- Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) geneNuria Pescador
, Facultad de Medicina, , Arzobispo Morcillo s/n, 28029 Madrid, Spain
Biochem J 390:189-97. 2005..Indeed, we were able to demonstrate that HIF was necessary and sufficient to induce gene expression from this enhancer sequence...
- A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machineryMaria L Alcaide-German
Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
BMC Cell Biol 9:18. 2008..Since the progression of the aforementioned pathologies might be influenced by activation of HIF-target genes, development of small molecules with the ability to interfere with the HIF-regulatory machinery is of great interest...
- Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cellsSusan C Short
UCL Cancer Institute, University College London, London, UK
Neuro Oncol 13:487-99. 2011..Agents targeting Rad51-dependent repair would be effective adjuvants in standard combination regimens...
- Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinomaB Martínez-Poveda
Departamento de Bioquimica, Instituto de Investigaciones Biomedicas CSIC UAM, 28029 Madrid, Spain
Int J Oncol 39:543-52. 2011..tumor expansion. Therefore, the readout based on HIF functional reporter could be conditioned by the dynamics of tumor growth and angiogenesis, which is highly variable depending on the tumor type, tumor model and stage of progression...