Research Topics
Genomes and Genes | James N ArnoldSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators
|
Detail Information
Publications
The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectinJames N Arnold
Medical Research Council MRC Immunochemistry Unit and Oxford Glycobiology Institute, University of Oxford, United Kingdom
J Immunol 173:6831-40. 2004..This is the first study of the glycosylation of human serum IgD and IgE from nonmyeloma proteins...- The impact of glycosylation on the biological function and structure of human immunoglobulinsJames N Arnold
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
Annu Rev Immunol 25:21-50. 2007..quot;.. - Mannan binding lectin and its interaction with immunoglobulins in health and in diseaseJames N Arnold
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
Immunol Lett 106:103-10. 2006..MBL has recently been demonstrated to bind Ig in the B cell receptor complex which expresses abnormal variable region glycosylation, in follicular lymphoma... - Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?James N Arnold
Medical Research Council Immunochemistry Unit and Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
J Biol Chem 281:6955-63. 2006..Binding would lead to opsonization or activation of enzyme systems such as complement... - Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectinJames N Arnold
Medical Research Council Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
J Biol Chem 280:29080-7. 2005..Antigen-bound IgM pentamers therefore do not activate complement via the lectin pathway, but MBL might have a role in the clearance of aggregated IgM... - Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptorCatherine M Radcliffe
Glycobiology Institute, Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
J Biol Chem 282:7405-15. 2007..These findings suggest a potential contribution to lymphoma pathogenesis involving antigen-independent interaction of surface immunoglobulin of the B-cell receptor with mannose-binding molecules of innate immunity in the germinal center... - Human immunoglobulin glycosylation and the lectin pathway of complement activationJames N Arnold
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Adv Exp Med Biol 564:27-43. 2005 - Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgGRadka Saldova
Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
Glycobiology 17:1344-56. 2007.... 
Novel glycan biomarkers for the detection of lung cancerJames N Arnold
Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, England
J Proteome Res 10:1755-64. 2011..The combination of all glyco-biomarkers had the highest sensitivity and specificity. This study identifies candidates for further study as potential biomarkers for the disease...- Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharidesStefanos A Tsiftsoglou
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, UK
Biochim Biophys Acta 1764:1757-66. 2006.... - Heterogeneity of MBL-MASP complexesKarine R Mayilyan
MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Roads, Oxford OX1 3QU, UK
Mol Immunol 43:1286-92. 2006..The findings are consistent with separate populations of MBL-MASP-1 complexes and MBL-MASP-2 complexes, the concentrations of which show wide inter-individual variation... - Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammationJames N Arnold
Department of Biochemistry, Glycobiology Institute, University of Oxford, Oxford, UK
Proteomics 8:3284-93. 2008..In this review, the glycoproteins which display these glycan epitopes, the glycosyl transferases which can generate them, their potential functions and their use as biomarkers are evaluated... - A chemical approach to immunoprotein engineering: chemoselective functionalization of thioester proteins in their native stateMichael A Cole
The Scripps Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Chembiochem 10:1340-3. 2009.... - Increased complement classical and mannan-binding lectin pathway activities in schizophreniaKarine R Mayilyan
MRC Immunochemistry Unit, Biochemistry Department, Oxford University, Oxford, UK
Neurosci Lett 404:336-41. 2006..01). The increase was accompanied by increased CH50 (P<0.02) and C4 CH50 (P<0.02). Our results support the idea that complement system alterations may be involved in schizophrenia...