M Akam

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Six3
    Patrick Rh Steinmetz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Evodevo 1:14. 2010
  2. pmc Arthropods: developmental diversity within a (super) phylum
    M Akam
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Proc Natl Acad Sci U S A 97:4438-41. 2000
  3. ncbi request reprint Homeotic gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabithorax and abdominal-A proteins
    R Kelsh
    Wellcome CRC Institute, Cambridge, United Kingdom
    Dev Genet 15:19-31. 1994
  4. ncbi request reprint Ultrabithorax and the control of cell morphology in Drosophila halteres
    F Roch
    University Museum of Zoology, Department of Zoology, Cambridge, UK fr213hermes cam ac uk
    Development 127:97-107. 2000
  5. ncbi request reprint A role for Fringe in segment morphogenesis but not segment formation in the grasshopper, Schistocerca gregaria
    P Dearden
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, UK
    Dev Genes Evol 210:329-36. 2000
  6. pmc Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria
    D E Ferrier
    Wellcome Cancer Research Campaign Institute, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 93:13024-9. 1996
  7. ncbi request reprint Early embryo patterning in the grasshopper, Schistocerca gregaria: wingless, decapentaplegic and caudal expression
    P K Dearden
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Development 128:3435-44. 2001
  8. ncbi request reprint Evolution of Ftz protein function in insects
    C R Alonso
    Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 11:1473-8. 2001
  9. ncbi request reprint Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregaria
    P Dearden
    University Museum of Zoology, Department of Zoology, Cambridge, UK
    Evol Dev 2:261-70. 2000
  10. ncbi request reprint Hox genes: from master genes to micromanagers
    M Akam
    University Museum of Zoology, Department of Zoology, Cambridge, UK
    Curr Biol 8:R676-8. 1998

Collaborators

Detail Information

Publications26

  1. pmc Six3
    Patrick Rh Steinmetz
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Evodevo 1:14. 2010
    ..abstract:..
  2. pmc Arthropods: developmental diversity within a (super) phylum
    M Akam
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Proc Natl Acad Sci U S A 97:4438-41. 2000
    ..They also confirm that arthropod tagmosis reflects underlying patterns of Hox gene regulation but they do not yet resolve to what extent Hox expression domains may serve to define segment homologies...
  3. ncbi request reprint Homeotic gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabithorax and abdominal-A proteins
    R Kelsh
    Wellcome CRC Institute, Cambridge, United Kingdom
    Dev Genet 15:19-31. 1994
    ....
  4. ncbi request reprint Ultrabithorax and the control of cell morphology in Drosophila halteres
    F Roch
    University Museum of Zoology, Department of Zoology, Cambridge, UK fr213hermes cam ac uk
    Development 127:97-107. 2000
    ..The response of wing cells to Ubx at this time is sensitive to both the duration and level of Ubx exposure...
  5. ncbi request reprint A role for Fringe in segment morphogenesis but not segment formation in the grasshopper, Schistocerca gregaria
    P Dearden
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, UK
    Dev Genes Evol 210:329-36. 2000
    ..Like its Drosophila counterpart, Schistocerca fringe is also expressed in the eye, in rings in the legs, and during oogenesis, in follicle cells...
  6. pmc Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria
    D E Ferrier
    Wellcome Cancer Research Campaign Institute, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 93:13024-9. 1996
    ....
  7. ncbi request reprint Early embryo patterning in the grasshopper, Schistocerca gregaria: wingless, decapentaplegic and caudal expression
    P K Dearden
    Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Development 128:3435-44. 2001
    ..The expression of these marker genes suggests that embryonic pattern formation in the grasshopper occurs as cells move together to form the blastodisc...
  8. ncbi request reprint Evolution of Ftz protein function in insects
    C R Alonso
    Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 11:1473-8. 2001
    ..These findings argue that this ftz CNS function is mediated by conserved parts of the protein, while efficient pair-rule function requires sequences present specifically in the Drosophila protein...
  9. ncbi request reprint Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregaria
    P Dearden
    University Museum of Zoology, Department of Zoology, Cambridge, UK
    Evol Dev 2:261-70. 2000
    ..The cytoplasmic localization of Sgzen protein in the oocyte, and at some stages during embryogenesis, implies that nuclear exclusion of this transcription factor is specifically controlled...
  10. ncbi request reprint Hox genes: from master genes to micromanagers
    M Akam
    University Museum of Zoology, Department of Zoology, Cambridge, UK
    Curr Biol 8:R676-8. 1998
    ....
  11. ncbi request reprint Hox genes and the phylogeny of the arthropods
    C E Cook
    University Museum of Zoology, Downing Street, CB2 3EJ, Cambridge, United Kingdom
    Curr Biol 11:759-63. 2001
    ..They also suggest that myriapods are more closely allied to the chelicerates than to this insect/crustacean clade...
  12. ncbi request reprint Hox genes, homeosis and the evolution of segment identity: no need for hopeless monsters
    M Akam
    University Museum of Zoology, Cambridge, United Kingdom
    Int J Dev Biol 42:445-51. 1998
    ....
  13. ncbi request reprint Segmentation in silico
    P Dearden
    Nature 406:131-2. 2000
  14. pmc Class 3 Hox genes in insects and the origin of zen
    F Falciani
    Department of Genetics, Wellcome Cancer Research Campaign Institute, Cambridge, England
    Proc Natl Acad Sci U S A 93:8479-84. 1996
    ..In the lineage leading to Drosophila, the zen genes have diverged particularly rapidly...
  15. ncbi request reprint The role of homeotic genes in the specification of the Drosophila gonad
    S Greig
    Wellcome CRC Institute, Cambridge, UK
    Curr Biol 5:1057-62. 1995
    ..Formation of the gonad requires the function of a specific homeotic gene, abdominal-A (abd-A). Other genes of the bithorax complex, Ultrabithorax (Ubx) or Abdominal-B (Abd-B), cannot substitute for this requirement when abd-A is removed...
  16. pmc Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila
    G Struhl
    EMBO J 4:3259-64. 1985
    ....
  17. pmc Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development
    V F Irish
    Department of Genetics, University of Cambridge, UK
    EMBO J 8:1527-37. 1989
    ..We propose a model in which the initial activation of each homeotic gene promoter depends on a unique combination of gap and pair-rule gene activities...
  18. ncbi request reprint Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila
    E Sánchez-Herrero
    Department of Genetics, University of Cambridge, UK
    Development 107:321-9. 1989
    ..We suggest that these early transcription patterns reflect the initial activation of the BX-C...
  19. ncbi request reprint The Drosophila posterior-group gene nanos functions by repressing hunchback activity
    V Irish
    Department of Genetics, Cambridge, UK
    Nature 338:646-8. 1989
    ..These results suggest that the nos gene product functions by repressing the activity of the maternal hb products in the posterior of the egg...
  20. pmc Oligonucleotide probes detect splicing variants in situ in Drosophila embryos
    R D Artero
    Department of Genetics, University of Valencia, Burjasot, Spain
    Nucleic Acids Res 20:5687-90. 1992
    ..Variant IVa is only detected in the CNS (ps6) at stages 16 and 17. We also present evidence indicating that the first splicing event is cotranscriptional...
  21. ncbi request reprint How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres
    J Castelli-Gair
    Wellcome CRC Institute, Cambridge, UK
    Development 121:2973-82. 1995
    ..The regulation of one downstream target of UBX, the Distalless gene, provides a model for this transition at the molecular level...
  22. ncbi request reprint Dax, a locust Hox gene related to fushi-tarazu but showing no pair-rule expression
    R Dawes
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1561-72. 1994
    ..We suggest that Schistocerca Dax and Drosophila ftz are homologous members of a gene family whose members are diverging relatively rapidly, both in terms of sequence and role in early development...
  23. ncbi request reprint Dissecting the temporal requirements for homeotic gene function
    J Castelli-Gair
    Wellcome CRC Institute, Cambridge, UK
    Development 120:1983-95. 1994
    ..We also provide evidence that supports the hypothesis of in vivo competition between the bithorax complex proteins for the regulation of their down-stream targets...
  24. ncbi request reprint Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm
    S Greig
    Wellcome CRC Institute, Cambridge, UK
    Nature 362:630-2. 1993
    ..We find that the pattern of adult muscle precursor cells characteristic of the thorax can be converted to that seen in the abdomen by expressing the homeotic gene abdominal-A specifically in the mesoderm...
  25. ncbi request reprint Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos
    I A Dawson
    Department of Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536 0812
    Development 117:359-76. 1993
    ..These results demonstrate that fizzy is a cell cycle mutation and that the normal function of the fizzy gene is required for dividing cells to exit metaphase and complete mitosis...
  26. pmc A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogaster
    A M Hoogwerf
    Biochemistry Department, Oxford University, England
    Genetics 118:665-70. 1988
    ..None was rescued by the active Lsp-2 gene transformed on to chromosome II and we conclude that, as yet, we have no lethal mutations of Lsp-2...