Arne N Akbar

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo
    John R Reed
    Dept of Immunology and Molecular Pathology, Div of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, England, UK
    J Exp Med 199:1433-43. 2004
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc Investigation of the cutaneous response to recall antigen in humans in vivo
    A N Akbar
    Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Clin Exp Immunol 173:163-72. 2013
  4. pmc Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Arthritis Res Ther 7:R784-95. 2005
  5. doi request reprint Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
    Arne N Akbar
    Division of Infection and Immunity, University College London, UK
    Nat Rev Immunol 11:289-95. 2011
  6. ncbi request reprint The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK
    Nat Rev Immunol 7:231-7. 2007
  7. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003
  8. ncbi request reprint Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion
    Jean M Fletcher
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London, United Kingdom
    J Immunol 175:8218-25. 2005
  9. pmc Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Clin Invest 116:2423-33. 2006
  10. doi request reprint Reversible senescence in human CD4+CD45RA+CD27- memory T cells
    Diletta Di Mitri
    Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    J Immunol 187:2093-100. 2011

Collaborators

Detail Information

Publications49

  1. pmc Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo
    John R Reed
    Dept of Immunology and Molecular Pathology, Div of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, England, UK
    J Exp Med 199:1433-43. 2004
    ..Therefore, these results suggest that the rate of telomere erosion in proliferating, antigen-specific CD4+ T cells may be accelerated by type I IFN during a secondary response in vivo...
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc Investigation of the cutaneous response to recall antigen in humans in vivo
    A N Akbar
    Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Clin Exp Immunol 173:163-72. 2013
    ..The use of the blister technology enables further characterization of the skin specific defect in older humans and also general mechanisms that govern immune regulation in vivo. ..
  4. pmc Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
    Karim Raza
    MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK
    Arthritis Res Ther 7:R784-95. 2005
    ..The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA...
  5. doi request reprint Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
    Arne N Akbar
    Division of Infection and Immunity, University College London, UK
    Nat Rev Immunol 11:289-95. 2011
    ..Available data suggest that both processes are regulated independently of each other and that it may be safer to block exhaustion than senescence to enhance immunity...
  6. ncbi request reprint The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK
    Nat Rev Immunol 7:231-7. 2007
    ..In this Opinion article, we discuss recent evidence in both mice and humans that supports the hypothesis that some CD4(+)CD25(+)FOXP3(+)regulatory T cells can differentiate from rapidly proliferating memory T cells in the periphery...
  7. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003
  8. ncbi request reprint Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion
    Jean M Fletcher
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London, United Kingdom
    J Immunol 175:8218-25. 2005
    ....
  9. pmc Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Clin Invest 116:2423-33. 2006
    ....
  10. doi request reprint Reversible senescence in human CD4+CD45RA+CD27- memory T cells
    Diletta Di Mitri
    Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    J Immunol 187:2093-100. 2011
    ..In particular, CD4(+) EMRA T cells have features of telomere-independent senescence that are regulated by active cell signaling pathways that are reversible...
  11. pmc The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology, University College London, London, UK
    J Clin Invest 118:3639-50. 2008
    ..Furthermore, it is possible to isolate effector CD4(+) T cell populations from inflamed tissues and manipulate them to generate Tregs with the potential to suppress inflammatory responses...
  12. ncbi request reprint The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation
    Fiona J Plunkett
    Department of Immunology and Molecular Pathology, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7710-9. 2007
    ..This limits the ability of memory CD8(+) T cells to be maintained by continuous proliferation in vivo...
  13. ncbi request reprint KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
    Sian M Henson
    Department of Immunology, University College London, 46 Cleveland Street, London, United Kingdom
    Blood 113:6619-28. 2009
    ....
  14. ncbi request reprint Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection
    Maria Vieira D Soares
    Department Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, United Kingdom
    Blood 103:162-7. 2004
    ..However, signals that induce telomerase ensure that the rescued cells retain their replicative capacity. Significantly, these processes operate identically in cells found in blood and secondary lymphoid tissue...
  15. ncbi request reprint The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
    Fiona J Plunkett
    Department of Immunology and Molecular Pathology, Royal Free and University College Medical School, London, UK
    Mech Ageing Dev 126:855-65. 2005
    ..This may contribute to the defective immunity found in XLP patients who survive acute EBV infection who develop EBV-related B cell lymphomas before the fourth decade of life...
  16. ncbi request reprint Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection
    Padraic J Dunne
    Division of Infection and Immunity, 46 Cleveland St, University College London, W1T 4JF United Kingdom
    Blood 106:558-65. 2005
    ....
  17. ncbi request reprint Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO
    Nicola J Booth
    Division of Infection and Immunity, Department of Immunology, University College London, London W1T 4JF, United Kingdom
    J Immunol 184:4317-26. 2010
    ..Furthermore, the different tissue compartmentalization of these cells suggests that different Treg niches exist in vivo, which may have important roles for their maturation and function...
  18. pmc Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA
    Stephen J Griffiths
    Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom
    J Immunol 190:5363-72. 2013
    ....
  19. pmc Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans
    Milica Vukmanovic-Stejic
    Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    J Immunol 190:977-86. 2013
    ..These results suggest a linkage between the expansion of Ag-specific CD4(+) T cells and CD4(+) Tregs that may provide controlled responsiveness during Ag-specific stimulation in tissues...
  20. ncbi request reprint Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells
    Richard Macaulay
    Division of Infection and Immunity, University College London, 5 University Street, London, WC1E 6JF, UK
    Hum Immunol 74:302-9. 2013
    ....
  21. pmc Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects
    Diana L Wallace
    Division of Infection and Immunity, University College London, Windeyer Institute, London, UK
    Immunology 132:27-38. 2011
    ..Our data suggest that HCMV-specific CD8(+) expansions in older subjects accumulate by extended lifespan, rather than accelerated proliferation...
  22. ncbi request reprint Memory T-cell homeostasis and senescence during aging
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Adv Exp Med Biol 684:189-97. 2010
    ..We discuss here mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases...
  23. pmc Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process
    Valentina Libri
    Division of Infection and Immunity, University College London, London, UK
    Immunology 132:326-39. 2011
    ....
  24. pmc Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
    Elaine Agius
    Department of Immunology, Division of Infection and Immunity, University College London, London, W1T 4JF, England, UK
    J Exp Med 206:1929-40. 2009
    ..This may be a predisposing factor for the development of malignancy and infection in the skin during aging...
  25. ncbi request reprint Mantoux Test as a model for a secondary immune response in humans
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK
    Immunol Lett 107:93-101. 2006
    ..Taken together with other studies, in humans and in mice, these observations shed new light on the importance of the microenvironment at the site of the immune response for the proliferation and differentiation of memory T cells...
  26. pmc Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
    Sian M Henson
    Division of Infection and Immunity, University College London, London, UK
    Immunology 135:355-63. 2012
    ..These data collectively highlight that some, but not all, functional changes that arise during progressive T-cell differentiation and during ageing are maintained actively by inhibitory receptor signalling...
  27. ncbi request reprint Immune responses in the skin in old age
    Milica Vukmanovic-Stejic
    Division of Infection and Immunity, Department of Immunology, University College London, London W1T 4JF, United Kingdom
    Curr Opin Immunol 23:525-31. 2011
    ....
  28. pmc The role of the T cell in age-related inflammation
    Richard Macaulay
    Division of Infection and Immunity, Rayne Institute, University College London, 5 University Street, London, WC1E 6JF, UK
    Age (Dordr) 35:563-72. 2013
    ....
  29. ncbi request reprint Telomerase in T lymphocytes: use it and lose it?
    Arne N Akbar
    Department of Immunology and Molecular Pathology, University College London, London, United Kingdom
    J Immunol 178:6689-94. 2007
    ..In this article, we review the data on telomerase regulation in T lymphocytes and the implications this has for the maintenance of T cell memory...
  30. pmc KLRG1--more than a marker for T cell senescence
    Sian M Henson
    Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, UK
    Age (Dordr) 31:285-91. 2009
    ..In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling...
  31. ncbi request reprint Memory T cell homeostasis and senescence during aging
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, UK
    Curr Opin Immunol 17:480-5. 2005
    ....
  32. ncbi request reprint Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential
    Padraic J Dunne
    Department of Clinical Immunology, Royal Free and University College Medical School, London, United Kingdom
    Blood 100:933-40. 2002
    ..The identification of mechanisms that enable stable virus-specific CD8(+) T cells to persist after acute infection may lead to the enhancement of antiviral immunity in immunocompromised and elderly persons...
  33. ncbi request reprint Will telomere erosion lead to a loss of T-cell memory?
    Arne N Akbar
    Department of Immunology and Molecular Pathology, The Windeyer Building, 46 Cleveland Street, Division of Infection and Immunity, Royal Free and University College Medical School, London W1T 4JF, UK
    Nat Rev Immunol 4:737-43. 2004
    ..We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases...
  34. doi request reprint Measurement of proliferation and disappearance of regulatory T cells in human studies using deuterium-labeled glucose
    Milica Vukmanovic-Stejic
    Department of Immunology, Infection, and Immunity, University College London, London, UK
    Methods Mol Biol 707:243-61. 2011
    ....
  35. ncbi request reprint Properties of end-stage human T cells defined by CD45RA re-expression
    Sian M Henson
    Division of Infection and Immunity, University College London, 5 University Street, London, WC1E 6JF, UK
    Curr Opin Immunol 24:476-81. 2012
    ..Finally we assess the potential for manipulation of their activity and whether this may improve immune function during ageing...
  36. pmc Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
    Abhishek Das
    Division of Infection and Immunity, University College London, London W1T 4JF, England, UK
    J Exp Med 205:2111-24. 2008
    ..These data imply that polarized CD8 T cells within the HBV-infected liver may impede proliferative antiviral effector function, while contributing to the proinflammatory cytokine environment...
  37. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
    ..The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity...
  38. ncbi request reprint Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily
    Giuseppina Colonna-Romano
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Exp Gerontol 42:995-1002. 2007
    ..These findings may reflect disparate hygienic and nutritional conditions 70-90 yr ago, which were very different in Northern and Southern Europe at that time, as well as a different genetic background...
  39. ncbi request reprint Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 32:1621-30. 2002
    ..This would provide a mechanism for the generation of regulatory cells that induce tolerance to a wide array of antigens that may not be encountered in the thymus...
  40. pmc Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length
    Diana L Wallace
    Edward Jenner Institute for Vaccine Research, Compton, UK
    Immunology 119:243-53. 2006
    ..These data show that IL-7 and IL-15 induce cell proliferation and rescue from apoptosis in a concentration, time and subset-dependent manner, and have implications for the homeostatic expansion of the naïve CD8+ T-cell pool...
  41. ncbi request reprint Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis
    S John Curnow
    Department of Rheumatology, Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham, United Kingdom
    J Immunol 172:7154-61. 2004
    ....
  42. ncbi request reprint Telomere-based therapy for immunosenescence
    Janet M Lord
    MRC Centre for Immune Regulation, Birmingham University, B15 2TT, Birmingham, UK
    Trends Immunol 23:175-6. 2002
    ..The International Workshop on Telomeres and the Immune System: Ageing and Novel Intervention Strategies was held at Birmingham University, UK from 1-3 December 2001...
  43. ncbi request reprint Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    Helene M Finney
    Celltech R and D, 208 Bath Road, Slough, Berkshire SL1 3WE, United Kingdom
    J Immunol 172:104-13. 2004
    ..This type of chimeric receptor may now be used to discover the most potent combination of costimulatory signals that will improve current immunotherapeutic strategies...
  44. ncbi request reprint Telomere erosion: a new link between HLA DR4 and rheumatoid arthritis?
    Mike Salmon
    Department of Rheumatology, MRC Centre for Immune Regulation, Division of Immunity and Infection, Medical School, The University of Birmingham, Birmingham, B15 2TT, UK
    Trends Immunol 25:339-41. 2004
  45. ncbi request reprint The generation and antigen-specificity of CD4+CD25+ regulatory T cells
    Leonie S Taams
    Dept Immunobiology, King s College London, St Thomas Street, London SE1 9RT, UK
    Inflamm Allergy Drug Targets 5:149-56. 2006
    ..The aim of this review is to summarize the evidence supporting these opposing viewpoints and to combine them into a general model for the origin, function and antigen-specificity of CD4+CD25+ regulatory T cells...
  46. pmc Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis
    Dagmar Scheel-Toellner
    MRC Centre of Immune Regulation, Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Apoptosis 13:109-17. 2008
    ..We conclude that these two intracellular pools of Bcl-2 are regulated through different mechanisms and only the cytokine-mediated regulation of the mitochondrial pool is relevant to the control of the initiation of apoptosis...
  47. ncbi request reprint Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation
    Dagmar Scheel-Toellner
    MRC Centre for Immune Regulation, The Medical School, University of Birmingham, Birmingham B15 2TT, GB
    Eur J Immunol 32:486-93. 2002
    ..These findings suggest that activation of PKB and inhibition of apoptosis can be dissociated in cytokine-mediated rescue of non-transformed CD4+ T cells and neutrophils...
  48. ncbi request reprint The assessment of T-cell apoptosis in synovial fluid
    Karim Raza
    MRC Centre for Immune Regulation, Institute for Biomedical Research Building, University of Birmingham, UK
    Methods Mol Med 136:117-38. 2007
    ..The choice of assay depends, in part, on the phase of apoptosis under investigation and this review puts this into context by introducing these phases and their regulation...
  49. pmc Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
    ..Together, these data demonstrate that CD4+CD25+ Tregs can exert direct suppressive effects on monocytes/macrophages, thereby affecting subsequent innate and adaptive immune responses...