Genomes and Genes
Affiliation: University College London
- Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studiesNazif Alic
Institute of Healthy Ageing, and GEE, University College London, London, United Kingdom
PLoS ONE 7:e45367. 2012..However, we also show that RNAi restricted to certain tissues may not be detrimental to lifespan...
- Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressorNazif Alic
Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Aging Cell 10:137-47. 2011..Our findings point to the possibility that an IGFBP or a related protein, such as IGFBP7, plays a role in mammalian aging...
- Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signallingNazif Alic
Institute of Healthy Ageing, and GEE, University College London, London, UK
Mol Syst Biol 7:502. 2011..We demonstrate genome-wide evolutionary conservation of dFOXO targets between the fly and the worm Caenorhabditis elegans, enriched for a second tier of regulators including the dHR96/daf-12 nuclear hormone receptor...
- Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkCathy Slack
Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000881. 2010..Our findings suggest that IIS signaling in Drosophila may require the activity of a second intracellular adaptor, thereby yielding fundamental new insights into the functioning and role of the IIS pathway in ageing and metabolism...
- The endosymbiont Wolbachia increases insulin/IGF-like signalling in DrosophilaTomoatsu Ikeya
UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
Proc Biol Sci 276:3799-807. 2009..This effect of Wolbachia infection on IIS could have an evolutionary explanation, and has some implications for studies of IIS in Drosophila and other organisms that harbour endosymbionts...
- Ageing in Drosophila: the role of the insulin/Igf and TOR signalling networkLinda Partridge
Institute of Healthy Ageing, London, WC1E 6BT, UK
Exp Gerontol 46:376-81. 2011..Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it...
- Cell-nonautonomous effects of dFOXO/DAF-16 in agingNazif Alic
Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
Cell Rep 6:608-16. 2014..Whereas FoxO-to-FoxO signaling appears to be required for metabolic homeostasis, our results pinpoint FoxO-to-other signaling as an important mechanism through which localized FoxO activity ameliorates aging. ..
- Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageingIrene Papatheodorou
European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
PLoS ONE 7:e50881. 2012..Our methods are available in the web-service NetEffects: http://www.ebi.ac.uk/thornton-srv/software/NetEffects...
- Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPsSusan Broughton
UCL Institute of Healthy Ageing, GEE, University College London, London, UK
PLoS ONE 3:e3721. 2008..To understand the normal regulation of expression of the dilps and any functional diversification between them will require independent control of the expression of different dilps...
- Death and dessert: nutrient signalling pathways and ageingNazif Alic
Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, UK
Curr Opin Cell Biol 23:738-43. 2011..Here we review the current knowledge of the interactions between nutrient signalling pathways and ageing, focusing on the findings emerged in the past few years...
- Stage debut for the elusive Drosophila insulin-like growth factor binding proteinNazif Alic
Institute of Healthy Ageing, GEE, University College London, London, WC1E 6BT, UK
J Biol 7:18. 2008....