanogaster euchromatic genome: a systematic review
    Sima Misra
    Department of Molecular and Cell Biology, University of California, Life Sciences Addition, Berkeley, CA 94720 3200, USA
    Genome Biol 3:RESEARCH0083. 2002
    ....
  20. ncbi request reprint Phenotype ontologies: the bridge between genomics and evolution
    Paula M Mabee
    Department of Biology, University of South Dakota, Vermillion, SD 57069, USA
    Trends Ecol Evol 22:345-50. 2007
    ....
  21. pmc The Sequence Ontology: a tool for the unification of genome annotations
    Karen Eilbeck
    Department of Molecular and Cellular Biology, Life Sciences Addition, University of California, Berkeley, CA 94729 3200, USA
    Genome Biol 6:R44. 2005
    ....
  22. pmc An ontology for cell types
    Jonathan Bard
    Department of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, UK
    Genome Biol 6:R21. 2005
    ..The ontology is freely available at http://obo.sourceforge.net/ and can be viewed using standard ontology visualization tools such as OBO-Edit and COBrA...
  23. pmc Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA
    Daniel P Kiehart
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 168:1337-52. 2004
    ..Together, our data suggest a key role for ck/myoVIIA in the formation of cellular projections and other actin-based functions required for viability...
  24. pmc Molecular characterization of the singed wings locus of Drosophila melanogaster
    Yuri B Schwartz
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia
    BMC Genet 5:15. 2004
    ..singed wings (swi) is the only gene known in Drosophila melanogaster for which mutations specifically interrupt the transmission of the regulatory signal from early to late ecdysone inducible genes...
  25. pmc Systematic determination of patterns of gene expression during Drosophila embryogenesis
    Pavel Tomancak
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 539 Life Sciences Addition, Berkeley, CA 94720 3200, USA
    Genome Biol 3:RESEARCH0088. 2002
    ..Cell-fate specification and tissue differentiation during development are largely achieved by the regulation of gene transcription...
  26. ncbi request reprint Taking stock of our models: the function and future of stock centres
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo, Rome, Italy
    Nat Rev Genet 3:711-7. 2002
    ..But they need forward planning, international cooperation and secure funding to keep pace with the explosion in functional genomics that relies so heavily on them...
  27. pmc Mapping and identification of essential gene functions on the X chromosome of Drosophila
    Annette Peter
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg, 37077 Gottingen, Germany
    EMBO Rep 3:34-8. 2002
    ..The distribution of the P element integration sites, the identified genes and transcription units as well as the expression patterns of the P-element-tagged enhancers is described and discussed...