J S Arthur
Affiliation: University of Dundee
Arthur J, Ley S. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 2013;13:679-92 pubmed publisher
..Finally, we consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases. ..
Dutt P, Croall D, Arthur J, Veyra T, Williams K, Elce J, et al
. m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol. 2006;6:3 pubmed
..This establishes that mu-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo. ..
Macdonald A, Campbell D, Toth R, McLauchlan H, Hastie C, Arthur J. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol. 2006;7:1 pubmed
..This would be consistent with the proposed function of Pim kinases in promoting cell proliferation and preventing cell death. ..
Arthur J, Cohen P. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett. 2000;482:44-8 pubmed
..Thus MSK1 is required for CREB and ATF1 phosphorylation after mitogenic stimulation of ES cells. ..
Arthur J. MSK activation and physiological roles. Front Biosci. 2008;13:5866-79 pubmed
..The physiological roles of MSKs still remain to be completely determined, however recent work has suggested a role for MSKs in neuronal synaptic plasticity and in regulating cytokine production in the innate immune system. ..
McGuire V, Rosner D, Ananieva O, Ross E, Elcombe S, Naqvi S, et al
. Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Mol Cell Biol. 2017;37: pubmed
Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al
. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
..This observation highlights fundamental differences in the signaling controlling IL-10 production in B cells and macrophages, even though these two cell types respond to a common TLR stimulus. ..