S M Allan

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes
    S M Allan
    School of Biological Sciences, University of Manchester, UK
    Mol Psychiatry 3:178-82. 1998
  2. ncbi request reprint The role of pro- and antiinflammatory cytokines in neurodegeneration
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Ann N Y Acad Sci 917:84-93. 2000
  3. ncbi request reprint Cytokines and acute neurodegeneration
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Neurosci 2:734-44. 2001
  4. ncbi request reprint Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Brain Res Mol Brain Res 93:180-9. 2001
  5. ncbi request reprint The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Curr Drug Targets CNS Neurol Disord 2:293-302. 2003
  6. pmc Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 97:5580-5. 2000
  7. ncbi request reprint Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo
    M W Craighead
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
    Brain Res 881:139-43. 2000
  8. ncbi request reprint Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity
    H C Patel
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Neurosci Res 83:385-91. 2006
  9. doi request reprint Systemic infection, inflammation and acute ischemic stroke
    B W McColl
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Neuroscience 158:1049-61. 2009
  10. doi request reprint Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
    A Denes
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Behav Immun 24:708-23. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes
    S M Allan
    School of Biological Sciences, University of Manchester, UK
    Mol Psychiatry 3:178-82. 1998
    ..Thus, our data suggest that IL-1 beta and IL-1ra influence neuronal damage in the striatum by acting to modify events that occur after excitatory amino acid receptor activation...
  2. ncbi request reprint The role of pro- and antiinflammatory cytokines in neurodegeneration
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Ann N Y Acad Sci 917:84-93. 2000
    ....
  3. ncbi request reprint Cytokines and acute neurodegeneration
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Neurosci 2:734-44. 2001
    ..Understanding cytokine action in acute neurodegeneration could lead to novel and effective therapeutic strategies, some of which are already in clinical trials...
  4. ncbi request reprint Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Brain Res Mol Brain Res 93:180-9. 2001
    ..Such cytokines may be involved in the ensuing damage, and further clarification of their actions could aid future therapeutic strategies for several acute neurodegenerative disorders...
  5. ncbi request reprint The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease
    S M Allan
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Curr Drug Targets CNS Neurol Disord 2:293-302. 2003
    ..Therefore, the IL-1 system represents an attractive and intensely competitive therapeutic target...
  6. pmc Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 97:5580-5. 2000
    ....
  7. ncbi request reprint Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo
    M W Craighead
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
    Brain Res 881:139-43. 2000
    ..g. on the vasculature) and/or that CRF is not the endogenous ligand which contributes to neurodegeneration through activation of CRF receptors...
  8. ncbi request reprint Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity
    H C Patel
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Neurosci Res 83:385-91. 2006
    ..These findings support our hypothesis that IL-1 enhances excitotoxic injury by enhancement of seizures, which may be of relevance to IL-1 actions in other forms of neuronal injury, including cerebral ischemia...
  9. doi request reprint Systemic infection, inflammation and acute ischemic stroke
    B W McColl
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Neuroscience 158:1049-61. 2009
    ..We discuss potential mechanisms underlying the impact on ischemic brain injury and highlight the implications for stroke prevention, therapy and modeling...
  10. doi request reprint Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
    A Denes
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Brain Behav Immun 24:708-23. 2010
    ..However, a greater understanding of the contribution of inflammation to CI is still required, and this review highlights some of the key mechanism that may offer future therapeutic targets...
  11. ncbi request reprint Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration
    H C Patel
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Manchester, M13 9PT, UK
    Ann N Y Acad Sci 992:39-47. 2003
    ..Therefore, IL-1 appears to induce acute neurodegeneration through a number of mechanisms...
  12. ncbi request reprint Systemic inflammation and stroke: aetiology, pathology and targets for therapy
    B W McColl
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, U K
    Biochem Soc Trans 35:1163-5. 2007
    ..We also highlight the need for stroke models to more adequately account for the involvement of underlying systemic inflammation...