..In a recent publication, Coleen Murphy and colleagues (Kaletsky et al., 2016) describe the transcriptional program that maintains youthful function of aging neurons in the nematode worm. ..
Al Saud S, Summerfield A, Alic N. Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila. Proc Biol Sci. 2015;282:20141720 pubmed publisher
..At the same time, pathways regulated by IIS may be suitable targets for treatment of obesity. ..
Dobson A, Ezcurra M, Flanagan C, Summerfield A, Piper M, Gems D, et al. Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets. Cell Rep. 2017;18:299-306 pubmed publisher
..Our study implicates FOXO factors, the evolutionarily conserved determinants of animal longevity, in the mechanisms of nutritional programming of animal lifespan. ..