R A Anderson

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Antimüllerian hormone, the assessment of the ovarian reserve, and the reproductive outcome of the young patient with cancer
    Richard A Anderson
    Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    Fertil Steril 99:1469-75. 2013
  2. doi request reprint What does anti-Müllerian hormone tell you about ovarian function?
    Richard A Anderson
    MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 77:652-5. 2012
  3. doi request reprint Measuring anti-Müllerian hormone for the assessment of ovarian reserve: when and for whom is it indicated?
    R A Anderson
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Maturitas 71:28-33. 2012
  4. doi request reprint Fertility preservation in girls and young women
    Richard A Anderson
    Division of Reproductive and Developmental Science, MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 75:409-19. 2011
  5. doi request reprint Pretreatment serum anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer
    Richard A Anderson
    Division of Reproduction and Developmental Sciences and Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 96:1336-43. 2011
  6. doi request reprint Cumulus gene expression as a predictor of human oocyte fertilisation, embryo development and competence to establish a pregnancy
    R A Anderson
    Division of Reproduction and Developmental Science, Queen s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Reproduction 138:629-37. 2009
  7. pmc Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis
    Richard A Anderson
    Division of Reproductive and Developmental Sciences, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    BMC Dev Biol 7:136. 2007
  8. doi request reprint Ovarian cryopreservation for fertility preservation: indications and outcomes
    R A Anderson
    The Queen s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Reproduction 136:681-9. 2008
  9. ncbi request reprint The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer
    R A Anderson
    Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Hum Reprod 21:2583-92. 2006
  10. doi request reprint The current status of preimplantation genetic screening: British Fertility Society Policy and Practice Guidelines
    Richard A Anderson
    Division of Reproductive and Developmental Science, Centre for Reproductive Biology, University of Edinburgh, UK
    Hum Fertil (Camb) 11:71-5. 2008

Collaborators

Detail Information

Publications88

  1. doi request reprint Antimüllerian hormone, the assessment of the ovarian reserve, and the reproductive outcome of the young patient with cancer
    Richard A Anderson
    Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    Fertil Steril 99:1469-75. 2013
    ..These therapies can adversely impact all aspects of female reproduction, including hypothalamic, pituitary, and ovarian hormonal activity, and the ability of the uterus to support a successful pregnancy...
  2. doi request reprint What does anti-Müllerian hormone tell you about ovarian function?
    Richard A Anderson
    MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 77:652-5. 2012
    ....
  3. doi request reprint Measuring anti-Müllerian hormone for the assessment of ovarian reserve: when and for whom is it indicated?
    R A Anderson
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Maturitas 71:28-33. 2012
    ..The increasingly routine use of AMH by IVF clinics heralds much wider adoption in a range of clinical situations across the reproductive lifespan...
  4. doi request reprint Fertility preservation in girls and young women
    Richard A Anderson
    Division of Reproductive and Developmental Science, MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 75:409-19. 2011
    ..Effective approaches for prepubertal boys are also required...
  5. doi request reprint Pretreatment serum anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer
    Richard A Anderson
    Division of Reproduction and Developmental Sciences and Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 96:1336-43. 2011
    ..However, age is the only patient characteristic currently recognized to be predictive of long-term ovarian function after chemotherapy...
  6. doi request reprint Cumulus gene expression as a predictor of human oocyte fertilisation, embryo development and competence to establish a pregnancy
    R A Anderson
    Division of Reproduction and Developmental Science, Queen s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Reproduction 138:629-37. 2009
    ....
  7. pmc Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis
    Richard A Anderson
    Division of Reproductive and Developmental Sciences, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    BMC Dev Biol 7:136. 2007
    ....
  8. doi request reprint Ovarian cryopreservation for fertility preservation: indications and outcomes
    R A Anderson
    The Queen s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Reproduction 136:681-9. 2008
    ..So far, none have requested reimplantation of their stored ovarian tissue. Ovarian cryopreservation appears to be a potentially valuable method for fertility preservation, but the indications and approaches best used remain unclear...
  9. ncbi request reprint The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer
    R A Anderson
    Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Hum Reprod 21:2583-92. 2006
    ..We therefore assessed the markers of the ovarian reserve in premenopausal women, to investigate and compare the effects of chemotherapy and long-term gonadotrophin withdrawal on ovarian function...
  10. doi request reprint The current status of preimplantation genetic screening: British Fertility Society Policy and Practice Guidelines
    Richard A Anderson
    Division of Reproductive and Developmental Science, Centre for Reproductive Biology, University of Edinburgh, UK
    Hum Fertil (Camb) 11:71-5. 2008
    ....
  11. ncbi request reprint Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception
    B M Brady
    Contraceptive Development Network and MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, UK
    Hum Reprod 19:2658-67. 2004
    ..Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks...
  12. ncbi request reprint Investigation of a novel preparation of testosterone decanoate in men: pharmacokinetics and spermatogenic suppression with etonogestrel implants
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
    Contraception 66:357-64. 2002
    ..The speed and degree of spermatogenic suppression suggest that this combination has promise as an effective male contraceptive...
  13. ncbi request reprint Demonstration of progesterone receptor-mediated gonadotrophin suppression in the human male
    B M Brady
    Contraceptive Development Network and MRC Human Reproductive Science Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 58:506-12. 2003
    ..In this study the effects of progesterone, with no significant androgen-receptor affinity are compared to desogestrel, a synthetic gestogen with relatively low affinity for the androgen receptor, on gonadotrophin secretion in normal men...
  14. ncbi request reprint Suppression of spermatogenesis by etonogestrel implants with depot testosterone: potential for long-acting male contraception
    R A Anderson
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:3640-9. 2002
    ....
  15. doi request reprint Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate
    R T Mitchell
    Medical Research Council University of Edinburgh Centre for Reproductive Health, The Queen s Medical Research Institute, Edinburgh Royal Hospital for Sick Children, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 97:E341-8. 2012
    ..g. di-n-butyl phthalate (DBP)] causes masculinization disorders in rats, raising concern for similar effects in humans. We investigated whether DBP exposure impairs steroidogenesis by the human fetal testis...
  16. ncbi request reprint Investigation of hormonal male contraception in African men: suppression of spermatogenesis by oral desogestrel with depot testosterone
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, Scotland
    Hum Reprod 17:2869-77. 2002
    ..In Sagamu, desogestrel was administered for 52 weeks with 200 mg testosterone (later increased to 400 mg) re-administered 12-weekly...
  17. ncbi request reprint Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
    S J Martins da Silva
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, UK
    Dev Biol 266:334-45. 2004
    ..These data indicate that activin may be involved in the autocrine and paracrine regulation of germ cell proliferation in the human ovary during the crucial period of development leading up to primordial follicle formation...
  18. ncbi request reprint Suppression of spermatogenesis with desogestrel and testosterone pellets is not enhanced by addition of finasteride
    D Kinniburgh
    Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, United Kingdom
    J Androl 22:88-95. 2001
    ..However, these data do not support the involvement of 5alpha-reductase in maintaining residual spermatogenesis during gonadotropin suppression for hormonal male contraception...
  19. ncbi request reprint A multicentre study investigating subcutaneous etonogestrel implants with injectable testosterone decanoate as a potential long-acting male contraceptive
    B M Brady
    Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Hum Reprod 21:285-94. 2006
    ..The combination of etonogestrel implants with injectable testosterone decanoate was investigated as a potential male contraceptive...
  20. ncbi request reprint Differential expression of estrogen receptor-alpha and -beta and androgen receptor in the ovaries of marmosets and humans
    P T Saunders
    MRC Human Reproductive Sciences Unit, Edinburgh, EH3 9ET, United Kingdom Oxford Brookes University, Oxford, OX3 0BP, United Kingdom
    Biol Reprod 63:1098-105. 2000
    ..In antral follicles, however, ERalpha is also expressed, and the formation of homo- or heterodimers containing ERalpha may influence the pattern of gene activation within these cells...
  21. ncbi request reprint Spontaneous conception in a young woman who had ovarian cortical tissue cryopreserved before chemotherapy and radiotherapy for a Ewing's sarcoma of the pelvis: case report
    L E Bath
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Department of Obstetrics and Gynaecology, Fife Acute Hospitals NHS Trust and MRC Human Reproductive Sciences Unit, Edinburgh, UK
    Hum Reprod 19:2569-72. 2004
    ..Clinicians should be aware of the possibility of spontaneous conception despite confirmed ovarian failure in young women successfully treated for cancer...
  22. ncbi request reprint Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    H N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, EH3 9ET, United Kingdom
    Br J Cancer 85:1023-31. 2001
    ..42 +/- 0.46 vs 1.15 +/- 0.05 respectively; P< 0.001). In conclusion, these data suggest that PGE(2)may regulate neoplastic cell function in an autocrine/paracrine manner via the EP2/EP4 receptors...
  23. ncbi request reprint Regulation of inhibin production in the human male and its clinical applications
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Int J Androl 23:136-44. 2000
    ..Finally, neonatal secretion of inhibin B as a measure of Sertoli cell number and/or as a predictor of adult reproductive function offers novel possibilities for assessment and intervention...
  24. pmc Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human
    R T Mitchell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Hum Reprod 23:2755-65. 2008
    ..We evaluated the marmoset (Callithrix jacchus) as a model by comparing perinatal germ cell differentiation with that in humans...
  25. ncbi request reprint Hypothalamic-pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia
    L E Bath
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, University of Edinburgh, UK
    Hum Reprod 16:1838-44. 2001
    ..Follow-up of these women is required to detect any effect on reproductive potential...
  26. ncbi request reprint Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis
    P S Hartley
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, Scotland, UK EH3 9ET
    J Clin Endocrinol Metab 87:3417-27. 2002
    ....
  27. ncbi request reprint Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Müllerian hormone, inhibin B and ovarian ultrasound
    L E Bath
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Hum Reprod 18:2368-74. 2003
    ..Treatment of cancer during childhood may result in loss of primordial follicles from the ovary...
  28. doi request reprint Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback
    J T George
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK
    Hum Reprod 27:3552-9. 2012
    ..Does sex-steroid feedback influence gonadotrophin responses to kisspeptin-10?..
  29. pmc The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation
    K Duffin
    Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Mol Hum Reprod 15:771-7. 2009
    ....
  30. ncbi request reprint Investigation of suppression of the hypothalamic-pituitary-gonadal axis to restore spermatogenesis in azoospermic men treated for childhood cancer
    A B Thomson
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH9 1LW, Scotland, UK
    Hum Reprod 17:1715-23. 2002
    ..Does suppression of the hypothalamic-pituitary-gonadal (HPG) axis restore spermatogenesis in men rendered azoospermic following treatment of childhood cancer?..
  31. doi request reprint How do chemotherapeutic agents damage the ovary?
    S Morgan
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Hum Reprod Update 18:525-35. 2012
    ..In this review we examine the current evidence for the direct action of chemotherapeutic agents on the ovary and discuss possible molecular pathways through which follicle loss may occur...
  32. ncbi request reprint 7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men
    R A Anderson
    Medical Research Council Reproductive Biology Unit, Center for Reproductive Biology, Edinburgh, Scotland
    J Clin Endocrinol Metab 84:3556-62. 1999
    ..The appropriate dose of MENT remains to be determined, but these results support its development as a potential androgen replacement therapy...
  33. ncbi request reprint Environmental toxicant-induced germ cell apoptosis in the human fetal testis
    S M Coutts
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Hum Reprod 22:2912-8. 2007
    ..Cigarette smoke contains agents acting on the aryl hydrocarbon receptor (AHR). We have investigated the presence of AHR in the developing human testis and the effects of functional activation...
  34. ncbi request reprint Germ cell proliferation and apoptosis in the developing human ovary
    N Fulton
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 90:4664-70. 2005
    ..The regulation of germ cell proliferation and loss during human ovarian development is poorly understood. This is of particular interest at the time leading up to the formation of primordial follicles, at 18 wk gestation onward...
  35. ncbi request reprint Brain-derived neurotrophic factor promotes bovine oocyte cytoplasmic competence for embryo development
    S J Martins da Silva
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Reproduction 129:423-34. 2005
    ....
  36. ncbi request reprint Differential patterns of inhibin secretion in response to gonadotrophin stimulation in normal men
    D Kinniburgh
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, UK
    Int J Androl 24:95-101. 2001
    ..The lack of change in inhibin B secretion in response to FSH suggests that more prolonged or intense stimulation of Sertoli cells may be required for secretion of the dimeric form...
  37. ncbi request reprint Clinical studies: inhibin in the adult male
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, EH39ET, Edinburgh, UK
    Mol Cell Endocrinol 180:109-16. 2001
    ..This relationship with sperm production may be a useful marker in some contexts, as changes are more dynamic than in the circulating hormone...
  38. doi request reprint Do doctors discuss fertility issues before they treat young patients with cancer?
    Richard A Anderson
    Division of Developmental and Reproductive Science, University of Edinburgh, Edinburgh, UK
    Hum Reprod 23:2246-51. 2008
    ..We have assessed UK practice relating to information provision about the effects of cancer treatment on fertility and options for fertility preservation...
  39. pmc Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development
    Andrew J Childs
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Dev Dyn 239:1211-9. 2010
    ..These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary...
  40. ncbi request reprint The human fetal testis is a site of expression of neurotrophins and their receptors: regulation of the germ cell and peritubular cell population
    Lynne L L Robinson
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:3943-51. 2003
    ..These data demonstrate the expression of NTs and their receptors in the human fetal testis during the second trimester and indicate possible roles in the regulation of proliferation and survival of germ cells and peritubular cells...
  41. pmc Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
    B Orr
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 31:1130-42. 2012
    ..Additionally, two molecules (ASPN and STC1) marked overlapping and distinct subregions of stroma associated with tumour epithelia and may represent new CAF markers...
  42. ncbi request reprint Germ cell specific expression of c-kit in the human fetal gonad
    L L Robinson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Mol Hum Reprod 7:845-52. 2001
    ....
  43. ncbi request reprint Male contraception
    R A Anderson
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, Scotland EH16 4SB, United Kingdom
    Endocr Rev 23:735-62. 2002
    ....
  44. ncbi request reprint The role of neurotrophin receptors in female germ-cell survival in mouse and human
    Norah Spears
    Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 130:5481-91. 2003
    ..The results indicate that signalling through TrkB is an important component of the mechanism that regulates the early survival of female germ cells...
  45. ncbi request reprint Fertility preservation for young patients with cancer: who is at risk and what can be offered?
    W Hamish B Wallace
    Department of Child Life and Health, Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet Oncol 6:209-18. 2005
    ....
  46. pmc Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
    J T George
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Clin Endocrinol Metab 96:E1228-36. 2011
    ..Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man...
  47. ncbi request reprint Haemostatic effects of supraphysiological levels of testosterone in normal men
    R A Anderson
    MRC Reproductive Biology Unit, Royal Infirmary, Edinburgh, Scotland, UK
    Thromb Haemost 74:693-7. 1995
    ..After several months the raised activation markers had returned to pretreatment levels indicating that a new equilibrium had been established which did not appear to be prothrombotic.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. doi request reprint Prostaglandin E2 as a regulator of germ cells during ovarian development
    Rosemary A L Bayne
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 94:4053-60. 2009
    ..The prostaglandins have pleiotrophic roles in reproduction, notably in ovulation and implantation, but there are no data regarding roles for prostaglandins in human fetal ovarian development...
  49. doi request reprint Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
    Shiona M Coutts
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, UK
    Dev Biol 314:189-99. 2008
    ..The effects of activin on germ cells are indirect and include mediation by the kit ligand/c-Kit pathway, rather than being an autocrine germ cell effect...
  50. doi request reprint Brain-derived neurotrophic factor is a regulator of human oocyte maturation and early embryo development
    Richard A Anderson
    Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Fertil Steril 93:1394-406. 2010
    ..To investigate a role for brain-derived neurotrophic factor (BDNF) in human oocyte maturation...
  51. ncbi request reprint Neurotropins and their receptors are expressed in the human fetal ovary
    Richard A Anderson
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 87:890-7. 2002
    ....
  52. ncbi request reprint Expression and localization of inhibin alpha, inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testis
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:779-88. 2002
    ....
  53. ncbi request reprint Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary
    Rosemary A L Bayne
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Mol Hum Reprod 10:373-81. 2004
    ..Similar mobility shifts were identified in human fetal ovary extracts. These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary...
  54. doi request reprint N- and E-cadherin expression in human ovarian and urogenital duct development
    Sarah R Smith
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, Scotland
    Fertil Steril 93:2348-53. 2010
    ..To investigate expression of N- and E-cadherin in the developing human ovary...
  55. doi request reprint Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh, United Kingdom
    Fertil Steril 92:1416-9. 2009
    ....
  56. ncbi request reprint Molecular profiling of the human testis reveals stringent pathway-specific regulation of RNA expression following gonadotropin suppression and progestogen treatment
    Rosemary A L Bayne
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Androl 29:389-403. 2008
    ....
  57. ncbi request reprint Ovarian cryopreservation: experimental or established and a cure for the menopause?
    W H Wallace
    Department of Haematology Oncology, Royal Hospital for Sick Children, Edinburgh, UK
    Reprod Biomed Online 25:93-5. 2012
    ..The ability of ovarian cryopreservation to preserve fertility for some young survivors of cancer is proven, but the indications for which patients should be offered this exciting new technology are not yet established...
  58. ncbi request reprint Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men
    D Kinniburgh
    Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    Hum Reprod 17:1490-501. 2002
    ....
  59. ncbi request reprint Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human fetal testis and ovary
    L L Robinson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, University of Edinburgh, Edinburgh EH3 9ET, UK
    Mol Hum Reprod 7:641-8. 2001
    ..MMP and TIMP are likely to play a role in ECM remodelling during gonadal development and also in the cell and matrix interactions that control a range of cellular functions...
  60. pmc Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulate
    S Battersby
    Medical Research Council Human Reproductive Science Unit, The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod 22:36-44. 2007
    ..Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma...
  61. ncbi request reprint Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study
    Angela B Thomson
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 360:361-7. 2002
    ..Our aim was to assess testicular function in survivors of childhood cancer...
  62. pmc Modelling germ cell development in vitro
    Andrew J Childs
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 14:501-11. 2008
    ....
  63. doi request reprint Establishment of long-term monolayer cultures of somatic cells from human fetal testes and expansion of peritubular myoid cells in the presence of androgen
    Gillian Cowan
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Reproduction 139:749-57. 2010
    ..This culture system provides an opportunity to study the impact of regulatory factors on gene expression in PTM cells, a population thought to play a key role in mediating androgen action within the developing testis...
  64. doi request reprint Gonadotrophin ovulation induction is a successful treatment for World Health Organisation Group II anovulatory subfertility in women aged up to 40 and with body mass index up to 34
    H W Raymond Li
    Edinburgh Fertility and Reproductive Endocrine Centre, Royal Infirmary of Edinburgh, Edinburgh, UK
    Hum Fertil (Camb) 13:35-40. 2010
    ....
  65. doi request reprint Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells
    John D Terrace
    Centre for Regenerative Medicine, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Exp Cell Res 316:1637-47. 2010
    ..This indicates that a temporal relationship might exist between progenitor cells in foetal liver development and adult liver regeneration, which may involve progeny of PVE...
  66. ncbi request reprint Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland
    Caroline Pope
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Dev Biol 297:172-81. 2006
    ..The mechanism(s) responsible for the different molecular regulation of alpha-GSU gene expression in gonadotropes and thyrotropes in the developing human fetal pituitary now requires investigation...
  67. ncbi request reprint Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation
    Pamela Brown
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh, United Kingdom
    J Clin Endocrinol Metab 88:1341-9. 2003
    ..These data extend the clinical and molecular information on DAX-1 mutations, confirm normal testicular development at the neonatal stage, and illustrate variability in Leydig cell function...
  68. ncbi request reprint Prospective analysis of the relationships between the ovarian follicle cohort and basal FSH concentration, the inhibin response to exogenous FSH and ovarian follicle number at different stages of the normal menstrual cycle and after pituitary down-regulat
    Peter Y K Yong
    Royal Infirmary of Edinburgh, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Hum Reprod 18:35-44. 2003
    ..We have carried out a prospective analysis of endocrine and biophysical assessments under three differing basal conditions: the early follicular and mid-luteal phases, and following GnRH analogue down-regulation...
  69. ncbi request reprint Differential expression of two estrogen receptor beta isoforms in the human fetal testis during the second trimester of pregnancy
    Terri L Gaskell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:424-32. 2003
    ..We suggest that during this period of fetal life, estrogenic ligands are most likely to act on somatic cells that contain ER beta 1 protein...
  70. ncbi request reprint Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum
    Hamish M Fraser
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, Scotland, United Kingdom
    J Clin Endocrinol Metab 90:427-34. 2005
    ..These results establish that in the human corpus luteum EG-VEGF is principally derived from granulosa lutein cells and that its synthesis is highest during the mid- to late luteal phase...
  71. pmc Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human
    Nina Hallmark
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Environ Health Perspect 115:390-6. 2007
    ..Certain phthalates can impair Leydig cell distribution and steroidogenesis in the fetal rat in utero, but it is unknown whether similar effects might occur in the human...
  72. ncbi request reprint 7alpha-methyl-19-nortestosterone (MENT) vs testosterone in combination with etonogestrel implants for spermatogenic suppression in healthy men
    Melanie J Walton
    Centre for Reproductive Biology, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ
    J Androl 28:679-88. 2007
    ..These data indicate the importance of the doses of progestogen and testosterone for optimum spermatogenic suppression while minimizing side effects...
  73. pmc Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma
    Alison E Wallace
    Medical Research Council Human Reproductive Sciences Unit, Department of Reproductive and Developmental Sciences, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Cancer Res 69:5726-33. 2009
    ..In conclusion, our results show a novel PGF(2alpha)-FP pathway that may regulate the inflammatory microenvironment in endometrial adenocarcinoma via neutrophil chemotaxis...
  74. ncbi request reprint Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis
    Melanie J Walton
    Centre for Reproductive Biology, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 91:2526-33. 2006
    ..The testicular response to gonadotropin withdrawal is important for the development of effective contraceptive methods...
  75. ncbi request reprint Immunohistochemical profiling of germ cells within the human fetal testis: identification of three subpopulations
    Terri L Gaskell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    Biol Reprod 71:2012-21. 2004
    ..These data provide evidence for the functional differentiation of human testicular germ cells during the second trimester of pregnancy, and they argue against these germ cells being considered as a homogeneous population, as in rodents...
  76. ncbi request reprint A strategy for future reproductive services for survivors of cancer
    Richard A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB
    Hum Fertil (Camb) 6:113-5. 2003
  77. ncbi request reprint Assessment of the effect of chemotherapy on ovarian function in women with breast cancer
    Richard A Anderson
    J Clin Oncol 25:1630-1; author reply 1632. 2007
  78. ncbi request reprint A diurnal variation in testicular hormone production is maintained following gonadotrophin suppression in normal men
    Melanie J Walton
    Division of Reproductive and Developmental Science, University of Edinburgh, Edinburgh, UK
    Clin Endocrinol (Oxf) 66:123-9. 2007
    ..A diurnal variation in serum testosterone in adult men is well recognized, but whether this occurs during exogenous testosterone administration and the degree to which it is endogenous to the testis is unclear...
  79. ncbi request reprint Impact of obesity on female reproductive health: British Fertility Society, Policy and Practice Guidelines
    Adam H Balen
    Reproductive Medicine and Surgery, Leeds Teaching Hospitals, Leeds, UK
    Hum Fertil (Camb) 10:195-206. 2007
    ..Even a moderate weight loss of 5-10% of body weight can be sufficient to restore fertility and improve metabolic markers...
  80. ncbi request reprint Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes
    Isabelle Hininger
    Laboratoire Nutrition, Vieillissement, Maladies Cardiovasculaires, EA 3746, J Fourier University, Domaine de la Merci, 38700 La Tronche, France
    Free Radic Biol Med 42:1759-65. 2007
    ..These data further support the low toxicity of trivalent Cr complexes used in nutrient supplements...
  81. pmc Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli
    Heping Cao
    Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture ARS, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Biotechnol Prog 24:326-33. 2008
    ..These results demonstrate that ZFP36L1 antiserum is useful in the detection of this protein and that TTP and ZFP36L1 are differentially expressed and regulated at the mRNA and protein levels in mouse adipocytes and macrophages...
  82. doi request reprint Insulin increases tristetraprolin and decreases VEGF gene expression in mouse 3T3-L1 adipocytes
    Heping Cao
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland, USA
    Obesity (Silver Spring) 16:1208-18. 2008
    ..We analyzed the relative abundance of TTP family mRNAs in 3T3-L1 adipocytes compared to RAW264.7 macrophages and investigated insulin effects on the expression of 43 genes in 3T3-L1 adipocytes...
  83. ncbi request reprint Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling
    Renee L Doughman
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 278:23036-45. 2003
    ..Combined, these data support a model where the localized production of PIP2 by PIPKIalpha is necessary for actin remodeling, whereas formation of membrane ruffles required Rac signaling...
  84. ncbi request reprint Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages
    Heping Cao
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Nutr 138:833-40. 2008
    ..These results suggest that CPE can affect immune responses by regulating anti- and proinflammatory and GLUT gene expression...
  85. ncbi request reprint Stress-ING out: phosphoinositides mediate the cellular stress response
    Matthew W Bunce
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Sci STKE 2006:pe46. 2006
    ..These findings highlight a previously uncharacterized function for phosphoinositides and implicate their metabolism in signaling pathways critical for cell survival...
  86. ncbi request reprint Cancer survivors and infertility: where do we go from here?
    W Hamish Wallace
    Royal Hospital for Sick Children, Edinburgh, Scotland
    J Support Oncol 4:183-4. 2006
  87. ncbi request reprint Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:6112-8. 2004
    ..These data suggest that PGE2 signaling may promote endometrial tumorigenesis by inactivation of tuberin after its phosphorylation via the Akt signaling pathway...
  88. ncbi request reprint A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception
    Cathy J Hay
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 90:2042-9. 2005
    ..one). In conclusion, the combination of 300 microg ENG with 400 mg TD every 4 wk was superior in terms of efficacy, hormone profiles, and safety. This represents a promising approach to male hormonal contraception...