Ian M Anderson

..Atypical antipsychotics may have efficacy as augmentation therapy in treatment resistant depression (TRD) but evidence is limited...

..If this is successful then phMRI will provide a genuinely exciting opportunity for the rapid development of better treatments for psychiatric conditions...

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..No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli...

..77% responding, P<0.05), with improvement maintained to 12 weeks. This therapy could be a useful addition to available treatments but further research is needed to determine the optimum treatment parameters...

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..Negative biases in emotional processing are well recognised in people who are currently depressed but are less well described in those with a history of depression, where such biases may contribute to vulnerability to relapse...

..This involves a personalised assessment of the likely benefits and risks of both psychological and drug approaches when recommending treatment for someone with depression...

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..This suggests the problem might lie in the integrated functioning of emotion processing circuits...

..However, further studies are needed to elucidate the role of CNR1 and the cannabinoid system in migraine...

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..In conclusion, our study demonstrates the role of the TPH2 gene and the serotonin system in risk taking and suggests that TPH2 gene may contribute to the expression of psychiatric phenotypes through altered decision making...

..They also provide targets for the further investigation into the pathophysiology of addiction and impulse-control disorders...

..Stimuli with social context represent a distinct class of emotional stimuli, which in healthy volunteers are associated with specific neural substrates but have not previously been studied relative to vulnerability to depression...

..Combining drug challenge with fMRI (pharmacoMRI; pMRI) is a promising tool for investigating these processes in healthy as well as patient groups...

..The results suggest that mCPP-challenge phMRI produces reliable patterns of response that are mediated by 5-HT(2C) receptors; these responses may therefore be useful in-vivo measures of 5-HT(2C) function in psychiatric disorders...

..This study also suggests that the CNR1 gene influences vulnerability to recent psychosocial adversity to produce current symptoms of depression...

..We hypothesize that patients with psoriasis, in this case male patients, develop a coping mechanism to protect them from stressful emotional responses by blocking the processing of disgusted facial expressions...

..The final section presents an overview of this literature and considers implications for understanding the pathophysiology of mood disorder as well as developing and evaluating new treatment strategies...

..Hydrocortisone infusion phMRI may be a useful tool to investigate hippocampal corticosteroid receptor function in depression...

..In line with previous research findings, impulsive-antisocial conduct shows an inverse relationship with 5-HT function. Arrogant/deceitful traits correlate positively with 5-HT function and may be an adaptive component of psychopathy...

..The technique of combining drug challenge with fMRI (pharmacoMRI) has promise for investigating human psychiatric disorders...

..The guidelines cover the diagnosis of anxiety disorders and key steps in clinical management, including acute treatment, relapse prevention and approaches for patients who do not respond to first-line treatments...

..Antidepressant discontinuation in depressed patients can be associated with worsening depression and increased suicidality...

..Acute tryptophan depletion (ATD) is a technique that produces a decrease in central 5-HT levels in vivo. This study investigated the role of 5-HT in the behavioral response to a C/UC stress paradigm with ATD...