N K Arden

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: a 19-year prospective study of 1003 women
    A S Nicholls
    NIHR Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Windmill Rd, University of Oxford, Oxford, OX3 7LD, UK
    Knee 19:316-9. 2012
  2. pmc Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months
    Catherine J Bowen
    Faculty of Health Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 4:25. 2011
  3. pmc Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy
    Catherine J Bowen
    School of Health Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 3:10. 2010
  4. pmc Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologist
    Catherine J Bowen
    School of Health Professions and Rehabilitation Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 1:5. 2008
  5. pmc Osteoporosis in patients with inflammatory bowel disease
    N K Arden
    MRC Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Gut 50:9-10. 2002
  6. ncbi request reprint A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study
    N K Arden
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 44:1399-406. 2005
  7. ncbi request reprint Osteoarthritis: epidemiology
    Nigel Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Best Pract Res Clin Rheumatol 20:3-25. 2006
  8. ncbi request reprint Early life influences on serum 1,25 (OH) vitamin D
    Nigel K Arden
    MRC Epidemiology Resource Centre, Southampton, UK
    Paediatr Perinat Epidemiol 19:36-42. 2005
  9. ncbi request reprint Persistence with teriparatide in patients with osteoporosis: the UK experience
    N K Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 17:1626-9. 2006
  10. ncbi request reprint Knee pain, knee osteoarthritis, and the risk of fracture
    Nigel K Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Arthritis Rheum 55:610-5. 2006

Detail Information

Publications68

  1. pmc Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: a 19-year prospective study of 1003 women
    A S Nicholls
    NIHR Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Windmill Rd, University of Oxford, Oxford, OX3 7LD, UK
    Knee 19:316-9. 2012
    ..The risk was greatest at baseline when the patients were in middle age suggesting that this is the most important time to target weight reduction interventions...
  2. pmc Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months
    Catherine J Bowen
    Faculty of Health Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 4:25. 2011
    ..abstract:..
  3. pmc Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy
    Catherine J Bowen
    School of Health Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 3:10. 2010
    ..The aim of this study was to evaluate whether anti-TNF therapy alters the presence of forefoot pathology and/or reduces foot pain and disability...
  4. pmc Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologist
    Catherine J Bowen
    School of Health Professions and Rehabilitation Sciences, University of Southampton, Southampton, UK
    J Foot Ankle Res 1:5. 2008
    ....
  5. pmc Osteoporosis in patients with inflammatory bowel disease
    N K Arden
    MRC Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Gut 50:9-10. 2002
  6. ncbi request reprint A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study
    N K Arden
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 44:1399-406. 2005
    ..We performed a 12-month, multicentre, double-blind, randomized, placebo-controlled, parallel-group trial in four secondary pain-care clinics in the Wessex Region...
  7. ncbi request reprint Osteoarthritis: epidemiology
    Nigel Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Best Pract Res Clin Rheumatol 20:3-25. 2006
    ..Despite this public health impact, OA remains an enigmatic condition to the epidemiologist. In this chapter, we will review the definition and classification of OA, its prevalence, incidence, risk factors and natural history...
  8. ncbi request reprint Early life influences on serum 1,25 (OH) vitamin D
    Nigel K Arden
    MRC Epidemiology Resource Centre, Southampton, UK
    Paediatr Perinat Epidemiol 19:36-42. 2005
    ..Highest levels of 1,25 (OH)2 vitamin D were associated with low BMD and high levels of urinary N-telopeptide suggesting that vitamin D metabolism may mediate the intrauterine and early postnatal environmental effects on adult BMD...
  9. ncbi request reprint Persistence with teriparatide in patients with osteoporosis: the UK experience
    N K Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 17:1626-9. 2006
    ..The objective of this paper was to determine the persistence with teriparatide at 12 months in all patients in the UK who were prescribed the treatment since its launch...
  10. ncbi request reprint Knee pain, knee osteoarthritis, and the risk of fracture
    Nigel K Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Arthritis Rheum 55:610-5. 2006
    ..Few data exist on the association between knee pain and fracture. We examined the association of knee OA and knee pain with fracture and falls in elderly men and women...
  11. ncbi request reprint A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study
    N K Arden
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, UK
    Osteoarthritis Cartilage 16:733-9. 2008
    ..The aim of this study was to compare the benefits of intra-articular corticosteroid injections (CSIs) and tidal irrigation (TI) in patients with OA of the knee...
  12. pmc Defining incident radiographic hip osteoarthritis for epidemiologic studies in women
    Nigel K Arden
    MRC Epidemiology Resource Centre, Southampton, UK and University of Oxford, Oxford, UK
    Arthritis Rheum 60:1052-9. 2009
    ..To evaluate definitions of radiographic hip osteoarthritis (RHOA) for use in longitudinal epidemiologic studies of disease incidence in women...
  13. doi request reprint What is a good patient reported outcome after total hip replacement?
    N K Arden
    Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
    Osteoarthritis Cartilage 19:155-62. 2011
    ..It is currently unclear how to use this information to determine outcome following surgery. The aim of this study was to define a threshold for the OHS that is correlated with patient satisfaction...
  14. ncbi request reprint Assessment of the risk of fracture in patients with gastrointestinal disease
    Nigel K Arden
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO 16 6YD, UK
    Eur J Gastroenterol Hepatol 15:865-8. 2003
    ..The best predictors of future fracture include a previous osteoporotic fracture, low bone density, active inflammatory bowel disease, the use of oral corticosteroids and an increased risk of falling...
  15. ncbi request reprint Size at birth, adult intestinal calcium absorption and 1,25(OH)(2) vitamin D
    N K Arden
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    QJM 95:15-21. 2002
    ..Intestinal calcium absorption and vitamin D metabolism are integrally involved in bone metabolism and may be programmed during early life...
  16. doi request reprint Changes in hip fracture rate before and after total knee replacement due to osteoarthritis: a population-based cohort study
    Daniel Prieto-Alhambra
    NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK
    Ann Rheum Dis 70:134-8. 2011
    ..This study describes the rates of hip fracture in subjects with knee osteoarthritis before and after having a total knee replacement (TKR), compared with matched controls...
  17. doi request reprint The hereditary predisposition to hip osteoarthritis and its association with abnormal joint morphology
    T C B Pollard
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre NHS Trust, Headington, Oxford, United Kingdom
    Osteoarthritis Cartilage 21:314-21. 2013
    ..Using a cohort with an hereditary predisposition to end-stage hip OA and a control group with no inherited risk, we aimed to identify associations with abnormal joint morphology and clinical features...
  18. ncbi request reprint The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study
    K M Leyland
    Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK
    Arthritis Rheum 64:2243-51. 2012
    ..To establish the natural history of radiographic knee osteoarthritis (OA) over 14 years in a community-based cohort...
  19. ncbi request reprint Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  20. ncbi request reprint Prevalence of reported knee pain over twelve years in a community-based cohort
    A Soni
    University of Oxford, Oxford, UK
    Arthritis Rheum 64:1145-52. 2012
    ..To describe the temporal patterns of knee pain in a community-based cohort over 12 years...
  21. ncbi request reprint Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?
    Lyndsey M Goulston
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    Arthritis Care Res (Hoboken) 63:1398-406. 2011
    ..To examine longitudinal patterns in body mass index (BMI) over 14 years and its association with knee pain in the Chingford Study...
  22. doi request reprint Weight in infancy and adult calcium absorption as determinants of bone mineral density in adult men: the Hertfordshire cohort study
    M B R Patel
    Medical Research Council MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Calcif Tissue Int 91:416-22. 2012
    ..This suggests that in men, although αCa is a contributing factor in FN bone density, it is not the main mechanism whereby the early environment modifies adult BMD...
  23. pmc Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men
    K M Jordan
    Bone and Joint, MRC Epidemiology Resource Centre, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann Rheum Dis 65:871-7. 2006
    ..To investigate the association between biochemical markers of bone, cartilage, and synovial turnover with the presence and severity of knee osteoarthritis (OA) in men...
  24. ncbi request reprint Umbilical cord leptin predicts neonatal bone mass
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Soumampton General Hospital, Southampton, SO16 6YD, UK
    Calcif Tissue Int 76:341-7. 2005
    ..In addition, among previously documented maternal determinants of neonatal bone mass in healthy pregnancies, maternal fat stores may mediate their effect on fetal bone accrual through variation in fetal leptin concentrations...
  25. pmc The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men
    C J Edwards
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Heart 93:1263-7. 2007
    ..This is most likely in those people with the autoantibody rheumatoid factor (RF). RF is strongly associated with rheumatoid arthritis (RA) but is also present in up to 15% of all adults...
  26. pmc Neuropathic features of joint pain: a community-based study
    A Soni
    University of Oxford, Oxford, UK
    Arthritis Rheum 65:1942-9. 2013
    ..The purpose of this study was to conduct an observational study to describe the characteristics of joint pain and to examine the relationship between QST measures and the PainDETECT Questionnaire (PD-Q)...
  27. doi request reprint Interpretation of patient-reported outcomes for hip and knee replacement surgery: identification of thresholds associated with satisfaction with surgery
    A Judge
    University of Oxford, Oxford NIHR Musculoskeletal Biomedical Research Unit, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 94:412-8. 2012
    ..The thresholds help to differentiate between patients with different levels of satisfaction, but external validation will be required prior to general implementation in clinical practice...
  28. ncbi request reprint Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, United Kingdom
    Calcif Tissue Int 74:401-6. 2004
    ....
  29. doi request reprint The effects of age on patient-reported outcome measures in total knee replacements
    D P Williams
    University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Windmill Road, Oxford OX3 7LD, UK
    Bone Joint J 95:38-44. 2013
    ....
  30. pmc Individual magnetic resonance imaging and radiographic features of knee osteoarthritis in subjects with unilateral knee pain: the health, aging, and body composition study
    M K Javaid
    University of Oxford, Oxford, UK
    Arthritis Rheum 64:3246-55. 2012
    ..This study was undertaken to compare radiographic and magnetic resonance imaging (MRI) features of knee OA and assess their ability to discriminate between painful and nonpainful knees in persons with unilateral symptoms...
  31. doi request reprint The lifetime risk of total hip and knee arthroplasty: results from the UK general practice research database
    D J Culliford
    Faculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Osteoarthritis Cartilage 20:519-24. 2012
    ..To estimate the lifetime risk of undergoing primary total hip (THR) or knee (TKR) replacement in the UK...
  32. doi request reprint Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis
    D Prieto-Alhambra
    NIHR Oxford Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
    Osteoporos Int 22:1555-71. 2011
    ..We conducted a population-based cohort study to assess the effect of bisphosphonate use on their post-surgery fracture risk. Cox regression adjusted by propensity score suggested a 50-55% reduction in risk of fracture post-surgery...
  33. ncbi request reprint Comparison of calcaneal ultrasound and DXA to assess the risk of corticosteroid-induced osteoporosis: a cross-sectional study
    M K Javaid
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Osteoporos Int 12:788-93. 2001
    ..However, the absolute T-score required to give similar discriminatory capacity to femoral neck T-score varied substantially (T= -0.81 to -1.5) between the different measurement techniques and sites...
  34. ncbi request reprint Birthweight, vitamin D receptor genotype and the programming of osteoporosis
    E M Dennison
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Paediatr Perinat Epidemiol 15:211-9. 2001
    ..02) after adjustment for age, sex and weight at baseline. These results suggest that genetic influences on adult bone size and mineral density may be modified by undernutrition in utero...
  35. doi request reprint Pre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centres
    A Judge
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
    Osteoarthritis Cartilage 19:659-67. 2011
    ..Identify patient characteristics associated with pre-operative expectations of total hip replacement (THR); (2). Explore whether pre-operative expectations predict surgical outcomes 12-months post-THR...
  36. ncbi request reprint Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)
    M B R Patel
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 37:833-41. 2005
    ..Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to support these hypotheses...
  37. pmc Growth and infectious exposure during infancy and the risk of rheumatoid factor in adult life
    C J Edwards
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann Rheum Dis 65:401-4. 2006
    ..The immune pathology leading to RA and RF may have similar genetic and environmental influences...
  38. doi request reprint Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortality
    D Prieto-Alhambra
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Osteoporos Int 23:2797-803. 2012
    ..There was a higher 3-year mortality in those admitted (17%) vs. those not admitted (6.3%). Given the substantial health burden, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes...
  39. doi request reprint The presence of anticardiolipin antibodies in adults may be influenced by infections in infancy
    C J Edwards
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton, UK
    QJM 101:41-7. 2008
    ..We measured anticardiolipin antibodies (aCL) in a general population with well-defined early lives to see whether fetal and infant growth and infections were associated with aCL positivity in adult life...
  40. doi request reprint Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis
    M Abdin-Mohamed
    MRC Epidemiology Resource Centre, Southampton, United Kingdom
    Osteoarthritis Cartilage 17:174-7. 2009
    ..Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available...
  41. ncbi request reprint The use of conventional and complementary treatments for knee osteoarthritis in the community
    K M Jordan
    MRC Epidemiology Resource Centre, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 43:381-4. 2004
    ....
  42. doi request reprint Body mass index is not a clinically meaningful predictor of patient reported outcomes of primary hip replacement surgery: prospective cohort study
    A Judge
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK MRC LifeCourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK Electronic address
    Osteoarthritis Cartilage 22:431-9. 2014
    ..To describe whether body mass index (BMI) is a clinically meaningful predictor of patient reported outcomes following primary total hip replacement (THR) surgery...
  43. doi request reprint Assessing patients for joint replacement: can pre-operative Oxford hip and knee scores be used to predict patient satisfaction following joint replacement surgery and to guide patient selection?
    A Judge
    Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Bone Joint Surg Br 93:1660-4. 2011
    ..Oxford hip and knee scores have no predictive accuracy in relation to post-operative patient satisfaction. This evidence does not support their current use in prioritising access to care...
  44. ncbi request reprint Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition
    M K Javaid
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Bone Miner Res 19:56-63. 2004
    ..However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton...
  45. doi request reprint High failure rates with a large-diameter hybrid metal-on-metal total hip replacement: clinical, radiological and retrieval analysis
    B J R F Bolland
    Metal Hips Research Group, Southampton University Hospitals NHS Trust, Southampton, United Kingdom
    J Bone Joint Surg Br 93:608-15. 2011
    ..This raises concerns about the use of large heads on conventional 12/14 tapers...
  46. ncbi request reprint Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
    Timothy Trebble
    The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 90:405-12. 2003
    ..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake...
  47. ncbi request reprint Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease
    Timothy M Trebble
    School of Medicine, Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Clin Nutr 23:647-55. 2004
    ..The aim of this study is to investigate n-3 and n-6 PUFA composition and synthetic function of peripheral blood mononuclear cells (PBMC) in the basal state...
  48. ncbi request reprint Temporal trends and geographical variation in the use of subacromial decompression and rotator cuff repair of the shoulder in England
    A Judge
    University of Oxford, Oxford NIHR Musculoskeletal Biomedical Research Unit, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Bone Joint J 96:70-4. 2014
    ....
  49. pmc Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial
    D Prieto-Alhambra
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, OX, OX3 7LD, UK
    Osteoporos Int 25:77-83. 2014
    ..Patients with cognitive impairment (CI) often do not receive secondary fracture prevention. Use of zoledronic acid led to a similar reduction in re-fracture risk but the survival benefit was limited to those without CI...
  50. pmc EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
    K M Jordan
    Southampton General Hospital, Southampton S016 6YD, UK
    Ann Rheum Dis 62:1145-55. 2003
    ..To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach...
  51. ncbi request reprint The changing use of disease-modifying anti-rheumatic drugs in individuals with rheumatoid arthritis from the United Kingdom General Practice Research Database
    C J Edwards
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Rheumatology (Oxford) 44:1394-8. 2005
    ..To describe the use of disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA) and changing trends in their use...
  52. ncbi request reprint High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial
    Timothy M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
    Br J Nutr 94:253-61. 2005
    ..Dietary supplementation in Crohn's disease with high intakes of EPA and DHA, as fish oil, plus antioxidants was associated with a modulated production of interferon-gamma by PBMC but not altered indices of bone turnover...
  53. ncbi request reprint Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation
    Timothy M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
    Am J Clin Nutr 78:376-82. 2003
    ..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants...
  54. ncbi request reprint Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease
    Timothy M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 80:1137-44. 2004
    ..Fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces disease activity in patients with CD with raised laboratory markers of inflammation and in healthy subjects alters PBMC function...
  55. doi request reprint Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: a twelve-month investigation
    Catherine J Bowen
    University of Southampton, Southampton University Hospitals National Health Service Trust, Southampton, UK
    Arthritis Care Res (Hoboken) 62:1756-62. 2010
    ..To determine the natural history and clinical significance of forefoot bursae over a 12-month period in patients with rheumatoid arthritis (RA)...
  56. ncbi request reprint The importance of the disease process and disease-modifying antirheumatic drug treatment in the development of septic arthritis in patients with rheumatoid arthritis
    Christopher J Edwards
    University of Southampton, and Southampton General Hospital, Southampton, UK
    Arthritis Rheum 57:1151-7. 2007
    ..To evaluate the effect of disease-modifying antirheumatic drugs (DMARDs) on the likelihood of patients with rheumatoid arthritis (RA) developing septic arthritis (SA)...
  57. ncbi request reprint The effect of body mass index on the risk of post-operative complications during the 6 months following total hip replacement or total knee replacement surgery
    G Wallace
    Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UK Electronic address
    Osteoarthritis Cartilage 22:918-27. 2014
    ..To assess the effect of obesity on 6-month post-operative complications following total knee (TKR) or hip (THR) replacement...
  58. doi request reprint Osteoarthritis year 2013 in review: clinical
    N K Arden
    Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK MRC LifeCourse Epidemiology Unit, University of Southampton, Southampton, UK Electronic address
    Osteoarthritis Cartilage 21:1409-13. 2013
    ..A systematic literature search was performed using PubMed from January 2012 to December 2012. The articles selected for this review represent topics the authors thought best highlight recent clinical OA research. ..
  59. ncbi request reprint Commentary: statins and fracture--why the confusion?
    C J Edwards
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Int J Epidemiol 35:1312-3. 2006
  60. doi request reprint The effect of hip and knee arthroplasty on oral anti-inflammatory use and the relationship to body mass index: results from the UK general practice research database
    B J R F Bolland
    Southampton General Hospital, Southampton University Hospital Trust, Tremona Road, Southampton, United Kingdom
    Osteoarthritis Cartilage 19:29-36. 2011
    ..To determine the use of oral anti-inflammatory drugs in the year before and the 2 years after primary total hip (THR) or knee (TKR) replacement, and whether this varies according to Body mass Index (BMI)...
  61. doi request reprint Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritis
    T C B Pollard
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
    Osteoarthritis Cartilage 20:368-75. 2012
    ..Using a middle-aged cohort with genetic predisposition to hip OA and a control group, we compared the prevalence of clinical and radiographic hip OA and incidence of progression over 5 years...
  62. ncbi request reprint Laboratory markers predict bone loss in Crohn's disease: relationship to blood mononuclear cell function and nutritional status
    T M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Aliment Pharmacol Ther 19:1063-71. 2004
    ..This relationship and the role of circulating (peripheral blood) mononuclear cells were investigated in a case-control study...
  63. ncbi request reprint Effective measurement of knee alignment using AP knee radiographs
    Alexandra N Colebatch
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Knee 16:42-5. 2009
    ..This will facilitate measurement of knee alignment in existing cohort studies to assess malalignment as a risk factor of incident OA, and in clinical practice...
  64. ncbi request reprint Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis
    Kelsey M Jordan
    MRC Epidemiology Resource Centre, Southampton University Hospitals NHS Trust, Southampton, England
    J Rheumatol 32:678-83. 2005
    ..To investigate risk factors for adult lumbar spine osteoarthritis (OA) including polymorphisms of the vitamin D receptor gene (VDR) and birthweight...
  65. pmc Different indices of fetal growth predict bone size and volumetric density at 4 years of age
    Nicholas C Harvey
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Bone Miner Res 25:920-7. 2010
    ..These results suggest a discordance between influences on skeletal size and volumetric density...
  66. ncbi request reprint Inflammatory bowel disease and the risk of fracture
    Tjeerd Pieter van Staa
    Department of Pharmacoepidemiology and Pharmacotherapy, Universtiy of Utrecht, The Netherlands
    Gastroenterology 125:1591-7. 2003
    ..Although patients with inflammatory bowel disease (IBD) have reduced bone mass, there is controversy whether there is an increased risk of fracture. This study examines the risk of fracture and its predictors in patients with IBD...
  67. pmc A case of leg pain and weakness in a man with diabetes
    Ruth B Poole
    Royal Hampshire County Hospital, Winchester, UK
    J Clin Pathol 60:938-9. 2007
  68. ncbi request reprint Evidence-based clinical guidelines: a new system to better determine true strength of recommendation
    Edward Roddy
    Academic Rheumatology, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham, UK
    J Eval Clin Pract 12:347-52. 2006
    ..The purpose of this study was to develop a new method of determining SOR, incorporating both research evidence and expert opinion...