Research Topics
Species | S M AndertonSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
Fas-mediated death and sensory adaptation limit the pathogenic potential of autoreactive T cells after strong antigenic stimulationKelli R Ryan
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, UK
J Leukoc Biol 78:43-50. 2005..Therefore, when TCR affinity is fixed, autoreactive T cell sensitivity can be shifted to below a threshold for harm by a combination of AICD and sensory adaptation...
TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitisRichard J Mellanby
Medical Research Council University of Edinburgh Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
J Neuroinflammation 9:248. 2012..We sought to test the feasibility of this approach and whether activation of the DC by toll-like receptor (TLR)-4 ligation was a sufficient stimulus to drive EAE...- Peptide immunotherapy for childhood allergy - addressing translational challengesKaren J Mackenzie
MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK
Clin Transl Allergy 1:13. 2011..This provides a context for discussion of the challenges for the application of PIT, both generally and more specifically in relation to children... - Post-translational modifications of self antigens: implications for autoimmunityStephen M Anderton
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
Curr Opin Immunol 16:753-8. 2004..Furthermore, intriguing insights into how the complex interactions between inflammation, enzyme activity and protein modification can direct self recognition are beginning to be unearthed... - Avoiding autoimmune disease--T cells know their limitsStephen M Anderton
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Trends Immunol 27:208-14. 2006..Evidence points to a model in which the three pillars of immune tolerance (deletion, anergy-adaptation and regulation) act to limit autoimmune disease from molecular mimicry... 
Treg and T-effector cells in autoimmune CNS inflammation: a delicate balance, easily disturbedStephen M Anderton
Medical Research Council University of Edinburgh Centre for Inflammation Research, Centre for Multiple Sclerosis Research, Queen s Medical Research Institute, Edinburgh, UK
Eur J Immunol 40:3321-4. 2010....- Selection and fine-tuning of the autoimmune T-cell repertoireStephen M Anderton
Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Nat Rev Immunol 2:487-98. 2002..This might maximize the peripheral T-cell repertoire by allowing the survival of T cells that can respond to self, but only at concentrations that are not normally reached in vivo... - Influence of a dominant cryptic epitope on autoimmune T cell toleranceStephen M Anderton
University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Nat Immunol 3:175-81. 2002..Our results highlight the need to use peptides that mimic the binding of processed antigen fragments to MHC molecules for successful modulation of disease-relevant T cells... 
Negative selection during the peripheral immune response to antigenS M Anderton
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Exp Med 193:1-11. 2001..This tuning mechanism provides a peripheral control against the expansion of autoreactive T cells and has implications for immunotherapy and vaccine design...- Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cellsS M Anderton
Department of Pathology and Microbiology, University of Bristol, GB
Eur J Immunol 29:1850-7. 1999..The implications of these findings for the requirements for EAE induction, the relative contribution of a given T cell subpopulation to pathology and the mechanism underlying EAE inhibition in this model are discussed... - Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoireDavid McCue
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
J Neuroimmunol 156:96-106. 2004..These data provide new evidence that self-reactive T cells bearing low-affinity TCRs are able to escape therapeutic induction of tolerance... - Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoproteinClaire H Sweenie
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
J Neuroimmunol 183:7-16. 2007..Our data also provide a basis for exploring the requirements for antigen processing of MOG... - Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicryKelli R Ryan
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
J Autoimmun 29:262-71. 2007..We show that each of the three pillars of immune tolerance (death, anergy/adaptation and regulation) has a role in limiting the risk of molecular mimicry by maintaining a threshold for harm... - PD-1 signalling in CD4(+) T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced toleranceJoanne E Konkel
Centre for Immunity Infection and Evolution, Institute of Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
Immunology 130:92-102. 2010..These observations contrast with the reported requirement for PD-1 signals in CD8(+) T-cell tolerance... - Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulationR A O'Connor
University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen s Medical Research Institute, Edinburgh, UK
Clin Exp Immunol 159:137-47. 2010.... - CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivityLeigh A Stephens
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK
Proc Natl Acad Sci U S A 102:17418-23. 2005..These data demonstrate the importance of Treg in raising the threshold of triggering of autoreactive T cell responses, thus limiting the risk of autoimmune disease due to molecular mimicry... - IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune diseaseGeorgia Perona Wright
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, UK
Int Immunol 19:1123-34. 2007..Our data suggest that IL-10 acts not by inhibiting maturation but instead by controlling the kinetics and the quality of DC activation. This alternative pathway of DC differentiation offers significant therapeutic promise... - RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levelsAnne L Astier
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 184:685-93. 2010..Hence, FL and FLT3 form a novel regulatory feedback loop that limits IL-10 production in T cells. Our results identified FLT3 as a new regulator of T cell function and offer a strategy to genetically dissect specific pathways in T cells... - Multi-faceted control of autoaggression: Foxp3+ regulatory T cells in murine models of organ-specific autoimmune diseaseRichard A O'Connor
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Cell Immunol 251:8-18. 2008..We reflect on these observations that clearly have relevance for the translation of Treg-targeting immune therapies to human disease... - Contribution of myelin autoantigen citrullination to T cell autoaggression in the central nervous systemAntonio Carrillo-Vico
Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
J Immunol 184:2839-46. 2010..The PAD2 and PAD4 enzymes were markedly upregulated in the inflamed CNS. Therefore, once inflammation is established, citrullination of target autoantigens can allow an expanded repertoire of T cells to contribute to CNS pathology... - Antigen-based therapies targeting the expansion of regulatory T cells in autoimmune and allergic diseaseMelanie D Leech
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Edinburgh, UK
Chem Immunol Allergy 94:201-10. 2008..We discuss some recent studies that might provide insight into how best to expand these protective T cells and highlight some outstanding issues requiring further investigation... - Cross-reactivity and T-cell receptor antagonism of myelin basic protein-reactive T cells is modulated by the activation state of the antigen presenting cellStephan Kissler
Department of Pathology and Microbiology, University of Bristol, Bristol, UK
J Autoimmun 19:183-93. 2002.... - Peptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxisMelanie D Leech
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Edinburgh, UK
Eur J Immunol 37:3576-81. 2007.... - The inflamed central nervous system drives the activation and rapid proliferation of Foxp3+ regulatory T cellsKaty H Malpass
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, United Kingdom
J Immunol 179:958-66. 2007..These data establish the CNS as an environment that permits extensive Treg proliferation and are the first to demonstrate Treg expansion specifically within the tissues during the natural resolution of autoimmune inflammation... - Immunological tolerance using synthetic peptides--basic mechanisms and clinical applicationKristin Hochweller
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Curr Mol Med 6:631-43. 2006..Here we review recent advances in our understanding of the requirements for tolerance induction and the potential for establishing dominant immune-regulation with peptide therapy... - Antigen-presenting cell activation: a link between infection and autoimmunity?S Kissler
Department of Pathology and Microbiology, University of Bristol, Bristol, UK
J Autoimmun 16:303-8. 2001..These results help explain how diverse infectious agents could cause autoimmune disease in susceptible individuals... - Antigen-based therapy and immune-regulation in experimental autoimmune encephalomyelitisMandy J McGeachy
Institute of Immunology and Infection Research, Iniversity of Edinburgh, UK
Methods Mol Biol 380:313-26. 2007..Sampling of the lymphoid cell infiltrate within the central nervous system has identified the accumulation of regulatory T cells in the target organ during this period of resolution... - Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administrationKristin Hochweller
ICAPB, University of Edinburgh, Edinburgh, GB
Eur J Immunol 34:990-8. 2004..These data implicate the CD40:CD40L interaction as a key checkpoint in the development of T cell immunity rather than tolerance... - Curing CNS autoimmune disease with myelin-reactive Foxp3+ TregLeigh A Stephens
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
Eur J Immunol 39:1108-17. 2009.... - Circumventing tolerance at the T cell or the antigen-presenting cell surface: antibodies that ligate CD40 and OX40 have different effectsKristin Hochweller
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Eur J Immunol 36:389-96. 2006..We conclude that, although these two antibodies seem to impact on the same molecular pathway of costimulation to prevent tolerance, their effects are qualitatively distinct and their use cannot be viewed as interchangeable... - Activated B cells in autoimmune diseases: the case for a regulatory roleStephen M Anderton
University of Edinburgh, Edinburgh, UK
Nat Clin Pract Rheumatol 4:657-66. 2008.... - Cytokines in the induction and resolution of experimental autoimmune encephalomyelitisMandy J McGeachy
Institute of Immunology and Infection Research, University of Edinburgh, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
Cytokine 32:81-4. 2005..However, the key IL-10-producing cell within the central nervous system is a CD4+CD25+ T cell population that has regulatory function and is critical to resolution of the disease... - B cells regulate autoimmunity by provision of IL-10Simon Fillatreau
University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
Nat Immunol 3:944-50. 2002..In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity... - Kinetics of costimulatory molecule expression by T cells and dendritic cells during the induction of tolerance versus immunity in vivoKristin Hochweller
Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
Eur J Immunol 35:1086-96. 2005.... - Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammationMark S Wilson
Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
Eur J Immunol 40:1682-96. 2010..These data expand previous observations and highlight the broad regulatory environment that develops during helminth infections that can abate diverse inflammatory disorders in vivo... - Immune cell entry to central nervous system--current understanding and prospective therapeutic targetsCatriona T Prendergast
University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Endocr Metab Immune Disord Drug Targets 9:315-27. 2009..Targeting specific molecules to prevent infiltration of inflammatory cells into the CNS could allow disease inhibition without compromising beneficial immune surveillance... - Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitisRichard A O'Connor
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Edinburgh, United Kingdom
J Immunol 181:3750-4. 2008..This has major implications for the design of therapeutic interventions, many of which are now aiming at Th17 rather than Th1 cells... - A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivoGeorgia Perona-Wright
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
J Immunol 182:2808-15. 2009..Our data delineate sequential requirements for DC expression of CD40 and production of IL-6 during Th17 polarization in vitro and in vivo, and reveal distinct costimulatory requirements for Th1 vs Th17 generation... - Foxp3+ regulatory T cells in the control of experimental CNS autoimmune diseaseRichard A O'Connor
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT UK
J Neuroimmunol 193:1-11. 2008..Current uncertainties and controversies are discussed in regard to EAE and multiple sclerosis as well as the potential for Treg-targeted immunotherapy... - Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous systemMandy J McGeachy
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
J Immunol 175:3025-32. 2005..These are the first data demonstrating the direct involvement of CD4+CD25+ regulatory T cells in the natural resolution of autoimmune disease within the target organ... - Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletionFriederike Frommer
I Medical Department, Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, Mainz, Germany
J Immunol 181:5748-59. 2008..In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells... - Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing miceNicolas Fazilleau
INSERM U277, Institut Pasteur, Paris, France
Eur J Immunol 36:533-43. 2006..These findings indicate that the MOG immunodominant determinant is unable to induce tolerance by deletion, and public anti-MOG T cell repertoires are selected for, regardless of the presence of MOG in the thymus and peripheral organs... - Not always the bad guys: B cells as regulators of autoimmune pathologySimon Fillatreau
Simon Fillatreau is at the Immune regulation group, Deutsches Rheuma ForschungsZentrum, Chariteplatz 1, 10117 Berlin, Germany
Nat Rev Immunol 8:391-7. 2008..According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases... - TLR-activated B cells suppress T cell-mediated autoimmunityVicky Lampropoulou
Deutsches Rheuma ForschungsZentrum, Berlin, Germany
J Immunol 180:4763-73. 2008..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...