Research Topics
Species | N K ArdenSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve monthsCatherine J Bowen
Faculty of Health Sciences, University of Southampton, Southampton, UK
J Foot Ankle Res 4:25. 2011..abstract:..- Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapyCatherine J Bowen
School of Health Sciences, University of Southampton, Southampton, UK
J Foot Ankle Res 3:10. 2010..The aim of this study was to evaluate whether anti-TNF therapy alters the presence of forefoot pathology and/or reduces foot pain and disability... - Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologistCatherine J Bowen
School of Health Professions and Rehabilitation Sciences, University of Southampton, Southampton, UK
J Foot Ankle Res 1:5. 2008.... 
What is a good patient reported outcome after total hip replacement?N K Arden
Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
Osteoarthritis Cartilage 19:155-62. 2011..It is currently unclear how to use this information to determine outcome following surgery. The aim of this study was to define a threshold for the OHS that is correlated with patient satisfaction...
Persistence with teriparatide in patients with osteoporosis: the UK experienceN K Arden
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
Osteoporos Int 17:1626-9. 2006..The objective of this paper was to determine the persistence with teriparatide at 12 months in all patients in the UK who were prescribed the treatment since its launch...- Early life influences on serum 1,25 (OH) vitamin DNigel K Arden
MRC Epidemiology Resource Centre, Southampton, UK
Paediatr Perinat Epidemiol 19:36-42. 2005..Highest levels of 1,25 (OH)2 vitamin D were associated with low BMD and high levels of urinary N-telopeptide suggesting that vitamin D metabolism may mediate the intrauterine and early postnatal environmental effects on adult BMD... - A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST studyN K Arden
Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Rheumatology (Oxford) 44:1399-406. 2005..We performed a 12-month, multicentre, double-blind, randomized, placebo-controlled, parallel-group trial in four secondary pain-care clinics in the Wessex Region... - Knee pain, knee osteoarthritis, and the risk of fractureNigel K Arden
MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
Arthritis Rheum 55:610-5. 2006..Few data exist on the association between knee pain and fracture. We examined the association of knee OA and knee pain with fracture and falls in elderly men and women... - Osteoarthritis: epidemiologyNigel Arden
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Best Pract Res Clin Rheumatol 20:3-25. 2006..Despite this public health impact, OA remains an enigmatic condition to the epidemiologist. In this chapter, we will review the definition and classification of OA, its prevalence, incidence, risk factors and natural history... - A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS StudyN K Arden
MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
Osteoarthritis Cartilage 16:733-9. 2008..The aim of this study was to compare the benefits of intra-articular corticosteroid injections (CSIs) and tidal irrigation (TI) in patients with OA of the knee... - Assessment of the risk of fracture in patients with gastrointestinal diseaseNigel K Arden
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO 16 6YD, UK
Eur J Gastroenterol Hepatol 15:865-8. 2003..The best predictors of future fracture include a previous osteoporotic fracture, low bone density, active inflammatory bowel disease, the use of oral corticosteroids and an increased risk of falling... - Osteoporosis in patients with inflammatory bowel diseaseN K Arden
MRC Epidemiology Unit, Southampton General Hospital, Southampton, UK
Gut 50:9-10. 2002 - Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin DN K Arden
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
QJM 95:15-21. 2002..Intestinal calcium absorption and vitamin D metabolism are integrally involved in bone metabolism and may be programmed during early life... - Defining incident radiographic hip osteoarthritis for epidemiologic studies in womenNigel K Arden
MRC Epidemiology Resource Centre, Southampton, UK and University of Oxford, Oxford, UK
Arthritis Rheum 60:1052-9. 2009..To evaluate definitions of radiographic hip osteoarthritis (RHOA) for use in longitudinal epidemiologic studies of disease incidence in women... - Changes in hip fracture rate before and after total knee replacement due to osteoarthritis: a population-based cohort studyDaniel Prieto-Alhambra
NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK
Ann Rheum Dis 70:134-8. 2011..This study describes the rates of hip fracture in subjects with knee osteoarthritis before and after having a total knee replacement (TKR), compared with matched controls... - The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort studyK M Leyland
Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK
Arthritis Rheum 64:2243-51. 2012..To establish the natural history of radiographic knee osteoarthritis (OA) over 14 years in a community-based cohort... - Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal studyM K Javaid
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
Lancet 367:36-43. 2006..Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring... - Prevalence of reported knee pain over twelve years in a community-based cohortA Soni
University of Oxford, Oxford, UK
Arthritis Rheum 64:1145-52. 2012..To describe the temporal patterns of knee pain in a community-based cohort over 12 years... - Umbilical cord leptin predicts neonatal bone massM K Javaid
MRC Epidemiology Resource Centre, University of Southampton, Soumampton General Hospital, Southampton, SO16 6YD, UK
Calcif Tissue Int 76:341-7. 2005..In addition, among previously documented maternal determinants of neonatal bone mass in healthy pregnancies, maternal fat stores may mediate their effect on fetal bone accrual through variation in fetal leptin concentrations... - Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in menK M Jordan
Bone and Joint, MRC Epidemiology Resource Centre, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Ann Rheum Dis 65:871-7. 2006..CONCLUSIONS: Urinary CTX-II and Glc-Gal-Pyd, but not systemic markers of bone turnover, are strongly associated with disease severity and the presence of OA at the tibiofemoral and patellofemoral joints in men... - The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in menC J Edwards
MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
Heart 93:1263-7. 2007..This is most likely in those people with the autoantibody rheumatoid factor (RF). RF is strongly associated with rheumatoid arthritis (RA) but is also present in up to 15% of all adults... - Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?Lyndsey M Goulston
MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
Arthritis Care Res (Hoboken) 63:1398-406. 2011..To examine longitudinal patterns in body mass index (BMI) over 14 years and its association with knee pain in the Chingford Study... - Interpretation of patient-reported outcomes for hip and knee replacement surgery: identification of thresholds associated with satisfaction with surgeryA Judge
University of Oxford, Oxford NIHR Musculoskeletal Biomedical Research Unit, Windmill Road, Headington, Oxford OX3 7LD, UK
J Bone Joint Surg Br 94:412-8. 2012..The thresholds help to differentiate between patients with different levels of satisfaction, but external validation will be required prior to general implementation in clinical practice... - Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: a 19-year prospective study of 1003 womenA S Nicholls
NIHR Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Windmill Rd, University of Oxford, Oxford, OX3 7LD, UK
Knee 19:316-9. 2012..The risk was greatest at baseline when the patients were in middle age suggesting that this is the most important time to target weight reduction interventions... - The lifetime risk of total hip and knee arthroplasty: results from the UK general practice research databaseD J Culliford
Faculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Osteoarthritis Cartilage 20:519-24. 2012..To estimate the lifetime risk of undergoing primary total hip (THR) or knee (TKR) replacement in the UK... - Comparison of calcaneal ultrasound and DXA to assess the risk of corticosteroid-induced osteoporosis: a cross-sectional studyM K Javaid
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
Osteoporos Int 12:788-93. 2001..However, the absolute T-score required to give similar discriminatory capacity to femoral neck T-score varied substantially (T= -0.81 to -1.5) between the different measurement techniques and sites... - Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysisD Prieto-Alhambra
NIHR Oxford Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
Osteoporos Int 22:1555-71. 2011..We conducted a population-based cohort study to assess the effect of bisphosphonate use on their post-surgery fracture risk. Cox regression adjusted by propensity score suggested a 50-55% reduction in risk of fracture post-surgery... - Pre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centresA Judge
Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
Osteoarthritis Cartilage 19:659-67. 2011..Identify patient characteristics associated with pre-operative expectations of total hip replacement (THR); (2). Explore whether pre-operative expectations predict surgical outcomes 12-months post-THR... - Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)M B R Patel
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
Bone 37:833-41. 2005..CONCLUSIONS: Men with reduced BMD have low IGF-I but normal GH secretion and reserve. Our data suggested, but could not confirm, hepatic resistance to GH as a mechanism for this association... - Birthweight, vitamin D receptor genotype and the programming of osteoporosisE M Dennison
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
Paediatr Perinat Epidemiol 15:211-9. 2001..02) after adjustment for age, sex and weight at baseline. These results suggest that genetic influences on adult bone size and mineral density may be modified by undernutrition in utero... - Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort StudyE M Dennison
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, United Kingdom
Calcif Tissue Int 74:401-6. 2004.... - Growth and infectious exposure during infancy and the risk of rheumatoid factor in adult lifeC J Edwards
Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Ann Rheum Dis 65:401-4. 2006..The immune pathology leading to RA and RF may have similar genetic and environmental influences... - Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the hertfordshire cohort studyM B R Patel
Medical Research Council MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
Calcif Tissue Int 91:416-22. 2012..This suggests that in men, although αCa is a contributing factor in FN bone density, it is not the main mechanism whereby the early environment modifies adult BMD... - Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritisM Abdin-Mohamed
MRC Epidemiology Resource Centre, Southampton, United Kingdom
Osteoarthritis Cartilage 17:174-7. 2009..Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available... - The presence of anticardiolipin antibodies in adults may be influenced by infections in infancyC J Edwards
Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton, UK
QJM 101:41-7. 2008..We measured anticardiolipin antibodies (aCL) in a general population with well-defined early lives to see whether fetal and infant growth and infections were associated with aCL positivity in adult life... - Assessing patients for joint replacement: can pre-operative Oxford hip and knee scores be used to predict patient satisfaction following joint replacement surgery and to guide patient selection?A Judge
Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
J Bone Joint Surg Br 93:1660-4. 2011..Oxford hip and knee scores have no predictive accuracy in relation to post-operative patient satisfaction. This evidence does not support their current use in prioritising access to care... - High failure rates with a large-diameter hybrid metal-on-metal total hip replacement: clinical, radiological and retrieval analysisB J R F Bolland
Metal Hips Research Group, Southampton University Hospitals NHS Trust, Southampton, United Kingdom
J Bone Joint Surg Br 93:608-15. 2011..This raises concerns about the use of large heads on conventional 12/14 tapers... - Umbilical venous IGF-1 concentration, neonatal bone mass, and body compositionM K Javaid
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
J Bone Miner Res 19:56-63. 2004..Documented maternal determinants of neonatal bone mass seem to mediate their effects independently of variations in cord serum IGF-1 in healthy pregnancies... - Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's diseaseTimothy M Trebble
School of Medicine, Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Clin Nutr 23:647-55. 2004..CONCLUSIONS: CD is associated with a greater availability, and not a deficiency, of n-3 PUFA in PBMC, but lower concentrations of AA, and lower rates of production of PGE2 and IFN-gamma, compared to healthy controls... - Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementationTimothy Trebble
The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 90:405-12. 2003..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake... - Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortalityD Prieto-Alhambra
Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD, UK
Osteoporos Int 23:2797-803. 2012..There was a higher 3-year mortality in those admitted (17%) vs. those not admitted (6.3%). Given the substantial health burden, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes... - The changing use of disease-modifying anti-rheumatic drugs in individuals with rheumatoid arthritis from the United Kingdom General Practice Research DatabaseC J Edwards
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Rheumatology (Oxford) 44:1394-8. 2005..To describe the use of disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA) and changing trends in their use... - The use of conventional and complementary treatments for knee osteoarthritis in the communityK M Jordan
MRC Epidemiology Resource Centre, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Rheumatology (Oxford) 43:381-4. 2004.... - Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn diseaseTimothy M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
Am J Clin Nutr 80:1137-44. 2004..Fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces disease activity in patients with CD with raised laboratory markers of inflammation and in healthy subjects alters PBMC function... - High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trialTimothy M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
Br J Nutr 94:253-61. 2005..Dietary supplementation in Crohn's disease with high intakes of EPA and DHA, as fish oil, plus antioxidants was associated with a modulated production of interferon-gamma by PBMC but not altered indices of bone turnover... - The importance of the disease process and disease-modifying antirheumatic drug treatment in the development of septic arthritis in patients with rheumatoid arthritisChristopher J Edwards
University of Southampton, and Southampton General Hospital, Southampton, UK
Arthritis Rheum 57:1151-7. 2007..To evaluate the effect of disease-modifying antirheumatic drugs (DMARDs) on the likelihood of patients with rheumatoid arthritis (RA) developing septic arthritis (SA)... - Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: a twelve-month investigationCatherine J Bowen
University of Southampton, Southampton University Hospitals National Health Service Trust, Southampton, UK
Arthritis Care Res (Hoboken) 62:1756-62. 2010..To determine the natural history and clinical significance of forefoot bursae over a 12-month period in patients with rheumatoid arthritis (RA)... - Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementationTimothy M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
Am J Clin Nutr 78:376-82. 2003..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants... - Commentary: statins and fracture--why the confusion?C J Edwards
MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
Int J Epidemiol 35:1312-3. 2006 - The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research databaseB J R F Bolland
Southampton General Hospital, Southampton University Hospital Trust, Tremona Road, Southampton, United Kingdom
Osteoarthritis Cartilage 19:29-36. 2011..To determine the use of oral anti-inflammatory drugs in the year before and the 2 years after primary total hip (THR) or knee (TKR) replacement, and whether this varies according to Body mass Index (BMI)... - The effects of age on patient-reported outcome measures in total knee replacementsD P Williams
University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Windmill Road, Oxford OX3 7LD, UK
Bone Joint J 95:38-44. 2013..Cite this article: Bone Joint J 2013;95-B:38-44... - Individual magnetic resonance imaging and radiographic features of knee osteoarthritis in subjects with unilateral knee pain: the health, aging, and body composition studyM K Javaid
University of Oxford, Oxford, UK
Arthritis Rheum 64:3246-55. 2012..This study was undertaken to compare radiographic and magnetic resonance imaging (MRI) features of knee OA and assess their ability to discriminate between painful and nonpainful knees in persons with unilateral symptoms... - Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritisT C B Pollard
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Osteoarthritis Cartilage 20:368-75. 2012..Using a middle-aged cohort with genetic predisposition to hip OA and a control group, we compared the prevalence of clinical and radiographic hip OA and incidence of progression over 5 years... - EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)K M Jordan
Southampton General Hospital, Southampton S016 6YD, UK
Ann Rheum Dis 62:1145-55. 2003..Although a large number of treatment options for knee OA exist, the evidence based format of the EULAR Recommendations continues to identify key clinical questions that currently are unanswered... - Laboratory markers predict bone loss in Crohn's disease: relationship to blood mononuclear cell function and nutritional statusT M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Aliment Pharmacol Ther 19:1063-71. 2004..This relationship and the role of circulating (peripheral blood) mononuclear cells were investigated in a case-control study... - Effective measurement of knee alignment using AP knee radiographsAlexandra N Colebatch
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Knee 16:42-5. 2009..This will facilitate measurement of knee alignment in existing cohort studies to assess malalignment as a risk factor of incident OA, and in clinical practice... - Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritisKelsey M Jordan
MRC Epidemiology Resource Centre, Southampton University Hospitals NHS Trust, Southampton, England
J Rheumatol 32:678-83. 2005..To investigate risk factors for adult lumbar spine osteoarthritis (OA) including polymorphisms of the vitamin D receptor gene (VDR) and birthweight... - Different indices of fetal growth predict bone size and volumetric density at 4 years of ageNicholas C Harvey
MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
J Bone Miner Res 25:920-7. 2010..These results suggest a discordance between influences on skeletal size and volumetric density... - Inflammatory bowel disease and the risk of fractureTjeerd-Pieter van Staa
Department of Pharmacoepidemiology and Pharmacotherapy, Universtiy of Utrecht, The Netherlands
Gastroenterology 125:1591-7. 2003..However, few of these patients are receiving optimal bone-sparing therapy, highlighting the importance of increasing awareness of osteoporosis in those managing these patients... - A case of leg pain and weakness in a man with diabetesRuth B Poole
Royal Hampshire County Hospital, Winchester, UK
J Clin Pathol 60:938-9. 2007 - Evidence-based clinical guidelines: a new system to better determine true strength of recommendationEdward Roddy
Academic Rheumatology, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham, UK
J Eval Clin Pract 12:347-52. 2006..The purpose of this study was to develop a new method of determining SOR, incorporating both research evidence and expert opinion...