J S Arthur

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers
    Suzanne E Elcombe
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 8:e60086. 2013
  2. pmc Regulation of miRNA transcription in macrophages in response to Candida albicans
    Claire E Monk
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, University of Dundee, Dundee, Scotland
    PLoS ONE 5:e13669. 2010
  3. pmc miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity
    Judit Remenyi
    Wellcome Trust Centre for Gene Regulation, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 8:e62509. 2013
  4. doi request reprint Mitogen-activated protein kinases in innate immunity
    J Simon C Arthur
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Rev Immunol 13:679-92. 2013
  5. pmc IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages
    Michael J Pattison
    MRC Protein Phosphorylation Unit, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    FEBS Lett 587:1496-503. 2013
  6. pmc The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells
    Sebastian Schuck
    Interfakultäres Institut für Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    BMC Mol Biol 4:6. 2003
  7. pmc m-Calpain is required for preimplantation embryonic development in mice
    Previn Dutt
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    BMC Dev Biol 6:3. 2006
  8. pmc Knockout of ERK5 causes multiple defects in placental and embryonic development
    Lijun Yan
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, DD1 5EH, UK
    BMC Dev Biol 3:11. 2003
  9. pmc Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
    Andrew Macdonald
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    BMC Cell Biol 7:1. 2006
  10. ncbi request reprint Signaling downstream of p38 in psoriasis
    J Simon C Arthur
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    J Invest Dermatol 126:1689-91. 2006

Collaborators

Detail Information

Publications46

  1. pmc Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers
    Suzanne E Elcombe
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, The University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 8:e60086. 2013
    ..The expression of these makers was further reinforced by the high level of IL-10 secreted in response to zymosan stimulation...
  2. pmc Regulation of miRNA transcription in macrophages in response to Candida albicans
    Claire E Monk
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Complex, University of Dundee, Dundee, Scotland
    PLoS ONE 5:e13669. 2010
    ..These results suggest that miR-455, miR-125, miR-146 and miR-155 may play important roles in regulating macrophage function following PRR stimulation...
  3. pmc miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity
    Judit Remenyi
    Wellcome Trust Centre for Gene Regulation, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 8:e62509. 2013
    ....
  4. doi request reprint Mitogen-activated protein kinases in innate immunity
    J Simon C Arthur
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Rev Immunol 13:679-92. 2013
    ..Finally, we consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases...
  5. pmc IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages
    Michael J Pattison
    MRC Protein Phosphorylation Unit, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    FEBS Lett 587:1496-503. 2013
    ..Overall, these results show the importance of the balance between IFNβ and IL-10 in the regulation of MCP-1...
  6. pmc The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells
    Sebastian Schuck
    Interfakultäres Institut für Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    BMC Mol Biol 4:6. 2003
    ..The regulation of the immediate-early gene c-fos serves as a paradigm for signal-activated gene induction. Lysophosphatidic acid is a potent serum-borne mitogen able to induce c-fos...
  7. pmc m-Calpain is required for preimplantation embryonic development in mice
    Previn Dutt
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    BMC Dev Biol 6:3. 2006
    ..Disruption of the Capn1 gene produced viable, fertile mice implying that either m-calpain could compensate for the loss of mu-calpain, or that the loss of m-calpain was responsible for death of Capn4-/- mice...
  8. pmc Knockout of ERK5 causes multiple defects in placental and embryonic development
    Lijun Yan
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, DD1 5EH, UK
    BMC Dev Biol 3:11. 2003
    ..ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear...
  9. pmc Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
    Andrew Macdonald
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    BMC Cell Biol 7:1. 2006
    ..Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers...
  10. ncbi request reprint Signaling downstream of p38 in psoriasis
    J Simon C Arthur
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    J Invest Dermatol 126:1689-91. 2006
    ....
  11. ncbi request reprint MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells
    J S Arthur
    MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 482:44-8. 2000
    ..Thus MSK1 is required for CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells...
  12. pmc MAPK activation by radio waves
    J Simon C Arthur
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD4 5EH, UK
    Biochem J 405:e5-6. 2007
    ..This study provides evidence that radio waves induce ERK1/2 activation downstream of the EGF (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species...
  13. ncbi request reprint MSK activation and physiological roles
    J Simon C Arthur
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Front Biosci 13:5866-79. 2008
    ..The physiological roles of MSKs still remain to be completely determined, however recent work has suggested a role for MSKs in neuronal synaptic plasticity and in regulating cytokine production in the innate immune system...
  14. ncbi request reprint The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    M R Williams
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, Scotland
    Curr Biol 10:439-48. 2000
    ....
  15. pmc MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
    Giselle R Wiggin
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Mol Cell Biol 22:2871-81. 2002
    ..The transcription of egr1 in response to both mitogenic and stress stimuli, as well as stress-induced apoptosis, was unaffected in the MSK1/MSK2 double knockout...
  16. ncbi request reprint Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
    G P Sapkota
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    J Biol Chem 276:19469-82. 2001
    ..In contrast, a mutant of LKB1 that cannot be prenylated was still able to suppress the growth of cells...
  17. pmc MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling
    Joanne Darragh
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 390:749-59. 2005
    ..Downstream of anisomycin signalling, a second ERK-dependent pathway, independent of MSK and CREB, was also required for the transcription of Nurr1 and Nor1...
  18. pmc A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs
    Helen McNeill
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 384:391-400. 2004
    ..We suggest that SAKS1 may be an adaptor that directs VCP to polyubiquitinated proteins, and PNGase to misfolded glycoproteins, facilitating their destruction by the proteasome...
  19. ncbi request reprint Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins
    Judit Remenyi
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 428:281-91. 2010
    ....
  20. pmc Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation
    Andrew D Wingate
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK
    Biochem J 393:715-24. 2006
    ..We have established that two related proteins, Nurr1 and Nor1, are also phosphorylated on the equivalent site by RSK in cells in response to mitogenic stimulation...
  21. pmc MSK1 activity is controlled by multiple phosphorylation sites
    Claire E McCoy
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 387:507-17. 2005
    ..This is in contrast with the closely related RSK (p90 ribosomal S6 kinase) proteins, whose activity requires phosphorylation by PDK1 (3-phosphoinositide-dependent protein kinase 1) in addition to phosphorylation by ERK1/2...
  22. ncbi request reprint Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins
    J Simon C Arthur
    Medical Research Council Protein Phosphorylation Unit, MSI WTB complex, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Neurosci 24:4324-32. 2004
    ..These results indicate that MSK1 is the major neurotrophin-activated Ser133 kinase in CNS neurons...
  23. pmc Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
    Claire E McCoy
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 402:491-501. 2007
    ....
  24. ncbi request reprint Evaluation of approaches to generation of tissue-specific knock-in mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit and School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 281:28772-81. 2006
    ..We discuss the merits and disadvantages of each of the conditional knock-in approaches, along with the applications for which they may be most suited, and suggest how they could be further refined...
  25. ncbi request reprint Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle
    Sophie Turban
    Division of Molecular Physiology, Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee, UK
    Diabetes 54:3161-8. 2005
    ....
  26. pmc The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
    Edward J McManus
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee, UK
    EMBO J 23:2071-82. 2004
    ..These experiments establish the roles of the PDK1 regulatory domains and illustrate the power of knockin technology to probe the physiological function of protein-lipid and protein-protein interactions...
  27. ncbi request reprint CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
    Cell Signal 18:1897-905. 2006
    ..These results demonstrate a general and essential role of the PAK-p38alpha MAPK-MAPKAP-K2-HSP27 signalling pathway in mediating the effects of chemotactic stimuli on cell migration...
  28. pmc In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
    Barry J Collins
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 22:4202-11. 2003
    ..They also illustrate the power of knock-in technology to probe the physiological roles of docking interactions in regulating the specificity of signal transduction pathways...
  29. ncbi request reprint The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
    Olga Ananieva
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:1028-36. 2008
    ..Our results establish MSK1 and MSK2 as key components of negative feedback mechanisms needed to limit Toll-like receptor-driven inflammation...
  30. ncbi request reprint The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
    Rossana Zaru
    Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 8:1227-35. 2007
    ..Thus, in DCs, p38 contributes to the activation of all known MK families...
  31. pmc The selectivity of protein kinase inhibitors: a further update
    Jenny Bain
    Division of Signal Transduction Therapy, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 408:297-315. 2007
    ..Despite being used widely, many of the compounds that we analysed were too non-specific for useful conclusions to be made, other than to exclude the involvement of particular protein kinases in cellular processes...
  32. doi request reprint ERK5 regulation in naïve T-cell activation and survival
    Olga Ananieva
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, UK
    Eur J Immunol 38:2534-47. 2008
    ..These results suggest that while ERK5 does contribute to Klf2 regulation in T cells, it is not essential for the expression of CD62L or T-cell survival...
  33. ncbi request reprint Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex
    Heidi Mendoza
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 409:711-22. 2008
    ....
  34. pmc MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
    Ana Soloaga
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:2788-97. 2003
    ..We conclude that MSKs are the major kinases for histone H3 and HMG-14 in response to mitogenic and stress stimuli in fibroblasts...
  35. pmc Generation and characterization of p38beta (MAPK11) gene-targeted mice
    Victoria A Beardmore
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
    Mol Cell Biol 25:10454-64. 2005
    ..Together these results suggest that p38alpha, and not p38beta, is the major p38 isoform involved in the immune response and that it would not be necessary to retain activity against p38beta during the development of p38 inhibitors...
  36. ncbi request reprint MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription
    Madlen Kaiser
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK
    Eur J Immunol 37:2583-95. 2007
    ..This correlated to a reduction in the TCR-induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2-induced CREB phosphorylation...
  37. ncbi request reprint Generation of a conditional CREB Ser133Ala knockin mouse
    Andrew D Wingate
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
    Genesis 47:688-96. 2009
    ..While some expression of the mutated protein was observed prior to Cre expression, following Cre expression in either T cells or neurons only the mutated CREB protein was detected...
  38. ncbi request reprint MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages
    Joanne Darragh
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 425:595-602. 2010
    ..MSKs therefore act as important negative regulators of inflammation following TLR activation...
  39. ncbi request reprint The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-a
    Yalini Chandramohan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Eur J Neurosci 27:2701-13. 2008
    ..We conclude that the forced swimming-induced behavioural immobility response requires histone H3 phospho-acetylation and c-Fos induction in distinct dentate granule neurons through recruitment of the NMDA/ERK/MSK 1/2 pathway...
  40. ncbi request reprint Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones
    Jane P Hughes
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK
    J Neurochem 86:25-32. 2003
    ..Together, these data indicate that MSK1 is a physiological kinase for CREB and that this activity is an essential component of activity-dependent neuronal cell death...
  41. pmc Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways
    Matthew Brook
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, Hammersmith, London W6 8LH, United Kingdom
    Mol Cell Biol 26:2408-18. 2006
    ..This effect is independent of kinases that are known to be synergistically activated by ERK and p38 MAPK. We present a model for the actions of TTP and the p38 MAPK pathway during distinct phases of the inflammatory response...
  42. ncbi request reprint Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide
    Padma Kannan-Thulasiraman
    Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, and Lakeside VA Hospital Chicago, Illinois 60611, USA
    J Biol Chem 281:22446-52. 2006
    ..Altogether, these findings indicate an important role for MSK1 downstream of p38 in the regulation of As2O3 responses...
  43. pmc C-terminal phosphorylation controls the stability and function of p27kip1
    Uta Kossatz
    Institute for Molecular Biology, Hannover Medical School, Hannover, Germany
    EMBO J 25:5159-70. 2006
    ..They also explain how the T187- and the T198-dependent turnover systems synergize to allow cell cycle progression in G1...
  44. ncbi request reprint Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1
    Karen Brami-Cherrier
    Universite Pierre et Marie Curie Paris 6, Paris, France, and CNRS, UMR 7102, Paris, France
    J Neurochem 101:697-708. 2007
    ..Altogether, our data highlight the crucial role of MSK1 in the nucleosomal response necessary for gene induction in neuronal cells...
  45. ncbi request reprint Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Immunity 23:319-29. 2005
    ..Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival...
  46. pmc The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    Chun Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:1019-27. 2008
    ..Our results suggest a dual function for p38 alpha in the regulation of inflammation and show mixed potential for its inhibition as a therapeutic strategy...