Stuart M Allan

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Brain inflammation is induced by co-morbidities and risk factors for stroke
    Caroline Drake
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Brain Behav Immun 25:1113-22. 2011
  2. pmc Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway
    Michelle E Edye
    From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 288:30485-94. 2013
  3. pmc Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, UK A D, C D, S M A, N J R
    J Am Heart Assoc 1:e002006. 2012
  4. ncbi request reprint Interleukin-1 and neuronal injury
    Stuart M Allan
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Manchester M13 9PT, UK
    Nat Rev Immunol 5:629-40. 2005
  5. doi request reprint Platelet interleukin-1alpha drives cerebrovascular inflammation
    Peter Thornton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Blood 115:3632-9. 2010
  6. ncbi request reprint Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity
    Peter Thornton
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Mol Cell Neurosci 37:135-42. 2008
  7. ncbi request reprint Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release
    Peter Thornton
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, UK
    J Neurochem 98:258-66. 2006
  8. pmc Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats
    Jesus M Pradillo
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 32:1810-9. 2012
  9. pmc Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices
    Sylvie Girard
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Glia 61:813-24. 2013
  10. pmc Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA
    Charlotte Allen
    Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Immunol 189:381-92. 2012

Collaborators

Detail Information

Publications40

  1. pmc Brain inflammation is induced by co-morbidities and risk factors for stroke
    Caroline Drake
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Brain Behav Immun 25:1113-22. 2011
    ..Thus a "primed" inflammatory environment in the brain may exist in individuals at risk of stroke and this can be adequately recapitulated in appropriate co-morbid animal models...
  2. pmc Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway
    Michelle E Edye
    From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 288:30485-94. 2013
    ..Therapeutic strategies directed to the inhibition of IL-1β processing should therefore consider alternative processing of IL-1β in addition to caspase-1-dependent processing. ..
  3. pmc Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, UK A D, C D, S M A, N J R
    J Am Heart Assoc 1:e002006. 2012
    ..Systemic inflammation contributes to brain pathology in cerebrovascular disease through mechanisms that are poorly understood...
  4. ncbi request reprint Interleukin-1 and neuronal injury
    Stuart M Allan
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Manchester M13 9PT, UK
    Nat Rev Immunol 5:629-40. 2005
    ..This article discusses the key evidence of a role for interleukin-1 in acute neurodegeneration - for example, stroke and brain trauma - and provides a rationale for targeting the interleukin-1 system as a therapeutic strategy...
  5. doi request reprint Platelet interleukin-1alpha drives cerebrovascular inflammation
    Peter Thornton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Blood 115:3632-9. 2010
    ....
  6. ncbi request reprint Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity
    Peter Thornton
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Mol Cell Neurosci 37:135-42. 2008
    ..In summary, IL-1-induced neurotoxicity is dependent on extracellular protease activity, and these mechanisms may contribute to neuronal cell death in CNS diseases...
  7. ncbi request reprint Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release
    Peter Thornton
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, UK
    J Neurochem 98:258-66. 2006
    ..Thus, IL-1 activates the IL-1 type 1 receptor in astrocytes to induce caspase-dependent neuronal death, which is dependent on the release of free radicals and may contribute to neuronal cell death in CNS diseases...
  8. pmc Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats
    Jesus M Pradillo
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 32:1810-9. 2012
    ..These data are the first to indicate that IL-1Ra protects against ischemic brain injury when administered via a clinically relevant route and time window in animals with multiple risk factors for stroke...
  9. pmc Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices
    Sylvie Girard
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Glia 61:813-24. 2013
    ..These data suggest that macrophages infiltrating the brain from the periphery after an injury may be cytotoxic, independently of their phenotype, while microglia may be protective...
  10. pmc Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA
    Charlotte Allen
    Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Immunol 189:381-92. 2012
    ..Such mechanisms have important implications for neuroinflammatory disorders, notably in the development of antileukocyte therapies...
  11. doi request reprint A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke
    Katie Z Chapman
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 29:1764-8. 2009
    ..This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis...
  12. ncbi request reprint Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways
    Peter Thornton
    Faculty of Life Sciences, A V Hill Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Curr Neurovasc Res 7:330-40. 2010
    ..Similar mechanisms may contribute to cerebrovascular inflammation in response to CNS injury...
  13. pmc Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice
    Elysse M Knight
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    Dis Model Mech 6:160-70. 2013
    ..The 3xTgAD mouse might therefore be an appropriate model for studying the underlying mechanisms involved in non-cognitive behavioural changes in AD...
  14. pmc Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    Dis Model Mech 6:1043-8. 2013
    ..Thus, both central and haematopoietic-derived IL-1 are important contributors to brain injury after cerebral ischaemia. Identification of the cellular sources of IL-1 in the periphery could allow targeted interventions at these sites. ..
  15. pmc Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology
    Andrew D Greenhalgh
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PL, UK
    Dis Model Mech 5:823-33. 2012
    ..These data provide new insights into inflammation after SAH-induced brain injury and suggest IL-1Ra as a candidate therapeutic for the disease...
  16. pmc Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 31:1036-50. 2011
    ....
  17. doi request reprint Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease
    Elysse M Knight
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Neurobiol Aging 33:187-93. 2012
    ..These data demonstrate for the first time the existence of a hypermetabolic state in an experimental model of AD, but whether this can explain the weight loss observed in AD patients remains to be determined...
  18. pmc The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury
    Beatriz Rodriguez-Grande
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 34:480-8. 2014
    ..This highlights the potential role for inflammatory molecules in brain recovery after injury and identifies APPs, in particular PTX3, as important targets in ischemic stroke and possibly other brain inflammatory disorders. ..
  19. doi request reprint Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    Barry W McColl
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:9451-62. 2008
    ..These mechanisms may contribute to the poor clinical outcome in stroke patients presenting with antecedent infection...
  20. ncbi request reprint IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells
    Elisabet Berglöf
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    J Neuroimmunol 139:36-43. 2003
    ..However, IL-1F9 failed to induce any of the classical IL-1beta responses, suggesting that it may trigger alternative pathway(s)...
  21. ncbi request reprint A dual role for interleukin-1 in LTP in mouse hippocampal slices
    Fiona M Ross
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    J Neuroimmunol 144:61-7. 2003
    ..These data suggest that IL-1 is required for LTP under physiological conditions but at higher doses, as encountered in pathological conditions, IL-1 inhibits LTP...
  22. doi request reprint Systemic immune activation shapes stroke outcome
    Katie N Murray
    Faculty of Life Sciences, A V Hill Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Mol Cell Neurosci 53:14-25. 2013
    ..This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'...
  23. doi request reprint Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Cerebrovasc Dis 32:517-27. 2011
    ....
  24. doi request reprint Assessing the contribution of inflammation in models of Alzheimer's disease
    Hannah Johnston
    Faculty of Life Sciences, University of Manchester, AV Hill Building, Manchester M13 9PT, UK
    Biochem Soc Trans 39:886-90. 2011
    ....
  25. doi request reprint Regulation of interleukin-1 in acute brain injury
    David Brough
    Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK
    Trends Pharmacol Sci 32:617-22. 2011
    ..Advances are summarised here in the context of addressing how dampening the inflammatory response and actions of IL-1 provides a strategy for reducing damage after acute brain injury such as stroke...
  26. ncbi request reprint Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα
    Adam Denes
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Ann Neurol 75:670-83. 2014
    ..Streptococcus pneumoniae, the most common infection in patients at risk of stroke, is a major cause of prolonged hospitalization and death of stroke patients, but how infection impacts clinical outcome is not known...
  27. ncbi request reprint Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms
    Barry W McColl
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 27:4403-12. 2007
    ....
  28. pmc Inflammation in central nervous system injury
    Stuart M Allan
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 358:1669-77. 2003
    ..Nevertheless, several anti-inflammatory targets have been identified as putative treatments for CNS disorders, initially in acute conditions, but which may also be appropriate to chronic neurodegenerative conditions...
  29. doi request reprint Inflammatory responses in the rat brain in response to different methods of intra-cerebral administration
    Lisa McCluskey
    Faculty of Life Sciences, Michael Smith Building, The University of Manchester, Manchester, M13 9PT, UK
    J Neuroimmunol 194:27-33. 2008
    ..Therefore, the use of a glass micro-needle to inject substances intra-cerebrally appears to cause minimal injection artefact and should be the method of choice...
  30. pmc High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
    Elysse M Knight
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Neurobiol Aging 35:1821-32. 2014
    ....
  31. ncbi request reprint Long-term functional recovery and compensation after cerebral ischemia in rats
    Sylvie Girard
    Faculty of Life Science, University of Manchester, Manchester, UK Electronic address
    Behav Brain Res 270:18-28. 2014
    ..Functional deficits in skilled movement after brain injury represent ideal predictors of long-term outcomes and should become standard measures in the assessment of preclinical animal models. ..
  32. ncbi request reprint Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system
    Stuart M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    J Neurosci Res 67:428-34. 2002
    ..Furthermore, TNFalpha shows neuroprotective effects against acute excitotoxic injury...
  33. doi request reprint Systematic review and meta-analysis of the efficacy of statins in experimental stroke
    Hardaman K Baryan
    Brain Injury Research Group, School of Biomedicine, University of Manchester, UK
    Int J Stroke 7:150-6. 2012
    ..Statins are postulated as candidate drugs for the treatment of acute stroke. The aim of this study was to critically appraise the evidence for the efficacy of statins administered after the onset of experimental focal cerebral ischemia...
  34. pmc Maternal High-Fat Diet Worsens Memory Deficits in the Triple-Transgenic (3xTgAD) Mouse Model of Alzheimer's Disease
    Sarah A L Martin
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS ONE 9:e99226. 2014
    ....
  35. pmc Experimental intracerebral hemorrhage: avoiding pitfalls in translational research
    Matthew A Kirkman
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 31:2135-51. 2011
    ....
  36. pmc Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease
    Jose J Rodriguez
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    PLoS ONE 3:e2935. 2008
    ..Thus it is conceivable to speculate that a recovery in neurogenesis rates in AD could help to rescue cognitive impairment...
  37. ncbi request reprint Proliferating resident microglia after focal cerebral ischaemia in mice
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    J Cereb Blood Flow Metab 27:1941-53. 2007
    ..These data further support possible beneficial actions of microglial cells in the injured brain...
  38. ncbi request reprint Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression
    Adam R Cole
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Neurochem 103:1132-44. 2007
    ..These observations implicate hyperphosphorylation of CRMP2 as an early event in the development of AD and suggest that it can be induced by a severe APP over-expression and/or processing defect...
  39. ncbi request reprint Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
    Anne Vroon
    Department of Anatomy and Neurosciences, Institute for Clinical and Experimental Neurosciences ICEN, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Exp Gerontol 42:762-71. 2007
    ..We suggest that differential regulation of IL-1 signaling can serve as an important mechanism to modulate neuroinflammatory activity after MPTP treatment and possibly during PD...
  40. ncbi request reprint Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum
    Robert I Grundy
    Schering Plough Research Institute, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Brain Res 926:142-8. 2002
    ..These findings enhance our understanding of the actions of IL-1, and the mechanisms by which it participates in neurodegeneration through both local and long-range effects...