Research Topics
Genomes and GenesSpecies | M AkamSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Six3Patrick Rh Steinmetz
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Evodevo 1:14. 2010..abstract:..- Arthropods: developmental diversity within a (super) phylumM Akam
Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
Proc Natl Acad Sci U S A 97:4438-41. 2000..They also confirm that arthropod tagmosis reflects underlying patterns of Hox gene regulation but they do not yet resolve to what extent Hox expression domains may serve to define segment homologies... 
Homeotic gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabithorax and abdominal-A proteinsR Kelsh
Wellcome CRC Institute, Cambridge, United Kingdom
Dev Genet 15:19-31. 1994....- Ultrabithorax and the control of cell morphology in Drosophila halteresF Roch
University Museum of Zoology, Department of Zoology, Cambridge, UK fr213hermes cam ac uk
Development 127:97-107. 2000..The response of wing cells to Ubx at this time is sensitive to both the duration and level of Ubx exposure... - A role for Fringe in segment morphogenesis but not segment formation in the grasshopper, Schistocerca gregariaP Dearden
Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, UK
Dev Genes Evol 210:329-36. 2000..Like its Drosophila counterpart, Schistocerca fringe is also expressed in the eye, in rings in the legs, and during oogenesis, in follicle cells... - Organization of the Hox gene cluster in the grasshopper, Schistocerca gregariaD E Ferrier
Wellcome Cancer Research Campaign Institute, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 93:13024-9. 1996.... - Early embryo patterning in the grasshopper, Schistocerca gregaria: wingless, decapentaplegic and caudal expressionP K Dearden
Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
Development 128:3435-44. 2001..The expression of these marker genes suggests that embryonic pattern formation in the grasshopper occurs as cells move together to form the blastodisc... - Evolution of Ftz protein function in insectsC R Alonso
Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
Curr Biol 11:1473-8. 2001..These findings argue that this ftz CNS function is mediated by conserved parts of the protein, while efficient pair-rule function requires sequences present specifically in the Drosophila protein... - Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregariaP Dearden
University Museum of Zoology, Department of Zoology, Cambridge, UK
Evol Dev 2:261-70. 2000..The cytoplasmic localization of Sgzen protein in the oocyte, and at some stages during embryogenesis, implies that nuclear exclusion of this transcription factor is specifically controlled... - Hox genes: from master genes to micromanagersM Akam
University Museum of Zoology, Department of Zoology, Cambridge, UK
Curr Biol 8:R676-8. 1998.... - Hox genes and the phylogeny of the arthropodsC E Cook
University Museum of Zoology, Downing Street, CB2 3EJ, Cambridge, United Kingdom
Curr Biol 11:759-63. 2001..They also suggest that myriapods are more closely allied to the chelicerates than to this insect/crustacean clade... - Hox genes, homeosis and the evolution of segment identity: no need for hopeless monstersM Akam
University Museum of Zoology, Cambridge, United Kingdom
Int J Dev Biol 42:445-51. 1998.... - Segmentation in silicoP Dearden
Nature 406:131-2. 2000 - Class 3 Hox genes in insects and the origin of zenF Falciani
Department of Genetics, Wellcome Cancer Research Campaign Institute, Cambridge, England
Proc Natl Acad Sci U S A 93:8479-84. 1996..In the lineage leading to Drosophila, the zen genes have diverged particularly rapidly... - The role of homeotic genes in the specification of the Drosophila gonadS Greig
Wellcome CRC Institute, Cambridge, UK
Curr Biol 5:1057-62. 1995..Formation of the gonad requires the function of a specific homeotic gene, abdominal-A (abd-A). Other genes of the bithorax complex, Ultrabithorax (Ubx) or Abdominal-B (Abd-B), cannot substitute for this requirement when abd-A is removed... - Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of DrosophilaG Struhl
EMBO J 4:3259-64. 1985.... - Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early developmentV F Irish
Department of Genetics, University of Cambridge, UK
EMBO J 8:1527-37. 1989..We propose a model in which the initial activation of each homeotic gene promoter depends on a unique combination of gap and pair-rule gene activities... - Spatially ordered transcription of regulatory DNA in the bithorax complex of DrosophilaE Sánchez-Herrero
Department of Genetics, University of Cambridge, UK
Development 107:321-9. 1989..We suggest that these early transcription patterns reflect the initial activation of the BX-C... - The Drosophila posterior-group gene nanos functions by repressing hunchback activityV Irish
Department of Genetics, Cambridge, UK
Nature 338:646-8. 1989..These results suggest that the nos gene product functions by repressing the activity of the maternal hb products in the posterior of the egg... - Oligonucleotide probes detect splicing variants in situ in Drosophila embryosR D Artero
Department of Genetics, University of Valencia, Burjasot, Spain
Nucleic Acids Res 20:5687-90. 1992..Variant IVa is only detected in the CNS (ps6) at stages 16 and 17. We also present evidence indicating that the first splicing event is cotranscriptional... - How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameresJ Castelli-Gair
Wellcome CRC Institute, Cambridge, UK
Development 121:2973-82. 1995..The regulation of one downstream target of UBX, the Distalless gene, provides a model for this transition at the molecular level... - Dax, a locust Hox gene related to fushi-tarazu but showing no pair-rule expressionR Dawes
Wellcome CRC Institute, Cambridge, UK
Development 120:1561-72. 1994..We suggest that Schistocerca Dax and Drosophila ftz are homologous members of a gene family whose members are diverging relatively rapidly, both in terms of sequence and role in early development... - Dissecting the temporal requirements for homeotic gene functionJ Castelli-Gair
Wellcome CRC Institute, Cambridge, UK
Development 120:1983-95. 1994..We also provide evidence that supports the hypothesis of in vivo competition between the bithorax complex proteins for the regulation of their down-stream targets... - Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesodermS Greig
Wellcome CRC Institute, Cambridge, UK
Nature 362:630-2. 1993..We find that the pattern of adult muscle precursor cells characteristic of the thorax can be converted to that seen in the abdomen by expressing the homeotic gene abdominal-A specifically in the mesoderm... - Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryosI A Dawson
Department of Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536 0812
Development 117:359-76. 1993..These results demonstrate that fizzy is a cell cycle mutation and that the normal function of the fizzy gene is required for dividing cells to exit metaphase and complete mitosis... - A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogasterA M Hoogwerf
Biochemistry Department, Oxford University, England
Genetics 118:665-70. 1988..None was rescued by the active Lsp-2 gene transformed on to chromosome II and we conclude that, as yet, we have no lethal mutations of Lsp-2...