H C Ardley

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7
    H C Ardley
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds, UK
    Biochim Biophys Acta 1491:57-64. 2000
  2. ncbi Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12
    H C Ardley
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 89:137-40. 2000
  3. ncbi Characterisation of the human and mouse orthologues of the Drosophila ariadne gene
    N G Tan
    Molecular Medicine Unit and Leeds Dental Institute, University of Leeds, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 90:242-5. 2000
  4. ncbi The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1
    T P Moynihan
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    J Biol Chem 274:30963-8. 1999
  5. ncbi Rapid isolation of genomic clones for individual members of human multigene families: identification and localisation of UBE2L4, a novel member of a ubiquitin conjugating enzyme dispersed gene family
    H C Ardley
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 79:188-92. 1997
  6. ncbi Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7
    H C Ardley
    Molecular Medicine Unit and the Leeds Dental Institute, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    J Biol Chem 276:19640-7. 2001
  7. ncbi Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3
    T P Moynihan
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mamm Genome 7:520-5. 1996
  8. ncbi Assignment of UBE2D1 to human chromosome bands 10q11.2-->q21 by in situ hybridization
    P A Robinson
    Molecular Medicine Unit and Leeds Dental Institute, University of Leeds, St. James's University Hospital, Leeds, UK
    Cytogenet Cell Genet 83:247-8. 1998
  9. ncbi Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization
    S A Rose
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds (UK
    Cytogenet Cell Genet 83:98-9. 1998
  10. ncbi Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4
    T P Moynihan
    Molecular Medicine Unit, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mamm Genome 10:977-82. 1999

Collaborators

  • P A Robinson
  • J Thompson
  • T P Moynihan
  • S A Rose
  • A F Markham
  • C-C Hung
  • J P Leek
  • N G Tan
  • M Scheffner
  • U Nuber
  • E J Davison
  • P F Jones
  • N S Brindle

Detail Information

Publications12

  1. ncbi Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7
    H C Ardley
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds, UK
    Biochim Biophys Acta 1491:57-64. 2000
    ..Deletion of these binding sites indicated that these factors are crucial for transcription of this gene...
  2. ncbi Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12
    H C Ardley
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 89:137-40. 2000
    ..We also describe the chromosomal localization of UBE2L6, which maps to chromosome 11q12...
  3. ncbi Characterisation of the human and mouse orthologues of the Drosophila ariadne gene
    N G Tan
    Molecular Medicine Unit and Leeds Dental Institute, University of Leeds, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 90:242-5. 2000
    ..The high degree of homology demonstrated by the mouse and human orthologues of Drosophila ariadne indicates an important, conserved biological function, consistent with a putative role in ubiquitylation...
  4. ncbi The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1
    T P Moynihan
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    J Biol Chem 274:30963-8. 1999
    ....
  5. ncbi Rapid isolation of genomic clones for individual members of human multigene families: identification and localisation of UBE2L4, a novel member of a ubiquitin conjugating enzyme dispersed gene family
    H C Ardley
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    Cytogenet Cell Genet 79:188-92. 1997
    ..1-->q13.2. This PCR-based approach to library screening has wider applicability in that it could be used to isolate alternate-spliced products from cDNA libraries...
  6. ncbi Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7
    H C Ardley
    Molecular Medicine Unit and the Leeds Dental Institute, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, United Kingdom
    J Biol Chem 276:19640-7. 2001
    ..These studies demonstrate that very subtle changes to the domains that regulate recognition between highly conserved components of the ubiquitin pathway can dramatically affect their ability to interact...
  7. ncbi Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3
    T P Moynihan
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mamm Genome 7:520-5. 1996
    ..This latter E2 has been demonstrated to participate in transcription factor NF-kappaB maturation, c-fos degradation, and human papilloma virus-mediated p53 degradation in vitro...
  8. ncbi Assignment of UBE2D1 to human chromosome bands 10q11.2-->q21 by in situ hybridization
    P A Robinson
    Molecular Medicine Unit and Leeds Dental Institute, University of Leeds, St. James's University Hospital, Leeds, UK
    Cytogenet Cell Genet 83:247-8. 1998
  9. ncbi Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization
    S A Rose
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds (UK
    Cytogenet Cell Genet 83:98-9. 1998
  10. ncbi Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4
    T P Moynihan
    Molecular Medicine Unit, Clinical Sciences Building, St James s University Hospital, Leeds LS9 7TF, UK
    Mamm Genome 10:977-82. 1999
    ..Furthermore, it suggests that a similar strategy may be applicable to disrupt the function of other ubiquitin-conjugating enzymes in vivo...
  11. ncbi The aggravating role of the ubiquitin-proteasome system in neurodegenerative disease
    C-C Hung
    Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, St James's University Hospital, University of Leeds, Leeds LS9 7TF, UK
    Biochem Soc Trans 34:743-5. 2006
    ..Identification of the mechanisms involved in inclusion formation is already aiding the development of novel therapeutic strategies to prevent or alleviate aggregate-associated neurodegenerative diseases...
  12. ncbi Ubiquitin-protein ligases
    P A Robinson
    Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds, LS9 7TF, UK
    J Cell Sci 117:5191-4. 2004