Affiliation: University of Bristol
- Neuronal calcium sensors and synaptic plasticityMascia Amici
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK
Biochem Soc Trans 37:1359-63. 2009..The present minireview aims to bring together evidence supporting a role for NCS proteins in plasticity, focusing on emerging roles of NCS-1 and hippocalcin...
- Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTPRobert Nistico
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, United Kingdom
Sci Rep 1:103. 2011..Thus three distinct glutamate receptors interact, in both an AND and OR gate fashion, to regulate both immediate and long-term presynaptic function in the brain...
- The Jak/STAT pathway is involved in synaptic plasticityCéline S Nicolas
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK
Neuron 73:374-90. 2012..Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain...
- Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientationJohn L Sherwood
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, BS8 1TD, UK
Neurochem Int 61:482-9. 2012..Transverse slices have denser fibre tracts but a smaller proportion of giant mossy fibre boutons. These results further demonstrate a considerable heterogeneity in the functional properties of the mossy fibre projection...
- Synaptic plasticity in the hippocampal slice preparationZuner A Bortolotto
MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
Curr Protoc Neurosci . 2011..Most of these principles also apply to the study of synaptic plasticity in other brain slice preparations...
- The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic PlasticityDaniel L Rocca
School of Biochemistry, Centre for Synaptic Plasticity, Medical Sciences Building and Dorothy Hodgkin Building, University of Bristol, University Walk, Bristol BS8 1TD, UK
Neuron 79:293-307. 2013..Furthermore, NMDAR stimulation downregulates Arf1 activation and binding to PICK1 via the Arf-GAP GIT1. This study defines Arf1 as a critical regulator of actin dynamics and synaptic function via modulation of PICK1. ..
- Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptorsMark W Irvine
MRC Centre for Synaptic Plasticity, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, U K
J Med Chem 55:327-41. 2012..Consistent with this idea, antagonist 18i (30 mg/kg ip) showed antinociceptive effects in an animal model of mild nerve injury...
- Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95Jihoon Jo
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
Nat Neurosci 13:1216-24. 2010....