Gianni D Angelini

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK
    J Cardiothorac Surg 9:137. 2014
  2. pmc Unexpected limited chronic dissection of the ascending aorta
    Andrea Venturini
    Department of Cardiac Surgery, Ospedale dell Angelo, Via Paccagnella 11, 30174 Venezia Mestre, Italy
    J Cardiothorac Surg 3:49. 2008
  3. pmc Insights into the pathogenesis of vein graft disease: lessons from intravascular ultrasound
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UK
    Cardiovasc Ultrasound 2:8. 2004
  4. ncbi request reprint Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Lancet 359:1194-9. 2002
  5. ncbi request reprint Towards the treatment of saphenous vein bypass graft failure--a perspective of the Bristol Heart Institute
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Biorheology 39:491-9. 2002
  6. ncbi request reprint Early and midterm clinical outcome in patients with severe left ventricular dysfunction undergoing coronary artery surgery
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 76:793-9. 2003
  7. ncbi request reprint Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath
    Vikram Vijayan
    Vascular Unit, The Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Vasc Surg 40:1011-9. 2004
  8. ncbi request reprint Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation and superoxide formation in the aorta of the rabbit
    Nilima Shukla
    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Eur J Pharmacol 531:201-8. 2006
  9. pmc Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells
    Saima Muzaffar
    Department of Cardiac Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, UK
    Br J Pharmacol 146:109-17. 2005
  10. doi request reprint Hemodynamic evaluation and midterm outcome of aortic valve replacement with size 19 Perimount prosthetic valve
    Pradeep Narayan
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 86:1799-803. 2008

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Preoperative anemia increases mortality and postoperative morbidity after cardiac surgery
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK
    J Cardiothorac Surg 9:137. 2014
    ..However, the effect of preoperative anemia is not well defined in heart surgery. This study evaluates the effect of preoperative anemia on early clinical outcomes in patients undergoing cardiac surgery...
  2. pmc Unexpected limited chronic dissection of the ascending aorta
    Andrea Venturini
    Department of Cardiac Surgery, Ospedale dell Angelo, Via Paccagnella 11, 30174 Venezia Mestre, Italy
    J Cardiothorac Surg 3:49. 2008
    ..The rarety of the report is that the chronic dissection is limited to a small area (approximatively 3.5 x 2.5 cm) of the ascending aorta)...
  3. pmc Insights into the pathogenesis of vein graft disease: lessons from intravascular ultrasound
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UK
    Cardiovasc Ultrasound 2:8. 2004
    ..IVUS is also the natural tool for evaluating the effectiveness of pharmacological and other treatments that may prevent or slow the progression of vein graft disease in clinical trials...
  4. ncbi request reprint Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Lancet 359:1194-9. 2002
    ..We did two randomised trials to compare the short-term morbidity associated with off-pump and on-pump myocardial revascularisation. Our aim was to pool the results to assess midterm outcomes...
  5. ncbi request reprint Towards the treatment of saphenous vein bypass graft failure--a perspective of the Bristol Heart Institute
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Biorheology 39:491-9. 2002
    ..The objective of this article, therefore, is to review these recent approaches and their potential clinical applications in the treatment of vein graft disease...
  6. ncbi request reprint Early and midterm clinical outcome in patients with severe left ventricular dysfunction undergoing coronary artery surgery
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 76:793-9. 2003
    ..The present study investigated early and midterm outcomes in a consecutive series of patients with severe LV dysfunction undergoing coronary surgery at our institution...
  7. ncbi request reprint Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath
    Vikram Vijayan
    Vascular Unit, The Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Vasc Surg 40:1011-9. 2004
    ....
  8. ncbi request reprint Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation and superoxide formation in the aorta of the rabbit
    Nilima Shukla
    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Eur J Pharmacol 531:201-8. 2006
    ..Since these effects were reversed by penicillamine, these data consolidate the hypothesis that copper plays a role in mediating homocysteine-induced vasculopathy...
  9. pmc Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells
    Saima Muzaffar
    Department of Cardiac Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, UK
    Br J Pharmacol 146:109-17. 2005
    ....
  10. doi request reprint Hemodynamic evaluation and midterm outcome of aortic valve replacement with size 19 Perimount prosthetic valve
    Pradeep Narayan
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 86:1799-803. 2008
    ....
  11. doi request reprint Phosphodiesterase-5 inhibition prevents postcardiopulmonary bypass acute kidney injury in swine
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 92:2168-76. 2011
    ..The aim of this study was to determine whether administration of the phosphodiesterase-5 inhibitor sildenafil citrate (SDF) would prevent the development of post-cardiopulmonary bypass (CPB) acute kidney injury in swine...
  12. ncbi request reprint Coronary collateral circulation: effect on early and midterm outcomes after off-pump coronary artery bypass surgery
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 85:71-9. 2008
    ..The purpose of this study was to assess the prognostic effect of coronary collaterals on early and midterm clinical outcomes in patients undergoing first time isolated off-pump coronary artery bypass (OPCAB) surgery...
  13. ncbi request reprint Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits
    Nilima Shukla
    Bristol Heart Institute, Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Pharmacol 517:224-31. 2005
    ..It also indicates that NO donating sildenafil may be therapeutically more beneficial than conventional sildenafil in treating erectile dysfunction with an oxidative stress-related aetiology...
  14. ncbi request reprint Basal metabolic state of hearts of patients with congenital heart disease: the effects of cyanosis, age, and pathology
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 78:1710-6. 2004
    ..We conducted this study to specifically look at the effects of cyanosis, age, and pathology upon the basal metabolic state of the immature human heart...
  15. doi request reprint Occult renal dysfunction: a mortality and morbidity risk factor in coronary artery bypass grafting surgery
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 141:771-6. 2011
    ..The aim of this study was to analyze the effects of occult renal dysfunction on early outcomes after coronary artery bypass grafting...
  16. pmc Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats
    Nilima Shukla
    Department of Urology, University of Bristol, UK
    BJU Int 103:1522-9. 2009
    ..CONCLUSIONS By virtue of a dual action on PKA and PKG activation, ACS6 not only promotes erection, acutely, but might also have a long-term beneficial effect through inhibition of oxidative stress and downregulation of PDE5...
  17. pmc Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, UK
    Am J Physiol Renal Physiol 301:F605-14. 2011
    ..Our study underlines the need for translational research into indications for transfusion and prevention strategies for acute kidney injury...
  18. doi request reprint Combined clopidogrel and aspirin treatment up to surgery increases the risk of postoperative myocardial infarction, blood loss and reoperation for bleeding in patients undergoing coronary artery bypass grafting
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Eur J Cardiothorac Surg 43:722-8. 2013
    ..The aim of our study was to evaluate the relationship between the timing of discontinuing clopidogrel + ASA and early clinical outcomes in patients undergoing CABG...
  19. doi request reprint On-pump coronary surgery with and without cardioplegic arrest: comparison of inflammation, myocardial, cerebral and renal injury and early and late health outcome in a single-centre randomised controlled trial
    Pradeep Narayan
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Eur J Cardiothorac Surg 39:675-83. 2011
    ..To assess the safety and efficacy of on-pump beating heart coronary surgery on organ function, and early and late health outcome as compared with conventional technique...
  20. doi request reprint Periadventitial rapamycin-eluting microbeads promote vein graft disease in long-term pig vein-into-artery interposition grafts
    Thirumaran Rajathurai
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circ Cardiovasc Interv 3:157-65. 2010
    ..We investigated the short- and long-term effects of periadventitial application of a sustained-release formulation of rapamycin on experimental pig vein grafts with similar dimensions and kinetics to human saphenous vein bypass grafts...
  21. ncbi request reprint Randomized comparison between normothermic and hypothermic cardiopulmonary bypass in pediatric open-heart surgery
    Massimo Caputo
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 80:982-8. 2005
    ..The purpose of this study is to investigate the effect of cardiopulmonary bypass (CPB) temperature on myocardial reperfusion injury, oxidative stress, and inflammatory response in pediatric open heart surgery...
  22. ncbi request reprint Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells
    Saima Muzaffar
    Bristol Heart Institute, University of Bristol, Bristol, UK
    J Vasc Res 45:521-8. 2008
    ....
  23. doi request reprint Training residents in off-pump coronary artery bypass surgery: a 14-year experience
    Michele Murzi
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 143:1247-53. 2012
    ..To evaluate evolution of training, outcomes were analyzed according to 3 different periods (1996-1999, 2000-2004, 2005-2009) and trainee seniority level...
  24. ncbi request reprint Free amino acids in hearts of pediatric patients with congenital heart disease: the effects of cyanosis, age, and pathology
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 81:943-9. 2006
    ..However, we have found no clinical studies that have looked at the free AA profile of the immature human heart or the effects of cyanosis, age, and pathology upon this...
  25. pmc The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: a randomized controlled trial
    Massimo Caputo
    Bristol Heart Institute, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 138:206-14. 2009
    ..This study investigates the effects of controlled reoxygenation cardiopulmonary bypass on oxidative stress, inflammatory response, and organ function in children undergoing repair of cyanotic congenital heart defects...
  26. pmc Transcriptomic analysis of patients with tetralogy of Fallot reveals the effect of chronic hypoxia on myocardial gene expression
    Mohamed T Ghorbel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 140:337-345.e26. 2010
    ..We sought to find an explanation to such a hypothesis by investigating the cardiac gene expression in patients with tetralogy of Fallot undergoing cardiac surgery...
  27. ncbi request reprint Prospective randomized comparison of CarboMedics and St. Jude Medical bileaflet mechanical heart valve prostheses: ten-year follow-up
    Alan J Bryan
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 133:614-22. 2007
    ..Austin, Tex) and St. Jude Medical (St. Jude Medical Inc, St Paul, Minn) bileaflet mechanical heart valve prostheses 10 years after surgery...
  28. pmc Retrograde hot-shot cardioplegia in patients with left ventricular hypertrophy undergoing aortic valve replacement
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 85:454-8. 2008
    ..The efficacy of this cardioplegic technique in patients with left ventricular hypertrophy secondary to aortic stenosis remains uncertain...
  29. ncbi request reprint Superoxide auto-augments superoxide formation and upregulates gp91(phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost
    Saima Muzaffar
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Eur J Pharmacol 538:108-14. 2006
    ..This constitutes a novel mechanism by which vascular superoxide creates a self-perpetuating cascade that may be of importance to the etiology of ARDS and other vasculopathies...
  30. doi request reprint On-pump and off-pump coronary artery bypass grafting in patients with left main stem disease: a propensity score analysis
    Michele Murzi
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 143:1382-8. 2012
    ..This study compared safety and efficacy between off-pump coronary artery bypass grafting (OPCAB), a relatively new technique, and conventional on-pump coronary artery bypass grafting (CCAB) in patients with left main stem disease...
  31. pmc Off-pump coronary artery bypass surgery is associated with fewer gene expression changes in the human myocardium in comparison with on-pump surgery
    Mohamed T Ghorbel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Physiol Genomics 42:67-75. 2010
    ..In conclusion, off-pump surgery is associated with fewer alterations in gene expression connected with inflammation, apoptosis, and remodeling seen after on-pump surgery with CPB and ischemic-CA...
  32. doi request reprint The administration of folic acid improves erectile function and reduces intracavernosal oxidative stress in the diabetic rabbit
    Nilima Shukla
    Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol, UK
    BJU Int 103:98-103. 2009
    ..To test the possibility that folic acid (FA) may be a means of treating erectile dysfunction (ED) in diabetes mellitus (DM), by studying the effect of FA administration to DM rabbits on cavernosal function and intrapenile oxidative stress...
  33. ncbi request reprint Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery
    Attilio A Lotto
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 76:1227-33; discussion 1233. 2003
    ..This study compared the cardioprotective efficacy of intermittent antegrade and retrograde cold blood cardioplegia with emphasis on metabolic stress in the left and right ventricles...
  34. ncbi request reprint Hybrid coronary revascularization in the era of drug-eluting stents
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 78:1861-7. 2004
    ....
  35. ncbi request reprint Ascending aorta or arch surgery: is previous cardiac surgery a risk factor?
    Pradeep Narayan
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Asian Cardiovasc Thorac Ann 14:14-9. 2006
    ..Outcomes in emergency cases carry a higher early mortality but still conform to contemporary expectations and are similar to emergency first-time aortic surgery...
  36. ncbi request reprint Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UK
    Cardiovasc Res 73:607-17. 2007
    ..We investigated short- and long-term effects of anti-proliferative pharmacological agents on experimental pig vein-grafts with similar dimensions and kinetics to human coronary grafts...
  37. pmc Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: long-term follow-up of 2 randomized controlled trials
    Gianni D Angelini
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 137:295-303. 2009
    ..Therefore our objective was to compare long-term outcomes in patients randomized to off-pump coronary artery bypass or coronary artery bypass grafting with cardiopulmonary bypass...
  38. ncbi request reprint A randomized trial of an external Dacron sheath for the prevention of vein graft disease: the Extent study
    Gavin J Murphy
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 134:504-5. 2007
  39. doi request reprint Interactions of cardiopulmonary bypass and erythrocyte transfusion in the pathogenesis of pulmonary dysfunction in Swine
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Anesthesiology 119:365-78. 2013
    ..Our objective was to develop a novel swine recovery model to determine how two clinical risk factors, allogenic erythrocyte transfusion and cardiopulmonary bypass, interact in the genesis of postcardiac surgery acute lung injury...
  40. doi request reprint Thoracic epidural anesthesia improves early outcomes in patients undergoing off-pump coronary artery bypass surgery: a prospective, randomized, controlled trial
    Massimo Caputo
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Anesthesiology 114:380-90. 2011
    ..The aim of this two-center, open, randomized, controlled trial was to evaluate the impact of thoracic epidural anesthesia on early clinical outcomes in patients undergoing off-pump coronary artery bypass surgery...
  41. ncbi request reprint Interactive effects of homocysteine and copper on angiogenesis in porcine isolated saphenous vein
    Nilima Shukla
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 84:43-9. 2007
    ..A novel in vitro model of angiogenesis in isolated pig saphenous veins was therefore developed to study the effect of homocysteine and copper and the role of superoxide on tubule growth, an index of angiogenesis...
  42. ncbi request reprint Changes in myocardial free amino acids during pediatric cardiac surgery: a randomised controlled trial of three cardioplegic techniques
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Cardiothorac Surg 30:41-8. 2006
    ..Blood cardioplegia preserves myocardial free AAs in adult hearts but no clinical studies have looked at the effect of different cardioplegic techniques on intracellular free AAs in the pediatric heart...
  43. ncbi request reprint Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK
    Circulation 116:2544-52. 2007
    ..Red blood cell transfusion can both benefit and harm. To inform decisions about transfusion, we aimed to quantify associations of transfusion with clinical outcomes and cost in patients having cardiac surgery...
  44. ncbi request reprint Trainees operating on high-risk patients without cardiopulmonary bypass: a high-risk strategy?
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol Roayl Infirmary, United Kingdom
    Ann Thorac Surg 78:26-33. 2004
    ..This study compared outcomes of off-pump coronary artery bypass grafting operations performed by consultants and trainees in high-risk patients...
  45. pmc A clinical score to predict the need for intraaortic balloon pump in patients undergoing coronary artery bypass grafting
    Antonio Miceli
    The Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 90:522-6. 2010
    ..The aim of this study was to develop a risk model to identify high-risk patients and predict the need for IABP insertion during CABG...
  46. ncbi request reprint Cardiac troponin I in neonates undergoing the arterial switch operation
    Hajime Imura
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 74:1998-2002. 2002
    ..We investigated whether TnI correlates with early clinical outcome in neonates undergoing the arterial switch operation (ASO) for transposition of the great arteries (TGA)...
  47. ncbi request reprint NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells
    Saima Muzaffar
    Bristol Heart Institute, University of Bristol, Bristol, UK
    J Cell Physiol 227:1941-50. 2012
    ..This mechanism may be central to vasculopathies associated with endothelial dysfunction since the PGI(2)-cAMP signaling axis plays a key role in mediating functions that include hemostasis and angiogenesis...
  48. doi request reprint Effect of normothermic cardiopulmonary bypass on renal injury in pediatric cardiac surgery: a randomized controlled trial
    Massimo Caputo
    Bristol Royal Hospital for Children, University of Bristol, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 142:1114-21, 1121.e1-2. 2011
    ..One of the aims of this trial was to compare the effect of normothermic and hypothermic CPB on renal injury in pediatric patients undergoing cardiac surgery...
  49. ncbi request reprint Increased airway mucins after cardiopulmonary bypass associated with postoperative respiratory complications in children
    Hajime Imura
    Bristol Heart Institute, United Kingdom
    J Thorac Cardiovasc Surg 127:963-9. 2004
    ..Our aim was to measure airway mucin levels before and after cardiopulmonary bypass and to determine whether changes in mucin levels were associated with the development of respiratory complications...
  50. ncbi request reprint Coronary surgery in patients with preexisting chronic atrial fibrillation: early and midterm clinical outcome
    Chris A Rogers
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 81:1676-82. 2006
    ..The purpose of this study was to investigate the effect of preexisting atrial fibrillation on early and midterm clinical outcome in patients undergoing coronary surgery...
  51. ncbi request reprint Predictors of new malignant ventricular arrhythmias after coronary surgery: a case-control study
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    J Am Coll Cardiol 43:1630-8. 2004
    ..We sought to investigate the relationship between perioperative factors and the occurrence of ventricular tachycardia (VT) and ventricular fibrillation (VF), as well as the impact of VT/VF on early and late mortality...
  52. ncbi request reprint Effect of cardiopulmonary bypass on cortical cerebral oxygenation during coronary artery bypass grafting
    Sudath P Talpahewa
    Cardiothoracic Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Eur J Cardiothorac Surg 26:676-81. 2004
    ..To investigate the changes in cerebral oxygenation during coronary artery bypass grafting (CABG) with normothermic cardiopulmonary bypass (CPB) using near infrared spectroscopy...
  53. doi request reprint The administration of folic acid reduces intravascular oxidative stress in diabetic rabbits
    Nilima Shukla
    Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol, UK
    Metabolism 57:774-81. 2008
    ....
  54. ncbi request reprint Cerebral cortical oxygenation changes during OPCAB surgery
    Sudath P Talpahewa
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 76:1516-22; discussion 1522. 2003
    ..We investigated the changes occurring in cerebral cortical oxygenation during off-pump coronary artery bypass (OPCAB) surgery using near infrared spectroscopy (NIRS)...
  55. ncbi request reprint Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 81:97-103. 2006
    ..We investigated the efficacy of coronary surgery with or without cardiopulmonary bypass in protecting the function of the small intestine, liver, and pancreas...
  56. ncbi request reprint Propofol is cardioprotective in a clinically relevant model of normothermic blood cardioplegic arrest and cardiopulmonary bypass
    Kelvin H H Lim
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    Exp Biol Med (Maywood) 230:413-20. 2005
    ..Propofol may therefore be a useful adjunct to cardioplegic solutions as well as being an appropriate anesthetic for cardiac surgery...
  57. pmc Warm-blood cardioplegia with low or high magnesium for coronary bypass surgery: a randomised controlled trial
    Massimo Caputo
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UK
    Eur J Cardiothorac Surg 40:722-9. 2011
    ..The aim of this study was to compare the effects of intermittent antegrade warm-blood cardioplegia supplemented with either low- or high-concentration Mg²⁺...
  58. ncbi request reprint Effects of angiotensin-converting enzyme inhibitor therapy on clinical outcome in patients undergoing coronary artery bypass grafting
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    J Am Coll Cardiol 54:1778-84. 2009
    ..This study evaluates the effect of pre-operative angiotensin-converting enzyme inhibitor (ACEI) therapy on early clinical outcomes after coronary artery bypass grafting (CABG)...
  59. ncbi request reprint Radial versus right internal thoracic artery as a second arterial conduit for coronary surgery: early and midterm outcomes
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    J Thorac Cardiovasc Surg 126:39-47. 2003
    ..We sought to compare early and midterm clinical outcomes in patients receiving a right internal thoracic artery or a radial artery as the second arterial conduit for myocardial revascularization...
  60. ncbi request reprint Early and late results of partial left ventriculectomy: single center experience and review of the literature
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol, England, United Kingdom
    J Card Surg 18:190-6. 2003
    ..To evaluate early and late outcome of partial left ventriculectomy (PLV) in a single center and to conduct a review of the literature...
  61. ncbi request reprint Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 74:2088-95; discussion 2095-6. 2002
    ..In this study we investigated the impact of the A-Med RVAD on inflammatory response and organ function in patients undergoing coronary artery bypass grafting...
  62. ncbi request reprint A bioabsorbable (polyglactin), nonrestrictive, external sheath inhibits porcine saphenous vein graft thickening
    Jamie Y Jeremy
    The Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    J Thorac Cardiovasc Surg 127:1766-72. 2004
    ..The effect of external macro-porous biodegradable (polyglactin) sheaths on neointimal and medial thickening in porcine vein grafts was therefore investigated...
  63. doi request reprint Myocardial, inflammatory, and stress responses in off-pump coronary artery bypass graft surgery with thoracic epidural anesthesia
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 87:1119-26. 2009
    ..The aim of this study was to evaluate the impact of thoracic epidural anesthesia on myocardial cell damage, inflammatory, and stress responses in patients undergoing off-pump coronary artery bypass graft (OPCABG) surgery...
  64. doi request reprint Mild renal dysfunction in patients undergoing cardiac surgery as a new risk factor for EuroSCORE
    Antonio Miceli
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Heart 97:362-5. 2011
    ..The aim of the present study was to assess the effect of mild renal dysfunction as a predictor of operative mortality and develop and validate a modified logistic EuroSCORE model...
  65. ncbi request reprint In-hospital patients exposed to clopidogrel before coronary artery bypass graft surgery: a word of caution
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 79:1210-6. 2005
    ....
  66. ncbi request reprint Pathology-related troponin I release and clinical outcome after pediatric open heart surgery
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol, UK
    J Card Surg 18:295-300. 2003
    ..Our aim was to evaluate pathology-related differences in troponin I (TnI) release, a sensitive and specific marker of myocardial injury, and its relation to clinical outcome after pediatric open heart surgery...
  67. ncbi request reprint Intracoronary shunts reduce transient intraoperative myocardial dysfunction during off-pump coronary operations
    Mark Yeatman
    Bristol Heart Institute, University of Bristol, United Kingdom
    Ann Thorac Surg 73:1411-7. 2002
    ..This study investigated the hemodynamic changes in patients undergoing multiple vessel beating heart coronary revascularization in the presence or absence of an intracoronary shunt...
  68. ncbi request reprint On the biology of saphenous vein grafts fitted with external synthetic sheaths and stents
    Jamie Y Jeremy
    Bristol Heart Institute, University of Bristol, UK
    Biomaterials 28:895-908. 2007
    ....
  69. ncbi request reprint Is the therapeutic action of sildenafil mediated partly through the inhibition of superoxide formation?
    Jamie Y Jeremy
    Bristol Heart Institute and Department of Urology, Bristol Royal Infirmary, UK
    BJU Int 95:930-1. 2005
  70. pmc Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase
    Saima Muzaffar
    Department of Cardiac Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol
    Br J Pharmacol 145:688-97. 2005
    ..Since O(2)(*-) promotes inflammation, this mechanism may explain why prednisolone is ineffective in treating ARDS. Therapeutically, the coadministration of an NO donor may render prednisolone more effective in treating ARDS...
  71. ncbi request reprint Control chart methods for monitoring cardiac surgical performance and their interpretation
    Chris A Rogers
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Thorac Cardiovasc Surg 128:811-9. 2004
  72. ncbi request reprint Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression
    Nilima Shukla
    Bristol Heart Institute, Department of Cardiac Surgery, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Pharmacol 509:21-30. 2005
    ....
  73. ncbi request reprint Reactive oxygen species, vascular disease and cardiovascular surgery
    Jamie Y Jeremy
    Bristol Heart Institute, The University of Bristol, UK
    Curr Vasc Pharmacol 2:229-36. 2004
    ..The interactions of risk factors and how this pathophysiology relates to the design of effective novel strategies to treat CVD is also considered. Particular emphasis is also placed on OS and cardiovascular surgery...
  74. ncbi request reprint Monitoring the performance of residents during training in off-pump coronary surgery
    Massimo Caputo
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Thorac Cardiovasc Surg 128:907-15. 2004
    ....
  75. ncbi request reprint Beating heart against cardioplegic arrest studies (BHACAS 1 and 2): quality of life at mid-term follow-up in two randomised controlled trials
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur Heart J 25:765-70. 2004
    ..We aimed to compare generic and disease specific quality of life (QoL) two to four years after surgery in participants in two randomised controlled trials of OPCAB vs. CABG-CPB...
  76. ncbi request reprint Effectiveness of coronary artery bypass grafting with or without cardiopulmonary bypass in overweight patients
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Circulation 106:1764-70. 2002
    ..Our goal was to investigate the effectiveness of on-pump and off-pump coronary artery bypass surgery on early clinical outcome in a consecutive series of overweight patients...
  77. ncbi request reprint An external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs
    Gianni D Angelini
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 124:950-6. 2002
    ..Supporting grafts externally with an oversized, highly porous polyester stent dramatically reduces neointima formation in normocholesterolemic pigs. However, its effects in the presence of hypercholesterolemia are unknown...
  78. ncbi request reprint Is obesity still a risk factor for patients undergoing coronary surgery?
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, England
    Ital Heart J 4:824-8. 2003
    ....
  79. ncbi request reprint Oxidative stress, nitric oxide, and vascular disease
    Jamie Y Jeremy
    Bristol Heart Institute, The University of Bristol, United Kingdom
    J Card Surg 17:324-7. 2002
    ..Antioxidant therapies, including the gene transfer of antioxidant enzymes, are potentially valuable in the treatment of CVD...
  80. ncbi request reprint Comparison of exercise and dobutamine echocardiography in the haemodynamic assessment of small size mechanical aortic valve prostheses
    Isaac Kadir
    Bristol Heart Institute and Department of Clinical Radiology, University of Bristol, Bristol, UK
    Eur J Cardiothorac Surg 21:692-7. 2002
    ..This study was carried out to compare dobutamine echocardiography with a symptom limited treadmill exercise echocardiography in patients following aortic valve replacement with a small size (19 mm) St. Jude Mechanical valve prosthesis...
  81. ncbi request reprint Magnesium-supplemented warm blood cardioplegia in patients undergoing coronary artery revascularization
    Mark Yeatman
    Bristol Heart Institute, University of Bristol, United Kingdom
    Ann Thorac Surg 73:112-8. 2002
    ..The aim of this study was to compare the effects of intermittent warm blood cardioplegia with and without Mg2+ supplementation on the early postoperative clinical outcomes in patients undergoing both elective or urgent CABG...
  82. ncbi request reprint Prospective randomized comparison of CarboMedics and St Jude Medical bileaflet mechanical heart valve prostheses: an interim report
    Kelvin H H Lim
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 123:21-32. 2002
    ..This is a midterm report of a study comparing the clinical performance of CarboMedics and St Jude Medical heart valve prostheses through a projected 10-year period...
  83. ncbi request reprint An initial evaluation of post-cardiopulmonary bypass acute kidney injury in swine
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Cardiothorac Surg 36:849-55. 2009
    ..This pilot study aims to characterise post-cardiopulmonary bypass (CPB) AKI in an animal model with potentially greater homology to cardiac surgery patients...
  84. ncbi request reprint Indications for blood transfusion in cardiac surgery
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 82:2323-34. 2006
    ..Future randomized studies must prospectively evaluate regional indicators of tissue oxygenation in transfusion algorithms...
  85. ncbi request reprint The pathobiology of endothelin-1 in vein graft disease: are ETA receptor antagonists the solution to prevent vein graft failure?
    Jamie Y Jeremy
    Bristol Heart Institute, University of Bristol, UK
    Curr Vasc Pharmacol 3:315-23. 2005
    ....
  86. ncbi request reprint Cold blood versus cold crystalloid cardioplegia for repair of ventricular septal defects in pediatric heart surgery: a randomized controlled trial
    Massimo Caputo
    Bristol Heart Institute, University of Bristol, United Kingdom
    Ann Thorac Surg 74:530-4; discussion 535. 2002
    ..This study investigates the effects of cold crystalloid versus cold blood cardioplegia on myocardial metabolism, reperfusion injury, and clinical outcomes in patients undergoing ventricular septal defect (VSD) repair...
  87. ncbi request reprint The evolution of training in off-pump coronary surgery in a single institution
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    Ann Thorac Surg 74:S1403-7. 2002
    ....
  88. ncbi request reprint Morbidity and mortality following acute conversion from off-pump to on-pump coronary surgery
    Barnaby C Reeves
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Cardiothorac Surg 29:941-7. 2006
    ..However, OPCAB is sometimes converted acutely to CABG-CPB. We describe the risk of acute conversion and compare patients' outcomes for acutely converted OPCAB with unconverted OPCAB and CABG-CPB...
  89. ncbi request reprint Sustained increases of plasma homocysteine, copper, and serum ceruloplasmin after coronary artery bypass grafting
    Jamie Y Jeremy
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    Ann Thorac Surg 74:1553-7. 2002
    ..The aim of this study was to assess the perioperative levels of Hcy, copper, ceruloplasmin (CP), folate, and vitamin B12 in patients undergoing myocardial revascularization surgery...
  90. ncbi request reprint Predictors of stroke in the modern era of coronary artery bypass grafting: a case control study
    Raimondo Ascione
    Bristol Heart Institute, Bristol Royal Infirmary, United Kingdom
    Ann Thorac Surg 74:474-80. 2002
    ..We used a case control design to investigate the extent to which preoperative and perioperative factors were associated with occurrence of stroke in a cohort of consecutive patients undergoing myocardial revascularization...
  91. ncbi request reprint Retinal and cerebral microembolization during coronary artery bypass surgery: a randomized, controlled trial
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol, England
    Circulation 112:3833-8. 2005
    ....
  92. ncbi request reprint Coronary artery bypass grafting on the beating heart: surgical revascularization for the next decade?
    Gavin J Murphy
    Department of Cardiac Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Eur Heart J 25:2077-85. 2004
    ..Whether it will ultimately replace conventional CABG, however, is dependent on the results of long-term patency studies and the wider development of adequate training programmes...
  93. ncbi request reprint A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting
    Gavin J Murphy
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 132:475-80, 480.e1-8. 2006
    ..We sought to evaluate the effectiveness of tranexamic acid in off-pump coronary artery bypass grafting surgery, either when used in combination with mechanical cell salvage or when used alone...
  94. ncbi request reprint Subsystem organ function during coronary surgery
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, UK
    Perfusion 17:295-303. 2002
    ..The review of observational reports, case-matched studies and prospective randomized trials seems to suggest that OPCAB surgery reduces postoperative subsystem organ dysfunction when compared with conventional coronary revascularisation...
  95. ncbi request reprint The endothelin 1A receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein-carotid artery interposition grafts
    Song Wan
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Thorac Cardiovasc Surg 127:1317-22. 2004
    ....
  96. ncbi request reprint Possible mechanisms underlying the effects of inhaled nitric oxide
    Nilima Shukla
    Anesthesiology 107:677-8. 2007
  97. ncbi request reprint Nitric oxide-donating aspirin (NCX 4016) inhibits neointimal thickening in a pig model of saphenous vein-carotid artery interposition grafting: a comparison with aspirin and morpholinosydnonimine (SIN-1)
    Song Wan
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    J Thorac Cardiovasc Surg 134:1033-9. 2007
    ..It was suggested, therefore, that co-administration of nitric oxide with aspirin may compensate for these limitations. A drug class that fulfills this pharmacologic criterion is nitric oxide-donating aspirin (NCX 4016)...
  98. ncbi request reprint Nitric oxide donating aspirins: novel drugs for the treatment of saphenous vein graft failure
    Nilima Shukla
    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol, United Kingdom
    Ann Thorac Surg 75:1437-42. 2003
    ....
  99. ncbi request reprint Effect of body mass index on early outcomes in patients undergoing coronary artery bypass surgery
    Barnaby C Reeves
    Health Services Research Unit, London School of Hygiene and Tropical Medicine, London, England, United Kingdom
    J Am Coll Cardiol 42:668-76. 2003
    ..This study sought to quantify the effect of body mass index (BMI) on early clinical outcomes following coronary artery bypass grafting (CABG)...
  100. ncbi request reprint Orally administered penicillamine is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein-carotid artery interposition grafts
    Song Wan
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    J Thorac Cardiovasc Surg 133:494-500. 2007
    ..This project therefore examined the effect of the copper chelator penicillamine on saphenous vein graft thickening in a pig model...