Saba Alzabin

Summary

Affiliation: University of Oxford
Location: , United Kingdom

Publications

  1. ncbi request reprint Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation
    Ignacio Perez de Castro
    Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    Cancer Res 65:3249-56. 2005
  2. doi request reprint Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice
    Andrew J Kinloch
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:3818-23. 2011
  3. doi request reprint Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists
    Christophe Lallemand
    Laboratory of Biotechnology and Applied Pharmacology, CNRS UMR8113, Ecole Normale Superieure de Cachan, Cachan, France
    J Immunol Methods 373:229-39. 2011
  4. doi request reprint IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    Thomas Krausgruber
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Immunol 12:231-8. 2011
  5. pmc Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response
    Saba Alzabin
    NYU Cancer Institute, Department of Medicine, New York University School of Medicine, New York, 10016, USA
    Cancer Immunol Immunother 59:419-29. 2010
  6. doi request reprint Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation
    Saba Alzabin
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 182:6187-94. 2009
  7. pmc Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
  8. pmc CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response
    E Simelyte
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Clin Exp Immunol 162:163-8. 2010
  9. doi request reprint IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011
  10. ncbi request reprint Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway
    Sansana Sawasdikosol
    New York University School of Medicine, New York University Cancer Institute, New York, New York 10016 6402, USA
    J Biol Chem 282:34693-9. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation
    Ignacio Perez de Castro
    Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    Cancer Res 65:3249-56. 2005
    ....
  2. doi request reprint Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice
    Andrew J Kinloch
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:3818-23. 2011
    ..To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized by antibodies to citrullinated α-enolase is mediated by Porphyromonas gingivalis enolase in the context of DR4 alleles...
  3. doi request reprint Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists
    Christophe Lallemand
    Laboratory of Biotechnology and Applied Pharmacology, CNRS UMR8113, Ecole Normale Superieure de Cachan, Cachan, France
    J Immunol Methods 373:229-39. 2011
    ....
  4. doi request reprint IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    Thomas Krausgruber
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Immunol 12:231-8. 2011
    ..Our data suggest a critical role for IRF5 in M1 macrophage polarization and define a previously unknown function for IRF5 as a transcriptional repressor...
  5. pmc Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response
    Saba Alzabin
    NYU Cancer Institute, Department of Medicine, New York University School of Medicine, New York, 10016, USA
    Cancer Immunol Immunother 59:419-29. 2010
    ..We conclude that PGE(2) utilizes HPK1 to suppress T cell-mediated anti-tumor responses...
  6. doi request reprint Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation
    Saba Alzabin
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 182:6187-94. 2009
    ..c. Lewis Lung Carcinoma more efficiently than their WT counterpart. Our data reveal a novel role for HPK1 as a negative regulator of DC functions, identifying its potential as a molecular target for DC-based immunotherapy against cancers...
  7. pmc Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
    ....
  8. pmc CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response
    E Simelyte
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Clin Exp Immunol 162:163-8. 2010
    ..In contrast, CD200R1 plays a minimal role in shaping the immune response to collagen in this model...
  9. doi request reprint IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011
    ..The subsequent production of keratinocyte chemoattractant then triggers neutrophil chemotaxis to the plantar tissue, releasing algesic mediators locally to sensitise the nerve...
  10. ncbi request reprint Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway
    Sansana Sawasdikosol
    New York University School of Medicine, New York University Cancer Institute, New York, New York 10016 6402, USA
    J Biol Chem 282:34693-9. 2007
    ..We speculate that this unique signaling pathway enables PGE(2) signals to engage a proven negative regulator of TCR signal transduction pathway and uses it to inhibit T cell activation...
  11. pmc Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance
    Saba Alzabin
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, W6 8LH, UK
    Arthritis Res Ther 14:R142. 2012
    ..This study aims to evaluate the role of endosomal TLRs and in particular TLR7 in the murine collagen induced arthritis (CIA) model...