R Andrew Moore

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Systematic review of topical capsaicin for the treatment of chronic pain
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ
    BMJ 328:991. 2004
  2. pmc Topical NSAIDs for acute pain: a meta-analysis
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Fam Pract 5:10. 2004
  3. doi request reprint A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine
    R A Moore
    Pain Research and Nuffield Division of Anaesthetics, University of Oxford, Oxford, OX3 7LJ, UK
    Eur J Pain 16:585-91. 2012
  4. pmc Do placebo response rates from cessation trials inform on strength of addictions?
    Robert A Moore
    Nuffield Division of Anaesthetics, University of Oxford, The Churchill, Oxford OX1 2JD, UK
    Int J Environ Res Public Health 9:192-211. 2012
  5. pmc Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials
    Jayne E Edwards
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, UK
    BMC Urol 2:14. 2002
  6. pmc Atypical antipsychotics in bipolar disorder: systematic review of randomised trials
    Sheena Derry
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Psychiatry 7:40. 2007
  7. pmc Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials
    Asquad Sultan
    Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Neurol 8:29. 2008
  8. pmc Longitudinal numbers-needed-to-treat (NNT) for achieving various levels of analgesic response and improvement with etoricoxib, naproxen, and placebo in ankylosing spondylitis
    Paul M Peloso
    Clinical Research, Merck Sharp and Dohme Corp, Whitehouse Station, NJ 08889, USA
    BMC Musculoskelet Disord 12:165. 2011
  9. pmc Pregabalin in fibromyalgia--responder analysis from individual patient data
    Sebastian Straube
    Department of Occupational and Social Medicine, University of Gottingen, Waldweg 37 B, D 37073 Gottingen, Germany
    BMC Musculoskelet Disord 11:150. 2010
  10. pmc Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Musculoskelet Disord 5:28. 2004

Detail Information

Publications87

  1. pmc Systematic review of topical capsaicin for the treatment of chronic pain
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ
    BMJ 328:991. 2004
    ..To determine the efficacy and safety of topically applied capsaicin for chronic pain from neuropathic or musculoskeletal disorders...
  2. pmc Topical NSAIDs for acute pain: a meta-analysis
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Fam Pract 5:10. 2004
    ..More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review...
  3. doi request reprint A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine
    R A Moore
    Pain Research and Nuffield Division of Anaesthetics, University of Oxford, Oxford, OX3 7LJ, UK
    Eur J Pain 16:585-91. 2012
    ..There was no evidence of synergy, defined as supra-additive effects...
  4. pmc Do placebo response rates from cessation trials inform on strength of addictions?
    Robert A Moore
    Nuffield Division of Anaesthetics, University of Oxford, The Churchill, Oxford OX1 2JD, UK
    Int J Environ Res Public Health 9:192-211. 2012
    ..Tobacco is also a severe addiction, with a number of major deleterious health effects in a large number of people...
  5. pmc Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials
    Jayne E Edwards
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, UK
    BMC Urol 2:14. 2002
    ..Benign prostatic hyperplasia affects older men. This systematic review determined efficacy and adverse effects of finasteride...
  6. pmc Atypical antipsychotics in bipolar disorder: systematic review of randomised trials
    Sheena Derry
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Psychiatry 7:40. 2007
    ..Atypical antipsychotics are increasingly used for treatment of mental illnesses like schizophrenia and bipolar disorder, and considered to have fewer extrapyramidal effects than older antipsychotics...
  7. pmc Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials
    Asquad Sultan
    Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Neurol 8:29. 2008
    ..We investigated the efficacy of duloxetine in painful diabetic neuropathy and fibromyalgia to allow comparison with other antidepressants...
  8. pmc Longitudinal numbers-needed-to-treat (NNT) for achieving various levels of analgesic response and improvement with etoricoxib, naproxen, and placebo in ankylosing spondylitis
    Paul M Peloso
    Clinical Research, Merck Sharp and Dohme Corp, Whitehouse Station, NJ 08889, USA
    BMC Musculoskelet Disord 12:165. 2011
    ..We evaluated levels of analgesic response and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score improvement and the associated NNTs...
  9. pmc Pregabalin in fibromyalgia--responder analysis from individual patient data
    Sebastian Straube
    Department of Occupational and Social Medicine, University of Gottingen, Waldweg 37 B, D 37073 Gottingen, Germany
    BMC Musculoskelet Disord 11:150. 2010
    ..A consensus group has defined what constitutes minimal, moderate, and substantial benefit based on pain intensity and Patient Global Impression of Change scores...
  10. pmc Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Musculoskelet Disord 5:28. 2004
    ..More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review...
  11. pmc Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg
    L A Smith
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    BMC Med Res Methodol 1:1. 2001
    ..This neglects other types of high quality information. This review explores using different information for the combination of paracetamol 1000 mg and codeine 60 mg in acute postoperative pain...
  12. pmc Is there an association between low dose aspirin and anemia (without overt bleeding)? Narrative review
    Helen Gaskell
    Department of Clinical Geratology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    BMC Geriatr 10:71. 2010
    ..Anemia in older people is associated with adverse outcomes including disability, morbidity and mortality. The purpose of this study was to review the evidence that LDA might cause anemia without overt bleeding...
  13. pmc Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use
    Sebastian Straube
    Department of Occupational and Social Medicine, University of Gottingen, Gottingen, Germany
    BMC Gastroenterol 9:41. 2009
    ..Better treatment is likely to have reduced mortality. An estimate of mortality is helpful in explaining to patients the risks of therapy, especially with NSAIDs...
  14. pmc Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials
    Jayne E Edwards
    Pain Research Unit and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Fam Pract 4:18. 2003
    ..Statins alter lipid concentrations. This systematic review determined the efficacy of particular statins, in terms of their ability to alter cholesterol...
  15. pmc Systematic review of the use of honey as a wound dressing
    O A Moore
    Pain Research Unit and Nuffield Department of Anaesthetics, University of Oxford, Oxford, Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    BMC Complement Altern Med 1:2. 2001
    ..To investigate topical honey in superficial burns and wounds though a systematic review of randomised controlled trials...
  16. doi request reprint Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Pain 149:360-4. 2010
    ..Pain intensity reduction is a simple and effective predictor of which patients should continue treatment, and which should discontinue and try an alternative therapy...
  17. pmc What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe NHS Trust, The Churchill, Headington, Oxford OX3 7LJ, UK
    Arthritis Res Ther 10:R20. 2008
    ....
  18. ncbi request reprint Acupuncture: not just needles?
    Andrew Moore
    Pain Research, The Churchill, Oxford OX3 7LJ, UK
    Lancet 366:100-1. 2005
  19. pmc Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, UK
    Ann Rheum Dis 69:374-9. 2010
    ..Population mean changes from clinical trials are difficult to apply to individuals in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration...
  20. pmc Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe NHS Trust, Oxford, UK
    Arthritis Res Ther 7:R644-65. 2005
    ..Adverse event information is clearly presented in company clinical trial reports, which are an ideal source of information for systematic review and meta-analysis...
  21. ncbi request reprint Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe NHS Trust, The Churchill, Headington, Oxford OX3 7LJ, UK
    Pain 116:322-31. 2005
    ....
  22. pmc Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes
    R Andrew Moore
    Pain Research, Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, OX3 7LJ, UK
    Arthritis Res Ther 10:R7. 2008
    ....
  23. pmc Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, UK
    BMC Musculoskelet Disord 8:73. 2007
    ..We calculated the absolute risk for each effect...
  24. pmc Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK
    Arthritis Res Ther 10:R39. 2008
    ..We investigated whether dichotomous responder analysis provides a more informative interpretation of drug efficacy...
  25. pmc Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford OX3 7LJ, UK
    Arthritis Res Ther 8:R182. 2006
    ..2%. The results form a basis on which to plan future studies and provide a guide for the use of MMF in lupus nephritis until results of larger studies are available. At least one such study is under way...
  26. pmc Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Oxford OX3 7LJ, UK
    Arthritis Res Ther 10:R53. 2008
    ..By contrast, company clinical trial reports include much more detail...
  27. ncbi request reprint Evidence-based policy-making
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    Clin Chem Lab Med 44:678-82. 2006
    ..These care pathways almost always have the ability to deliver better care for patients, with less fuss for professionals and at lower cost to the community. They may be the single best way of improving healthcare...
  28. pmc Indirect comparison of interventions using published randomised trials: systematic review of PDE-5 inhibitors for erectile dysfunction
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe NHS Trust, The Churchill, Headington, Oxford, OX37LJ, UK
    BMC Urol 5:18. 2005
    ..Valid indirect comparisons with a common comparator must examine equivalent doses, similar duration, similar populations, with the same outcomes reported in the same way...
  29. pmc Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford, UK
    Arthritis Res Ther 7:R1046-51. 2005
    ..Because most trials were short, less than four weeks, and because few titrated the dose, these results have limited applicability to longer-term use of opioids in clinical practice. Suggestions for improved studies are made...
  30. pmc Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Musculoskelet Disord 7:79. 2006
    ....
  31. ncbi request reprint Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: verification from independent data
    A Moore
    Oxford Pain Relief Unit, University of Oxford, Oxford Radcliffe Hospital, Headington, UK
    Pain 69:127-30. 1997
    ..Showing that dichotomous data can reliably be derived from mean data in acute pain studies enables data published as means to be used for quantitative systematic reviews which require data in dichotomous form...
  32. pmc S-carboxymethylcysteine in the treatment of glue ear: quantitative systematic review
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill Headington, Oxford, OX3 7LJ, UK
    BMC Fam Pract 2:3. 2001
    ..To establish the clinical relevance of S-carboxymethylcysteine in the treatment of glue ear in children using measures approximating those saving a child from operation for grommet insertion...
  33. pmc Imiquimod for the treatment of genital warts: a quantitative systematic review
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics University of Oxford, The Churchill, Headington Oxford OX3 7LJ, UK
    BMC Infect Dis 1:3. 2001
    ..To review published randomised controlled trials to assess the benefit and harm of imiquimod in the treatment of external genital warts...
  34. pmc Are the pneumococcal polysaccharide vaccines effective? Meta-analysis of the prospective trials
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, Oxford Radcliffe Hospitals, The Churchill Oxford OX3 7LJ, UK
    BMC Fam Pract 1:1. 2000
    ..Present guidelines recommend pneumococcal vaccination for "high-risk" groups. There is no evidence from randomised trials that this is of any benefit...
  35. pmc Meta-analysis of efficacy and safety of intravenous ferric carboxymaltose (Ferinject) from clinical trial reports and published trial data
    R Andrew Moore
    Pain Research, Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Oxford, OX3 7LJ, UK
    BMC Blood Disord 11:4. 2011
    ..abstract:..
  36. ncbi request reprint Size is everything--large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects
    R A Moore
    Pain Research, Nuffield Department of Anaesthetics, The Churchill, Oxford Radcliffe Hospital, UK
    Pain 78:209-16. 1998
    ..Credible estimates of clinical efficacy are only likely to come from large trials or from pooling multiple trials of conventional (small) size...
  37. pmc Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs
    R A Moore
    University of Oxford, Oxford Radcliffe Hospital, Headington
    BMJ 316:333-8. 1998
    ..To review the effectiveness and safety of topical non-steroidal anti-inflammatory drugs in acute and chronic pain conditions...
  38. ncbi request reprint Paracetamol with and without codeine in acute pain: a quantitative systematic review
    A Moore
    Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, UK
    Pain 70:193-201. 1997
    ..This was an NNT for adding codeine 60 mg of 9.1 (5.8-24). The results confirm that paracetamol is an effective analgesic, and that codeine 60 mg added to paracetamol produces worthwhile additional pain relief even in single oral doses...
  39. pmc Systematic review of dexketoprofen in acute and chronic pain
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    BMC Clin Pharmacol 8:11. 2008
    ..We used published and unpublished information from randomised clinical trials (RCTs) of dexketoprofen in painful conditions to assess evidence on efficacy and harm...
  40. ncbi request reprint Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: use of pain intensity and visual analogue scales
    A Moore
    Oxford Pain Relief Unit, University of Oxford, UK
    Pain 69:311-5. 1997
    ..Showing that dichotomous data can reliably be derived from mean SPID, VAS-SPID and VAS-TOTPAR as well as TOTPAR data in previously published acute pain studies makes much more information accessible for meta-analysis...
  41. ncbi request reprint Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, UK
    Pain 69:287-94. 1997
    ..Absolute ranking of analgesic performance should be done separately for postsurgical and dental pain...
  42. ncbi request reprint Pain and systematic reviews
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Oxford, UK
    Acta Anaesthesiol Scand 45:1136-9. 2001
    ..Using appropriate tools, like numbers needed to treat (NNT), we can provide a solid basis to allow practitioners and their patients to make the best, and best informed, choices about their care...
  43. doi request reprint Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Churchill Hospital, Oxford, UK
    Pain 152:982-9. 2011
    ..5 and 1.6, respectively) produced the lowest (best) NNTs in the dental pain model. Timing of patient request for additional analgesia is an alternative analgesic efficacy outcome measure...
  44. doi request reprint Numbers-needed-to-treat analyses--do timing, dropouts, and outcome matter? Pooled analysis of two randomized, placebo-controlled chronic low back pain trials
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    Pain 151:592-7. 2010
    ..Outcome, imputation method, and reporting method are intimately connected and need to be considered alongside trial quality and validity to make sensible comparisons between treatments...
  45. pmc Pooling data for number needed to treat: no problems for apples
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, UK
    BMC Med Res Methodol 2:2. 2002
    ....
  46. doi request reprint Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion
    Robert A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Anaesthesiol 28:427-32. 2011
    ..We used a large individual patient dataset to examine the distribution of analgesic consumption, the validity of such analyses and alternative dichotomous outcomes...
  47. pmc Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports
    R A Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, UK
    BMC Urol 2:6. 2002
    ..Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology...
  48. ncbi request reprint Relative efficacy of oral analgesics after third molar extraction
    J Barden
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    Br Dent J 197:407-11; discussion 397. 2004
    ..To compare the relative efficacy of analgesics after third molar extraction from systematic reviews of randomised, double blind studies...
  49. ncbi request reprint Pain and analgesic response after third molar extraction and other postsurgical pain
    Jodie Barden
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    Pain 107:86-90. 2004
    ..Systematic difference in the estimate of analgesic efficacy between dental and postsurgical pain models remains unproven, and, on balance, no major difference is likely...
  50. doi request reprint Acute pain: combination treatments and how we measure their efficacy
    H J McQuay
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford OX3 7LJ, UK
    Br J Anaesth 101:69-76. 2008
    ....
  51. ncbi request reprint Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies
    S Straube
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    Acta Anaesthesiol Scand 49:601-13. 2005
    ..Preoperative use of coxibs has been claimed to reduce postoperative pain and analgesic consumption, and to affect other postoperative outcomes...
  52. pmc Impact of covert duplicate publication on meta-analysis: a case study
    M R Tramer
    Nuffield Department of Anaesthetics, Churchill Hospital, Oxford
    BMJ 315:635-40. 1997
    ..To quantify the impact of duplicate data on estimates of efficacy...
  53. pmc Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ
    BMJ 328:995. 2004
    ..To determine the efficacy and safety of topical rubefacients containing salicylates in acute and chronic pain...
  54. ncbi request reprint The hidden costs of arthritis treatment and the cost of new therapy--the burden of non-steroidal anti-inflammatory drug gastropathy
    R A Moore
    Pain Research Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Rheumatology (Oxford) 41:7-15; discussion 35-42. 2002
    ....
  55. ncbi request reprint Systematic review of systematic reviews of acupuncture published 1996-2005
    C J Derry
    Pain Research and Nuffield, Department of Anaesthetics, The Churchill, Oxford
    Clin Med 6:381-6. 2006
    ..Systematic reviews of acupuncture have overstated effectiveness by including studies likely to be biased. They provide no robust evidence that acupuncture works for any indication...
  56. ncbi request reprint Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain
    Jayne E Edwards
    Pain Research and Nuffield Department of Anesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford, United Kingdom
    J Pain Symptom Manage 23:121-30. 2002
    ..Common adverse effects were dizziness, drowsiness, nausea, vomiting, and headache. In sum, this meta-analysis demonstrated analgesic superiority of the combination drug over its components, without additional toxicity...
  57. pmc Prevalence of anaemia in older persons: systematic review
    Helen Gaskell
    Pain Research, Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospitals, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Geriatr 8:1. 2008
    ..Anaemia may be one such problem. We report on the prevalence of anaemia in cohorts of elderly people in the general population. The presence of anaemia is associated with a worse prognosis for both morbidity and mortality...
  58. pmc End-to-end military pain management
    D J Aldington
    Pain Relief Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Philos Trans R Soc Lond B Biol Sci 366:268-75. 2011
    ..Particular attention is paid to the evidence for the interventions used for both acute pain and chronic pain management. Also highlighted are possible differences in pain management techniques between civilian and military casualties...
  59. doi request reprint Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain
    R J Ni Mhuircheartaigh
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Level 6 West Wing, Oxford, UK
    Br J Anaesth 103:874-81. 2009
    ..Individual patient information from clinical trials is infrequently available, but can provide insights for clinical trials and practice...
  60. ncbi request reprint An evaluation of homogeneity tests in meta-analyses in pain using simulations of individual patient data
    D J Gavaghan
    Oxford University Computing Laboratory, Wolfson Building, Parks Road, Oxford, UK
    Pain 85:415-24. 2000
    ..In pain relief, for example, the first of these would be satisfied by all patients having moderate or severe pain, whilst the second would be satisfied by using at least 50% pain relief as the successful outcome measure...
  61. ncbi request reprint Seeking a simple measure of analgesia for mega-trials: is a single global assessment good enough?
    S L Collins
    Pain Research Unit and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, OX3 7LJ, Oxford, UK
    Pain 91:189-94. 2001
    ..A global assessment provides similar measures of analgesic efficacy as TOTPAR derived from hourly measurements, but the effects of adverse effects have yet to be understood...
  62. pmc A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting
    M R Tramer
    Department of Anaesthetics, Churchill Oxford, Radcliffe Hospital
    BMJ 314:1088-92. 1997
    ..To test the evidence for a dose-response with ondansetron for treatment of postoperative nausea and vomiting and to establish whether differences in efficacy between doses are of clinical relevance...
  63. ncbi request reprint Evaluating analgesia: the challenges
    Henry J McQuay
    Pain Research, Nuffield Department of Anesthetics, University of Oxford, The Churchill Oxford Radcliffe Hospital, Headington, UK
    Am J Ther 9:179-87. 2002
    ..Databases of patient experience, with all the caveats, may be the most reliable data from which to work...
  64. pmc Dose-response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies
    Henry J McQuay
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Churchill Hospital, Oxford, UK
    Br J Clin Pharmacol 63:271-8. 2007
    ..Establishing the dose-response relationship for clinically useful doses of aspirin, ibuprofen and paracetamol has been difficult. Indirect comparison from meta-analysis is compromised by too little information at some doses...
  65. ncbi request reprint Outcomes in acute pain trials: systematic review of what was reported?
    Jodie Barden
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    Pain 109:351-6. 2004
    ..Most useful would be all three. Further exploration would only be possible from analysis at the individual patient level...
  66. ncbi request reprint Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials
    M R Tramer
    Nuffield Department of Anaesthetics, The Churchill, and Oxford Radcliffe Hospital, United Kingdom
    Anesthesiology 87:1277-89. 1997
    ..The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV)...
  67. pmc Placebo
    H J McQuay
    Pain Research, Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Oxford OX3 7LJ, UK
    Postgrad Med J 81:155-60. 2005
    ....
  68. ncbi request reprint Single dose oral diflunisal for acute postoperative pain in adults
    Jack O Wasey
    Magdalen College, University of Oxford, High Street, Oxford, Oxfordshire, UK, OX1 4AU
    Cochrane Database Syst Rev 4:CD007440. 2010
    ..This property may be useful when regular dosing is needed, or when taking several doses of a shorter acting analgesic is impractical...
  69. ncbi request reprint Aspirin with or without an antiemetic for acute migraine headaches in adults
    Varo Kirthi
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU
    Cochrane Database Syst Rev 4:CD008041. 2010
    ..Addition of metoclopramide 10 mg improves relief of nausea and vomiting. Adverse events were mainly mild and transient, and were slightly more common with aspirin than placebo, but less common than with sumatriptan 100 mg...
  70. ncbi request reprint Single dose oral codeine, as a single agent, for acute postoperative pain in adults
    Sheena Derry
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU
    Cochrane Database Syst Rev 4:CD008099. 2010
    ..Higher doses were not evaluated...
  71. ncbi request reprint Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials
    Jayne E Edwards
    Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ, UK
    Pain 111:286-96. 2004
    ..There were fewer gastrointestinal adverse event withdrawals and endoscopically detected ulcers. Convincing evidence of reduced major gastrointestinal adverse events could not be addressed by the trials...
  72. doi request reprint Enriched enrolment with randomised withdrawal (EERW): Time for a new look at clinical trial design in chronic pain
    Henry J McQuay
    Pain Research, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Pain 135:217-20. 2008
  73. ncbi request reprint Bias from industry trial funding? A framework, a suggested approach, and a negative result
    Jodie Barden
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford OX3 7LJ, UK
    Pain 121:207-18. 2006
    ..We propose a method based on potential conflict of interest within industry-sponsored trials. Using this method, established clinical trial results in acute pain and migraine appear to be unbiased...
  74. ncbi request reprint Women's knowledge of, and attitudes to, contraceptive effectiveness and adverse health effects
    J E Edwards
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Oxford Radcliffe NHS Trust, Headington, Oxford, UK
    Br J Fam Plann 26:73-80. 2000
    ..Women tended to overestimate the risks and underestimate the effectiveness of hormonal contraceptives. They were resistant to interference with their bleeding patterns and weight...
  75. pmc Enriched enrollment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review
    Sebastian Straube
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford, UK
    Br J Clin Pharmacol 66:266-75. 2008
    ..We aim to investigate whether this really is the case in trials of pregabalin and gabapentin in neuropathic pain...
  76. ncbi request reprint Pharmacological treatments for acute migraine: quantitative systematic review
    Anna D Oldman
    Pain Research, Nuffield Department of Anaesthetics, Oxford Radcliffe Hospital, University of Oxford, The Churchill, Headington, UK
    Pain 97:247-57. 2002
    ..8 for eletriptan 80mg to 8.3 for rizatriptan 5mg. It was not possible to systematically review adverse effects data. Most interventions are effective. There is considerable information on relative efficacy for a number of outcomes...
  77. ncbi request reprint Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults
    Sheena Derry
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU
    Cochrane Database Syst Rev 11:CD008040. 2010
    ..Many sufferers choose not to, or are unable to, seek professional help and rely on over-the-counter analgesics. Co-therapy with an antiemetic should help to reduce nausea and vomiting commonly associated with migraine...
  78. doi request reprint Can observational studies provide a realistic alternative to randomized controlled trials in palliative care?
    Gina Hadley
    Pain Research Unit, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    J Pain Palliat Care Pharmacother 23:106-13. 2009
    ..We found that palliative care is deficient not only in RCTs, but also good quality observational studies. Those that exist are extremely heterogeneous in subject, design, outcome reporting, and intervention...
  79. doi request reprint Topical agents in the treatment of rheumatic pain
    R Andrew Moore
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, The Churchill, Headington, Oxford OX3 9DU, UK
    Rheum Dis Clin North Am 34:415-32. 2008
    ..The best information is for topical diclofenac. For topical capsaicin, evidence of efficacy is trivial. For topical rubefacients there is no evidence of efficacy...
  80. ncbi request reprint Self-monitoring of blood glucose in type-2 diabetes: what is the evidence?
    Grace McGeoch
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, OX3 7LJ, UK
    Diabetes Metab Res Rev 23:423-40. 2007
    ..There is a controversy about self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes who are not using insulin. Randomized trials are limited in duration, size, and validity...
  81. ncbi request reprint Incidence of epidural hematoma, infection, and neurologic injury in obstetric patients with epidural analgesia/anesthesia
    Wilhelm Ruppen
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford, UK
    Anesthesiology 105:394-9. 2006
    ..Earlier and smaller studies produced significantly higher risk estimates for transient neurologic injury plus injury of unknown duration...
  82. doi request reprint Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports
    Sebastian Straube
    Department of Occupational and Social Medicine, University of Gottingen, Gottingen, Germany
    Rheumatology (Oxford) 49:706-15. 2010
    ..Meta-analysis of pregabalin trials in FM using company trial reports, which provide more detailed information about trials than published papers. FM is a common condition with a significant impact on quality of life...
  83. ncbi request reprint Topical nonsteroidal antiinflammatory drugs are effective in osteoarthritis of the knee
    R Andrew Moore
    J Rheumatol 31:1893-5. 2004
  84. ncbi request reprint Five easy pieces on evidence-based medicine (4)
    Eija Kalso
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Eur J Pain 6:89-93. 2002
  85. ncbi request reprint Opioids in chronic non-cancer pain: systematic review of efficacy and safety
    Eija Kalso
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, P O Box 340, FIN 00029 HUS, Finland
    Pain 112:372-80. 2004
    ..The small number of selected patients and the short follow-ups do not allow conclusions concerning problems such as tolerance and addiction...
  86. ncbi request reprint Five easy pieces on evidence based medicine (5). Trading benefit against harm--pain relief vs. adverse effects
    Eija Kalso
    Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Eur J Pain 6:409-12. 2002
  87. ncbi request reprint Clinically important changes-what's important and whose change is it anyway?
    Henry J McQuay
    J Pain Symptom Manage 25:395-6. 2003