Research Topics
Genomes and Genes | Yassine AmraniSummaryAffiliation: University of Leicester Country: UK Publications
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Publications
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13Yassine Amrani
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
Respir Res 11:104. 2010..The purpose of this study was to define the role of oxytocin in modulating human airway smooth muscle (HASMCs) function in the presence and absence of IL-13 and TNFalpha, cytokines known to be important in asthma...- Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1Omar Tliba
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Room 1214, Philadelphia, PA 19104 3403, USA
Am J Respir Cell Mol Biol 38:463-72. 2008..Collectively, our findings demonstrate for the first time that IRF-1 is a novel alternative GRbeta-independent mechanism mediating steroid dysfunction induced by pro-asthmatic cytokines, in part via the suppression of GRalpha activities... - Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsivenessDeepika Jain
Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Immunobiology 213:499-509. 2008..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR... - Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cellsReena Bhandare
Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
Am J Respir Cell Mol Biol 42:9-15. 2010.... - Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosisElena A Goncharova
Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
Mol Pharmacol 76:766-77. 2009..Thus, STAT3 may provide a novel therapeutic target for diseases associated with TSC1/TSC2 dysfunction... 
Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathwayOmar Tliba
Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6160, USA
Mol Pharmacol 66:322-9. 2004..Our study is the first to demonstrate that IFNbeta-dependent activation of CD38 pathway is a novel component by which TNFalpha differentially regulates the expression of inflammatory genes in ASM cells...- TGF-beta potentiates airway smooth muscle responsiveness to bradykininJenny H Kim
Pulmonary, Allergy, and Critical Care Division, Dept. of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005.... - IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscleOmar Tliba
Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Br J Pharmacol 140:1159-62. 2003..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling... - Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferationElena A Goncharova
Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
Mol Pharmacol 73:778-88. 2008.... - An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthmaGautam Damera
Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e28504. 2012..These studies indicate that increased RGS4 expression promotes a phenotypic switch of ASM, evoking irreversible airway obstruction in subjects with severe asthma... - Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon betaOmar Tliba
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:50615-23. 2003..Together these data show that TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis... - CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoformOmar Tliba
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, 19104 6160, USA
Mol Pharmacol 69:588-96. 2006.... - Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activityStefan Keslacy
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, University of Pennsylvania School of Medicine, Translational Research Laboratories Building, Philadelphia PA 19104 3403, USA
Mol Pharmacol 71:609-18. 2007..Together, our data indicate that IFNgamma is a potent inhibitor of specific TNFalpha-inducible inflammatory genes by acting on NF-kappaB transactivation via the modulation of HDAC function... - Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genesFloyd Dukes
Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
BMC Complement Altern Med 12:47. 2012..We therefore postulated that flaxseed might modulate gene expression of vital signaling pathways, thus interfering with the development of tissue injury... - Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatasesBelaid Bouazza
Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107 5233, USA
Am J Respir Cell Mol Biol 47:464-73. 2012..We propose that the novel mechanism that proasthmatic cytokine-induced CSI in ASMCs is due, in part, to PP5-mediated impairment of GR-Ser211 phosphorylation... - Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependentAltaf S Kazi
Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004..We conclude that ASM-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma... - Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contactE Berla Thangam
Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6002, USA
FASEB J 19:798-800. 2005.... - Bronchial hyperresponsiveness: insights into new signaling moleculesYassine Amrani
Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Curr Opin Pharmacol 4:230-4. 2004..Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness... - Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathwaysOmar Tliba
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Proc Am Thorac Soc 5:106-12. 2008.... 
Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?Omar Tliba
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104 3403, USA
Chest 133:236-42. 2008..This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma...- TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KClHang Chen
Deparment of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 1904, USA
J Appl Physiol 95:864-72; discussion 863. 2003..Taken together, these data suggest that TNF-alpha may participate in the development of airway hyperresponsiveness in asthma via the modulation of ASM responsiveness to both contractile and beta-adrenoceptor GPCR agonists... - Immunopathogenesis of severe asthmaChristopher E Brightling
Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, UK
Curr Pharm Des 17:667-73. 2011.... - Targeting TNF-alpha: a novel therapeutic approach for asthmaChristopher Brightling
Institute of Lung Health, University of Leicester, Leicester, United Kingdom
J Allergy Clin Immunol 121:5-10; quiz 11-2. 2008..Therefore the challenge for clinicians is to evaluate the risk/benefit ratio of these therapies in individual patients with asthma... - Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in micePaul Kinniry
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, USA
J Nutr 136:1545-51. 2006..0001), and decreased with FS treatment following acid aspiration (P = 0.011). Dietary FS decreased lung inflammation and lipid peroxidation, suggesting a protective role against pro-oxidant-induced tissue damage in vivo... - IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathwayYassine Amrani
Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003.... - Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthmaYassine Amrani
Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, 848 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Curr Opin Allergy Clin Immunol 2:39-45. 2002..Studies using isolated bronchial preparations or cultured cells show that inflammatory mediators and cytokines may alter calcium homeostasis in airway smooth muscle and render the cells nonspecifically hyperreactive to agonists...
Research Grants
- Mechanisims Regulation Functions of Airway Smooth MuscleYassine Amrani; Fiscal Year: 2006..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..