James M Allan

Summary

Affiliation: University of York
Country: UK

Publications

  1. doi request reprint A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
    Maria Chiara Di Bernardo
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 40:1204-10. 2008
  2. doi request reprint Polymorphisms in the nucleotide excision repair gene ERCC2/XPD and risk of non-Hodgkin lymphoma
    Lisa Worrillow
    Department of Biology, University of York, York, YO10 5YW, United Kingdom
    Cancer Epidemiol 33:257-60. 2009
  3. ncbi request reprint Mechanisms of therapy-related carcinogenesis
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Nat Rev Cancer 5:943-55. 2005
  4. ncbi request reprint Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, York, United Kingdom, YO10 5YW
    Blood 104:3872-7. 2004
  5. ncbi request reprint Genetic susceptibility to iatrogenic malignancy
    James M Allan
    Department of Biology, Epidemiology and Genetics Unit, University of York, York, UK
    Pharmacogenomics 6:615-28. 2005
  6. pmc Genetic variation in the folate metabolic pathway and risk of childhood leukemia
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK
    Blood 115:3923-9. 2010
  7. ncbi request reprint Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Area 3, Seebohm Rowntree Building YO10 5DD, York, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2999-3003. 2005
  8. ncbi request reprint Application of DNA pooling to large studies of disease
    Graham R Law
    Department of Health Sciences, Epidemiology and Genetics Unit, University of York, UK
    Stat Med 23:3841-50. 2004
  9. ncbi request reprint Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia
    Kathryn Sibley
    Leukaemia Research Fund, Epidemiology and Genetics Unit, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Cancer Res 63:4327-30. 2003
  10. ncbi request reprint A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukemia
    Alexandra G Smith
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, UK
    Blood 109:1233-6. 2007

Collaborators

Detail Information

Publications26

  1. doi request reprint A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
    Maria Chiara Di Bernardo
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 40:1204-10. 2008
    ..32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL...
  2. doi request reprint Polymorphisms in the nucleotide excision repair gene ERCC2/XPD and risk of non-Hodgkin lymphoma
    Lisa Worrillow
    Department of Biology, University of York, York, YO10 5YW, United Kingdom
    Cancer Epidemiol 33:257-60. 2009
    ..02), the major subtype of NHL. Overall, our study identifies that XPD polymorphisms may be important in the aetiology of NHL although analysis of additional polymorphisms and extended haplotype studies are required to clarify their role...
  3. ncbi request reprint Mechanisms of therapy-related carcinogenesis
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Nat Rev Cancer 5:943-55. 2005
    ..Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers...
  4. ncbi request reprint Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, York, United Kingdom, YO10 5YW
    Blood 104:3872-7. 2004
    ..22 for Gln/Gln vs Lys/Lys; 95% CI, 1.04-4.74). These data suggest that the XPD codon 751 glutamine variant protects against myeloid cell death after chemotherapy...
  5. ncbi request reprint Genetic susceptibility to iatrogenic malignancy
    James M Allan
    Department of Biology, Epidemiology and Genetics Unit, University of York, York, UK
    Pharmacogenomics 6:615-28. 2005
    ..g., nucleotide excision DNA repair, base excision DNA repair, DNA mismatch repair, and cell death signaling) after therapy has provided insight into how host genetics may impact on the risk of developing iatrogenic malignancy...
  6. pmc Genetic variation in the folate metabolic pathway and risk of childhood leukemia
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK
    Blood 115:3923-9. 2010
    ..90; 95% CI, 1.30-18.45; P = .019). These data suggest that genetic variation in methionine synthase could mediate risk of childhood leukemia, either via effects on DNA methylation or via effects on fetal growth and development...
  7. ncbi request reprint Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Area 3, Seebohm Rowntree Building YO10 5DD, York, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2999-3003. 2005
    ..Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma...
  8. ncbi request reprint Application of DNA pooling to large studies of disease
    Graham R Law
    Department of Health Sciences, Epidemiology and Genetics Unit, University of York, UK
    Stat Med 23:3841-50. 2004
    ..K. Biobank, to take advantage of this method. Furthermore, a set-based logistic regression is presented which allows the investigation of joint effects and interactions with other genes or environmental factors...
  9. ncbi request reprint Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia
    Kathryn Sibley
    Leukaemia Research Fund, Epidemiology and Genetics Unit, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Cancer Res 63:4327-30. 2003
    ..5%; odds ratio, 6.72; 95% confidence interval, 3.13-14.51). These data suggest that variation in the FAS gene promoter may affect FAS gene expression and modulate apoptotic signaling, contributing to an increased risk of AML...
  10. ncbi request reprint A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukemia
    Alexandra G Smith
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, UK
    Blood 109:1233-6. 2007
    ..09; 95% confidence interval [CI] 1.14-3.81; n=69; P=.02) or a chromosome 7q deletion (OR 2.27; 95% CI 1.09-4.71; n=47; P=.03), but not with any other commonly recurring cytogenetic lesion...
  11. ncbi request reprint Molar pregnancy, childhood cancer and genomic imprinting - is there a link?
    Eve Roman
    Department of Health Sciences, University of York, York, UK
    Hum Fertil (Camb) 9:171-4. 2006
    ..Accordingly, we suggest that there may be an aetiologic connection between molar pregnancy and childhood cancer, and speculate here on the various genetic/epigenetic mechanisms that could be involved...
  12. ncbi request reprint Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity
    Sara Rollinson
    Epidemiology and Genetics Unit, University of Leeds, Leeds, United Kingdom
    Blood 102:1007-11. 2003
    ..29; 95% CI 6.92-150-63). These results support the hypothesis that the risk of developing GMZL is influenced by inter-individual variation in the cellular inflammatory immune responses to H pylori infection, and to antioxidative capacity...
  13. doi request reprint Genetic susceptibility to radiogenic cancer in humans
    James M Allan
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    Health Phys 95:677-86. 2008
    ....
  14. doi request reprint The genetics of cancer survivorship
    James M Allan
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Hematol Oncol Clin North Am 22:257-69, vi-vii. 2008
    ..This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies...
  15. ncbi request reprint RAG1 and BRCA2 polymorphisms in non-Hodgkin lymphoma
    Kathryn Scott
    Blood 109:5522-3. 2007
  16. pmc MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility
    Nathan A Ellis
    Department of Medicine, University of Chicago Cancer Research Center, University of Chicago, IL 60637, USA
    Blood 112:741-9. 2008
    ..These data indicate that the MDM2 and TP53 variants interact to modulate responses to genotoxic therapy and are determinants of risk for t-AML...
  17. ncbi request reprint RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia
    Sara Rollinson
    Division of Laboratory and Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Leuk Res 31:169-74. 2007
    ..9% versus controls 6.5%, OR 0.61, 95% CI 0.42-0.90). These data suggest that variants in the RAD51 HR gene may modulate genetic predisposition to AML...
  18. ncbi request reprint Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients
    Sara J Schonfeld
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    J Natl Cancer Inst 98:215-8. 2006
    ..The EAR of AML declined statistically significantly after 1984 (7.0 to 4.2 and 16.4 to 9.9 in the < 35 and > or = 35 age groups, respectively), which may be associated with modifications in chemotherapy...
  19. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  20. pmc Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors
    Deirdre A Hill
    Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Blood 106:3358-65. 2005
    ..The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women...
  21. ncbi request reprint Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma
    Ranjit K Dasgupta
    Academic Unit of Hematology and Oncology, University of Leeds, United Kingdom
    Blood 102:2345-50. 2003
    ..No difference in outcome by genotype was found for patients treated with high-dose therapy. However, the progression-free survival advantage of the high-dose arm was seen only in patients homozygous for 105Ile (P =.008)...
  22. ncbi request reprint An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents
    Lisa J Worrillow
    Leukaemia Research Fund Epidemiology and Genetics Unit, Academic Unit of Epidemiology, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Clin Cancer Res 9:3012-20. 2003
    ..MSI was evaluated in presentation bone marrow from 34 cases using the mononucleotide microsatellite markers BAT16, BAT25, and BAT26...
  23. ncbi request reprint High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia
    Sara Rollinson
    Leukaemia Research Fund Epidemiology and Genetics Unit, School of Medicine, University of Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:795-800. 2004
    ..76, 95% confidence interval 1.26-2.44). These data suggest that quantitative AS PCR can be used as an efficient screening technique for disease associations of genetic variants in DNA pools made from case-control studies...
  24. doi request reprint MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer
    James M Allan
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    Int J Cancer 123:2456-9. 2008
    ..68, 95% confidence interval (CI) 1.00-2.83, n = 1,518, p = 0.05, proximal vs distal CRC). These findings suggest that the MLH1 -93G>A polymorphism defines a low penetrance risk allele for CRC...
  25. doi request reprint Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients
    Regan Howard
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Ann Epidemiol 18:416-21. 2008
    ..The aim of this study is to quantify excess absolute risk (EAR) and excess relative risk (ERR) of secondary leukemia among a large population-based group of testicular cancer survivors...
  26. ncbi request reprint Poor metabolizer status at the cytochrome P450 2C9 and 2D6 loci does not modulate susceptibility to therapy-related acute myeloid leukaemia
    Philippa L Roddam
    Br J Haematol 121:192-4. 2003