John Anderson

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype
    Daniel Williamson
    Molecular Cytogenetics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
    J Clin Oncol 23:880-8. 2005
  2. ncbi request reprint Rapid and accurate determination of MYCN copy number and 1p deletion in neuroblastoma by quantitative PCR
    John Anderson
    Department of Oncology, Great Ormond Street Hospital, Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
    Pediatr Blood Cancer 46:820-4. 2006
  3. pmc STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro
    Sam Behjati
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Sarcoma 2012:987239. 2012
  4. pmc Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein
    Stephen Nabarro
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London WC1N 1EH, England, UK
    J Exp Med 202:1399-410. 2005
  5. pmc Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma
    J Anderson
    Section of Paediatric Oncology, Institute of Cancer Research, Sutton, Surrey, UK
    Neoplasia 1:340-8. 1999
  6. pmc PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma
    J Anderson
    Unit of Molecular Haematology, Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
    Am J Pathol 159:1089-96. 2001
  7. doi request reprint Clinical and pathological features of paediatric malignant rhabdoid tumours
    Daniel A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
    Pediatr Blood Cancer 54:29-34. 2010
  8. ncbi request reprint Response without shrinkage in bilateral Wilms tumor: significance of rhabdomyomatous histology
    John Anderson
    Department of Hematology and Oncology, Great Ormond Street Hospital for Children, NHS Trust and Institute of Child Health, London, United Kingdom
    J Pediatr Hematol Oncol 24:31-4. 2002
  9. ncbi request reprint Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells
    Nourredine Himoudi
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
    J Immunol 181:6654-63. 2008
  10. pmc Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas
    Olesya Chayka
    Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
    J Natl Cancer Inst 101:663-77. 2009

Detail Information

Publications80

  1. ncbi request reprint Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype
    Daniel Williamson
    Molecular Cytogenetics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
    J Clin Oncol 23:880-8. 2005
    ..We aimed to study the phenomenon in the largest series to date...
  2. ncbi request reprint Rapid and accurate determination of MYCN copy number and 1p deletion in neuroblastoma by quantitative PCR
    John Anderson
    Department of Oncology, Great Ormond Street Hospital, Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
    Pediatr Blood Cancer 46:820-4. 2006
    ..There was no discordance between FISH and PCR results. Real time PCR is a reliable, accurate, and simple technique that can be applied to small neuroblastoma biopsies allowing rapid diagnosis...
  3. pmc STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro
    Sam Behjati
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Sarcoma 2012:987239. 2012
    ..Together these data support the investigation of STAT3 inhibitors for the Ewing family of tumors...
  4. pmc Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein
    Stephen Nabarro
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London WC1N 1EH, England, UK
    J Exp Med 202:1399-410. 2005
    ..This is the first time that an immunomodulatory role has been described for an oncogenic fusion protein...
  5. pmc Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma
    J Anderson
    Section of Paediatric Oncology, Institute of Cancer Research, Sutton, Surrey, UK
    Neoplasia 1:340-8. 1999
    ..Moreover, in tumours with p57(KIP2) expression, there was no evidence for inactivating mutations, suggesting that p57(KIP2) is not a tumour suppressor in rhabdomyosarcoma...
  6. pmc PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma
    J Anderson
    Unit of Molecular Haematology, Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
    Am J Pathol 159:1089-96. 2001
    ..In contrast, tumors grown as xenografts from individual clones derived from ARMS cell lines showed all of the classical morphological features of ARMS suggesting divergence in vivo from precursor cells propagated in culture...
  7. doi request reprint Clinical and pathological features of paediatric malignant rhabdoid tumours
    Daniel A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
    Pediatr Blood Cancer 54:29-34. 2010
    ..Although there are isolated reports of long-term survival with intensive, multimodal therapy, outcomes are generally poor...
  8. ncbi request reprint Response without shrinkage in bilateral Wilms tumor: significance of rhabdomyomatous histology
    John Anderson
    Department of Hematology and Oncology, Great Ormond Street Hospital for Children, NHS Trust and Institute of Child Health, London, United Kingdom
    J Pediatr Hematol Oncol 24:31-4. 2002
    ..To test the hypothesis that poor response to chemotherapy in patients with bilateral Wilms tumor may be associated with the appearance of rhabdomyomatous histology, suggesting a differentiation response...
  9. ncbi request reprint Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cells
    Nourredine Himoudi
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
    J Immunol 181:6654-63. 2008
    ..Our data suggest that bone marrow-derived IKDC represent a population that has powerful tumoricidal activity in vivo...
  10. pmc Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas
    Olesya Chayka
    Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
    J Natl Cancer Inst 101:663-77. 2009
    ..We investigated the role of clusterin in tumor development in mouse models of neuroblastoma...
  11. doi request reprint PAX5 expression in nonhematopoietic tissues. Reappraisal of previous studies
    Daniel A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, University College London, 30 Guilford Street, London, England
    Am J Clin Pathol 133:407-15. 2010
    ..Since the same PAX5 monoclonal antibody has been used consistently in the literature, these findings indicate a need for reappraisal of published PAX5 immunostaining results...
  12. ncbi request reprint Polyphenon [corrected] E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells
    Giorgia Santilli
    Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom
    Clin Cancer Res 19:1116-25. 2013
    ....
  13. ncbi request reprint MYCN as a target for cancer immunotherapy
    Nourredine Himoudi
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, WC1N 1EH, London, UK
    Cancer Immunol Immunother 57:693-700. 2008
    ..5 nM of VIL peptide. Therefore strong and specific immune responses against MYCN expressing tumours are possible in patients with the most common HLA class 1 type in the Caucasian population...
  14. doi request reprint Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures
    Rong Dong
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
    Cell Immunol 272:1-10. 2011
    ..Blockade of dendritic cell-specific transmembrane protein (DC-STAMP) decreased the number of binuclear cells in DC cultures. BNiDC represent a potentially tolerogenic population within DC preparations for clinical use...
  15. ncbi request reprint The MET receptor tyrosine kinase contributes to invasive tumour growth in rhabdomyosarcomas
    Helen Rees
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, WC1N 1EH, UK
    Growth Factors 24:197-208. 2006
    ..8-fold up regulated following addition of HGF to RH30 cells and in RMS tumours, CCN1 expression correlated with HGF expression. Surprisingly, we identified MET as a consistent feature of embryonal and not alveolar RMS...
  16. doi request reprint Increased PRAME antigen-specific killing of malignant cell lines by low avidity CTL clones, following treatment with 5-Aza-2'-Deoxycytidine
    Mengyong Yan
    Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Cancer Immunol Immunother 60:1243-55. 2011
    ..Together these data point to a general increased augmentation of cancer immunogenocity by DAC involving both antigen-specific and non-specific mechanisms...
  17. doi request reprint Development of cellular immune responses against PAX5, a novel target for cancer immunotherapy
    Mengyong Yan
    Units of Molecular Haematology and Cancer Biology, Institute of Child Health, University College London, London, United Kingdom
    Cancer Res 68:8058-65. 2008
    ..human tumors resulted in specific growth inhibition of PAX5-expressing tumors. This knowledge can be used for the therapeutic generation of CTL lines or the cloning of high-avidity T-cell receptor genes for use in adoptive immunotherapy...
  18. doi request reprint Patterns and predictors of the use of different antiretroviral drug regimens at treatment initiation in the UK
    P J Easterbrook
    Department of HIV GU Medicine, Kings College London School of Medicine at Guy s, London, UK
    HIV Med 9:47-56. 2008
    ..We describe the patterns of antiretroviral drug use at treatment initiation from 1996 to 2005 in a large UK multicentre cohort...
  19. ncbi request reprint The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo
    Shazia Irshad
    Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 12EH, UK
    J Biol Chem 279:21617-27. 2004
    ..It is possible that decreasing Brn-3b levels may reverse some effects on growth and proliferation of these cells...
  20. ncbi request reprint Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case
    Anthony Gordon
    Section of Molecular Carcinogenesis, Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, UK SM2 5NG, Surrey, UK
    Cancer Genet Cytogenet 140:73-7. 2003
    ..In addition, one of the cases classified as PRMS showed evidence for the presence of a PAX3-FOXO1A fusion gene, which is characteristic of the alveolar subtype of RMS...
  21. doi request reprint Persistent complete response after single-agent sunitinib treatment in a case of TFE translocation positive relapsed metastatic pediatric renal cell carcinoma
    Tanzina Chowdhury
    Department of Oncology, Great Ormond Street Hospital, UCL Institute of Child Health, London, UK
    J Pediatr Hematol Oncol 35:e1-3. 2013
    ..The published experience of sunitinib in TFE-RCC is limited, and prospective evaluation of its activity in a larger number of patients is warranted...
  22. ncbi request reprint Development of anti-PAX3 immune responses; a target for cancer immunotherapy
    Nourredine Himoudi
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, WC1N 1EH, UK
    Cancer Immunol Immunother 56:1381-95. 2007
    ..The ability to generate strong and specific anti PAX3 immune responses from the T cell repertoire in both mice and humans, provides evidence for PAX3 as a promising target for immunotherapy of cancer...
  23. pmc Detection of the PAX3-FKHR fusion gene in paediatric rhabdomyosarcoma: a reproducible predictor of outcome?
    J Anderson
    Section of Paediatric Oncology, Institute of Cancer Research, Sutton, Surrey, UK
    Br J Cancer 85:831-5. 2001
    ..This hypothesis requires testing in a prospective study. Variant t(1;13)/PAX7-FKHR appears biologically different, occurring in younger patients with more localised disease...
  24. ncbi request reprint Distant metastatic spread of molecularly proven infantile fibrosarcoma of the chest in a 2-month-old girl: case report and review of literature
    Martine van Grotel
    Departments of Pediatric Oncology Pathology, Great Ormond Street Hospital for Children NHS Trust Unit of Molecular Hematology and Cancer Biology, Institute of Child Health, University College London, London, UK Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr Hematol Oncol 36:231-3. 2014
    ..She achieved complete remission with chemotherapy and surgery. To our knowledge, this is the first reported case of molecularly proven IFS with distant metastatic spread. ..
  25. doi request reprint Migratory and antigen presentation functions of IFN-producing killer dendritic cells
    Nourredine Himoudi
    University College London Institute of Child Health, Great Ormond Street Hospital, United Kingdom
    Cancer Res 69:6598-606. 2009
    ..Therefore, BM-IKDCs are capable of cytotoxic killing of tumor targets and also of potent antigen presentation after encountering antigen in the context of a viable target cell...
  26. doi request reprint Ultrasound-guided core needle biopsy for the diagnosis of rhabdomyosarcoma in childhood
    Tanzina Chowdhury
    Department of Oncology, Great Ormond Street Hospital, London, UK
    Pediatr Blood Cancer 53:356-60. 2009
    ..We therefore sought to assess diagnostic accuracy and completeness, and procedure safety of consecutive patients diagnosed by needle biopsies in a single institution...
  27. doi request reprint The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation
    Ruth Lyons
    Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, United Kingdom
    Leuk Res 34:109-15. 2010
    ..In haemopoietic transplantation reconstitution assays Asef and TEL-AML1 together failed to induce a leukaemic phenotype...
  28. ncbi request reprint British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy
    A Pozniak
    Chelsea and Westminster Hospital, London, UK
    HIV Med 4:1-41. 2003
  29. ncbi request reprint Multicenter study of human immunodeficiency virus-related germ cell tumors
    T Powles
    Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 21:1922-7. 2003
    ..Testicular germ cell tumors (GCT) occur at increased frequency in men with human immunodeficiency virus (HIV). This multicenter study addresses the characteristics of these tumors...
  30. pmc New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK
    Giuseppe Barone
    Authors Affiliations Paediatric Solid Tumour Biology and Therapeutics Team, Division of Clinical Studies, The Institute of Cancer Research Children s and Young People s Unit Royal Marsden NHS Trust, Sutton and Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
    Clin Cancer Res 19:5814-21. 2013
    ....
  31. doi request reprint A novel small-molecule inhibitor of IL-6 signalling
    Giovanna Zinzalla
    Cancer Research UK Protein, The School of Pharmacy, University of London, London, United Kingdom
    Bioorg Med Chem Lett 20:7029-32. 2010
    ..It was also selectively cytostatic in MDA-MB-231 (STAT3-dependent) versus A4 (STAT3-null) cells suggesting STAT3-specific inhibitory properties...
  32. doi request reprint The immune environment of paediatric solid malignancies: evidence from an immunohistochemical study of clinical cases
    John R Apps
    UCL Institute of Child Health, London, UK
    Fetal Pediatr Pathol 32:298-307. 2013
    ..There was evidence for activation of STAT3 in pPNET (50%), ependymoma (45%) and undifferentiated sarcoma (38%), but it was rarely activated in other tumours...
  33. doi request reprint The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  34. doi request reprint Trends over calendar time in antiretroviral treatment success and failure in HIV clinic populations
    L Bansi
    UCL Medical School, Royal Free Campus, London, UK
    HIV Med 11:432-8. 2010
    ..Effective antiretroviral therapy (ART) has transformed the care of people with HIV, but it is important to monitor time trends in indicators of treatment success and antic future changes...
  35. pmc Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen
    Zoe Fox
    Copenhagen HIV Programme, University of Copenhagen Rigshospitalet, Copenhagen, Denmark
    AIDS 22:2279-89. 2008
    ..Limited data exist to guide clinical practice on the best interruption strategy to use...
  36. doi request reprint Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study
    R J C Gilson
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    HIV Med 11:152-60. 2010
    ..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes...
  37. pmc Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection
    Alison J Rodger
    HIV Epidemiology and Biostatistics Group, Research Dept of Infection and Population Health, UCL Medical School, University College London, London, UK
    J Infect Dis 200:973-83. 2009
    ..Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)-positive patients were examined...
  38. pmc Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarction
    C A Sabin
    Dept of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill St, London, NW3 2PF, United Kingdom
    Clin Infect Dis 46:1101-10. 2008
    ..We evaluated changes in risk factors for CVD and the use of lipid-lowering therapy in HIV-infected individuals and assessed the impact of any changes on the incidence of myocardial infarction...
  39. pmc Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  40. doi request reprint Feasibility and acceptability of offering rapid HIV tests to patients registering with primary care in London (UK): a pilot study
    A Prost
    MRC Social and Public HealthSciences Unit, Glasgow, UK
    Sex Transm Infect 85:326-9. 2009
    ..To assess the acceptability and feasibility of offering rapid HIV tests to patients registering with primary care in London, UK...
  41. doi request reprint Assessment of hospitalizations among HIV patients in the UK: a national cross-sectional survey
    A J Rodger
    Research Department of Infection and Population Health, Division of Population Health, University College London, UK
    Int J STD AIDS 21:752-4. 2010
    ..ADIs still make up a substantial proportion of inpatient work in the UK and late diagnosis and failure to benefit from cART remain too common...
  42. pmc Interruption of antiretroviral therapy is associated with increased plasma cystatin C
    Amanda Mocroft
    University College London Medical School, London, UK
    AIDS 23:71-82. 2009
    ....
  43. doi request reprint United Kingdom acquisition of HIV infection in African residents in London: more than previously thought
    Fiona M Burns
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, UK
    AIDS 23:262-6. 2009
    ..HIV prevention interventions for Africans must focus on reducing transmission within the UK as well as addressing infections acquired abroad...
  44. pmc CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  45. ncbi request reprint Previously unidentified complex cytogenetic changes found in a pediatric case of solid-pseudopapillary neoplasm of the pancreas
    H M Kempski
    Paediatric Malignancy Cytogenetics Unit, Great Ormond Street Hospital for Children, London, UK
    Cancer Genet Cytogenet 164:54-60. 2006
    ..These cumulative changes seem insufficient for activation of cell transformation, but could possibly play a role in priming the cell for future mutagenic events...
  46. doi request reprint Congenital malignant rhabdoid tumor of the scalp
    Alistair R M Cobb
    Craniofacial Centre, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    J Craniomaxillofac Surg 40:e258-60. 2012
    ..First thought a variant of Wilms' tumor in the kidney, it is recognized as presenting at renal, central nervous system and other extra-renal primary sites. It is uniformly of very poor prognosis, however...
  47. doi request reprint Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature
    D A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Pathol Oncol Res 14:233-8. 2008
    ..0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology...
  48. ncbi request reprint PAX3-FKHR chimeric oncoprotein: hiding itself from immune detection?
    John Anderson
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Cell Cycle 5:563-4. 2006
  49. ncbi request reprint B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survival
    Rebekka Schwab
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Blood Cells Mol Dis 39:263-71. 2007
    ..Thus, expression of stable, hypophosphorylated B-MYB in neuroblastoma may promote cell survival and induce aggressive tumour growth...
  50. ncbi request reprint Partner notification in pregnant women with HIV: findings from three inner-city clinics
    K M Forbes
    Barts and The London NHS Trust, London, UK
    HIV Med 9:433-5. 2008
    ..Care plans should include screening for intimate partner violence and housing problems; referral pathways should be established clearly when involving other agencies...
  51. doi request reprint The prevalence of hepatitis C virus (HCV) infection in HIV-positive individuals in the UK - trends in HCV testing and the impact of HCV on HIV treatment outcomes
    J Turner
    Centre for Sexual Health and HIV Research, UCL Medical School and The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    J Viral Hepat 17:569-77. 2010
    ..HCV infection had no impact on HIV virological outcomes or immunological response to HIV treatment. The long-term impact on morbidity and mortality remain to be determined...
  52. ncbi request reprint Women from Africa living with HIV in London: a descriptive study
    J Anderson
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, The Andrewes Unit, St Bartholomew s Hospital, London, UK
    AIDS Care 16:95-105. 2004
    ..Such similarities and differences need to be properly understood by health and social care professionals if they are to offer the most appropriate care for this growing population of patients...
  53. doi request reprint Social and economic hardship among people living with HIV in London
    F Ibrahim
    Department of Public Health, City University London, London, UK
    HIV Med 9:616-24. 2008
    ..To examine the social and economic circumstances of people living with HIV in London...
  54. ncbi request reprint Safety of nevirapine in pregnancy
    U Natarajan
    Department of Genitourinary Medicine, Guy s and St Thomas NHS Foundation Trust, London, UK
    HIV Med 8:64-9. 2007
    ..Nevirapine has been widely used in pregnancy for its efficacy, low pill burden, bioavailability and rapid transplacental transfer. Concern about nevirapine toxicity during pregnancy has emerged over recent years...
  55. ncbi request reprint Experience of delivering women with HIV in an inner city London hospital 1994-2004
    Maryam Parisaei
    Department of Obstetrics and Gynaecology, Homerton University Hospital, Homerton Row, London, UK
    Int J STD AIDS 18:527-30. 2007
    ..In conclusion, our observations suggest that with appropriate monitoring and management strategies, successful pregnancy outcomes can be achieved in a complex HIV-positive patient population...
  56. doi request reprint Licensing of killer dendritic cells in mouse and humans: functional similarities between IKDC and human blood γδ T-lymphocytes
    John Anderson
    Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
    J Immunotoxicol 9:259-66. 2012
    ....
  57. doi request reprint Inflammation: what role in pediatric cancer?
    Daniel A Morgenstern
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, London, UK
    Pediatr Blood Cancer 58:659-64. 2012
    ..An enhanced understanding of these processes will be of critical importance in developing novel therapeutic strategies...
  58. doi request reprint Patterns of shift in ADC distributions in abdominal tumours during chemotherapy-feasibility study
    Kirsteen McDonald
    Radiology Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Pediatr Radiol 41:99-106. 2011
    ..Apparent diffusion coefficient (ADC) relates to tissue cellularity, and change in ADC during chemotherapy may be a promising tool for assessing oncological response...
  59. ncbi request reprint Cytogenetic abnormalities in 42 rhabdomyosarcoma: a United Kingdom Cancer Cytogenetics Group Study
    T Gordon
    Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Med Pediatr Oncol 36:259-67. 2001
    ..There was no evidence for involvement of the PAX3/7-FKHR genes in ERMS, and cryptic involvement was found in some ARMS. There were no consistent chromosomal rearrangements associated with apparently translocation negative ARMS cases...
  60. pmc Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial
    Matthew R Sydes
    MRC Clinical Trials Unit, London, UK
    Trials 13:168. 2012
    ..We describe methodological and practical issues arising with (1) stopping recruitment to research arms following a pre-planned intermediate analysis and (2) adding a new research arm during the trial...
  61. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
    ..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...
  62. ncbi request reprint Uneventful administration of vincristine in Charcot-Marie-Tooth disease type 1X
    Richa Ajitsaria
    Department of Paediatric Oncology, Great Ormond Street Hospital, London, UK
    Pediatr Blood Cancer 50:874-6. 2008
    ..CMT should be excluded in any patient who develops a profound, acute neuropathy following vincristine, as many patients in the cases reviewed were asymptomatic prior to treatment...
  63. ncbi request reprint Immunohistochemical nuclear positivity for WT1 in childhood acute myeloid leukemia
    Mudner Al-Adnani
    Department of Paediatric Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, United Kingdom
    Fetal Pediatr Pathol 26:193-7. 2007
    ....
  64. pmc Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
    Rosalind A Eeles
    The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 41:1116-21. 2009
    ..In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33))...
  65. ncbi request reprint EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A
    D M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London, UK
    Oncogene 29:3134-45. 2010
    ..These results extend the hypothesis that EWS/ETS proteins induce expression of neuronal markers such as BRN3A in EFT by showing that the function of those same markers may be restricted or controlled in an EWS/ETS-dependent manner...
  66. ncbi request reprint An HIV-associated mediastinal germ cell tumour complicated by acute myeloid leukaemia
    A M Young
    Dept of Oncology, Chelsea and Westminster Hospital, London, UK
    J HIV Ther 12:68-71. 2007
  67. pmc Outcome of patients with HIV-related germ cell tumours: a case-control study
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    Br J Cancer 90:1526-30. 2004
    ..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population...
  68. ncbi request reprint A novel and consistent amplicon at 13q31 associated with alveolar rhabdomyosarcoma
    A T Gordon
    Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, Surrey, UK
    Genes Chromosomes Cancer 28:220-6. 2000
    ..This indicates that a gene or genes at 13q31 are significant in the development or progression of alveolar rhabdomyosarcoma...
  69. pmc Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43
    N A Alam
    Molecular and Population Genetics Laboratory and Skin Tumour Laboratory, Imperial Cancer Research Fund, Royal London Hospital, London, United Kingdom
    Am J Hum Genet 68:1264-9. 2001
    ..Identification of MCUL1 should have wide interest, since this gene may harbor low-penetrance variants predisposing to the common form of uterine fibroids and/or may undergo somatic mutation in sporadic leiomyomata...
  70. pmc Neuroblastoma in monozygotic twins--a case of probable twin-to-twin metastasis
    J Anderson
    Unit of Molecular Haematology, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Br J Cancer 85:493-6. 2001
    ..We propose an acquired neuroblastoma predisposition specific for twin 1, and in utero metastatic spread of tumour cells to twin 2 via the shared placental circulation...
  71. ncbi request reprint Platelet-derived growth factor receptors and ligands are up-regulated in paediatric fibromatoses
    S Gibson
    Department of Histopathology, Great Ormond Street Hospital for Children, London, UK
    Histopathology 51:752-7. 2007
    ..Overexpression of PDGF/R is reported in a wide range of solid tumours. The aim was to determine levels of PDGF/R expression in paediatric fibromatoses and myofibromatosis...
  72. ncbi request reprint Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephroma
    J Anderson
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Histopathology 48:748-53. 2006
    ..The aim was to investigate the relationship between the presence of this product and morphological phenotype using paraffin-embedded archival material...
  73. ncbi request reprint Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV
    S Parida
    Institute for Animal Health, Pirbright Laboratory, Surrey, UK
    Vaccine 24:964-9. 2006
    ..In these studies, combining the results of the IFN-gamma assay with virus neutralising antibody titre, in groups of vaccinated animals, provided a correlation with the capacity to control virus replication after subsequent challenge...
  74. pmc Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial
    Martin F Muers
    Leeds General Infirmary, Leeds, UK
    Lancet 371:1685-94. 2008
    ..We investigated whether the addition of chemotherapy to ASC improved survival and quality of life...
  75. ncbi request reprint Tolerability, efficacy and pharmacokinetics of bicalutamide 300 mg, 450 mg or 600 mg as monotherapy for patients with locally advanced or metastatic prostate cancer, compared with castration
    Chris J Tyrrell
    Derriford Hospital, Plymouth, UK
    BJU Int 98:563-72. 2006
    ....
  76. ncbi request reprint MYCN deregulation as a potential target for novel therapies in rhabdomyosarcoma
    Daniel A Morgenstern
    Northwick Park Hospital, Harrow, HA1 3UJ, UK
    Expert Rev Anticancer Ther 6:217-24. 2006
    ..A range of possible approaches to target MYCN is discussed, including nucleic acid-based and immunotherapy strategies...
  77. ncbi request reprint Bicalutamide 150 mg: practical prescribing in patients with early prostate cancer
    John Anderson
    Department of Urology, Royal Hallamshire Hospital, Sheffield, UK
    BJU Int 94:758-9. 2004
  78. ncbi request reprint Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA
    Andrew Godfrey
    Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London, United Kingdom WC1E 6BT
    Blood 105:2510-8. 2005
    ..This shows the use of lentiviral-mediated RNA interference in vivo as a potential therapeutic against a virally driven human cancer...
  79. ncbi request reprint Symptomatic thromboembolism after one-stage bilateral THA with a multimodal prophylaxis protocol
    Burak Beksac
    Hospital for Special Surgery and Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Clin Orthop Relat Res 463:114-9. 2007
    ....
  80. pmc Rescue of a chimeric rinderpest virus with the nucleocapsid protein derived from peste-des-petits-ruminants virus: use as a marker vaccine
    Satya Parida
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 88:2019-27. 2007
    ..The possibility of using this virus as a marker vaccine in association with a new diagnostic ELISA in the rinderpest eradication programme is discussed...