Linda A Amos

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Structural/functional homology between the bacterial and eukaryotic cytoskeletons
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Opin Cell Biol 16:24-31. 2004
  2. ncbi request reprint Studying the structure of microtubules by electron microscopy
    Linda A Amos
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Methods Mol Med 137:65-91. 2007
  3. ncbi request reprint Molecules of the bacterial cytoskeleton
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Annu Rev Biophys Biomol Struct 33:177-98. 2004
  4. doi request reprint New insights into the mechanisms of cytomotive actin and tubulin filaments
    Christopher H S Aylett
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Int Rev Cell Mol Biol 292:1-71. 2011
  5. doi request reprint Evolution of cytomotive filaments: the cytoskeleton from prokaryotes to eukaryotes
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Int J Biochem Cell Biol 41:323-9. 2009
  6. pmc F-actin-like filaments formed by plasmid segregation protein ParM
    Fusinita van den Ent
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 21:6935-43. 2002
  7. pmc A cool look at the structural changes in kinesin motor domains
    Linda A Amos
    MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
    J Cell Sci 120:3919-27. 2007
  8. ncbi request reprint Microtubules and maps
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Adv Protein Chem 71:257-98. 2005
  9. pmc Structure of the tubulin/FtsZ-like protein TubZ from Pseudomonas bacteriophage ΦKZ
    Christopher H S Aylett
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    J Mol Biol 425:2164-73. 2013
  10. pmc Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving
    Harry H Low
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Cell 139:1342-52. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Structural/functional homology between the bacterial and eukaryotic cytoskeletons
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Opin Cell Biol 16:24-31. 2004
    ..Bacterial MinD and eukaryotic dynamin appear to have similar functions in membrane control. In dividing eukaryotic organelles of bacterial origin, bacterial and eukaryotic proteins work together...
  2. ncbi request reprint Studying the structure of microtubules by electron microscopy
    Linda A Amos
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Methods Mol Med 137:65-91. 2007
    ..Gold labeling can be used to mark the positions of certain regions of protein sequence...
  3. ncbi request reprint Molecules of the bacterial cytoskeleton
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Annu Rev Biophys Biomol Struct 33:177-98. 2004
    ..Mollicutes seem to have developed special systems for cell shape determination and motility, such as the fibril protein in Spiroplasma...
  4. doi request reprint New insights into the mechanisms of cytomotive actin and tubulin filaments
    Christopher H S Aylett
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Int Rev Cell Mol Biol 292:1-71. 2011
    ..Detailed comparisons of the structures of related proteins from eubacteria, archaea, and eukaryotes are helping to illuminate the course of evolution...
  5. doi request reprint Evolution of cytomotive filaments: the cytoskeleton from prokaryotes to eukaryotes
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Int J Biochem Cell Biol 41:323-9. 2009
    ..A possible evolutionary relationship of WACAs with eukaryotic septins is discussed...
  6. pmc F-actin-like filaments formed by plasmid segregation protein ParM
    Fusinita van den Ent
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 21:6935-43. 2002
    ..Thus, there is now evidence for cytoskeletal structures, formed by actin-like filaments that are involved in plasmid partitioning in E.coli...
  7. pmc A cool look at the structural changes in kinesin motor domains
    Linda A Amos
    MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
    J Cell Sci 120:3919-27. 2007
    ....
  8. ncbi request reprint Microtubules and maps
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Adv Protein Chem 71:257-98. 2005
    ..We review the recent progress that has been made in obtaining a glimpse of the structural interactions involved...
  9. pmc Structure of the tubulin/FtsZ-like protein TubZ from Pseudomonas bacteriophage ΦKZ
    Christopher H S Aylett
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    J Mol Biol 425:2164-73. 2013
    ....
  10. pmc Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curving
    Harry H Low
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Cell 139:1342-52. 2009
    ..Observed structural similarities with rat dynamin 1 suggest that our results have broad implication for other dynamin family members...
  11. pmc Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice
    Amédée des Georges
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Struct Mol Biol 15:1102-8. 2008
    ..We propose that Mal3 promotes assembly by binding to freshly formed tubulin polymer and particularly favors any with A-lattice arrangement. These results reopen the question of microtubule structure in cells...
  12. pmc Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
    Santwana Kar
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 22:70-7. 2003
    ..We propose that loops in bound tau stabilize microtubules in a similar way to taxol, although with lower affinity so that assembly is reversible...
  13. doi request reprint What tubulin drugs tell us about microtubule structure and dynamics
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Semin Cell Dev Biol 22:916-26. 2011
    ..The activities of assembly inhibitors are discussed in relation to different nucleotide states of tubulin family protein structures...
  14. pmc The tektin family of microtubule-stabilizing proteins
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Genome Biol 9:229. 2008
    ..In doublet microtubules, the 2 nm filaments may also help to organize the longitudinal spacing of accessory structures, such as groups of inner dynein arms and radial spokes...
  15. ncbi request reprint Microtubule structure and its stabilisation
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UKCB2 2QH
    Org Biomol Chem 2:2153-60. 2004
    ..Microtubule destabilizing drugs such as colchicine alter the longitudinal interfaces of the subunits so that they cannot assemble into a microtubule lattice. These mechanisms are discussed in terms of the atomic structure of the protein...
  16. ncbi request reprint Bending at microtubule interfaces
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Chem Biol 11:745-7. 2004
  17. ncbi request reprint Aaron Klug and the revolution in biomolecular structure determination
    Linda A Amos
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK CB2 2QH
    Trends Cell Biol 14:148-52. 2004
    ..Thus, he has played a major part in developing the ideas and techniques that established structural molecular biology as an exciting new science during the second half of the twentieth century...
  18. ncbi request reprint Discodermolide interferes with the binding of tau protein to microtubules
    Santwana Kar
    MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK
    FEBS Lett 539:34-6. 2003
    ....
  19. pmc Interaction of tau protein with the dynactin complex
    Enrico Magnani
    Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK
    EMBO J 26:4546-54. 2007
    ..These findings, which suggest a direct involvement of tau in axonal transport, have implications for understanding the pathogenesis of tauopathies...
  20. ncbi request reprint High-resolution structural analysis of the kinesin-microtubule complex by electron cryo-microscopy
    Keiko Hirose
    Gene Function Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Methods Mol Biol 392:213-30. 2007
    ..To study the structural changes during ATP hydrolysis, structures of the complexes in the presence and absence of different nucleotides are compared...
  21. pmc Large conformational changes in a kinesin motor catalyzed by interaction with microtubules
    Keiko Hirose
    Gene Function Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8562, Japan
    Mol Cell 23:913-23. 2006
    ....
  22. ncbi request reprint Molecular motors: rocking and rolling
    Linda A Amos
    Nat Chem Biol 1:319-20. 2005