Affiliation: University of Manchester
- Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infectionD Artis
Immunology Group, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
J Exp Med 190:953-62. 1999..These results provide the first demonstration of the role of TNF-alpha in regulating Th2 cytokine-mediated responses at mucosal sites, and have implications for the design of rational therapies against helminth infection and allergy...
- Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependentA J Bancroft
School of Biological Sciences, University of Manchester, GB
Eur J Immunol 30:2083-91. 2000..muris from the gut. Moreover, the present data highlight the functional importance of gender and background strain in interpretation of studies using gene-targeted animals...
- Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infectionD Artis
Immunology Group, School of Biological Sciences, University of Manchester, GB
Eur J Immunol 30:1656-64. 2000..Furthermore, these results suggest that beta7 integrin-independent adhesion molecule interactions are deployed in the large but not small intestine during intestinal inflammation...
- Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gutS A Keilbaugh
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, USA
Gut 54:623-9. 2005..These innate immune responses may play a role in the pathogenesis of colitis in SCID adoptive transfer models in mice and possibly in patients with IBD...