Zubair Ahmed

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi request reprint Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Neurobiol Dis 37:441-54. 2010
  2. ncbi request reprint Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling
    Vasanthy Vigneswara
    1 Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Brain 137:1656-75. 2014
  3. pmc Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e53473. 2012
  4. pmc Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e57861. 2013
  5. pmc Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration
    Vasanthy Vigneswara
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Signal Transduct 2012:361721. 2012
  6. doi request reprint Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds
    Zubair Ahmed
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Electronic address
    Neurobiol Dis 64:163-76. 2014
  7. pmc AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury
    Zubair Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e61878. 2013
  8. ncbi request reprint Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 28:64-78. 2005
  9. doi request reprint Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Institute of Biomedical Research West, Edgbaston, Birmingham B15 2TT, UK
    Neurobiol Dis 36:142-50. 2009
  10. doi request reprint Satellite glia not DRG neurons constitutively activate EGFR but EGFR inactivation is not correlated with axon regeneration
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Neurobiol Dis 39:292-300. 2010

Collaborators

Detail Information

Publications36

  1. doi request reprint Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Neurobiol Dis 37:441-54. 2010
    ....
  2. ncbi request reprint Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling
    Vasanthy Vigneswara
    1 Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    Brain 137:1656-75. 2014
    ..This study offers insights for the development of effective therapeutics for promoting retinal ganglion cell survival and axon regeneration. ..
  3. pmc Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e53473. 2012
    ....
  4. pmc Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e57861. 2013
    ..Accordingly, inhibiting CASP2 expression is a potential therapy for improving both the SN regeneration response and peripheral sensory recovery...
  5. pmc Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration
    Vasanthy Vigneswara
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Signal Transduct 2012:361721. 2012
    ..This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration...
  6. doi request reprint Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds
    Zubair Ahmed
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Electronic address
    Neurobiol Dis 64:163-76. 2014
    ..Accordingly, intrathecal delivery of Decorin offers a potential translatable treatment for scar tissue attenuation in patients with spinal cord injury. ..
  7. pmc AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury
    Zubair Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e61878. 2013
    ..Thus, antagonizing AMIGO3 rather than LINGO-1 immediately after CNS injury is likely to be a more effective therapeutic strategy for promoting CNS axon regeneration when combined with neurotrophic factor administration...
  8. ncbi request reprint Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 28:64-78. 2005
    ..These results suggest that activation of MMP and coincident down-regulation of TIMP may act to attenuate the inhibitory scarring in the regenerating ON, thus transforming the ON into a noninhibitory pathway for axon regrowth...
  9. doi request reprint Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Institute of Biomedical Research West, Edgbaston, Birmingham B15 2TT, UK
    Neurobiol Dis 36:142-50. 2009
    ..Accordingly, we suggest that chemical EGFR inhibitors act independently of EGFR, inducing glia and neurons to secrete NT and raising cAMP levels in DRG cultures, leading to Trk-dependent disinhibited DRGN neurite outgrowth...
  10. doi request reprint Satellite glia not DRG neurons constitutively activate EGFR but EGFR inactivation is not correlated with axon regeneration
    Zubair Ahmed
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Neurobiol Dis 39:292-300. 2010
    ..Together, these data argue against a direct intra-axonal involvement of pEGFR in axon regeneration...
  11. doi request reprint Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA
    Zubair Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Neurobiol Dis 41:421-9. 2011
    ..We conclude that Citron-K regulates actin polymerisation downstream of RhoA and may offer a potentially novel therapeutic approach for promoting CNS axon regeneration...
  12. pmc Ocular neuroprotection by siRNA targeting caspase-2
    Z Ahmed
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Cell Death Dis 2:e173. 2011
    ....
  13. ncbi request reprint Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A
    Zubair Ahmed
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham, 3rd Floor Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH, UK
    Mol Cell Neurosci 28:509-23. 2005
    ..Together, these results suggest that Rho-A knockdown might be the most effective target for a disinhibition strategy to promote CNS axon regeneration in vivo...
  14. doi request reprint ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors
    Zubair Ahmed
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Room WX2 17 Institute of Biomedical Research West, Edgbaston, Birmingham, B15 2TT, UK
    Mol Cell Neurosci 42:128-33. 2009
    ..Our results suggest that Y27632-induced ROCK inhibition promotes robust disinhibited axon regeneration of adult neurons only when growth promoting factors are added and/or cAMP levels are raised...
  15. doi request reprint Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth
    Michael R Douglas
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Brain 132:3102-21. 2009
    ..These off-target effects of epidermal growth factor receptor kinase inhibition suggest a novel therapeutic approach for designing treatments to promote central nervous system axon regeneration...
  16. ncbi request reprint Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Brain 129:1517-33. 2006
    ..In all the above experimental paradigms, Schwann cell-derived factor/NTF-induced attenuation of NgR/p75NTR signalling suppresses EGFR activation, thereby potentiating axon growth disinhibition...
  17. ncbi request reprint Optimisation of siRNA-mediated RhoA silencing in neuronal cultures
    Ellen L Suggate
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B152TT, UK
    Mol Cell Neurosci 40:451-62. 2009
    ....
  18. ncbi request reprint Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury
    Ann Logan
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Brain 129:490-502. 2006
    ..Thus, combinatorial NTF administration synergistically enhanced neuronal survival, disinhibited axon growth and promoted axon regeneration through the hostile CNS environment without the intervention of scar tissue at the lesion site...
  19. doi request reprint Profiling RNA interference (RNAi)-mediated toxicity in neural cultures for effective short interfering RNA design
    Martin L Read
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Gene Med 11:523-34. 2009
    ..However, it is important to profile the biological impact of siRNA on cell homeostasis in order to develop safe and effective therapies...
  20. doi request reprint Targeting adenoviral transgene expression to neurons
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, Institute of Biomedical Research West, University of Birmingham, Edgbaston, Birmingham, UK
    Mol Cell Neurosci 39:411-7. 2008
    ..Moreover, since the effective titres of delivered Ad5 are reduced with this neuron specific promoter/WPRE expression cassette, the viral immune challenge should be attenuated when used in vivo...
  21. ncbi request reprint TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FASEB J 20:1939-41. 2006
    ..Thus, TACE-induced cleavage of NgR and RIP of p75(NTR) abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth...
  22. pmc Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury
    Vasanthy Vigneswara
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 54:2624-33. 2013
    ..To investigate neuroprotective and axogenic properties of pigment epithelium-derived factor (PEDF) in retinal ganglion cells (RGC) in vitro and in vivo...
  23. ncbi request reprint Regeneration of axons in the visual system
    Martin Berry
    Molecular Neuroscience Group, School of Experimental and Clinical Medicine, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Restor Neurol Neurosci 26:147-74. 2008
    ....
  24. doi request reprint In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones
    Karen Sims
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Gene Med 11:335-44. 2009
    ..Polymer coating of adenovirus type 5 (Ad5) particles produces a 'stealth' Ad5 (sAd5) that confers protection from immune recognition, blocks receptor-mediated uptake, and favours uptake into pinocytic cells...
  25. doi request reprint AAV8(gfp) preferentially targets large diameter dorsal root ganglion neurones after both intra-dorsal root ganglion and intrathecal injection
    Steven J Jacques
    Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Mol Cell Neurosci 49:464-74. 2012
    ..These results open up opportunities for targeted delivery of therapeutics such as neurotrophic factors to the injured spinal cord...
  26. doi request reprint Epidermal growth factor receptor antagonists and CNS axon regeneration: mechanisms and controversies
    Martin Berry
    Molecular Neuroscience Group, Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK
    Brain Res Bull 84:289-99. 2011
    ..This review discusses the current evidences for and against the involvement of EGFR in signalling myelin inhibition...
  27. doi request reprint Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy?
    Peter J Morgan-Warren
    Neurotrauma and Neurodegeneration Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 54:6903-16. 2013
    ..In this review, we explore the molecular basis of RGC regenerative failure and assess the potential for manipulations of mTOR signaling as a novel translatable treatment for TON. ..
  28. pmc A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids
    Martin L Read
    Molecular Neuroscience Group, Department of Medicine, University of Birmingham Birmingham, B15 2TT, UK
    Nucleic Acids Res 33:e86. 2005
    ..This should enable different or a combination of therapeutic strategies to be evaluated using a single type of polycation-based vector...
  29. doi request reprint Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization
    Richard J Blanch
    Neurotrauma and Neurodegeneration Section, Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 53:7220-6. 2012
    ..We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma...
  30. doi request reprint Animal models of retinal injury
    Richard J Blanch
    Neuropharmacology and Neurobiology Section, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 53:2913-20. 2012
    ..An understanding of the mechanisms underlying injury responses is critical to the successful development of therapeutic strategies to promote ocular repair...
  31. doi request reprint The role of angiogenic and wound-healing factors after spinal cord injury in mammals
    Sarina Kundi
    Neurotrauma and Neurodegeneration, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Neurosci Res 76:1-9. 2013
    ....
  32. ncbi request reprint Interleukin-12 induces mild experimental allergic encephalomyelitis following local central nervous system injury in the Lewis rat
    Zubair Ahmed
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neuroimmunol 140:109-17. 2003
    ..These results suggest that immune-mediated events in which IL-12 production is stimulated as for example viral infection, superimposed on a brain injury, could provide a trigger for a MS-like pathology...
  33. pmc A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow
    Ewan A Ross
    Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom
    PLoS ONE 3:e2338. 2008
    ..These findings suggest a novel role for PECAM-1 as a regulator of resting homeostatic progenitor cell numbers in the blood...
  34. pmc A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis : inflammation versus degeneration
    Zubair Ahmed
    Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
    Am J Pathol 161:1577-86. 2002
    ..Because caspase-3 is a downstream cell death signal it may be possible to reduce apoptosis by selectively blocking caspase-3 and therefore provide a therapeutic target for EAE and potentially, multiple sclerosis...
  35. ncbi request reprint Stabilisation of cables of fibronectin with micromolar concentrations of copper: in vitro cell substrate properties
    Zubair Ahmed
    University College London, Tissue Repair and Engineering Centre, Institute of Orthopaedics, RNOH Campus, Brockley Hill, HA7 4LP Stanmore, UK
    Biomaterials 25:803-12. 2004
    ..These results could be used to design biomaterials with optimum properties for promoting cellular ingrowth and survival in tissue engineered grafts which may be used to improve peripheral nerve repair...
  36. ncbi request reprint Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    Gareth Pryce
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 126:2191-202. 2003
    ..Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases...