A C Antoniou

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Risk models for familial ovarian and breast cancer
    A C Antoniou
    CRC Genetic Epidemiology Unit, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 18:173-90. 2000
  2. ncbi request reprint Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study
    A C Antoniou
    CRC Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 21:1-18. 2001
  3. pmc The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes
    S A Gayther
    Department of Oncology, Cancer Research Campaign, Strangeways Research Laboratory, Cambridge, United Kingdom
    Am J Hum Genet 65:1021-9. 1999
  4. pmc The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Br J Cancer 98:1457-66. 2008
  5. pmc Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
    D R Barnes
    Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
    Br J Cancer 108:2610-22. 2013
  6. ncbi request reprint Models of genetic susceptibility to breast cancer
    A C Antoniou
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Oncogene 25:5898-905. 2006
  7. pmc A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes
    A C Antoniou
    CRC Genetic Epidemiology Unit, Institute of Public Health, Strangeways Research Laboratory, Worts Causeway, University of Cambridge, Cambridge CB1 8RN, UK
    Br J Cancer 86:76-83. 2002
  8. doi request reprint Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers
    D R Barnes
    Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
    J Intern Med 271:331-43. 2012
  9. doi request reprint Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    J Med Genet 45:425-31. 2008
  10. pmc The BOADICEA model of genetic susceptibility to breast and ovarian cancer
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Strangeways Research Laboratory, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    Br J Cancer 91:1580-90. 2004

Detail Information

Publications11

  1. ncbi request reprint Risk models for familial ovarian and breast cancer
    A C Antoniou
    CRC Genetic Epidemiology Unit, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 18:173-90. 2000
    ..The high penetrance estimate for ovarian cancer, compared with other studies, suggests that modifying genetic or environmental factors may be important determinants of risk...
  2. ncbi request reprint Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study
    A C Antoniou
    CRC Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 21:1-18. 2001
    ....
  3. pmc The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes
    S A Gayther
    Department of Oncology, Cancer Research Campaign, Strangeways Research Laboratory, Cambridge, United Kingdom
    Am J Hum Genet 65:1021-9. 1999
    ..We discuss the implications for genetic testing and clinical management of familial ovarian cancer arising from the data presented in these studies...
  4. pmc The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Br J Cancer 98:1457-66. 2008
    ..BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html)...
  5. pmc Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
    D R Barnes
    Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
    Br J Cancer 108:2610-22. 2013
    ..84-1.06), P=0.33). No other SNP exhibited POE.Conclusion:Our pedigree-based methods provide a valuable and efficient tool for characterising genetic associations with BC risk or other diseases and can complement population-based studies. ..
  6. ncbi request reprint Models of genetic susceptibility to breast cancer
    A C Antoniou
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Oncogene 25:5898-905. 2006
    ..Such a model of susceptibility has implications for both risk prediction and for future gene identification studies...
  7. pmc A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes
    A C Antoniou
    CRC Genetic Epidemiology Unit, Institute of Public Health, Strangeways Research Laboratory, Worts Causeway, University of Cambridge, Cambridge CB1 8RN, UK
    Br J Cancer 86:76-83. 2002
    ..The modifying effect may explain the previously reported differences between population based estimates for BRCA1/2 penetrance and estimates based on high-risk families...
  8. doi request reprint Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers
    D R Barnes
    Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
    J Intern Med 271:331-43. 2012
    ..However, to be able to provide more individualized risk estimates, it will be important to understand how the associations vary with different tumour characteristics and their interactions with other genetic and environmental modifiers...
  9. doi request reprint Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    J Med Genet 45:425-31. 2008
    ..Several algorithms that predict the likelihood of carrying a BRCA1 or a BRCA2 mutation are currently used in clinical practice to identify such individuals...
  10. pmc The BOADICEA model of genetic susceptibility to breast and ovarian cancer
    A C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Strangeways Research Laboratory, Department of Public Health and Primary Care, Worts Causeway, Cambridge CB1 8RN, UK
    Br J Cancer 91:1580-90. 2004
    ..We conclude that this model provides a rational basis for risk assessment in individuals with a FH of breast or ovarian cancer...
  11. pmc Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
    A C Antoniou
    J Med Genet 42:602-3. 2005
    ..These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population...