James N Arnold

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin
    James N Arnold
    Medical Research Council MRC Immunochemistry Unit and Oxford Glycobiology Institute, University of Oxford, United Kingdom
    J Immunol 173:6831-40. 2004
  2. ncbi request reprint The impact of glycosylation on the biological function and structure of human immunoglobulins
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Annu Rev Immunol 25:21-50. 2007
  3. ncbi request reprint Mannan binding lectin and its interaction with immunoglobulins in health and in disease
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Immunol Lett 106:103-10. 2006
  4. ncbi request reprint Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
    James N Arnold
    Medical Research Council Immunochemistry Unit and Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Biol Chem 281:6955-63. 2006
  5. ncbi request reprint Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
    Catherine M Radcliffe
    Glycobiology Institute, Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 282:7405-15. 2007
  6. ncbi request reprint Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin
    James N Arnold
    Medical Research Council Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:29080-7. 2005
  7. ncbi request reprint Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG
    Radka Saldova
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
    Glycobiology 17:1344-56. 2007
  8. ncbi request reprint Human immunoglobulin glycosylation and the lectin pathway of complement activation
    James N Arnold
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Adv Exp Med Biol 564:27-43. 2005
  9. doi request reprint Novel glycan biomarkers for the detection of lung cancer
    James N Arnold
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Proteome Res 10:1755-64. 2011
  10. ncbi request reprint Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides
    Stefanos A Tsiftsoglou
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, UK
    Biochim Biophys Acta 1764:1757-66. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin
    James N Arnold
    Medical Research Council MRC Immunochemistry Unit and Oxford Glycobiology Institute, University of Oxford, United Kingdom
    J Immunol 173:6831-40. 2004
    ..This is the first study of the glycosylation of human serum IgD and IgE from nonmyeloma proteins...
  2. ncbi request reprint The impact of glycosylation on the biological function and structure of human immunoglobulins
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Annu Rev Immunol 25:21-50. 2007
    ..The models were constructed by combining glycan sequencing data with oligosaccharide linkage and dynamics information from the Glycobiology Institute experimental database and protein structural data from "The Protein Data Bank."..
  3. ncbi request reprint Mannan binding lectin and its interaction with immunoglobulins in health and in disease
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Immunol Lett 106:103-10. 2006
    ..MBL has recently been demonstrated to bind Ig in the B cell receptor complex which expresses abnormal variable region glycosylation, in follicular lymphoma...
  4. ncbi request reprint Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
    James N Arnold
    Medical Research Council Immunochemistry Unit and Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Biol Chem 281:6955-63. 2006
    ..Binding would lead to opsonization or activation of enzyme systems such as complement...
  5. ncbi request reprint Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
    Catherine M Radcliffe
    Glycobiology Institute, Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 282:7405-15. 2007
    ..These findings suggest a potential contribution to lymphoma pathogenesis involving antigen-independent interaction of surface immunoglobulin of the B-cell receptor with mannose-binding molecules of innate immunity in the germinal center...
  6. ncbi request reprint Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin
    James N Arnold
    Medical Research Council Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:29080-7. 2005
    ..Antigen-bound IgM pentamers therefore do not activate complement via the lectin pathway, but MBL might have a role in the clearance of aggregated IgM...
  7. ncbi request reprint Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG
    Radka Saldova
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
    Glycobiology 17:1344-56. 2007
    ....
  8. ncbi request reprint Human immunoglobulin glycosylation and the lectin pathway of complement activation
    James N Arnold
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Adv Exp Med Biol 564:27-43. 2005
  9. doi request reprint Novel glycan biomarkers for the detection of lung cancer
    James N Arnold
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Proteome Res 10:1755-64. 2011
    ..The combination of all glyco-biomarkers had the highest sensitivity and specificity. This study identifies candidates for further study as potential biomarkers for the disease...
  10. ncbi request reprint Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides
    Stefanos A Tsiftsoglou
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, UK
    Biochim Biophys Acta 1764:1757-66. 2006
    ....
  11. ncbi request reprint Heterogeneity of MBL-MASP complexes
    Karine R Mayilyan
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Roads, Oxford OX1 3QU, UK
    Mol Immunol 43:1286-92. 2006
    ..The findings are consistent with separate populations of MBL-MASP-1 complexes and MBL-MASP-2 complexes, the concentrations of which show wide inter-individual variation...
  12. ncbi request reprint Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation
    James N Arnold
    Department of Biochemistry, Glycobiology Institute, University of Oxford, Oxford, UK
    Proteomics 8:3284-93. 2008
    ..In this review, the glycoproteins which display these glycan epitopes, the glycosyl transferases which can generate them, their potential functions and their use as biomarkers are evaluated...
  13. doi request reprint A chemical approach to immunoprotein engineering: chemoselective functionalization of thioester proteins in their native state
    Michael A Cole
    The Scripps Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Chembiochem 10:1340-3. 2009
    ....
  14. ncbi request reprint Purification, quantification, and functional analysis of Complement Factor H
    Bing bin Yu
    Department of Biochemistry, University of Oxford, Oxford, UK
    Methods Mol Biol 1100:207-23. 2014
    ..Cleavage occurs only in the presence of a cofactor, and FH is one of a small number of cofactors for this reaction. ..
  15. ncbi request reprint Increased complement classical and mannan-binding lectin pathway activities in schizophrenia
    Karine R Mayilyan
    MRC Immunochemistry Unit, Biochemistry Department, Oxford University, Oxford, UK
    Neurosci Lett 404:336-41. 2006
    ..01). The increase was accompanied by increased CH50 (P<0.02) and C4 CH50 (P<0.02). Our results support the idea that complement system alterations may be involved in schizophrenia...