Yassine Amrani

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
  2. pmc Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Room 1214, Philadelphia, PA 19104 3403, USA
    Am J Respir Cell Mol Biol 38:463-72. 2008
  3. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
  4. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
  5. pmc Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    Mol Pharmacol 76:766-77. 2009
  6. ncbi Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
  7. ncbi TGF-beta potentiates airway smooth muscle responsiveness to bradykinin
    Jenny H Kim
    Pulmonary, Allergy, and Critical Care Division, Dept of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005
  8. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
  9. ncbi Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
  10. pmc An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28504. 2012

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Respir Res 11:104. 2010
    ..The purpose of this study was to define the role of oxytocin in modulating human airway smooth muscle (HASMCs) function in the presence and absence of IL-13 and TNFalpha, cytokines known to be important in asthma...
  2. pmc Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Room 1214, Philadelphia, PA 19104 3403, USA
    Am J Respir Cell Mol Biol 38:463-72. 2008
    ..Collectively, our findings demonstrate for the first time that IRF-1 is a novel alternative GRbeta-independent mechanism mediating steroid dysfunction induced by pro-asthmatic cytokines, in part via the suppression of GRalpha activities...
  3. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
    ..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR...
  4. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
    ....
  5. pmc Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    Mol Pharmacol 76:766-77. 2009
    ..Thus, STAT3 may provide a novel therapeutic target for diseases associated with TSC1/TSC2 dysfunction...
  6. ncbi Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
    ..Our study is the first to demonstrate that IFNbeta-dependent activation of CD38 pathway is a novel component by which TNFalpha differentially regulates the expression of inflammatory genes in ASM cells...
  7. ncbi TGF-beta potentiates airway smooth muscle responsiveness to bradykinin
    Jenny H Kim
    Pulmonary, Allergy, and Critical Care Division, Dept of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005
    ....
  8. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  9. ncbi Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
    ....
  10. pmc An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
    Gautam Damera
    Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e28504. 2012
    ..These studies indicate that increased RGS4 expression promotes a phenotypic switch of ASM, evoking irreversible airway obstruction in subjects with severe asthma...
  11. ncbi Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:50615-23. 2003
    ..Together these data show that TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis...
  12. ncbi CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, 19104 6160, USA
    Mol Pharmacol 69:588-96. 2006
    ....
  13. ncbi Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity
    Stefan Keslacy
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, University of Pennsylvania School of Medicine, Translational Research Laboratories Building, Philadelphia PA 19104 3403, USA
    Mol Pharmacol 71:609-18. 2007
    ..Together, our data indicate that IFNgamma is a potent inhibitor of specific TNFalpha-inducible inflammatory genes by acting on NF-kappaB transactivation via the modulation of HDAC function...
  14. pmc Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
    Floyd Dukes
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Complement Altern Med 12:47. 2012
    ..We therefore postulated that flaxseed might modulate gene expression of vital signaling pathways, thus interfering with the development of tissue injury...
  15. pmc Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases
    Belaid Bouazza
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 47:464-73. 2012
    ..We propose that the novel mechanism that proasthmatic cytokine-induced CSI in ASMCs is due, in part, to PP5-mediated impairment of GR-Ser211 phosphorylation...
  16. ncbi Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
    Altaf S Kazi
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004
    ..We conclude that ASM-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma...
  17. ncbi Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact
    E Berla Thangam
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    FASEB J 19:798-800. 2005
    ....
  18. ncbi Bronchial hyperresponsiveness: insights into new signaling molecules
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Pharmacol 4:230-4. 2004
    ..Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness...
  19. pmc Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Proc Am Thorac Soc 5:106-12. 2008
    ....
  20. ncbi Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104 3403, USA
    Chest 133:236-42. 2008
    ..This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma...
  21. ncbi TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl
    Hang Chen
    Deparment of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 1904, USA
    J Appl Physiol (1985) 95:864-72; discussion 863. 2003
    ..Taken together, these data suggest that TNF-alpha may participate in the development of airway hyperresponsiveness in asthma via the modulation of ASM responsiveness to both contractile and beta-adrenoceptor GPCR agonists...
  22. ncbi Immunopathogenesis of severe asthma
    Christopher E Brightling
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, UK
    Curr Pharm Des 17:667-73. 2011
    ....
  23. pmc Targeting TNF-alpha: a novel therapeutic approach for asthma
    Christopher Brightling
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:5-10; quiz 11-2. 2008
    ..Therefore the challenge for clinicians is to evaluate the risk/benefit ratio of these therapies in individual patients with asthma...
  24. ncbi Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice
    Paul Kinniry
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, USA
    J Nutr 136:1545-51. 2006
    ..0001), and decreased with FS treatment following acid aspiration (P = 0.011). Dietary FS decreased lung inflammation and lipid peroxidation, suggesting a protective role against pro-oxidant-induced tissue damage in vivo...
  25. ncbi IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  26. ncbi Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma
    Yassine Amrani
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, 848 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 2:39-45. 2002
    ..Studies using isolated bronchial preparations or cultured cells show that inflammatory mediators and cytokines may alter calcium homeostasis in airway smooth muscle and render the cells nonspecifically hyperreactive to agonists...

Research Grants3

  1. Mechanisms Regulation Functions of Airway Smooth Muscle
    Yassine Amrani; Fiscal Year: 2004
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  2. Mechanisims Regulation Functions of Airway Smooth Muscle
    Yassine Amrani; Fiscal Year: 2005
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  3. Mechanisims Regulation Functions of Airway Smooth Muscle
    Yassine Amrani; Fiscal Year: 2006
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..