Asif Ahmed

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125
    A Ahmed
    Department of Obstetrics and Gynaecology, Birmingham Women s Hospital, University of Birmingham, Edgbaston, UK
    FASEB J 12:831-43. 1998
  2. ncbi Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Circ Res 99:715-22. 2006
  3. pmc Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide
    Asif Ahmed
    Institute for Biomedical Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Circ Res 104:1333-6. 2009
  4. doi Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?
    Asif Ahmed
    Department of Reproductive and Vascular Biology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 37:1237-42. 2009
  5. pmc Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation
    A Ahmed
    Department of Reproductive and Vascular Biology, The University of Birmingham, Birmingham Women s Hospital, Edgbaston, UK
    Mol Med 6:391-409. 2000
  6. ncbi Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review
    A Ahmed
    Department of Reproductive and Vascular Biology, University of Birmingham, Birmingham Women s Hospital, Edgbaston, UK
    Placenta 21:S16-24. 2000
  7. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
  8. ncbi Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1
    Melissa Cudmore
    Department of Reproductive and Vascular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
    Circulation 115:1789-97. 2007
  9. doi Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells
    Bahjat Al-Ani
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Hypertension 55:689-97. 2010
  10. ncbi Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
    C Dunk
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, UK
    Histol Histopathol 16:359-75. 2001

Collaborators

Detail Information

Publications30

  1. ncbi Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125
    A Ahmed
    Department of Obstetrics and Gynaecology, Birmingham Women s Hospital, University of Birmingham, Edgbaston, UK
    FASEB J 12:831-43. 1998
    ..These data support our premise that this autocoid acts as an angiogenic mediator in the regeneration of the endometrium after menses and as a vasodilator to promote blastocyst attachment during the implantation process...
  2. ncbi Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Circ Res 99:715-22. 2006
    ..These studies provide new sites of modulation in VEGF-mediated vascular morphogenesis and highlight new therapeutic targets for management of vascular diseases...
  3. pmc Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide
    Asif Ahmed
    Institute for Biomedical Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Circ Res 104:1333-6. 2009
    ..These findings demonstrate a novel atheroprotective role for Ang-2 when endothelial cell function is compromised and suggest that growth factors, which stimulate NO release without inducing inflammation, could offer atheroprotection...
  4. doi Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?
    Asif Ahmed
    Department of Reproductive and Vascular Biology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 37:1237-42. 2009
    ..Any intervention achieving even a modest prolongation of pregnancy or amelioration of the condition could have a significant beneficial health impact worldwide...
  5. pmc Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation
    A Ahmed
    Department of Reproductive and Vascular Biology, The University of Birmingham, Birmingham Women s Hospital, Edgbaston, UK
    Mol Med 6:391-409. 2000
    ..The heme oxygenase (HO) enzymes generate carbon monoxide (CO) that induces blood vessel relaxation and biliverdin that acts as an endogenous antioxidant...
  6. ncbi Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review
    A Ahmed
    Department of Reproductive and Vascular Biology, University of Birmingham, Birmingham Women s Hospital, Edgbaston, UK
    Placenta 21:S16-24. 2000
    ..Taken together these changes provide a molecular explanation for the observed poor angiogenesis in the pathogenesis of IUGR...
  7. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
  8. ncbi Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1
    Melissa Cudmore
    Department of Reproductive and Vascular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK
    Circulation 115:1789-97. 2007
    ..Thus, we hypothesized that HO-1 upregulation may offer protection against preeclampsia by inhibiting sFlt-1 and sEng release...
  9. doi Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells
    Bahjat Al-Ani
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Hypertension 55:689-97. 2010
    ....
  10. ncbi Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
    C Dunk
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, UK
    Histol Histopathol 16:359-75. 2001
    ..The results demonstrate functional VEGFR-2 and VEGFR-3 receptors on trophoblast and suggest that the decreased expression of VEGF-C and VEGFR-3 may contribute to the abnormal villous development observed in IUGR placenta...
  11. ncbi VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways
    Melissa Cudmore
    Department of Reproductive and Vascular Biology, Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, UK
    Biochem Biophys Res Commun 345:1275-82. 2006
    ..Our data provide the first demonstration that VEGFR-2-mediated NO signaling and subsequent angiogenesis is through a mechanism that is dependent on PLCgamma but independent of cGMP and PKG...
  12. pmc Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide
    B Bussolati
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Pathol 159:993-1008. 2001
    ....
  13. pmc Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells
    C Dunk
    Department of Reproductive and Vascular Biology, Division of Reproductive and Child Health, The Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Pathol 158:265-73. 2001
    ..It shows that VEGFR-1 induces cell cytostasis via NO and as such is a suitable target for molecular strategies suppressing tumorigenesis...
  14. ncbi Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Endothelium 12:89-95. 2005
    ..Our study demonstrates that hypoxia positively regulates sVEGFR-1 protein expression in ex vivo trophoblasts, which control VEGF-driven angiogenesis...
  15. ncbi Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia
    Keqing Wang
    Vascular Medicine Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
    Circulation 127:2514-22. 2013
    ..We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and maternal hypertension...
  16. ncbi Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration
    Benedetta Bussolati
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, B12 2TG, United Kingdom
    Blood 103:761-6. 2004
    ....
  17. pmc Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Hypertension 51:1010-9. 2008
    ..These autoantibodies represent potentially important targets for diagnosis and therapeutic intervention...
  18. pmc Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development
    C Dunk
    Department of Reproductive and Vascular Biology, University of Birmingham, Birmingham Women s Hospital, United Kingdom
    Am J Pathol 156:2185-99. 2000
    ....
  19. pmc Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to Ets binding sites
    Peter W Hewett
    Department of Vascular and Reproductive Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Mol Med 12:8-16. 2006
    ....
  20. doi Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner
    Christopher J Mee
    Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    Gastroenterology 138:1134-42. 2010
    ..The mechanisms underlying liver injury in chronic hepatitis C are poorly understood. This study evaluated the role of vascular endothelial growth factor (VEGF) in hepatocyte polarity and HCV infection...
  21. ncbi Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells
    Jonathan R Roberts
    Lung Injury and Fibrosis Treatment Program, Department of Medical Sciences, The Medical School University of Birmingham, Birmingham, UK
    Crit Care Med 35:2164-70. 2007
    ..This study tested the hypothesis that VEGF acts as an autocrine trophic factor for human adult alveolar epithelial cells and that under situations of pro-apoptotic stress, VEGF reduces cell death...
  22. pmc Down-regulation of angiopoietin-1 expression in menorrhagia
    Peter Hewett
    Department of Reproductive and Vascular Biology, TheMedical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Pathol 160:773-80. 2002
    ..These results suggest that the angiopoietin/Tie-2 system promotes vascular remodeling in endometrium and loss of normal Ang-1 expression may contribute to the excessive blood loss observed in menorrhagia...
  23. pmc Modulation of trophoblast cell death by oxygen and EGF
    Jonathan Perkins
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Birmingham, UK
    Mol Med 8:847-56. 2002
    ....
  24. ncbi Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3',5'-monophosphate
    J D Ramsden
    Department of Medicine, University of Birmingham, Birmingham, United Kingdom B15 2TT
    J Clin Endocrinol Metab 86:2709-16. 2001
    ..Tie-2 expression is increased in goiter in both humans and rats, consistent with a role in goitrogenesis...
  25. ncbi VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling
    CLARENCE M FINDLEY
    Department of Pharmacology and Cancer Biology, Duke University Medical Center and the Duke University School of Medicine, Durham, NC, Durham, NC 27710, USA
    Arterioscler Thromb Vasc Biol 27:2619-26. 2007
    ..We investigated mechanisms responsible for Tie2 shedding and its effects on Tie2 signaling and endothelial cellular responses...
  26. pmc Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin, MSB 6 200 Houston, TX 77030, USA
    Circ Res 100:88-95. 2007
    ....
  27. ncbi Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, UK
    Microvasc Res 71:20-31. 2006
    ....
  28. ncbi Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells
    Jun Cai
    Department of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
    Diabetes 52:2959-68. 2003
    ..Together, these findings indicate that PlGF-containing ligands contribute to pathological angiogenesis by prolonging cell survival signals and maintaining vascular networks...
  29. doi Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses
    Fatima Crispi
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Instituto de Salud Carlos III, Hospital Clinic University of Barcelona, Barcelona, Spain
    Am J Obstet Gynecol 199:254.e1-8. 2008
    ..The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration...