Research Topics
Genomes and Genes | Linda A AmosSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Structural/functional homology between the bacterial and eukaryotic cytoskeletonsLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Curr Opin Cell Biol 16:24-31. 2004..Bacterial MinD and eukaryotic dynamin appear to have similar functions in membrane control. In dividing eukaryotic organelles of bacterial origin, bacterial and eukaryotic proteins work together...- Studying the structure of microtubules by electron microscopyLinda A Amos
MRC Laboratory of Molecular Biology, Cambridge, UK
Methods Mol Med 137:65-91. 2007..Gold labeling can be used to mark the positions of certain regions of protein sequence... - Molecules of the bacterial cytoskeletonJan Lowe
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Annu Rev Biophys Biomol Struct 33:177-98. 2004..Mollicutes seem to have developed special systems for cell shape determination and motility, such as the fibril protein in Spiroplasma... 
New insights into the mechanisms of cytomotive actin and tubulin filamentsChristopher H S Aylett
MRC Laboratory of Molecular Biology, Cambridge, UK
Int Rev Cell Mol Biol 292:1-71. 2011..Detailed comparisons of the structures of related proteins from eubacteria, archaea, and eukaryotes are helping to illuminate the course of evolution...- Evolution of cytomotive filaments: the cytoskeleton from prokaryotes to eukaryotesJan Lowe
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Int J Biochem Cell Biol 41:323-9. 2009..A possible evolutionary relationship of WACAs with eukaryotic septins is discussed... 
A cool look at the structural changes in kinesin motor domainsLinda A Amos
MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
J Cell Sci 120:3919-27. 2007....- F-actin-like filaments formed by plasmid segregation protein ParMFusinita van den Ent
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
EMBO J 21:6935-43. 2002..Thus, there is now evidence for cytoskeletal structures, formed by actin-like filaments that are involved in plasmid partitioning in E.coli... - Microtubules and mapsLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Adv Protein Chem 71:257-98. 2005..We review the recent progress that has been made in obtaining a glimpse of the structural interactions involved... - Structure of a bacterial dynamin-like protein lipid tube provides a mechanism for assembly and membrane curvingHarry H Low
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Cell 139:1342-52. 2009..Observed structural similarities with rat dynamin 1 suggest that our results have broad implication for other dynamin family members... - Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule latticeAmédée des Georges
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Nat Struct Mol Biol 15:1102-8. 2008..We propose that Mal3 promotes assembly by binding to freshly formed tubulin polymer and particularly favors any with A-lattice arrangement. These results reopen the question of microtubule structure in cells... - Repeat motifs of tau bind to the insides of microtubules in the absence of taxolSantwana Kar
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
EMBO J 22:70-7. 2003..We propose that loops in bound tau stabilize microtubules in a similar way to taxol, although with lower affinity so that assembly is reversible... - What tubulin drugs tell us about microtubule structure and dynamicsLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Semin Cell Dev Biol 22:916-26. 2011..The activities of assembly inhibitors are discussed in relation to different nucleotide states of tubulin family protein structures... - Microtubule structure and its stabilisationLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UKCB2 2QH
Org Biomol Chem 2:2153-60. 2004..Microtubule destabilizing drugs such as colchicine alter the longitudinal interfaces of the subunits so that they cannot assemble into a microtubule lattice. These mechanisms are discussed in terms of the atomic structure of the protein... - Bending at microtubule interfacesLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Chem Biol 11:745-7. 2004 - The tektin family of microtubule-stabilizing proteinsLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
Genome Biol 9:229. 2008..In doublet microtubules, the 2 nm filaments may also help to organize the longitudinal spacing of accessory structures, such as groups of inner dynein arms and radial spokes... - Discodermolide interferes with the binding of tau protein to microtubulesSantwana Kar
MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK
FEBS Lett 539:34-6. 2003.... - Aaron Klug and the revolution in biomolecular structure determinationLinda A Amos
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK CB2 2QH
Trends Cell Biol 14:148-52. 2004..Thus, he has played a major part in developing the ideas and techniques that established structural molecular biology as an exciting new science during the second half of the twentieth century... - High-resolution structural analysis of the kinesin-microtubule complex by electron cryo-microscopyKeiko Hirose
Gene Function Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
Methods Mol Biol 392:213-30. 2007..To study the structural changes during ATP hydrolysis, structures of the complexes in the presence and absence of different nucleotides are compared... - Interaction of tau protein with the dynactin complexEnrico Magnani
Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK
EMBO J 26:4546-54. 2007..These findings, which suggest a direct involvement of tau in axonal transport, have implications for understanding the pathogenesis of tauopathies... - Large conformational changes in a kinesin motor catalyzed by interaction with microtubulesKeiko Hirose
Gene Function Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8562, Japan
Mol Cell 23:913-23. 2006.... - Molecular motors: rocking and rollingLinda A Amos
Nat Chem Biol 1:319-20. 2005