Vincent Archambault

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Polo-like kinases: conservation and divergence in their functions and regulation
    Vincent Archambault
    Cancer Research UK, Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK
    Nat Rev Mol Cell Biol 10:265-75. 2009
  2. pmc Yeast Polo-like kinase substrates are nailed with the right tools
    Vincent Archambault
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Genome Biol 9:203. 2008
  3. doi request reprint A bitter PP1 fights the sweet polo
    Vincent Archambault
    Department of Genetics, Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Downing Street, CB2 3EH Cambridge, UK
    Mol Cell 30:541-2. 2008
  4. pmc Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes
    Emilie Montembault
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Cell Biol 191:1351-65. 2010
  5. pmc Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex
    Pier Paolo D'Avino
    Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e572. 2007
  6. doi request reprint Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development
    Sarah P Blagden
    Cancer Research UK Cell Cycle Genetics Group, University of Cambridge, Department of Genetics, Cambridge CB2 3EH, UK
    Dev Biol 334:186-97. 2009
  7. pmc Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis
    Luisa Capalbo
    Cancer Research United Kingdom Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Proc Natl Acad Sci U S A 108:17343-8. 2011
  8. pmc Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster
    Marcin R Przewloka
    Cancer Research UK, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e478. 2007
  9. pmc Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis
    Vincent Archambault
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom
    Genes Dev 22:2707-20. 2008
  10. doi request reprint Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells
    Pier Paolo D'Avino
    Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Methods Mol Biol 545:99-112. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint Polo-like kinases: conservation and divergence in their functions and regulation
    Vincent Archambault
    Cancer Research UK, Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK
    Nat Rev Mol Cell Biol 10:265-75. 2009
    ..Plks are now recognized to link cell division to developmental processes and to function in differentiated cells. A comparison of Plk function and regulation between organisms offers insight into the rich variations of cell division...
  2. pmc Yeast Polo-like kinase substrates are nailed with the right tools
    Vincent Archambault
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Genome Biol 9:203. 2008
    ..A novel role for this kinase in regulating the mitotic spindle is revealed...
  3. doi request reprint A bitter PP1 fights the sweet polo
    Vincent Archambault
    Department of Genetics, Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Downing Street, CB2 3EH Cambridge, UK
    Mol Cell 30:541-2. 2008
    ..2008) report that the PP1 regulatory subunit MYPT1 interacts with PLK1 and antagonizes essential mitotic functions of PLK1, at least in part by promoting the dephosphorylation of PLK1 at Thr210...
  4. pmc Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes
    Emilie Montembault
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Cell Biol 191:1351-65. 2010
    ..Our findings indicate that Nesd is a novel carbohydrate-binding protein that functions together with centralspindlin in late cytokinesis, thus highlighting the importance of glycosylation in this process...
  5. pmc Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex
    Pier Paolo D'Avino
    Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e572. 2007
    ..Their roles during cytokinesis, however, are not well understood because the requirement of these kinases during early stages of mitosis complicates the study of their functions after anaphase onset...
  6. doi request reprint Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development
    Sarah P Blagden
    Cancer Research UK Cell Cycle Genetics Group, University of Cambridge, Department of Genetics, Cambridge CB2 3EH, UK
    Dev Biol 334:186-97. 2009
    ..We discuss why the syncytial mitotic cycles and male meiosis should have a particularly sensitive requirement for Larp proteins in regulating not only transcript stability but also potentially the translation of mRNAs...
  7. pmc Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis
    Luisa Capalbo
    Cancer Research United Kingdom Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Proc Natl Acad Sci U S A 108:17343-8. 2011
    ..Our results indicate a role for Rab5 in mitosis and reinforce the emerging view of the contributions made by cell membrane dynamics to spindle function...
  8. pmc Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster
    Marcin R Przewloka
    Cancer Research UK, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e478. 2007
    ..Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochores...
  9. pmc Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis
    Vincent Archambault
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom
    Genes Dev 22:2707-20. 2008
    ..We propose that Map205-dependent targeting of Polo to microtubules provides a stable reservoir of Polo that can be rapidly mobilized by the activity of Cdk1 at mitotic entry...
  10. doi request reprint Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells
    Pier Paolo D'Avino
    Cancer Research UK Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Methods Mol Biol 545:99-112. 2009
    ..Although this method has proven very successful in isolating mitotic and cytokinetic complexes, it can also be used to characterise protein complexes involved in many other cellular processes...
  11. pmc Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase
    Vincent Archambault
    CRUK Cell Cycle Genetics Group, Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 3:e200. 2007
    ..Our results indicate that Gwl activity antagonizes Polo and thus identify an important regulatory interaction of the cell cycle...
  12. ncbi request reprint Affinity purification of protein complexes from Drosophila embryos in cell cycle studies
    Zoltán Lipinszki
    Department of Genetics, University of Cambridge, Cambridge, UK
    Methods Mol Biol 1170:571-88. 2014
    ..This in vivo proteomics approach has allowed the identification of several known and novel mitotic protein interactions using mass spectrometry, and it expands the use of the Drosophila model in modern molecular biology. ..
  13. ncbi request reprint Multiple protein phosphatases are required for mitosis in Drosophila
    Feng Chen
    Cancer Research United Kingdom, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Curr Biol 17:293-303. 2007
    ..Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles...
  14. ncbi request reprint Cell cycle: proteomics gives it a spin
    Vincent Archambault
    Department of Genetics, University of Cambridge, Downing Street, CB2 3EH, UK
    Expert Rev Proteomics 2:615-25. 2005
    ..The near future should see the application of more quantitative proteomic approaches to probe the dynamic aspects of the molecular system that underlie the cell cycle in model organisms and in human cells...
  15. pmc Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit
    Vincent Archambault
    The Rockefeller University, New York, New York 10021, USA
    Mol Biol Cell 14:4592-604. 2003
    ..We conclude, therefore, that although both Cdc6 and Sic1 have the potential to facilitate mitotic exit by inhibiting Clb2-Cdk, mitotic exit nevertheless does not require any identified stoichiometric inhibitor of Cdk activity...
  16. ncbi request reprint Targeted proteomic study of the cyclin-Cdk module
    Vincent Archambault
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell 14:699-711. 2004
    ..Our results demonstrate that this approach can be used to detect a host of transient and dynamic protein associations within a biological module...
  17. pmc Testing a mathematical model of the yeast cell cycle
    Frederick R Cross
    The Rockefeller University, New York, NY 10021, USA
    Mol Biol Cell 13:52-70. 2002
    ..Thus, the model is a strong but incomplete attempt at a realistic representation of cell cycle control. Constraints of the sort developed here will be important in development of a truly predictive model...
  18. pmc Disruption of mechanisms that prevent rereplication triggers a DNA damage response
    Vincent Archambault
    The Rockefeller University, 1230 York Ave, Box 237, New York, NY 10021, USA
    Mol Cell Biol 25:6707-21. 2005
    ..Our results implicate an Mre11-Mec1-dependent pathway in limiting the extent of rereplication...
  19. pmc Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition
    Amy E Ikui
    The Rockefeller University, New York, New York 10021, USA
    Genetics 175:1011-22. 2007
    ....
  20. ncbi request reprint Two-faced cyclins with eyes on the targets
    Vincent Archambault
    Rockefeller University, New York, New York, USA
    Cell Cycle 4:125-30. 2005
    ..The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions...
  21. pmc Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch
    Gwendolyn M Wilmes
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genes Dev 18:981-91. 2004
    ..We propose that Clb5 binding to ORC provides an origin-localized replication control switch that specifically prevents reinitiation at replicated origins...
  22. ncbi request reprint Analysis of protein phosphorylation by hypothesis-driven multiple-stage mass spectrometry
    Emmanuel J Chang
    Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Anal Chem 76:4472-83. 2004
    ..Our results demonstrate that HMS-MS is a sensitive, highly specific tool for systematically surveying proteins for Ser/Thr phosphorylation, and represents a significant step toward our goal of comprehensive phosphorylation mapping...