Research Topics
Genomes and Genes
| J S ArthurSummaryAffiliation: University of Dundee Country: UK Publications
| Collaborators
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Detail Information
Publications
The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cellsSebastian Schuck
Interfakultäres Institut für Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
BMC Mol Biol 4:6. 2003..The regulation of the immediate-early gene c-fos serves as a paradigm for signal-activated gene induction. Lysophosphatidic acid is a potent serum-borne mitogen able to induce c-fos...- m-Calpain is required for preimplantation embryonic development in micePrevin Dutt
Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
BMC Dev Biol 6:3. 2006..Disruption of the Capn1 gene produced viable, fertile mice implying that either m-calpain could compensate for the loss of mu-calpain, or that the loss of m-calpain was responsible for death of Capn4-/- mice... - Knockout of ERK5 causes multiple defects in placental and embryonic developmentLijun Yan
MRC Protein Phosphorylation Unit, University of Dundee, Dundee, DD1 5EH, UK
BMC Dev Biol 3:11. 2003..ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear... - Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XLAndrew Macdonald
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
BMC Cell Biol 7:1. 2006..Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers... 
Signaling downstream of p38 in psoriasisJ Simon C Arthur
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
J Invest Dermatol 126:1689-91. 2006....- MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cellsJ S Arthur
MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dow Street, Dundee DD1 5EH, UK
FEBS Lett 482:44-8. 2000..Thus MSK1 is required for CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells... - MSK activation and physiological rolesJ Simon C Arthur
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
Front Biosci 13:5866-79. 2008..The physiological roles of MSKs still remain to be completely determined, however recent work has suggested a role for MSKs in neuronal synaptic plasticity and in regulating cytokine production in the innate immune system... - MAPK activation by radio wavesJ Simon C Arthur
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, DD4 5EH, UK
Biochem J 405:e5-6. 2007..This study provides evidence that radio waves induce ERK1/2 activation downstream of the EGF (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species... - The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cellsM R Williams
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, Scotland
Curr Biol 10:439-48. 2000.... - MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblastsGiselle R Wiggin
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
Mol Cell Biol 22:2871-81. 2002..The transcription of egr1 in response to both mitogenic and stress stimuli, as well as stress-induced apoptosis, was unaffected in the MSK1/MSK2 double knockout... - Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthG P Sapkota
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
J Biol Chem 276:19469-82. 2001..In contrast, a mutant of LKB1 that cannot be prenylated was still able to suppress the growth of cells... - MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signallingJoanne Darragh
MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 390:749-59. 2005..Downstream of anisomycin signalling, a second ERK-dependent pathway, independent of MSK and CREB, was also required for the transcription of Nurr1 and Nor1... - A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKsHelen McNeill
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Biochem J 384:391-400. 2004..We suggest that SAKS1 may be an adaptor that directs VCP to polyubiquitinated proteins, and PNGase to misfolded glycoproteins, facilitating their destruction by the proteasome... - Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulationAndrew D Wingate
MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK
Biochem J 393:715-24. 2006..We have established that two related proteins, Nurr1 and Nor1, are also phosphorylated on the equivalent site by RSK in cells in response to mitogenic stimulation... 
Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophinsJudit Remenyi
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U K
Biochem J 428:281-91. 2010....- MSK1 activity is controlled by multiple phosphorylation sitesClaire E McCoy
MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 387:507-17. 2005..This is in contrast with the closely related RSK (p90 ribosomal S6 kinase) proteins, whose activity requires phosphorylation by PDK1 (3-phosphoinositide-dependent protein kinase 1) in addition to phosphorylation by ERK1/2... - Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophinsJ Simon C Arthur
Medical Research Council Protein Phosphorylation Unit, MSI WTB complex, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
J Neurosci 24:4324-32. 2004..These results indicate that MSK1 is the major neurotrophin-activated Ser133 kinase in CNS neurons... - Evaluation of approaches to generation of tissue-specific knock-in miceJose R Bayascas
MRC Protein Phosphorylation Unit and School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
J Biol Chem 281:28772-81. 2006..We discuss the merits and disadvantages of each of the conditional knock-in approaches, along with the applications for which they may be most suited, and suggest how they could be further refined... - CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathwaySimon Rousseau
MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
Cell Signal 18:1897-905. 2006..These results demonstrate a general and essential role of the PAK-p38alpha MAPK-MAPKAP-K2-HSP27 signalling pathway in mediating the effects of chemotactic stimuli on cell migration... - In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutationBarry J Collins
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
EMBO J 22:4202-11. 2003..They also illustrate the power of knock-in technology to probe the physiological roles of docking interactions in regulating the specificity of signal transduction pathways... - The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutationEdward J McManus
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee, UK
EMBO J 23:2071-82. 2004..These experiments establish the roles of the PDK1 regulatory domains and illustrate the power of knockin technology to probe the physiological function of protein-lipid and protein-protein interactions... - Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscleSophie Turban
Division of Molecular Physiology, Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee, UK
Diabetes 54:3161-8. 2005.... - Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MSClaire E McCoy
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 402:491-501. 2007.... - The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathwaysRossana Zaru
Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Nat Immunol 8:1227-35. 2007..Thus, in DCs, p38 contributes to the activation of all known MK families... - Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complexHeidi Mendoza
MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 409:711-22. 2008.... - ERK5 regulation in naïve T-cell activation and survivalOlga Ananieva
MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, UK
Eur J Immunol 38:2534-47. 2008..These results suggest that while ERK5 does contribute to Klf2 regulation in T cells, it is not essential for the expression of CD62L or T-cell survival... - The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signalingOlga Ananieva
Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Nat Immunol 9:1028-36. 2008..Our results establish MSK1 and MSK2 as key components of negative feedback mechanisms needed to limit Toll-like receptor-driven inflammation... - The selectivity of protein kinase inhibitors: a further updateJenny Bain
Division of Signal Transduction Therapy, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 408:297-315. 2007..Despite being used widely, many of the compounds that we analysed were too non-specific for useful conclusions to be made, other than to exclude the involvement of particular protein kinases in cellular processes... - MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcriptionMadlen Kaiser
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, UK
Eur J Immunol 37:2583-95. 2007..This correlated to a reduction in the TCR-induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2-induced CREB phosphorylation... - Generation and characterization of p38beta (MAPK11) gene-targeted miceVictoria A Beardmore
MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
Mol Cell Biol 25:10454-64. 2005..Together these results suggest that p38alpha, and not p38beta, is the major p38 isoform involved in the immune response and that it would not be necessary to retain activity against p38beta during the development of p38 inhibitors... - MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14Ana Soloaga
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:2788-97. 2003..We conclude that MSKs are the major kinases for histone H3 and HMG-14 in response to mitogenic and stress stimuli in fibroblasts... - MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophagesJoanne Darragh
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 425:595-602. 2010..MSKs therefore act as important negative regulators of inflammation following TLR activation... - Generation of a conditional CREB Ser133Ala knockin mouseAndrew D Wingate
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom
Genesis 47:688-96. 2009..While some expression of the mutated protein was observed prior to Cre expression, following Cre expression in either T cells or neurons only the mutated CREB protein was detected... - Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1Karen Brami Cherrier
Universite Pierre et Marie Curie Paris 6, Paris, France, and CNRS, UMR 7102, Paris, France
J Neurochem 101:697-708. 2007..Altogether, our data highlight the crucial role of MSK1 in the nucleosomal response necessary for gene induction in neuronal cells... - Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neuronesJane P Hughes
Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, UK
J Neurochem 86:25-32. 2003..Together, these data indicate that MSK1 is a physiological kinase for CREB and that this activity is an essential component of activity-dependent neuronal cell death... - Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathwaysMatthew Brook
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, Hammersmith, London W6 8LH, United Kingdom
Mol Cell Biol 26:2408-18. 2006..This effect is independent of kinases that are known to be synergistically activated by ERK and p38 MAPK. We present a model for the actions of TTP and the p38 MAPK pathway during distinct phases of the inflammatory response... - The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-aYalini Chandramohan
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
Eur J Neurosci 27:2701-13. 2008..We conclude that the forced swimming-induced behavioural immobility response requires histone H3 phospho-acetylation and c-Fos induction in distinct dentate granule neurons through recruitment of the NMDA/ERK/MSK 1/2 pathway... - Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulatorsJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
Immunity 23:319-29. 2005..Here we describe key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, a target for CREB, in maintenance of macrophage survival... - Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxidePadma Kannan-Thulasiraman
Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, and Lakeside VA Hospital Chicago, Illinois 60611, USA
J Biol Chem 281:22446-52. 2006..Altogether, these findings indicate an important role for MSK1 downstream of p38 in the regulation of As2O3 responses... - C-terminal phosphorylation controls the stability and function of p27kip1Uta Kossatz
Institute for Molecular Biology, Hannover Medical School, Hannover, Germany
EMBO J 25:5159-70. 2006..They also explain how the T187- and the T198-dependent turnover systems synergize to allow cell cycle progression in G1... - The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expressionChun Kim
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Nat Immunol 9:1019-27. 2008..Our results suggest a dual function for p38 alpha in the regulation of inflammation and show mixed potential for its inhibition as a therapeutic strategy...