Research Topics
Genomes and Genes
| John AndersonSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtypeDaniel Williamson
Molecular Cytogenetics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
J Clin Oncol 23:880-8. 2005..CONCLUSION: MYCN deregulation is a feature of rhabdomyosarcoma tumorigenesis, defines groups of patients with a poor prognosis, and is a potential target for novel therapies...- Rapid and accurate determination of MYCN copy number and 1p deletion in neuroblastoma by quantitative PCRJohn Anderson
Department of Oncology, Great Ormond Street Hospital, Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
Pediatr Blood Cancer 46:820-4. 2006..There was no discordance between FISH and PCR results. Real time PCR is a reliable, accurate, and simple technique that can be applied to small neuroblastoma biopsies allowing rapid diagnosis... 
Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcomaJ Anderson
Section of Paediatric Oncology, Institute of Cancer Research, Sutton, Surrey, UK
Neoplasia 1:340-8. 1999..Moreover, in tumours with p57(KIP2) expression, there was no evidence for inactivating mutations, suggesting that p57(KIP2) is not a tumour suppressor in rhabdomyosarcoma...
Clinical and pathological features of paediatric malignant rhabdoid tumoursDaniel A Morgenstern
Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
Pediatr Blood Cancer 54:29-34. 2010..Although there are isolated reports of long-term survival with intensive, multimodal therapy, outcomes are generally poor...- PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcomaJ Anderson
Unit of Molecular Haematology, Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
Am J Pathol 159:1089-96. 2001..In contrast, tumors grown as xenografts from individual clones derived from ARMS cell lines showed all of the classical morphological features of ARMS suggesting divergence in vivo from precursor cells propagated in culture... - Response without shrinkage in bilateral Wilms tumor: significance of rhabdomyomatous histologyJohn Anderson
Department of Hematology and Oncology, Great Ormond Street Hospital for Children, NHS Trust and Institute of Child Health, London, United Kingdom
J Pediatr Hematol Oncol 24:31-4. 2002..To test the hypothesis that poor response to chemotherapy in patients with bilateral Wilms tumor may be associated with the appearance of rhabdomyomatous histology, suggesting a differentiation response... - Bone marrow-derived IFN-producing killer dendritic cells account for the tumoricidal activity of unpulsed dendritic cellsNourredine Himoudi
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, United Kingdom
J Immunol 181:6654-63. 2008..Our data suggest that bone marrow-derived IKDC represent a population that has powerful tumoricidal activity in vivo... - Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomasOlesya Chayka
Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
J Natl Cancer Inst 101:663-77. 2009..We investigated the role of clusterin in tumor development in mouse models of neuroblastoma... - PAX5 expression in nonhematopoietic tissues. Reappraisal of previous studiesDaniel A Morgenstern
Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, University College London, 30 Guilford Street, London, England
Am J Clin Pathol 133:407-15. 2010..Since the same PAX5 monoclonal antibody has been used consistently in the literature, these findings indicate a need for reappraisal of published PAX5 immunostaining results... - MYCN as a target for cancer immunotherapyNourredine Himoudi
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, WC1N 1EH, London, UK
Cancer Immunol Immunother 57:693-700. 2008..5 nM of VIL peptide. Therefore strong and specific immune responses against MYCN expressing tumours are possible in patients with the most common HLA class 1 type in the Caucasian population... - Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell culturesRong Dong
Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
Cell Immunol 272:1-10. 2011..Blockade of dendritic cell-specific transmembrane protein (DC-STAMP) decreased the number of binuclear cells in DC cultures. BNiDC represent a potentially tolerogenic population within DC preparations for clinical use... - Increased PRAME antigen-specific killing of malignant cell lines by low avidity CTL clones, following treatment with 5-Aza-2'-DeoxycytidineMengyong Yan
Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Cancer Immunol Immunother 60:1243-55. 2011..Together these data point to a general increased augmentation of cancer immunogenocity by DAC involving both antigen-specific and non-specific mechanisms... - Development of cellular immune responses against PAX5, a novel target for cancer immunotherapyMengyong Yan
Units of Molecular Haematology and Cancer Biology, Institute of Child Health, University College London, London, United Kingdom
Cancer Res 68:8058-65. 2008..human tumors resulted in specific growth inhibition of PAX5-expressing tumors. This knowledge can be used for the therapeutic generation of CTL lines or the cloning of high-avidity T-cell receptor genes for use in adoptive immunotherapy... - The MET receptor tyrosine kinase contributes to invasive tumour growth in rhabdomyosarcomasHelen Rees
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, WC1N 1EH, UK
Growth Factors 24:197-208. 2006..8-fold up regulated following addition of HGF to RH30 cells and in RMS tumours, CCN1 expression correlated with HGF expression. Surprisingly, we identified MET as a consistent feature of embryonal and not alveolar RMS... - Patterns and predictors of the use of different antiretroviral drug regimens at treatment initiation in the UKP J Easterbrook
Department of HIV GU Medicine, Kings College London School of Medicine at Guy s, London, UK
HIV Med 9:47-56. 2008..We describe the patterns of antiretroviral drug use at treatment initiation from 1996 to 2005 in a large UK multicentre cohort... - Development of anti-PAX3 immune responses; a target for cancer immunotherapyNourredine Himoudi
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, WC1N 1EH, UK
Cancer Immunol Immunother 56:1381-95. 2007..The ability to generate strong and specific anti PAX3 immune responses from the T cell repertoire in both mice and humans, provides evidence for PAX3 as a promising target for immunotherapy of cancer... - Detection of the PAX3-FKHR fusion gene in paediatric rhabdomyosarcoma: a reproducible predictor of outcome?J Anderson
Section of Paediatric Oncology, Institute of Cancer Research, Sutton, Surrey, UK
Br J Cancer 85:831-5. 2001..This hypothesis requires testing in a prospective study. Variant t(1;13)/PAX7-FKHR appears biologically different, occurring in younger patients with more localised disease... - The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivoShazia Irshad
Medical Molecular Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 12EH, UK
J Biol Chem 279:21617-27. 2004..It is possible that decreasing Brn-3b levels may reverse some effects on growth and proliferation of these cells... - Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one caseAnthony Gordon
Section of Molecular Carcinogenesis, Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, UK SM2 5NG, Surrey, UK
Cancer Genet Cytogenet 140:73-7. 2003..In addition, one of the cases classified as PRMS showed evidence for the presence of a PAX3-FOXO1A fusion gene, which is characteristic of the alveolar subtype of RMS... - Ultrasound-guided core needle biopsy for the diagnosis of rhabdomyosarcoma in childhoodTanzina Chowdhury
Department of Oncology, Great Ormond Street Hospital, London, UK
Pediatr Blood Cancer 53:356-60. 2009..We therefore sought to assess diagnostic accuracy and completeness, and procedure safety of consecutive patients diagnosed by needle biopsies in a single institution... - The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformationRuth Lyons
Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, United Kingdom
Leuk Res 34:109-15. 2010..In haemopoietic transplantation reconstitution assays Asef and TEL-AML1 together failed to induce a leukaemic phenotype... - Multicenter study of human immunodeficiency virus-related germ cell tumorsT Powles
Chelsea and Westminster Hospital, London, United Kingdom
J Clin Oncol 21:1922-7. 2003..After a median follow-up of 4.6 years, 9% of the patients died from GCT. Most of the mortality relates to HIV infection... - British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapyA Pozniak
Chelsea and Westminster Hospital, London, UK
HIV Med 4:1-41. 2003 - STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In VitroSam Behjati
Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Sarcoma 2012:987239. 2012..Together these data support the investigation of STAT3 inhibitors for the Ewing family of tumors... - Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoproteinStephen Nabarro
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London WC1N 1EH, England, UK
J Exp Med 202:1399-410. 2005..This is the first time that an immunomodulatory role has been described for an oncogenic fusion protein... - Migratory and antigen presentation functions of IFN-producing killer dendritic cellsNourredine Himoudi
University College London Institute of Child Health, Great Ormond Street Hospital, United Kingdom
Cancer Res 69:6598-606. 2009..Therefore, BM-IKDCs are capable of cytotoxic killing of tumor targets and also of potent antigen presentation after encountering antigen in the context of a viable target cell... - The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapyC A Sabin
Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
HIV Med 10:35-43. 2009.... - Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarctionC A Sabin
Dept of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill St, London, NW3 2PF, United Kingdom
Clin Infect Dis 46:1101-10. 2008..We evaluated changes in risk factors for CVD and the use of lipid-lowering therapy in HIV-infected individuals and assessed the impact of any changes on the incidence of myocardial infarction... - Interruption of antiretroviral therapy is associated with increased plasma cystatin CAmanda Mocroft
University College London Medical School, London, UK
AIDS 23:71-82. 2009.... - United Kingdom acquisition of HIV infection in African residents in London: more than previously thoughtFiona M Burns
Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, UK
AIDS 23:262-6. 2009..HIV prevention interventions for Africans must focus on reducing transmission within the UK as well as addressing infections acquired abroad... - CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UKMark Bower
Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
Haematologica 94:875-80. 2009..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma... - Feasibility and acceptability of offering rapid HIV tests to patients registering with primary care in London (UK): a pilot studyA Prost
MRC Social and Public HealthSciences Unit, Glasgow, UK
Sex Transm Infect 85:326-9. 2009..To assess the acceptability and feasibility of offering rapid HIV tests to patients registering with primary care in London, UK... - Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) StudyR J C Gilson
Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
HIV Med 11:152-60. 2010..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes... - Trends over calendar time in antiretroviral treatment success and failure in HIV clinic populationsL Bansi
UCL Medical School, Royal Free Campus, London, UK
HIV Med 11:432-8. 2010..Effective antiretroviral therapy (ART) has transformed the care of people with HIV, but it is important to monitor time trends in indicators of treatment success and antic future changes... - Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational studyRebecca K Lodwick
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
Lancet 376:340-5. 2010..We aimed to examine this by analysis of pooled data from industrialised countries... - Assessment of hospitalizations among HIV patients in the UK: a national cross-sectional surveyA J Rodger
Research Department of Infection and Population Health, Division of Population Health, University College London, UK
Int J STD AIDS 21:752-4. 2010..ADIs still make up a substantial proportion of inpatient work in the UK and late diagnosis and failure to benefit from cART remain too common... - Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infectionAlison J Rodger
HIV Epidemiology and Biostatistics Group, Research Dept of Infection and Population Health, UCL Medical School, University College London, London, UK
J Infect Dis 200:973-83. 2009..Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)-positive patients were examined... - Viral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimenZoe Fox
Copenhagen HIV Programme, University of Copenhagen Rigshospitalet, Copenhagen, Denmark
AIDS 22:2279-89. 2008..Limited data exist to guide clinical practice on the best interruption strategy to use... - Previously unidentified complex cytogenetic changes found in a pediatric case of solid-pseudopapillary neoplasm of the pancreasH M Kempski
Paediatric Malignancy Cytogenetics Unit, Great Ormond Street Hospital for Children, London, UK
Cancer Genet Cytogenet 164:54-60. 2006..These cumulative changes seem insufficient for activation of cell transformation, but could possibly play a role in priming the cell for future mutagenic events... - Persistent Complete Response After Single-agent Sunitinib Treatment in a Case of TFE Translocation Positive Relapsed Metastatic Pediatric Renal Cell CarcinomaTanzina Chowdhury
Departments of Oncology Histopathology Urology, Great Ormond Street Hospital Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK Our Lady s Children s Hospital, Dublin, Republic of Ireland
J Pediatr Hematol Oncol 35:e1-3. 2013..The published experience of sunitinib in TFE-RCC is limited, and prospective evaluation of its activity in a larger number of patients is warranted... - B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survivalRebekka Schwab
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Blood Cells Mol Dis 39:263-71. 2007..Thus, expression of stable, hypophosphorylated B-MYB in neuroblastoma may promote cell survival and induce aggressive tumour growth... - A novel small-molecule inhibitor of IL-6 signallingGiovanna Zinzalla
Cancer Research UK Protein, The School of Pharmacy, University of London, London, United Kingdom
Bioorg Med Chem Lett 20:7029-32. 2010..It was also selectively cytostatic in MDA-MB-231 (STAT3-dependent) versus A4 (STAT3-null) cells suggesting STAT3-specific inhibitory properties... - PAX3-FKHR chimeric oncoprotein: hiding itself from immune detection?John Anderson
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
Cell Cycle 5:563-4. 2006 - Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literatureD A Morgenstern
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
Pathol Oncol Res 14:233-8. 2008..0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology... - Social and economic hardship among people living with HIV in LondonF Ibrahim
Department of Public Health, City University London, London, UK
HIV Med 9:616-24. 2008..To examine the social and economic circumstances of people living with HIV in London... - Partner notification in pregnant women with HIV: findings from three inner-city clinicsK M Forbes
Barts and The London NHS Trust, London, UK
HIV Med 9:433-5. 2008..Care plans should include screening for intimate partner violence and housing problems; referral pathways should be established clearly when involving other agencies... - Women from Africa living with HIV in London: a descriptive studyJ Anderson
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, The Andrewes Unit, St Bartholomew s Hospital, London, UK
AIDS Care 16:95-105. 2004..Such similarities and differences need to be properly understood by health and social care professionals if they are to offer the most appropriate care for this growing population of patients... - The prevalence of hepatitis C virus (HCV) infection in HIV-positive individuals in the UK - trends in HCV testing and the impact of HCV on HIV treatment outcomesJ Turner
Centre for Sexual Health and HIV Research, UCL Medical School and The Mortimer Market Centre, Camden Primary Care Trust, London, UK
J Viral Hepat 17:569-77. 2010..HCV infection had no impact on HIV virological outcomes or immunological response to HIV treatment. The long-term impact on morbidity and mortality remain to be determined... - Safety of nevirapine in pregnancyU Natarajan
Department of Genitourinary Medicine, Guy s and St Thomas NHS Foundation Trust, London, UK
HIV Med 8:64-9. 2007..Nevirapine has been widely used in pregnancy for its efficacy, low pill burden, bioavailability and rapid transplacental transfer. Concern about nevirapine toxicity during pregnancy has emerged over recent years... - Experience of delivering women with HIV in an inner city London hospital 1994-2004Maryam Parisaei
Department of Obstetrics and Gynaecology, Homerton University Hospital, Homerton Row, London, UK
Int J STD AIDS 18:527-30. 2007..In conclusion, our observations suggest that with appropriate monitoring and management strategies, successful pregnancy outcomes can be achieved in a complex HIV-positive patient population... - Licensing of killer dendritic cells in mouse and humans: functional similarities between IKDC and human blood γδ T-lymphocytesJohn Anderson
Unit of Molecular Haematology and Cancer Biology, UCL Institute of Child Health, London, UK
J Immunotoxicol 9:259-66. 2012.... - Inflammation: what role in pediatric cancer?Daniel A Morgenstern
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, London, UK
Pediatr Blood Cancer 58:659-64. 2012..An enhanced understanding of these processes will be of critical importance in developing novel therapeutic strategies... - Patterns of shift in ADC distributions in abdominal tumours during chemotherapy-feasibility studyKirsteen McDonald
Radiology Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
Pediatr Radiol 41:99-106. 2011..Apparent diffusion coefficient (ADC) relates to tissue cellularity, and change in ADC during chemotherapy may be a promising tool for assessing oncological response... - Cytogenetic abnormalities in 42 rhabdomyosarcoma: a United Kingdom Cancer Cytogenetics Group StudyT Gordon
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Med Pediatr Oncol 36:259-67. 2001..There was no evidence for involvement of the PAX3/7-FKHR genes in ERMS, and cryptic involvement was found in some ARMS. There were no consistent chromosomal rearrangements associated with apparently translocation negative ARMS cases... 
A molecular map of mesenchymal tumorsStephen R Henderson
Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
Genome Biol 6:R76. 2005..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...- Uneventful administration of vincristine in Charcot-Marie-Tooth disease type 1XRicha Ajitsaria
Department of Paediatric Oncology, Great Ormond Street Hospital, London, UK
Pediatr Blood Cancer 50:874-6. 2008..CMT should be excluded in any patient who develops a profound, acute neuropathy following vincristine, as many patients in the cases reviewed were asymptomatic prior to treatment... - Immunohistochemical nuclear positivity for WT1 in childhood acute myeloid leukemiaMudner Al Adnani
Department of Paediatric Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, United Kingdom
Fetal Pediatr Pathol 26:193-7. 2007.... - Identification of seven new prostate cancer susceptibility loci through a genome-wide association studyRosalind A Eeles
The Institute of Cancer Research, Sutton, Surrey, UK
Nat Genet 41:1116-21. 2009..In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33))... - Outcome of patients with HIV-related germ cell tumours: a case-control studyT Powles
Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
Br J Cancer 90:1526-30. 2004..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population... - EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3AD M Gascoyne
Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London, UK
Oncogene 29:3134-45. 2010..These results extend the hypothesis that EWS/ETS proteins induce expression of neuronal markers such as BRN3A in EFT by showing that the function of those same markers may be restricted or controlled in an EWS/ETS-dependent manner... - An HIV-associated mediastinal germ cell tumour complicated by acute myeloid leukaemiaA M Young
Dept. of Oncology, Chelsea and Westminster Hospital, London, UK
J HIV Ther 12:68-71. 2007 - A novel and consistent amplicon at 13q31 associated with alveolar rhabdomyosarcomaA T Gordon
Molecular Cytogenetics Laboratory, Institute of Cancer Research, Sutton, Surrey, UK
Genes Chromosomes Cancer 28:220-6. 2000..This indicates that a gene or genes at 13q31 are significant in the development or progression of alveolar rhabdomyosarcoma... - Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43N A Alam
Molecular and Population Genetics Laboratory and Skin Tumour Laboratory, Imperial Cancer Research Fund, Royal London Hospital, London, United Kingdom
Am J Hum Genet 68:1264-9. 2001..Identification of MCUL1 should have wide interest, since this gene may harbor low-penetrance variants predisposing to the common form of uterine fibroids and/or may undergo somatic mutation in sporadic leiomyomata... - Platelet-derived growth factor receptors and ligands are up-regulated in paediatric fibromatosesS Gibson
Department of Histopathology, Great Ormond Street Hospital for Children, London, UK
Histopathology 51:752-7. 2007..Overexpression of PDGF/R is reported in a wide range of solid tumours. The aim was to determine levels of PDGF/R expression in paediatric fibromatoses and myofibromatosis... - Neuroblastoma in monozygotic twins--a case of probable twin-to-twin metastasisJ Anderson
Unit of Molecular Haematology, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, UK
Br J Cancer 85:493-6. 2001..We propose an acquired neuroblastoma predisposition specific for twin 1, and in utero metastatic spread of tumour cells to twin 2 via the shared placental circulation... - Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDVS Parida
Institute for Animal Health, Pirbright Laboratory, Surrey, UK
Vaccine 24:964-9. 2006..In these studies, combining the results of the IFN-gamma assay with virus neutralising antibody titre, in groups of vaccinated animals, provided a correlation with the capacity to control virus replication after subsequent challenge... - Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephromaJ Anderson
Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
Histopathology 48:748-53. 2006..Differences in expression levels may explain previous conflicting data on fusion gene detection in these tumours... - Tolerability, efficacy and pharmacokinetics of bicalutamide 300 mg, 450 mg or 600 mg as monotherapy for patients with locally advanced or metastatic prostate cancer, compared with castrationChris J Tyrrell
Derriford Hospital, Plymouth, UK
BJU Int 98:563-72. 2006.... - MYCN deregulation as a potential target for novel therapies in rhabdomyosarcomaDaniel A Morgenstern
Northwick Park Hospital, Harrow, HA1 3UJ, UK
Expert Rev Anticancer Ther 6:217-24. 2006..A range of possible approaches to target MYCN is discussed, including nucleic acid-based and immunotherapy strategies... - Bicalutamide 150 mg: practical prescribing in patients with early prostate cancerJohn Anderson
Department of Urology, Royal Hallamshire Hospital, Sheffield, UK
BJU Int 94:758-9. 2004 - Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trialMartin F Muers
Leeds General Infirmary, Leeds, UK
Lancet 371:1685-94. 2008..We investigated whether the addition of chemotherapy to ASC improved survival and quality of life... - Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNAAndrew Godfrey
Cancer Research United Kingdom Viral Oncology Group, Wolfson Institute for Biomedical Research, UCL, Gower Street, London, United Kingdom WC1E 6BT
Blood 105:2510-8. 2005..This shows the use of lentiviral-mediated RNA interference in vivo as a potential therapeutic against a virally driven human cancer... - Symptomatic thromboembolism after one-stage bilateral THA with a multimodal prophylaxis protocolBurak Beksac
Hospital for Special Surgery and Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
Clin Orthop Relat Res 463:114-9. 2007.... - Rescue of a chimeric rinderpest virus with the nucleocapsid protein derived from peste-des-petits-ruminants virus: use as a marker vaccineSatya Parida
Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
J Gen Virol 88:2019-27. 2007..The possibility of using this virus as a marker vaccine in association with a new diagnostic ELISA in the rinderpest eradication programme is discussed...