Nazif Alic

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, United Kingdom
    PLoS ONE 7:e45367. 2012
  2. pmc Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 10:137-47. 2011
  3. pmc Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    Mol Syst Biol 7:502. 2011
  4. pmc Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
    Cathy Slack
    Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000881. 2010
  5. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
  6. pmc Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    Linda Partridge
    Institute of Healthy Ageing, London, WC1E 6BT, UK
    Exp Gerontol 46:376-81. 2011
  7. pmc Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing
    Irene Papatheodorou
    European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e50881. 2012
  8. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
  9. doi request reprint Death and dessert: nutrient signalling pathways and ageing
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, UK
    Curr Opin Cell Biol 23:738-43. 2011
  10. pmc Stage debut for the elusive Drosophila insulin-like growth factor binding protein
    Nazif Alic
    Institute of Healthy Ageing, GEE, University College London, London, WC1E 6BT, UK
    J Biol 7:18. 2008

Collaborators

Detail Information

Publications10

  1. pmc Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, United Kingdom
    PLoS ONE 7:e45367. 2012
    ..However, we also show that RNAi restricted to certain tissues may not be detrimental to lifespan...
  2. pmc Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 10:137-47. 2011
    ..Our findings point to the possibility that an IGFBP or a related protein, such as IGFBP7, plays a role in mammalian aging...
  3. pmc Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    Mol Syst Biol 7:502. 2011
    ..We demonstrate genome-wide evolutionary conservation of dFOXO targets between the fly and the worm Caenorhabditis elegans, enriched for a second tier of regulators including the dHR96/daf-12 nuclear hormone receptor...
  4. pmc Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
    Cathy Slack
    Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000881. 2010
    ..Our findings suggest that IIS signaling in Drosophila may require the activity of a second intracellular adaptor, thereby yielding fundamental new insights into the functioning and role of the IIS pathway in ageing and metabolism...
  5. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
    ..This effect of Wolbachia infection on IIS could have an evolutionary explanation, and has some implications for studies of IIS in Drosophila and other organisms that harbour endosymbionts...
  6. pmc Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    Linda Partridge
    Institute of Healthy Ageing, London, WC1E 6BT, UK
    Exp Gerontol 46:376-81. 2011
    ..Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it...
  7. pmc Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing
    Irene Papatheodorou
    European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e50881. 2012
    ..Our methods are available in the web-service NetEffects: http://www.ebi.ac.uk/thornton-srv/software/NetEffects...
  8. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
    ..To understand the normal regulation of expression of the dilps and any functional diversification between them will require independent control of the expression of different dilps...
  9. doi request reprint Death and dessert: nutrient signalling pathways and ageing
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London WC1E 6BT, UK
    Curr Opin Cell Biol 23:738-43. 2011
    ..Here we review the current knowledge of the interactions between nutrient signalling pathways and ageing, focusing on the findings emerged in the past few years...
  10. pmc Stage debut for the elusive Drosophila insulin-like growth factor binding protein
    Nazif Alic
    Institute of Healthy Ageing, GEE, University College London, London, WC1E 6BT, UK
    J Biol 7:18. 2008
    ....