W Arlt

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint The approach to the adult with newly diagnosed adrenal insufficiency
    Wiebke Arlt
    School of Clinical and Experimental Medicine, University of Birmingham, Institute of Biomedical Research, Birmingham, United Kingdom
    J Clin Endocrinol Metab 94:1059-67. 2009
  2. ncbi request reprint Management of the androgen-deficient woman
    Wiebke Arlt
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    Growth Horm IGF Res 13:S85-9. 2003
  3. ncbi request reprint Dehydroepiandrosterone replacement therapy
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
    Semin Reprod Med 22:379-88. 2004
  4. ncbi request reprint Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements
    Wiebke Arlt
    Division of Medical Sciences Institute of Biomedical Research IBR Endocrinology and Metabolism, The Medical School, University of Birmingham, Edgbaston, UK
    Clin Endocrinol (Oxf) 64:384-9. 2006
  5. ncbi request reprint P450 oxidoreductase deficiency and Antley-Bixler syndrome
    Wiebke Arlt
    Division of Medical Sciences, School of Medicine University of Birmingham, Birmingham, UK
    Rev Endocr Metab Disord 8:301-7. 2007
  6. pmc Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
    Dorota Tomalik-Scharte
    School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism CEDAM, University of Birmingham, Birmingham B15 2TT, UK
    Eur J Endocrinol 163:919-24. 2010
  7. pmc Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
    Jan Idkowiak
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 96:E453-62. 2011
  8. pmc Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione
    Michael W O'Reilly
    Centre for Endocrinology, Diabetes, and Metabolism M W O, A E T, B A H, R K C, P M S, J W T, W A, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom Department of Nuclear Medicine N J C, University Hospitals Birmingham, Edgbaston, and National Institute of Health Research Wellcome Trust Clinical Research Facility F C, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham B15 2TH, United Kingdom and University of Leeds P M S, Leeds, LS2 9NL, United Kingdom
    J Clin Endocrinol Metab 99:1027-36. 2014
  9. pmc Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency
    Nicole Reisch
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:E528-36. 2013
  10. doi request reprint Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement
    Vasileios Chortis
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:161-71. 2013

Detail Information

Publications63

  1. doi request reprint The approach to the adult with newly diagnosed adrenal insufficiency
    Wiebke Arlt
    School of Clinical and Experimental Medicine, University of Birmingham, Institute of Biomedical Research, Birmingham, United Kingdom
    J Clin Endocrinol Metab 94:1059-67. 2009
    ..Future studies will have to explore the potential of dehydroepiandrosterone replacement and modified delayed-release hydrocortisone to improve the prospects of patients with adrenal insufficiency...
  2. ncbi request reprint Management of the androgen-deficient woman
    Wiebke Arlt
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
    Growth Horm IGF Res 13:S85-9. 2003
    ..Thus, androgen replacement should not be routinely considered in postmenopausal women but should be reserved for women with established androgen deficiency and related symptoms...
  3. ncbi request reprint Dehydroepiandrosterone replacement therapy
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
    Semin Reprod Med 22:379-88. 2004
    ..However, DHEA may be a suitable option for androgen replacement in women with established androgen deficiency, for example, bilateral oophorectomy and premature menopause...
  4. ncbi request reprint Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements
    Wiebke Arlt
    Division of Medical Sciences Institute of Biomedical Research IBR Endocrinology and Metabolism, The Medical School, University of Birmingham, Edgbaston, UK
    Clin Endocrinol (Oxf) 64:384-9. 2006
    ..Here we compared the results of a structured clinical assessment to the outcome of repeated, timed serum cortisol measurements...
  5. ncbi request reprint P450 oxidoreductase deficiency and Antley-Bixler syndrome
    Wiebke Arlt
    Division of Medical Sciences, School of Medicine University of Birmingham, Birmingham, UK
    Rev Endocr Metab Disord 8:301-7. 2007
    ....
  6. pmc Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
    Dorota Tomalik-Scharte
    School of Clinical and Experimental Medicine, Centre for Endocrinology, Diabetes and Metabolism CEDAM, University of Birmingham, Birmingham B15 2TT, UK
    Eur J Endocrinol 163:919-24. 2010
    ..POR also transfers electrons to all major drug-metabolizing CYP enzymes, including CYP3A4 that inactivates glucocorticoid and oestrogens. However, whether ORD results in impairment of in vivo drug metabolism has never been studied...
  7. pmc Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
    Jan Idkowiak
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 96:E453-62. 2011
    ..P450 oxidoreductase deficiency (ORD) commonly presents neonatally, with disordered sex development in both sexes, skeletal malformations, and glucocorticoid deficiency...
  8. pmc Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione
    Michael W O'Reilly
    Centre for Endocrinology, Diabetes, and Metabolism M W O, A E T, B A H, R K C, P M S, J W T, W A, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom Department of Nuclear Medicine N J C, University Hospitals Birmingham, Edgbaston, and National Institute of Health Research Wellcome Trust Clinical Research Facility F C, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham B15 2TH, United Kingdom and University of Leeds P M S, Leeds, LS2 9NL, United Kingdom
    J Clin Endocrinol Metab 99:1027-36. 2014
    ..Here we studied the utility of the androgen precursor serum androstenedione (A) in conjunction with serum T for predicting metabolic dysfunction in PCOS...
  9. pmc Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency
    Nicole Reisch
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:E528-36. 2013
    ..ObjECTIVE: The objective of the study was to establish a noninvasive approach to prenatal diagnosis of PORD including assessment of malformation severity to facilitate optimized prenatal diagnosis and timely treatment...
  10. doi request reprint Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement
    Vasileios Chortis
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:161-71. 2013
    ..Mitotane is considered an adrenolytic substance, but there is limited information on distinct effects on steroidogenesis. However, adrenal insufficiency and male hypogonadism are widely recognized side effects of mitotane treatment...
  11. pmc A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency
    Jan Idkowiak
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 97:E465-75. 2012
    ..Cytochrome b5 (CYB5A) is thought to selectively enhance 17,20 lyase activity by facilitating the allosteric interaction of CYP17A1 with its electron donor P450 oxidoreductase (POR)...
  12. pmc Genotype-phenotype analysis in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency
    Nils Krone
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK
    J Clin Endocrinol Metab 97:E257-67. 2012
    ..No comprehensive data on genotype-phenotype correlations in Caucasian patients are available...
  13. ncbi request reprint Androgen therapy in women
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Room 233, University of Birmingham, Birmingham, B15 2TT, UK
    Eur J Endocrinol 154:1-11. 2006
    ..Currently, androgen replacement should be reserved for women with severe androgen deficiency due to an established cause and matching clinical signs and symptoms...
  14. ncbi request reprint Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...
  15. doi request reprint Adult consequences of congenital adrenal hyperplasia
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Horm Res 68:158-64. 2007
    ....
  16. ncbi request reprint Androgen replacement in women
    W Arlt
    Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, Division of Medical Sciences, University of Birmingham Medical School, Rm 225, Wolfson Drive, Birmingham, B15 2TT, Birmingham, UK
    Ann Endocrinol (Paris) 68:251-7. 2007
  17. ncbi request reprint Adrenal insufficiency
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham
    Clin Med 8:211-5. 2008
  18. ncbi request reprint Androgen replacement therapy in women
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, Endocrinology, Birmingham, UK
    Curr Opin Investig Drugs 6:1028-36. 2005
    ..Choosing both a convenient and efficient mode of androgen administration in women remains a challenge and currently none of the available preparations is officially approved for use in women...
  19. ncbi request reprint Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, Medical School, Birmingham B15 2TT, UK
    Lancet 363:2128-35. 2004
    ..We aimed to investigate the underlying molecular basis of congenital adrenal hyperplasia with apparent combined P450C17 and P450C21 deficiency in affected children...
  20. pmc Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors
    Wiebke Arlt
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 96:3775-84. 2011
    ..Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values...
  21. ncbi request reprint Hormones and immune function: implications of aging
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, B15 2TT, UK
    Aging Cell 3:209-16. 2004
    ..As a step in this direction, the present review summarizes established facts on the physiology of secretion and function of hormones that, in most cases, decline with aging and that are likely to affect the immune system...
  22. ncbi request reprint Dehydroepiandrosterone and ageing
    Wiebke Arlt
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Best Pract Res Clin Endocrinol Metab 18:363-80. 2004
    ....
  23. pmc Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients
    Wiebke Arlt
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    J Clin Endocrinol Metab 95:5110-21. 2010
    ..No consensus exists for management of adults with congenital adrenal hyperplasia (CAH) due to a paucity of data from cohorts of meaningful size...
  24. ncbi request reprint Age-specific changes in sex steroid biosynthesis and sex development
    Nils Krone
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Best Pract Res Clin Endocrinol Metab 21:393-401. 2007
    ....
  25. ncbi request reprint Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P
    Vivek Dhir
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Endocrinol 21:1958-68. 2007
    ..Differential interaction of POR with electron-accepting CYP enzymes may explain the phenotypic variability in POR deficiency, with additional implications for hepatic drug metabolism by POR-dependant CYP enzymes...
  26. ncbi request reprint Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study
    Anna C Phillips
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, England, UK
    Eur J Endocrinol 163:285-92. 2010
    ..The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality...
  27. doi request reprint Genetics of congenital adrenal hyperplasia
    Nils Krone
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, Institute of Biomedical Research, Edgbaston, Birmingham, UK
    Best Pract Res Clin Endocrinol Metab 23:181-92. 2009
    ..P450 oxidoreductase deficiency (ORD) has a complex phenotype including two unique features not observed in any other CAH variant: skeletal malformations and severe genital ambiguity in both sexes...
  28. doi request reprint Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study
    Anna C Phillips
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    Eur J Endocrinol 162:919-23. 2010
    ..The aim of these analyses was to examine the association of cortisol, DHEAS and the cortisol:DHEAS ratio with the metabolic syndrome (MetS) and its components. Design The analyses were cross-sectional...
  29. pmc Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)
    Nils Krone
    Centre for Endocrinology, Diabetes and Metabolism, School for Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    J Steroid Biochem Mol Biol 121:496-504. 2010
    ..Our work has led us to develop a simplified graphical representation of quantitative urinary steroid hormone profiles and diagnostic ratios...
  30. doi request reprint Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study
    D Carroll
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    J Hum Hypertens 25:418-24. 2011
    ..The present analyses provide confirmation of a positive association between cortisol and the cortisol:DHEAS ratio and population hypertension...
  31. doi request reprint Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome
    Dimitra A Vassiliadi
    Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 94:3558-66. 2009
    ..Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and susceptibility to the metabolic syndrome. Altered peripheral cortisol metabolism has been reported in PCOS, but also in simple obesity...
  32. pmc Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency
    Louise A Metherell
    Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 94:3865-71. 2009
    ..Mutations of the ACTH receptor (MC2R) and the melanocortin 2 receptor accessory protein (MRAP), FGD types 1 and 2 respectively, account for approximately 45% of cases...
  33. ncbi request reprint Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene
    Vivek Dhir
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Institute of Biomedical Research, Wolfson Drive, Birmingham, United Kingdom
    J Clin Endocrinol Metab 94:3058-64. 2009
    ..Steroid 17alpha-hydroxylase (CYP17A1, alias P450c17) deficiency (17OHD) is a rare form of congenital adrenal hyperplasia. The CYP17A1 enzyme catalyzes two distinct reactions, 17alpha-hydroxylase and 17,20-lyase activities...
  34. ncbi request reprint Adrenal insufficiency
    Wiebke Arlt
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Lancet 361:1881-93. 2003
    ..Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an experienced specialist. However, all doctors should know how to diagnose and manage suspected acute adrenal failure...
  35. ncbi request reprint Congenital adrenal hyperplasia and P450 oxidoreductase deficiency
    Nils Krone
    Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 66:162-72. 2007
    ..This review discusses the biochemical and clinical presentation and the genetic and functional basis of the currently known CAH variants, with a specific focus on ORD...
  36. pmc Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11{beta}-hydroxylase deficiency
    Silvia Parajes
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Institute of Biomedical Research, Wolfson Drive, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 95:779-88. 2010
    ..Our data are important to predict phenotypic expression and provide important information for clinical and genetic counseling in 11OHD...
  37. ncbi request reprint Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5
    Marcus Quinkler
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
    J Endocrinol 183:331-42. 2004
    ..Thus, human adipose tissue is capable of active androgen synthesis catalysed by 17beta-HSD5, and increased expression in obesity may contribute to circulating androgen excess...
  38. doi request reprint Fine tuning for quality of life: 21st century approach to treatment of Addison's disease
    Nicole Reisch
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Endocrinol Metab Clin North Am 38:407-18, ix-x. 2009
    ..Such preparations are currently being evaluated and may play a role in management of patients who have adrenal insufficiency...
  39. doi request reprint Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation
    David J Radford
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Mol Endocrinol 24:813-21. 2010
    ....
  40. pmc Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche
    Jan Idkowiak
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 95:3418-27. 2010
    ..g. due to mutations in 17alpha-hydroxylase (CYP17A1). Like all other microsomal cytochrome P450 (CYP) enzymes, CYP17A1 requires electron transfer from P450 oxidoreductase (POR)...
  41. pmc Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 93:3827-32. 2008
    ..Recent association studies have failed to corroborate findings that polymorphisms in the genes encoding H6PDH (R453Q) and 11beta-HSD1 (Intron 3 inserted adenine) interact to cause CRD...
  42. doi request reprint Functional characterization of three CYP21A2 sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system
    Caroline Bleicken
    Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    Hum Mutat 30:E443-50. 2009
    ..W302S and p.D322G could be confirmed as functionally relevant mutations. These findings emphasize the value of in vitro functional analysis of sequence variations in predicting genotype-phenotype correlations and disease severity...
  43. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  44. ncbi request reprint Dehydroepiandrosterone supplementation in elderly men: the role of estrogens versus androgens on the male skeleton
    Lorenz C Hofbauer
    J Clin Endocrinol Metab 87:4009; author reply 4009. 2002
  45. ncbi request reprint DHEA treatment: myth or reality?
    Bruno Allolio
    Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Endocrinol Metab 13:288-94. 2002
    ..Future research should focus on DHEA treatment for adrenal insufficiency, and DHEA administration in both patients receiving chronic glucocorticoid treatment and women with androgen deficiency...
  46. ncbi request reprint Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome
    Martin Fassnacht
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 88:2760-6. 2003
    ..05). Taken together, these data indicate enhanced peripheral 5 alpha-reductase activity in PCOS. Thus, not only ovary and adrenal, but also liver and peripheral target tissues, significantly contribute to steroid alterations in PCOS...
  47. ncbi request reprint Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome
    Christa E Flück
    Department of Pediatrics, University of California San Francisco, San Francisco, California 94143 0978, USA
    Nat Genet 36:228-30. 2004
    ..Mutations of POR also affect drug-metabolizing P450 enzymes, explaining the association of ABS with maternal fluconazole ingestion...
  48. ncbi request reprint Biochemical diagnosis of Antley-Bixler syndrome by steroid analysis
    Cedric Shackleton
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Am J Med Genet A 128:223-31. 2004
    ..This paper proposes use of the distinctive steroid metabolome as the primary biochemical parameter for diagnosis of ABS, at least the form not associated with FGFR2 mutations...
  49. ncbi request reprint Quality of life in Addison's disease--the case for DHEA replacement
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Clin Endocrinol (Oxf) 56:573-4. 2002
  50. ncbi request reprint Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:6283-9. 2005
    ..In vitro DHEA has been shown to enhance IL-2 release from T lymphocytes, whereas it inhibits IL-6 secretion. Conversely, aging is associated with a decline in both DHEA and IL-2, whereas IL-6 increases...
  51. ncbi request reprint Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis
    Stefanie Hahner
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    J Clin Endocrinol Metab 92:3912-22. 2007
    ..Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease...
  52. ncbi request reprint No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 90:3600-5. 2005
    ..DHEAS does not seem to represent a circulating storage pool for DHEA regeneration, and therefore serum DHEAS is unlikely to reflect bioavailable DHEA...
  53. ncbi request reprint Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature
    G Umberto Meduri
    University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
    Intensive Care Med 34:61-9. 2008
    ....
  54. ncbi request reprint Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species
    Wiebke Arlt
    Department of Pediatrics and the Metabolic Research Unit, University of California, San Francisco, California 94143 0978, USA
    Endocrinology 143:4665-72. 2002
    ..These data establish that Arg255 is important for 17alpha-hydroxylase activity and show that the evolution of adrenarche in higher primates is not determined by variations in the sequence of P450c17...
  55. ncbi request reprint The human fetal adrenal cortex and the window of sexual differentiation
    Neil A Hanley
    Centre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton, UK
    Trends Endocrinol Metab 17:391-7. 2006
    ..In this setting, in vitro research of normal human development complements clinical investigation of patients born with congenital disorders...
  56. ncbi request reprint DHEA replacement in adrenal insufficiency
    Wiebke Arlt
    J Clin Endocrinol Metab 88:4001; author reply 4001-2. 2003
  57. ncbi request reprint Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006
  58. ncbi request reprint Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
    Wiebke Arlt
    Department of Medicine, Endocrine and Diabetes Unit, University of Wuerzburg, Germany
    Eur J Endocrinol 146:215-22. 2002
    ..Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously...
  59. ncbi request reprint Junior doctors' working hours and the circadian rhythm of hormones
    Wiebke Arlt
    Clin Med 6:127-9. 2006
  60. ncbi request reprint Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype
    Cedric Shackleton
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Am J Med Genet A 129:105-12. 2004
    ..We propose that excessive excretion of epiallopregnanediol together with low estriol may be prenatally diagnostic for OR deficiency (ORD)...
  61. ncbi request reprint POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait
    Masanori Adachi
    Department of Endocrinology and Metabolism, Clinical Research Institute, Kanagawa Children s Medical Center, Yokohama, Japan
    Am J Med Genet A 140:633-5. 2006
  62. ncbi request reprint A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency
    Stefan A Wudy
    Steroid Research Unit, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
    Endocr Res 30:957-64. 2004
    ..Clinical features may include an ABS phenotype, ambiguous genitalia (virilization in girls, feminization in boys), and glucocorticoid deficiency. If required, hydrocortisone replacement should be provided...
  63. ncbi request reprint Gorham-Stout disease--stabilization during bisphosphonate treatment
    Fabian Hammer
    Department of Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Wurzburg, Germany
    J Bone Miner Res 20:350-3. 2005
    ..v. every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction...