Charalambos Antoniades


Affiliation: University of Oxford
Country: UK


  1. Oikonomou E, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nat Rev Cardiol. 2018;: pubmed publisher
  2. Oikonomou E, Marwan M, Desai M, Mâncio J, Alashi A, Hutt Centeno E, et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet. 2018;392:929-939 pubmed publisher
    ..British Heart Foundation, and the National Institute of Health Research Oxford Biomedical Research Centre. ..
  3. request reprint
    Antoniades C, Antonopoulos A, Tousoulis D, Bakogiannis C, Stefanadi E, Stefanadis C. Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system. Curr Drug Metab. 2009;10:95-103 pubmed
    ..In this review article we provide a pharmacokinetic approach for the use of levosimendan in cardiovascular system by discussing its metabolism and mainly the pharmacology of its active metabolites in humans. ..
  4. Antonopoulos A, Antoniades C. Mechanisms of testosterone deficiency-related endothelial dysfunction: Invited commentary for the Hellenic Journal of Cardiology on: Tsikas et al. "Associations between asymmetric dimethylarginine, nitrite-dependent renal carbonic anhydrase activity . Hellenic J Cardiol. 2018;: pubmed publisher
    ..Further research in the field is expected to clarify whether changes in ADMA metabolism constitute the central mechanism through which a low testosterone level leads to endothelial dysfunction. ..
  5. Antoniades C, Demosthenous M, Reilly S, Margaritis M, Zhang M, Antonopoulos A, et al. Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. J Am Coll Cardiol. 2012;59:60-70 pubmed publisher
    ..Effects of Atorvastatin on Endothelial Function, Vascular and Myocardial Redox State in High Cardiovascular Risk Patients; NCT01013103). ..
  6. Antonopoulos A, Margaritis M, Coutinho P, Digby J, Patel R, Psarros C, et al. Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol. 2014;34:2151-9 pubmed publisher
    ..Any interpretation of circulating adiponectin as a biomarker should take into account the underlying disease state, background inflammation, and BNP levels. ..
  7. Antonopoulos A, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, et al. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes. 2015;64:2207-19 pubmed publisher
    ..This PVAT-vessel interaction is identified as a novel therapeutic target for the prevention of vascular complications of type 2 diabetes. ..
  8. Antonopoulos A, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, et al. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling. Circ Res. 2016;118:842-55 pubmed publisher
    ..Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress. ..
  9. Antoniades C, Bakogiannis C, Tousoulis D, Reilly S, Zhang M, Paschalis A, et al. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation. 2010;122:S66-73 pubmed publisher
    ..These novel findings suggest that statin therapy should be maintained or initiated in patients undergoing CABG, independently of LDL levels. Clinical Trial Registration-URL: Unique identifier: NCT01013103. ..

More Information


  1. Antoniades C, Mussa S, Shirodaria C, Lee J, Diesch J, Taggart D, et al. Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting. Am J Cardiol. 2009;103:216-20 pubmed publisher
    ..These differences are present and can be identified preoperatively by FMD...
  2. Akoumianakis I, Antoniades C. Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease. Vascul Pharmacol. 2017;96-98:1-4 pubmed publisher
    ..However, the exact pleiotropic mechanisms that underlie the cardiovascular effects of DPP-IV inhibition need to be clarified, while the in vivo benefit of DPP-IV inhibition in humans remains unclear. ..
  3. Antonopoulos A, Sanna F, Sabharwal N, Thomas S, Oikonomou E, Herdman L, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017;9: pubmed publisher
    ..This methodology can be implemented in clinical practice to noninvasively detect plaque instability in the human coronary vasculature. ..
  4. Akoumianakis I, Antoniades C. Impaired Vascular Redox Signalling in the Vascular Complications of Obesity and Diabetes Mellitus. Antioxid Redox Signal. 2017;: pubmed publisher
    ..Recent evidence has revealed that vascular redox state is dysregulated in cases of obesity, systemic insulin resistance and diabetes mellitus, potentially participating to the well-known vascular complications of these disease entities...