Victor Appay

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint RANTES: a versatile and controversial chemokine
    V Appay
    Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK
    Trends Immunol 22:83-7. 2001
  2. ncbi request reprint Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 16:161-70. 2002
  3. ncbi request reprint Dynamics of T cell responses in HIV infection
    Victor Appay
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:3660-6. 2002
  4. ncbi request reprint Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
  5. ncbi request reprint Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
  6. ncbi request reprint The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Immunol Methods 268:9-19. 2002
  7. ncbi request reprint Premature ageing of the immune system: the cause of AIDS?
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS
    Trends Immunol 23:580-5. 2002
  8. pmc Mature CD8(+) T lymphocyte response to viral infection during fetal life
    Arnaud Marchant
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 111:1747-55. 2003
  9. pmc HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor
    Tao Dong
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS UK
    J Exp Med 200:1547-57. 2004
  10. pmc Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    Laura Papagno
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Biol 2:E20. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint RANTES: a versatile and controversial chemokine
    V Appay
    Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK
    Trends Immunol 22:83-7. 2001
    ..RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans...
  2. ncbi request reprint Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 16:161-70. 2002
    ..It leads to significant reductions of plasma viremia, often to undetectable levels, but it can also be linked with the reduction and disappearance of detectable HIV-specific CD8 T-cell responses...
  3. ncbi request reprint Dynamics of T cell responses in HIV infection
    Victor Appay
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:3660-6. 2002
    ..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision...
  4. ncbi request reprint Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
    ..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate...
  5. ncbi request reprint Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
    ..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...
  6. ncbi request reprint The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Immunol Methods 268:9-19. 2002
    ..Understanding how antigen-specific cells develop and function in different circumstances and pathologies will be the key to unravelling the secrets of our cellular immune system...
  7. ncbi request reprint Premature ageing of the immune system: the cause of AIDS?
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS
    Trends Immunol 23:580-5. 2002
    ..This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus...
  8. pmc Mature CD8(+) T lymphocyte response to viral infection during fetal life
    Arnaud Marchant
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 111:1747-55. 2003
    ..The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens...
  9. pmc HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor
    Tao Dong
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS UK
    J Exp Med 200:1547-57. 2004
    ..Selection of Vbeta13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome...
  10. pmc Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    Laura Papagno
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Biol 2:E20. 2004
    ..It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system...
  11. ncbi request reprint Lessons from the study of T-cell differentiation in persistent human virus infection
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Semin Immunol 16:205-12. 2004
    ....
  12. ncbi request reprint Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages
    Victor Appay
    Cellular Immunology Laboratory, Institut National de la Santé et de la Recherche Médical U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol 179:7406-14. 2007
    ....
  13. pmc Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
    Jorge R Almeida
    Cellular Immunology Laboratory, U543, Institut National de la Sante et de la Recherche Medicale, Avenir Group, 75013 Paris, France
    J Exp Med 204:2473-85. 2007
    ..Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines...
  14. ncbi request reprint PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    Delphine Sauce
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    AIDS 21:2005-13. 2007
    ..Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans...
  15. ncbi request reprint Accelerated immune senescence and HIV-1 infection
    Victor Appay
    Laboratoire d Immunologie Cellulaire et Tissulaire, INSERM U543, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    Exp Gerontol 42:432-7. 2007
    ..Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation...
  16. ncbi request reprint New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol 177:1670-8. 2006
    ....
  17. ncbi request reprint Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples
    Victor Appay
    Immunology Group, Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Immunol Methods 309:192-9. 2006
    ..While the need to purify and cryopreserve PBMC for subsequent studies is obvious, the use of whole blood has the advantage of providing unbiased results and only small amounts of blood are used...
  18. ncbi request reprint Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  19. pmc Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation
    Robert Thimme
    Institute for Medical Microbiology and Hygiene, Department of Immunology, Hermann Herder Str 11, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 79:12112-6. 2005
    ..Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation...
  20. ncbi request reprint Correlates of delayed disease progression in HIV-1-infected Kenyan children
    Rana Chakraborty
    Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
    J Immunol 174:8191-9. 2005
    ..As HIV-1-specific helper cells support anti-HIV-1 effector responses in active disease, their presence may be important in delaying disease progression...
  21. doi request reprint CD8+ T cell efficacy in vaccination and disease
    Victor Appay
    Cellular Immunology Laboratory, Institut Nationale de la Santé et de la Recherche Médicale U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 06, 91 Boulevard de l Hopital, 75013 Paris, France
    Nat Med 14:623-8. 2008
    ..This new knowledge paves the way to the design of more effective T cell vaccines and highlights the importance of comprehensive immunomonitoring...
  22. ncbi request reprint Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Immunol 36:1805-14. 2006
    ..Importantly, these cells are tumor-reactive...
  23. ncbi request reprint Combination of transient lymphodepletion with busulfan and fludarabine and peptide vaccination in a phase I clinical trial for patients with advanced melanoma
    Victor Appay
    Multidisciplinary Oncology Center, University of Lausanne Hospitals CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunother 30:240-50. 2007
    ..Overall, these data provide further ground for the development of immunotherapeutic approaches to be both effective against melanoma and applicable in clinic...
  24. ncbi request reprint Cell permeabilization for the assessment of T lymphocyte polyfunctional capacity
    Laura Papagno
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Immunol Methods 328:182-8. 2007
    ..It is important to be aware of this potential bias and to design specific application/experimental procedures in order to obtain optimal results...